• Cincinnati Children's Hospital Medical Center. Evidence-based clinical care guideline for acute gastroenteritis (AGE) in children aged 2 months through 5 years. Cincinnati (OH): Cincinnati Children's Hospital Medical Center; 2006 May. 15 p. [50 references]

This is the current release of the guideline.

This guideline updates a previous version: Cincinnati Children's Hospital Medical Center. Evidence based clinical practice guideline for children with acute gastroenteritis (AGE). Cincinnati (OH): Cincinnati Children's Hospital Medical Center; 2001 Apr. 13 p.

The guideline was reviewed for currency in May 2006, using updated literature searches and was determined to be current.

Each recommendation is followed by evidence classification (A-X) identifying the type of supporting evidence. Definitions for the types of evidence are presented at the end of the "Major Recommendations" field.

Assessment and Diagnosis

Clinical Assessment

1. It is recommended that the history and physical examination be the primary basis for the diagnosis of acute gastroenteritis (AGE). See Figure and Appendix 1 in the original guideline document (Local Expert Consensus, 2005 [E]).
2. It is recommended that clinical assessment be initially performed for the presence and degree of dehydration (Steiner, DeWalt, & Byerley, 2004 [M]). See Appendix 2 in the original guideline document for physical parameters associated with degree of dehydration. See Table 2 and Table 3 in the original guideline document for likelihood ratios of clinical signs.

   Note 1: Prolonged capillary refill time, abnormal skin turgor, and absent tears are the best individual examination measures (Steiner, DeWalt, & Byerley, 2004 [M]) (see Table 2, Table 3, and Appendix 2 in the original guideline document).

   Note 2: Clinical diagnosis of dehydration has been shown to be imprecise and thus a general classification of a child's dehydration status such as none, some (mild/moderate), or severe is suggested by the literature as a useful starting point in the management of the child at risk for dehydration (Steiner, DeWalt, & Byerley, 2004 [M]; King et al., 2003 [S, E]).

   Note 3: Acute body weight change is considered the gold standard measure of dehydration in a child but is often impractical for the initial assessment due to lack of an accurate pre-illness weight measurement (Gorelick, Shaw, & Murphy, 1997 [C]; Duggan et al., 1996 [C]).

Laboratory Studies

3. It is recommended that laboratory tests not be routinely performed in children with signs and symptoms of AGE, including tests for specific pathogens, such as those for rotavirus, ova and parasites, bacteria, and fecal antigen tests for parasites (Northrup & Flanigan, 1994 [S]; Local Expert Consensus, 2005 [E]).

   Note: Serum electrolytes are sometimes useful in assessing children with moderate to severe dehydration and who require intravenous (IV) or nasogastric (NG) fluids. A normal bicarbonate concentration may be useful in ruling out dehydration (Steiner, DeWalt & Byerley, 2004 [M]).

Management Recommendations

Prevention of Dehydration

4. It is recommended that continued use of the child's preferred, usual, and age appropriate diet be encouraged to prevent or limit dehydration (Brown, Peerson, & Fontaine, 1994 [M]; Fayad et al., 1993 [A]; Alarcon et al., 1992 [A]). Regular diets are generally more effective than restricted and progressive diets, and in numerous trials have consistently produced a reduction in the duration of diarrhea (Alarcon et al., 1991 [A]; Margolis et al., 1990 [B]; Placzek & Walker-Smith, 1984 [B]; Khin et al., 1985 [C]).

   Note 1: The historical BRAT diet (consisting of bananas, rice, applesauce, and toast) is unnecessarily restrictive, but may be offered as part of the child's usual diet (King et al., 2003 [S,E]).

   Note 2: Clear liquids are not recommended as a substitute for oral rehydration solutions (ORS) or regular diets in the prevention or therapy of dehydration (King et al., 2003 [S,E]) (See Appendix 4 in the original guideline document).

   Note 3: The vast majority of patients with AGE do not develop clinically important lactose intolerance. In selected patients with documented, persistent lactose intolerance, lactose-free formulas are recommended (Brown, Peerson, & Fontaine, 1994 [M]).

   Note 4: A meta-analysis of 16 studies found no significant clinical advantage to diluting milk or formula in the management of AGE (Brown, Peerson, & Fontaine, 1994 [M]).

5. It is recommended that the vomiting child be offered frequent small feedings (every 10 to 60 minutes) of any tolerated foods or ORS (Wan et al., 1999 [A]; Santosham et al., 1985 [A]).
6. It is recommended that a child with recurrent vomiting but no signs of significant dehydration may be managed by frequent telephone follow up or by direct supervision in the office, emergency department, or in a hospital setting (see Appendix 1 in the original guideline document for triage suggestions) (Local Expert Consensus, 2005 [E]).

Rehydration

7. It is recommended that dehydration be treated with ORS, if tolerated and if intake exceeds losses, for a period of 4 to 6 hours or until an adequate degree of rehydration is achieved (Gavin, Merrick, & Davidson, 1996 [M]; Gore, Fontaine, & Pierce, 1992 [M]; Cohen et al., 1995 [A]; Molina et al., 1995 [A]; Fayad et al., 1993 [A]; Santosham et al., 1985 [A]; Santosham et al., 1982 [A]; Atherly-John, Cunningham, & Crain, 2002 [B]; Nager & Wang, 2002 [B]; Listernick, Zieserl, & Davis, 1986 [B]; Tamer et al., 1985 [C]; King et al., 2003 [S,E]; Holliday, 1996 [S,E]).
8. It is recommended
   • when unable to replace the estimated fluid deficit and keep up with the on-going losses using oral feedings alone, and/or
   • for severely dehydrated children with obtunded mental status

   that IV fluids or NG ORS be given for a period of 4 to 6 hours or until an adequate degree of rehydration is achieved. It is appropriate to involve the family in the decision regarding the method of fluid replacement (Cohen et al., 1995 [A]; Mackenzie & Barnes, 1991 [A]; Santosham et al., 1982 [A]; Nager & Wang, 2002 [B]; Vesikari, Isolauri, & Baer, 1987 [B]; Listernick, Zieserl, & Davis, 1986 [B]; Tamer et al., 1985 [C]; King et al., 2003 [S,E]).

Oral Feeding Following Rehydration

9. It is recommended that refeeding of the usual diet be started at the earliest opportunity after an adequate degree of rehydration is achieved (Cohen et al., 1995 [A]; Fayad et al., 1993 A]; Santosham et al., 1982 [A]; Fox et al., 1990 [B]; Hjelt et al., 1989 [B]; Gazala et al., 1988 [B]; Walker-Smith et al., 1997 [S,E]).

   Note 1: Following rehydration therapy in the child with mild to moderate dehydration, regular diets may be supplemented with oral rehydration solutions containing at least 45 mEq Na⁺/L, and targeted to deliver 10mL/kg for each stool or emesis (Cohen et al., 1995 [A]) (see Appendix 4 in the original guideline document).

   Note 2: It is advisable to reassess hydration status by phone or in the office when a child refuses ORS. Refusal may indicate an absence of salt craving, and, as such, the absence or resolution of dehydration (Local expert Consensus, 2005 [E]).

On-going IV or NG Fluids following Rehydration

10. It is recommended that maintenance IV fluids or NG ORS be given:
    • when unable to replace the estimated fluid deficit and keep up with the on-going losses using oral feedings alone, and/or
    • to severely dehydrated children with obtunded mental status, and after discussion with family regarding choice of IV or NG (Cohen et al., 1995 [A]; Mackenzie & Barnes, 1991 [A]; Santosham et al., 1982 [A]; Nager & Wang, 2002 [B]; Vesikari, Isolauri, & Baer, 1987 [B]; Listernick, Zieserl, & Davis, 1986 [B]; Tamer et al., 1985 [C]).

Other Therapy

11. It is recommended that anti-diarrheal agents or antiemetics not be used in the routine management of children with AGE (King et al., 2003 [S,E]).

    Note: Ondansetron may decrease vomiting and hospitalization rates in those patients who require IV or NG fluids (Reeves, Shannon, & Fleisher, 2002 [A]; Ramsook et al., 2002 [B]).

12. It is recommended that antimicrobial therapies be used only for selected children with AGE who present with special risks or evidence of a serious bacterial infection (SBI) (Barbara et al., 2000 [C]) (see Appendix 5 in the original guideline document).

    Note: Giardia lamblia and Cryptosporidium are common causes of persistent diarrhea and, if found, treatment is available with metronidazole or nitazoxanide (American Academy of Pediatrics, 2003 [O]).

13. It is recommended that probiotics be considered as adjunctive therapy, as they have been shown to reduce the duration of diarrhea (Allen et al., 2004 [M]). Family preference may be central to the decision to use probiotics. Parameters influencing the family's decision may include cost, degree of potential benefit, availability, and unverified effectiveness of commercial products.

    Note 1: A Cochrane meta-analysis of 23 randomized controlled trials found mild therapeutic benefit from probiotics that was generally reproducible regardless of organism, quality of study design, or outcome measure (Allen et al., 2004 [M]). The following organisms/combinations showed benefit in one or more study (in alphabetical order):

    • Enterococcus LAB strain SF68
    • Lactobacillus acidophilus and Lactobacillus bifidus
    • Lactobacillus acidophilus LB strain (killed)
    • Lactobacillus casei strain GG
    • Lactobacillus reuteri

    Note 2: Probiotics may be more effective for rotavirus diarrhea, compared to all-cause diarrhea (Allen et al., 2004 [M]).

    Note 3: The microorganisms used to culture yogurt, Streptococcus thermophilus and Lactobacillus bulgaricus, are not considered probiotics because they do not survive the acidity of the stomach to colonize the intestines. One study of malnourished infants found that yogurt, compared to milk, was not effective in reducing the duration of diarrhea (Allen et al., 2004 [M]; Bhatnagar et al., 1998 [B]).

Inpatient Management Considerations

14. It is recommended that those patients who are treated in the hospital setting and who are eligible for the AGE guideline be placed as Short Stay patients with a discharge goal of 23 hours or less (Browne & Penna, 1996 [C]; McConnochie et al., 1999 [D]).
15. It is recommended that for children receiving care in a hospital setting, prompt discharge be considered when the following levels of recovery are reached:
    • Sufficient rehydration achieved as indicated by weight gain and/or clinical status
    • IV or NG fluids not required
    • Oral intake equals or exceeds losses
    • Adequate family teaching has occurred
    • Medical follow up is available via telephone or office visit

    (Local Expert Consensus, 2005 [E]).

Education

16. It is recommended that return to school/daycare be discussed in the context of the following parameters:
    • Consideration for controlling disease transmission
      • No vomiting for 24 hours
      • Stools are able to be adequately contained
      • Assurance that daycare/school adheres to appropriate handwashing policies
    • Temperature less than 38.0 degrees C (100.4 degrees F)

    (Local Expert Consensus, 2005 [E]).

17. It is recommended that risk factors and preventive activities be discussed with parents, including:
    • Continue breastfeeding (Wan et al., 1999 [A]; Khin et al., 1985 [C])
    • Handwashing

Definitions:

Evidence Grading Scale:

A: Randomized controlled trial: large sample
B: Randomized controlled trial: small sample
C: Prospective trial or large case series
D: Retrospective analysis
E: Expert opinion or consensus
F: Basic laboratory research
S: Review article
M: Meta-analysis
Q: Decision analysis
L: Legal requirement
O: Other evidence
X: No evidence

Algorithms are provided in the original guideline document for:

• The evaluation and management for acute gastroenteritis in children aged 2 months through 5 years
• A decision tool for helping decide when to obtain stool cultures and when a child may benefit from antimicrobial therapies

The type of evidence is classified for the recommendations (see "Major Recommendations").

Evidence Grading Scale:

A: Randomized controlled trial: large sample
B: Randomized controlled trial: small sample
C: Prospective trial or large case series
D: Retrospective analysis
E: Expert opinion or consensus
F: Basic laboratory research
S: Review article
M: Meta-analysis
Q: Decision analysis
L: Legal requirement
O: Other evidence
X: No evidence

• Cincinnati Children's Hospital Medical Center. Evidence-based clinical care guideline for acute gastroenteritis (AGE) in children aged 2 months through 5 years. Cincinnati (OH): Cincinnati Children's Hospital Medical Center; 2006 May. 15 p. [50 references]

Not applicable: The guideline was not adapted from another source.

1999 Nov (revised 2005 Oct 31; reviewed 2006 May)

Cincinnati Children's Hospital Medical Center - Hospital/Medical Center

Cincinnati Children's Hospital Medical Center

Acute Gastroenteritis Team

Acute Gastroenteritis Team 2005

Community Physicians: *Philip Lichtenstein, MD, Chair; William DeBuys, MD

Cincinnati Children's Hospital Medical Center Physicians: *Mitchell Cohen, MD, Gastroenterology; *Scott Reeves, MD, Emergency Medicine; *Mary Staat, MD, MPH, Infectious Diseases; *Stavra Xanthakos, MD, Gastroenterology; Katie Kerrey, MD, Chief Resident; Anne McCarthy, MD, Resident

Patient Services: *Lynn Daum, RN, Emergency Department; Michelle Widecan, RN, CRNP, Emergency Department; *Shirley Salway, RN, Inpatient; *Susan Smith, RD, Nutrition Services

Division of Health Policy & Clinical Effectiveness Support: Eloise Clark, MPH, Facilitator; Danette Stanko, MA, MPH, Epidemiologist; *Kate Rich, Lead Decision Support Analyst; Carol Frese, RN, Medical Reviewer; Edward Donovan, MD, Medical Director, Clinical Effectiveness; *Uma Kotagal, MBBS, MSc, VP, Division Director; Eduardo Mendez, RN, MPH, Dir. Evidence-Based Care; Detrice Barry, RN, MSN, Education Coordinator

All Team Members and Clinical Effectiveness support staff listed above have signed a conflict of interest declaration.

Ad hoc Advisors: *Michael Farrell, MD, Chief of Staff; *Richard Ruddy, MD, Emergency Medicine, Director; *Tom DeWitt, MD, Gen. & Community Pediatrics, Director; *Mel Rutherford, Esq, VP, Legal Services; *Dorine Sequist, RN, VP, Patient Services; Joel Mortensen, PhD, PhD, HCLD, FAAM, Dir. Laboratory; Barbarie Hill, Pratt Library; Elizabeth Elliott, MBBS, MD, FRACP, Gastro., U Sydney, Australia; Greg Randolph, MD, Pediatrician, UNC, Chapel Hill; Joan Bothner, MD, Emergency Med, The Children's Hosp, Denver

*Member of previous Acute Gastroenteritis guideline development Teams

The guideline was developed without external funding. All Team Members and Clinical Effectiveness support staff listed have declared whether they have any conflict of interest and none were identified.

This is the current release of the guideline.

This guideline updates a previous version: Cincinnati Children's Hospital Medical Center. Evidence based clinical practice guideline for children with acute gastroenteritis (AGE). Cincinnati (OH): Cincinnati Children's Hospital Medical Center; 2001 Apr. 13 p.

The guideline was reviewed for currency in May 2006, using updated literature searches and was determined to be current.

This summary was completed by ECRI on September 1, 1998. The information was verified by the guideline developer on December 1, 1998. This summary was updated by ECRI on March 18, 2002, and reviewed by the guideline developer as of May 7, 2002. This summary was updated by ECRI on December 19, 2005. The updated information was verified by the guideline developer on January 9, 2006. This summary was updated by ECRI on July 14, 2006. The updated information was verified by the guideline developer on July 21, 2006.