• Verma S, Quirt I, McCready D, Bak K, Charette M, Iscoe N, Melanoma Disease Site Group. Systemic adjuvant therapy for patients at high risk for recurrent melanoma: a clinical practice guideline. Toronto (ON): Cancer Care Ontario (CCO); 2005 Aug 30. 39 p. (Evidence-based series; no. 8-1). [61 references]

It is recommended that high-dose interferon alpha therapy (20 X10⁶ U/m²/d intravenously five days/week for four weeks, then 10 X 10⁶ U/m² subcutaneously three times weekly for 48 weeks) be discussed and offered to the high-risk group as defined in the guideline question (see "Target Population" field). It may be used as adjuvant treatment, provided that each patient has been made aware of the relative risks, benefits, and costs of this therapy and wishes to proceed.

None provided

The recommendations are supported by randomized controlled trials and meta-analyses.

• Verma S, Quirt I, McCready D, Bak K, Charette M, Iscoe N, Melanoma Disease Site Group. Systemic adjuvant therapy for patients at high risk for recurrent melanoma: a clinical practice guideline. Toronto (ON): Cancer Care Ontario (CCO); 2005 Aug 30. 39 p. (Evidence-based series; no. 8-1). [61 references]

Not applicable: The guideline was not adapted from another source.

1998 May 27 (revised 2005 Aug 30)

Program in Evidence-based Care - State/Local Government Agency [Non-U.S.]

The Program in Evidence-based Care (PEBC) is a Province of Ontario initiative sponsored by Cancer Care Ontario and the Ontario Ministry of Health and Long-Term Care.

Cancer Care Ontario
Ontario Ministry of Health and Long-Term Care

Provincial Melanoma Disease Site Group

Melanoma Disease Site Group members were asked to disclose potential conflict of interest information; no conflicts were declared.

None available

This summary was completed by ECRI on August 19, 1999. The information was verified by the guideline developer as of September 17, 1999. The summary was updated by ECRI on August 10, 2001 and verified by the guideline developer as of August 22, 2001. This NGC summary was updated by ECRI on March 20, 2003. The information was verified by the guideline developer on May 8, 2003. This NGC summary was most recently updated on September 27, 2004. The updated information was verified by the guideline developer on October 20, 2004. This NGC summary was updated by ECRI on June 29, 2006. The updated information was verified by the guideline developer on July 7, 2006.