This is the current release of the guideline.

Male infertility

Treatment

Family Practice
Internal Medicine
Medical Genetics
Obstetrics and Gynecology
Urology

Physicians

To present recommendations for the treatment of male infertility using round spermatid nucleus injection (ROSNI)

Men who are infertile

Round spermatid nucleus injection (ROSNI)

• Fertilization rates
• Adverse effects of procedure

Searches of Electronic Databases

Not stated

Not stated

Not stated

Not applicable

Review

Not stated

Not stated

Not applicable

A formal cost analysis was not performed and published cost analyses were not reviewed.

Internal Peer Review

This bulletin was approved by the Practice Committee of the American Society for Reproductive Medicine and the Board of Directors of the American Society of Reproductive Medicine.

• Round spermatid nucleus injection (ROSNI) is a method of assisted fertilization in which precursors of mature spermatozoa are injected into oocytes.
• ROSNI should not be performed when more mature sperm forms (elongating spermatids or spermatozoa) can be identified and used for intracytoplasmic sperm injection (ICSI).
• Patients who may be candidates for ROSNI should receive careful and thorough pretreatment counseling to ensure they are clearly informed of the limitations and potential risks of the procedure.
• Application of ROSNI in clinical human in vitro fertilization (IVF) should be considered experimental and therefore requires approval and oversight by an appropriately constituted Institutional Review Board.

None provided

The type of supporting evidence is not specifically stated for each recommendation.

Effective treatment of male infertility using round spermatid nucleus injection (ROSNI)

Offspring conceived via in vitro fertilization (IVF) with round spermatid nucleus injection (ROSNI) may be at risk for infertility or even more severe genetic defects.

• While this document reflects appropriate management of a problem encountered in the practice of reproductive medicine, it is not intended to be the only approved standard of practice or to dictate an exclusive course of treatment. Other plans of management may be appropriate, taking into account the needs of the individual patient, available resources and institutional or clinical practice limitations.
• The Practice Committee recommends that round spermatid nucleus injection (RSNI) be considered an experimental procedure that should be applied only in the setting of a clinical trial approved and overseen by a properly constituted Institutional Review Board.

An implementation strategy was not provided.

Getting Better

Effectiveness
Patient-centeredness

Not applicable: The guideline was not adapted from another source.

2003 Sep

American Society for Reproductive Medicine - Private Nonprofit Organization

American Society for Reproductive Medicine

Practice Committee of the American Society for Reproductive Medicine

Practice Committee of the Society for Assisted Reproductive Technology

Not stated

Not stated

This is the current release of the guideline.

None available

None available

This NGC summary was completed by ECRI on August 23, 2004.

This NGC summary is based on the original guideline, which is subject to the guideline developer's copyright restrictions.