• March 2, 2005, Crestor (rosuvastatin calcium): Revisions to the WARNINGS, DOSAGE AND ADMINISTRATION, CLINICAL PHARMACOLOGY, and PRECAUTIONS sections of the labeling.

Screening Algorithm

Note: A list of all abbreviations is provided at the end of the "Major Recommendations" field.

1. Adult Patient Enrolled in the Health Care System

   Definition

   This guideline addresses adults (age 17 years or older) eligible for care in the Veterans Health Administration/ Department of Defense (VHA/DoD) healthcare systems.

2. Does Patient Have a History of Cardiovascular Disease (CVD)?

   Objective

   Identify patients who may benefit from lipid lowering therapy.

   Recommendations

   1. All patients with known CVD are considered high-risk and should be treated with aggressive lipid-lowering therapy to prevent acute vascular events. These include, but are not limited to, acute myocardial infarction (AMI) or cerebrovascular accident (CVA).

3. Does Patient Have Diabetes Mellitus?

   Objective

   Identify patients known to be at high-risk due to diabetes mellitus (DM).

   Recommendation

   1. Patients with Type 2 DM are at significantly increased risk of CVD compared with non-diabetic patients of similar age and should, therefore, be treated more aggressively according to secondary prevention protocols. [A]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

4. Assess Risk Factors for Cardiovascular Disease

   Objective

   Identify clinical markers that predict an increased risk for developing CVD, thereby changing the interpretation of low-density lipoprotein (LDL) levels.

   Recommendations

   1. Patients screened for dyslipidemia should be assessed for risk factors for CVD. Assessment should include, but not be limited to, the following:
      1. Age (males >age 45 and females >age 55)
      2. Family history of premature coronary artery disease; definite myocardial infarction (MI) or sudden death before age 55 in father or other male first-degree relative, or before age 65 in mother or other female first-degree relative
      3. Current tobacco use/cigarette smoking (or within the last month)
      4. Hypertension (systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg confirmed on more than one occasion, or current therapy with anti-hypertensive medications)
      5. Diabetes mellitus (DM) (elevated fasting blood sugar [>126 mg/dL], or a random blood sugar [>200 mg/dL] confirmed on more than one occasion, an abnormal glucose tolerance test or current therapy with anti-diabetic medications)
      6. Level of high-density lipoprotein cholesterol (HDL-C) (less than 40 mg/dL confirmed on more than one occasion).
   2. In obese patients (body mass index [BMI] >30), waist circumference measurement should be obtained to assist in the diagnosis of metabolic syndrome.

5. Lipid Screening Criteria

   Objective

   Appropriately target individuals for lipid profile screening.

   Lipid Screening Criteria
   Male age 35 or older OR female age 45 or older OR Young adults with more than one of the following: Family history of premature CVD Patient is smoking Patient has or is being treated for hypertension Consider obtaining lipid profile for young adults with abdominal obesity

   Recommendations

   1. Fasting lipid profile testing should be obtained in all men age 35 and older and women age 45 years or older every 5 years. [A]
   2. Fasting lipid profile testing should be obtained in individuals with a family history or clinical evidence of familial hyperlipidemia. [A]
   3. Fasting lipid profile testing in young adults may be considered depending upon the association with other risk factors. Younger adults (men younger than age 35 and women age 45 or younger) should be screened for lipid disorders if they have one or more of the following risk factors: family history of premature CVD, hypertension (or under treatment for hypertension [HTN]), or smoking. [B]
   4. A lipid profile should be obtained for individuals with abdominal obesity (waist circumference >40 inches in men and >35 inches in women) to aid in assessment of metabolic syndrome. [B]
   5. All persons with average or below average risk for atherosclerotic events should be screened for dyslipidemia every five years. [I]
   6. Elderly patients age 75 or older should be screened if they have multiple CVD risk factors, or a history of CVD and good quality of life with no other major life-limiting diseases. [I]

   The Recommended Screening Schedules for Dyslipidemia

   For young adults (men <age 35; women <age 45) Every 5 years when no CVD risk factors are present More often, if family history of premature CVD exists (definite MI or sudden death before 55 years of age in father or other male first-degree relative or before age 65 in mother or other female first-degree relative) For middle-aged adults (men >age 35; women >age 45) Every 5 years, when no CVD risk factors are present Annually, if CVD risk factors exist (HTN, smoking, family history of premature CVD) For elderly patients up to age 75 years Every 5 years when no CVD risk factors are present More often if CVD risk factors exist For elderly patients >age 75 Evaluate if patient has multiple CVD risk factors, established CVD, or a history of revascularization procedures and good quality of life with no other major life-limiting diseases.

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

6. Obtain a Fasting Lipid Profile

   Objective

   Screen appropriate patients for the presence of dyslipidemia.

   Lipid Screening Test
   Ensure test obtained in fasting state (9 to 14 hour fast) Total cholesterol (TC), triglycerides (TG), and HDL-C are measured directly LDL-C is calculated, therefore, TG level should be considered (If TG >400 mg/dL, try to reduce with diet and exercise, or consider direct measurement of LDL-C)

   Recommendations

   1. A complete fasting lipid profile should be obtained in an individual with other risk factors for coronary disease. [A]
   2. Clinical decisions should be based upon lipid profiles done 1 to 8 weeks apart (fasting) with an LDL-C or TC difference of <30 mg/dL. [I]
   3. Lipid profiles should not be obtained within 8 weeks of acute hospitalization, surgery, trauma, or infection unless they are obtained within 12 to 24 hours of the event to ensure accuracy. [I]
   4. Lipid profiles should not be measured in pregnant women until three to four months post partum. [I]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

7. TG >400 mg/dL, Apply Diet and Exercise to Reduce TG; Consider Direct Measurement of LDL-C

   Objective

   Identify patients whose LDL-C is confounded by secondary/modifiable causes of hypertriglyceridemia.

   Recommendations

   1. If TG levels can be brought to <400 mg/dL by dietary or other interventions, then Friedewald's formula can be used to calculate a more exact LDL-C level. [C]
   2. If TGs cannot be brought to levels less than 400 mg/dL, then consider measuring LDL-C directly, or estimate the LDL-C using the following equation: [I]

      Estimated LDL-C = (TC – HDL) – 30

   3. Screen and treat common causes of elevated TGs: fatty diet, high carbohydrate diets, alcohol use, hypothyroidism, and hyperglycemia. [B]
   4. In the absence of secondary causes, the first-line therapy for elevated TGs should be therapeutic life-style changes. [C]

QE = Quality of Evidence R = Strength of Recommendation (see Appendix A in the original guideline document)

8. Is Lipid Profile Abnormal?

   Objective

   Identify patients who require further evaluation and/or therapy for dyslipidemia.

   Classification of Serum Lipids
   Total Cholesterol (TC) mg/dL (mmol/L)	Category
   <200 (<5.2) 200 to 239 (5.2 to 6.1) >240 (> 6.2)	Normal Borderline high High
   LDL-Cholesterol mg/dL (mmol/L)
   <100 (<2.6) 100 to 129 (2.6 to 3.3) 130 to 159 (3.4 to 4.0) 160 to 189 (4.1 to 4.8) >190 (>4.9)	Normal Above, near optimal Borderline high High Very high
   HDL- Cholesterol mg/dL (mmol/L)
   <40 (<1.0) >60 (>1.6)	Low High
   Triglycerides (TG) mg/dL (mmol/L)
   <150 mg/dL (<1.7) 150 to 199 mg/dL (1.7 to 2.2) 200 to 499 mg/dL (2.3 to 5.6) >500 mg/dL (>5.6)	Normal Borderline High High Very High

   Recommendation

   1. Patients with LDL >130 mg/dL, HDL <40 mg/dL, or TG >200 mg/dL should be assessed for further management of dyslipidemia. [C]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

9. Encourage Healthy Lifestyle

   Objective

   Promote lifestyle changes that will decrease the risk of CVD.

   Recommendations

   1. All adults should be encouraged to adopt healthy lifestyles that may reduce the risk of cardiovascular disease, to include:
      1. Tobacco cessation interventions offered to all smokers [A]
      2. Eat a healthy diet [B]
      3. Engage in 30 minutes or more of moderate intensity physical activity on most days of the week. [B]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

10. Repeat Dyslipidemia Evaluation in 1 to 5 Years

    Objective

    Provide appropriate clinical follow-up for patients initially at low-risk for CVD.

    Recommendations

    1. Patients with average or below average risk for atherosclerotic events should be screened for dyslipidemia every five years. [B]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

Initiation of Therapy Algorithm

11. Patient with Abnormal Lipid Profile or History of CVD or Diabetes

    Patients managed by this guideline algorithm have abnormal lipid profiles (dyslipidemia) or evidence of cardiovascular disease (CVD) or diabetes.

L1. Obtain History, Physical Examination, and Laboratory Tests. Assess for Secondary Causes, Familial Disorders, and Comorbidities

Objective

Detect and if needed treat health disorders that present with an elevated LDL-C or TG, low HDL-C, or metabolic syndrome.

Recommendations

1. Adults with abnormal lipid profiles (dyslipidemia) should be assessed for secondary causes, familial disorders, and other underlying conditions that may influence lipid levels. [I]
2. Assessment for secondary causes should be based on medical history, physical examination and laboratory tests:
   1. Measurement of serum thyroid-stimulating hormone (TSH), blood urea nitrogen (BUN)/creatinine, liver function tests (LFTs), and a dipstick urinalysis should be obtained to exclude hypothyroidism, chronic renal failure, obstructive liver disease, and nephrotic syndrome conditions. [I]
   2. If dipstick urine protein is >1+ (detected in two urine tests), nephrotic syndrome as a secondary cause of elevated LDL-C should be ruled out. [I]
   3. Serum lipids should be assayed six to eight weeks post-TSH normalization to determine the need for additional treatment. [I]
   4. Patients with hypertriglyceridemia should be evaluated for alcohol use, diabetes, and hypothyroidism. Addressing these underlying conditions can improve or normalize triglyceride levels, and failure to address these can render therapy ineffective. [I]
   5. Lipid levels in patients treated for secondary hyperlipidemia should be repeated six to eight weeks post correction of the underlying disorder.
   6. Family members of patients presenting with very severe hypercholesterolemia should be screened to detect other candidates for therapy.
   7. Consider consulting with a specialist to assist the primary care clinician in co-managing patients with familial disorders who do not respond to therapy. [I]

AIDS = acquired immune deficiency syndrome; DM = diabetes mellitus; HAART = highly active antiretroviral therapy; HbA1c = glycosylated hemoglobin; HDL-C = high-density lipoprotein cholesterol; HIV = human immunodeficiency virus; LDL-C = low-density lipoprotein cholesterol; LFTs = liver function tests; SCr = serum creatinine; TC = total cholesterol; TG = triglycerides; TSH = thyroid-stimulating hormone

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

L2. Obtain Baseline Serum Transaminase (ALT/AST) Prior to Starting Lipid Lowering Therapy

Objective

Establish baseline transaminase monitoring parameters prior to initiating lipid lowering therapy.

Recommendations

1. Baseline serum transaminase (alanine aminotransferase [ALT]/aspartate aminotransferase [AST]) should be obtained prior to starting lipid-lowering therapy. [I]
2. Levels of serum transaminase (ALT/AST) should be obtained in patients on statin, 6 to 12 weeks after starting statin therapy, and/or change in dose or combination therapy, then annually or more frequently, if indicated. [I]
3. Levels of serum transaminase (ALT/AST) should be obtained in patients on niacin, 6 to 12 weeks after reaching a daily dose of 1,500 mg and 6 to 12 weeks after reaching the maximum daily dose, then annually or more frequently, if indicated. [I]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

M1. History of Acute Coronary Syndrome in Past 6 Months?

Objective

Identify patients with recent acute coronary syndrome (ACS) for whom there is a compelling need for statin therapy regardless of current lipid levels.

Recommendations

1. A lipid panel should be drawn at the time of admission for all patients with suspected acute coronary syndrome (ACS). [C]
2. Initiating a moderate- to high-dose statin therapy prior to hospital discharge may be considered in patients admitted with ACS irrespective of their lipid profile. [B]
3. Patients with recent ACS (within the past 6 months) should be on a moderate dose of statin therapy to reduce LDL-C level below 100 mg/dL. [A]
4. A lower target (70 mg/dL) may be considered for very high-risk patients. [B]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

M2. History of CVD or DM and LDL-C Above Goal?

(See Screening Algorithm,  Annotations B and C)

M3. Calculate 10-Year Risk Score for CVD

Objective

Determine short-term risk (i.e., over ten years) as the basis for determining the type and intensity of interventions.

Recommendations

1. A global 10-year risk for CVD should be calculated to assess the short-term (10-year) absolute risk of a CVD event. [A]
2. The Framingham Risk Calculator should be used, as it is the most commonly used and readily available calculator validated in numerous populations. [I]
   http://hin.nhlbi.nih.gov/atpiii/calculator.asp?usertype=prof
3. Other risk markers or measure of atherosclerotic burden may be useful to adjust the risk category, if they have been validated to have independent prognostic value. [C]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

14. Determine Risk for CVD and Establish the Goal for Interventions

    Recommendations

    1. Goals of lipid lowering therapy should be tailored to risk level and based upon the balance between benefits, risks, and patient preferences. [C]

    Goals of Therapy for Secondary Prevention

    2. LDL-C should be lowered to <100 mg/dL for patients with a recent ACS. [A]
    3. An optional lower target for LDL-C (<70 mg/dL) may be considered for very high-risk post-ACS patients. [B]
    4. LDL-C should be lowered to <100 mg/dL for patients with previous documented CHD or CVD equivalent (DM with other major risk factors) for secondary prevention. [A]
    5. LDL-C should be lowered to <130 mg/dL for patients with DM without other major risk factors for secondary prevention. [C]

    Goals of Therapy for Primary Prevention

    6. LDL-C should be lowered to <100 mg/dL for patients with high 10-year risk >20 percent. [B]
    7. LDL-C should be lowered to <130 mg/dL for patients with intermediate 10-year risk (15 to 20 percent). [B]
    8. LDL-C should be lowered to <130 mg/dL for patients with intermediate 10-year risk (10 to 14 percent). [C]
    9. LDL-C should be lowered to <160 mg/dL for patients with low 10-year risk. [I]
    10. LDL-C reduction of 30 to 40 percent from baseline may be considered an alternative therapeutic strategy for patients who cannot meet the above goal.

    Table. Goals of Lipid Lowering Therapy

    	Risk Category	Number of Risk Factors (RF)	10-Year Risk	LDL-C Goal mg/dL *	Remarks
    1	Recent ACS	N/A	N/A	<100	Option <70 mg/dL
    2	CHD or equivalent (DM with other risk factors)	N/A	N/A	<100	Optional <130 for DM with no other risk factors
    3	High	2 + RF	>20%	<100	--
    4	Intermediate	2 +RF	15 to 20%	<130	--
    5			10 to 14% **	<130	--
    6	Low	0-1 RF	N/A	<160	--

    N/A = Not applicable
    * Recommendations are based on quality of evidence for improving CVD outcomes.
    ** There is insufficient evidence at this time to recommend routine screening for other risk markers not included in the risk index (e.g., FH, high sensitive C-reactive protein [hsCRP], metabolic syndrome, depression), or evidence of significant atherosclerotic burden (e.g., high coronary artery calcification scores, intima medial thickness, abnormal brachial reactivity, or abnormal ankle-brachial index). These risk markers have independent prognostic value whereby abnormal values can shift risk percent upward across treatment thresholds with more robust evidence for efficacy. Therefore, they may be useful in the intermediate risk patient for whom it is less convincing that drug therapy would have a meaningful impact on outcomes. Example: Patient with a 10-year risk of 13 percent in whom an abnormal test with a proven adjusted relative risk of >2 would shift the patient to a high-risk category (across a 20 percent, 10-year risk threshold).

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

15. Initiate Lipid Lowering Therapy to Achieve Goal

    Objective

    Select an appropriate therapy based on LDL-C baseline level and other risk factors for CVD.

    Recommendations

    Non-Pharmacologic Therapy

    1. Therapeutic lifestyle changes (TLC) should be recommended for ALL patients with dyslipidemia, regardless of risk or baseline LDL-C level. [C]

    Drug Therapy for Secondary Prevention

    2. All patients with a recent ACS should be on at least a moderate dose of statin therapy. [A]
    3. Statin drug therapy should be initiated for patients with previous documented CHD or CVD equivalent (diabetes with other major risk factors) if baseline LDL-C is >100 mg/dL. [A]
    4. Statin drug therapy should be initiated for patients with documented DM with no major risk factors if baseline LDL-C is >130 mg/dL. [C]
    5. Statin drug therapy may be considered optional for all patients with CHD or CVD equivalent (diabetes with other major risk factors) regardless of LDL-C baseline. [B]

    Drug Therapy for Primary Prevention

    6. Drug therapy should be initiated for high-risk patients (>20%) if baseline LDL is >130 mg/dL. [B]
    7. Drug therapy is optional to consider in high-risk patients (>20%) if baseline LDL is 100 to 129 mg/dL. [B]
    8. Drug therapy may be offered to patients with high-intermediate risk (15 to 20 percent) if baseline LDL is >130 mg/dL. [B]
    9. Drug therapy may be offered to patients with low-intermediate risk (10 to 14 percent) if baseline LDL is >160 mg/dL. [C]
    10. Drug therapy may be offered to low-risk patients (<10 percent) if baseline LDL is >190 mg/dL. [I]

    The following table summarizes the lipid lowering strategy for patients in primary prevention. Individual management of cardiovascular risk should be informed mainly by the probable absolute magnitude of treatment benefits. Lowering absolute risk involves modification of multiple risk factors/co-morbidities, not only LDL-C levels. Therefore, these goals should serve as a general guide and clinical judgment should be used to modify the goals as appropriate for each patient.

    Table. Dyslipidemia Therapy Thresholds and Goals

    	Risk Category	Disease Status or Risk Factors	Calculated 10-Year Risk	TLC	LDL-C Level for Considering Statin Drug Therapy	LDL Goal of Therapy
    Secondary Prevention	Very high	Recent ACS	N/A	All	All	<100 mg/dL <70 optional
    		CHD or DM with other risk factors	N/A	All	>100 mg/dL	<100 mg/dL
    		DM with no other risk factors	N/A	All	>130 mg/dL 100 to 129 optional	<130 mg/dL
    Primary Prevention	High	More than 2 RF	>20%	All	>130 (or HDL <40) 100 to 129 optional	<100 mg/dL
    	Intermediate	More than 2 RF	15 to 20%	All	>130 mg/dL	<130 mg/dL
    			10 to 14% *	All	>160 mg/dL	<130 mg/dL
    	Low	0 or 1 RF	N/A	All	>190 mg/dL	<160 mg/dL

    LDL-C reduction of 30-40 percent from baseline may be considered an alternative therapeutic strategy for patients who cannot meet the above goals.

    N/A = Not applicable; TLC = Therapeutic Lifestyle Changes; RF = Risk Factor
    * There is insufficient evidence at this time to recommend routine screening for other risk markers not included in the risk index (e.g., FH, hsCRP, metabolic syndrome, depression), or evidence of significant atherosclerotic burden (e.g., high coronary artery calcification scores, intima medial thickness, abnormal brachial reactivity, or abnormal ankle-brachial index). These risk markers may be useful in the intermediate risk patient for whom it is less convincing that drug therapy would have a meaningful impact on outcomes.

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

16. Therapeutic Lifestyle Change (TLC)

    For secondary prevention of recurrent CVD events, non-pharmacologic therapy is always indicated, but should not delay appropriate pharmacotherapy.

    For primary prevention of CVD, emphasis on TLC is an important component and is effective in reducing CVD risk by lowering LDL-C and blood pressure. Ample time should be given (3 to 6 months) for patients to improve their LDL-C and total lipid profile prior to starting lipid-lowering medication. Patients failing primary clinician efforts may benefit from medical nutrition therapy (MNT) provided by a registered dietician or other qualified nutritionist (see Appendix C, Medical Nutrition Therapy in the original guideline document).

    TLC is provided in a step-wise approach focused on initiating TLC components and followed by subsequent evaluation of the effect on LDL-C and moving to intensify MNT as indicated. See Figure 2 "Step Wise Care Approach" in the original guideline document.

P1. Medical Nutrition Therapy

Objective

Improve dyslipidemia using medical nutrition therapy (MNT).

Recommendations

1. Diet intervention should be the first step in lipid lowering therapy. [B]
2. Patients whose initial treatment is TLC should be given 3 to 6 months of dietary therapy prior to beginning medication and longer, if lipids are improving and nearing LDL thresholds. [B]
3. Initial diet should focus on reduction of saturated fats to <7 percent of total calories and dietary cholesterol to <200 mg/day similar in composition to the TLC diet (formerly Step II diet). [B]
   1. The range of 25 to 35 percent of total calories from fat is to be paired with keeping saturated fats and trans-fatty acid percents of total calories low.
   2. Advise 10 percent monounsaturated fat, <7 percent saturated fat, <200 mg cholesterol diet.
   3. If TGs are elevated, ensure that blood glucose is under control, limit alcohol and simple sugars, and evaluate need for weight loss. Emphasis should be placed on weight reduction and physical activity.
   4. Limit foods with trans fatty acids (e.g., stick margarine, shortening, and commercially baked products and processed food).
   5. Select >5 to 6 servings/day fruits and vegetables and six servings/day whole-grain products.

4. Patient's specific diet should be individualized based on nutrition assessment, other CVD risk factors, other disease conditions, and patient's lifestyle. [I]
5. Patients should be evaluated 4 to 6 weeks after their initial consultation. A lipid profile and anthropometric data should be analyzed. Further dietary intervention may include:
   1. Increase soluble (viscous) fiber to 10 to 25 g/day to lower LDL-C. [B]
   2. Increase plant sterols/stanols to 2 g/day to lower LDL-C. [B]
   3. Include nuts such as walnuts and almonds (1 oz. ~5 times/week) and soy protein (25 g/day or 8 oz. of tofu) to lower LDL-C. [B]
   4. Select fatty fish (average of 7 oz./week) (fish oil) to lower TG. [B]

6. Weight management for overweight and obese patients should be encouraged to lower LDL-C and TG and to reduce CV risk. [B]
7. Patients in whom triglycerides >500 mg/dL should receive strict diet therapy including avoidance of alcohol, restriction of dietary fat, and avoidance of concentrated carbohydrates (sweets). For triglycerides >1000 mg/dL a very low fat diet should be instituted quickly to reduce chylomicronemia and risk of acute pancreatitis.
8. Patients with evidence of metabolic syndrome should receive MNT that incorporates the additional protocol for weight management with increased physical activity. [B]

QE = Quality of Evidence; Strength of Recommendation (see Appendix A in the original guideline document)

P2. Physical Activity/Exercise and Weight Control

Recommendations

1. Moderate intensity levels of physical activity should be performed for at least 30 minutes most, preferably all, days of the week. [B]
2. In patients with CVD, aerobic exercise should not precipitate angina.
3. Increased physical activity through lifestyle change should be encouraged, as it is equally as effective as structured exercise in reducing body fat, improving cardiorespiratory fitness, and improving cardiovascular risk factors. [B]
4. Physical activity, through lifestyle change or structured exercise, should be encouraged to maintain weight control (or weight loss if overweight or obese), to improve insulin resistance, and increase HDL-C. [B]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

Q1. Pharmacotherapy: Monotherapy

Objective

Reduce the risk of CVD events and achieve lipid goals through the use of optimal pharmacotherapy.

Recommendations

1. Pharmacologic treatment of dyslipidemia should be individualized and dictated by lipid levels. [B]

Elevated LDL-C

2. Statins are first line agents in primary and secondary prevention of CVD regardless of HDL-C or TG level. [A]
3. Moderate doses of formulary statins (to achieve an LDL-C reduction of 25 percent or greater) should be initiated unless a patient is considered to be at greater than usual risk for adverse events from statins (e.g., myopathy). [A]
4. For patients who cannot tolerate statins, niacin or resins should be considered for treatment. [A]
5. There is insufficient clinical outcome evidence to recommend ezetimibe monotherapy for reduction of CV risk. [I]
6. Ezetimibe can be considered for lowering LDL-C in patients who are unable to tolerate other lipid-lowering drugs. [A]
7. The dose of statin should be adjusted at 6 to 12 week intervals until individual LDL-C goals are achieved or statin doses have been maximized. [I]

Isolated Hypertriglyceridemia

8. Niacin, fibrates, or fish oil supplements may be used in treatment of hypertriglyceridemia. [B]

Isolated Low HDL-C

9. For secondary prevention, gemfibrozil or niacin may be used in patients with isolated low HDL-C and normal LDL-C. [A-Gemfibrozil; B-Niacin]

Safety and Follow-Up

10. Patients treated with statins or fibrates should be educated regarding the importance of recognizing and reporting any unexplained muscle tenderness, pain, or weakness. [I]
11. Lipid profiles should be repeated 6-12 weeks after initiation of therapy and/or change in dose and/or combination therapy. [B]
12. Liver function tests (LFTs) should be performed prior to and after 12 weeks following initiation of treatment, any elevation in dose, and periodically thereafter in those receiving statins, fibrates, or niacin. [I]
13. Creatine kinase (CK) levels should be obtained in patients who develop muscle pain, weakness, or tenderness after institution of statin or fibrate therapy. [I]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

Q2. Pharmacotherapy: Combination Therapy

Objective

Achieve lipid goals through the use of combination pharmacologic agents.

Recommendations

LDL-C Lowering Combination Therapy [ONLY FOR SECONDARY PREVENTION]

1. For patients not at goal, monotherapy should be titrated until goal is achieved or maximum tolerable dose has been reached. [C]
2. Combination therapy to achieve LDL-C goal may be considered for carefully selected patients who do not achieve the LDL-C goal with maximally tolerated monotherapy. [I]
3. Combination lipid-lowering therapy should include a statin unless the patient is unable to tolerate statins. [A]
4. Addition of a resin to the statin can be considered for secondary prevention in patients not meeting their LDL-C goals on maximally tolerated doses of statins. [B]
5. Addition of niacin or a resin to the statin can be considered in patients not meeting their LDL-C goals to further reduce the LDL-C level. [B]
6. Addition of ezetimibe to the statin can be considered in patients not meeting their LDL-C goals on maximally tolerated doses of statins and unable to tolerate niacin or a resin to reduce the LCL-C level. [I]
7. In patients unable to tolerate statins and not achieving their LDL-C goals with niacin or resins, a combination of both resin and niacin may be considered. [B]
8. In any combination therapy the lowest possible dose of statin should be used to achieve lipid goals. When combined with fibrates (greatest risk), niacin, or possibly ezetimibe, the risk of adverse events with statins (e.g., muscle toxicity) appears to increase with increasing statin doses. [C]

Elevated LDL-C and Very High Triglycerides (>500 mg/dL)

If non-HDL goals cannot be achieved with a statin (or other LDL-lowering regimen) alone, a TG-lowering drug may be added to the statin. Choices are niacin, a fibrate, and fish oils.

9. Combination therapy with statins and niacin, fish oils, or fibrates can be considered for the secondary prevention of CVD in patients with elevated LDL-C and very high TGs. [C]
10. Combination therapy with niacin and fibrates can be considered for the secondary prevention of CVD in patients with elevated LDL-C and very high TGs in patients unable to tolerate statins. [C]

Very High Triglycerides and/or Low HDL-C Without Elevated LDL-C

11. For secondary prevention of CVD in patients with either low HDL-C or very high triglycerides and no elevation of LDL-C levels, combination therapy with statin plus niacin, fibrate, or fish oil may be considered. [C]
12. Combination therapy with niacin and fibrates and/or fish oils can be considered in patients unable to tolerate statins. [C]

QE = Quality of Evidence; OQ = Overall Quality; SR = Strength of Recommendation (see Appendix A in the original guideline document)

18. Repeat Dyslipidemia Evaluation in 1 to 2 Years (Patients NOT on Therapy)

    Objective

    Provide appropriate clinical follow-up for patients not on therapy.

    Recommendation

    1. If the initial dyslipidemia screening reveals TC >200 mg/dL, or fasting LDL-C >130 mg/dL or HDL-C <40 mg/dL, but LDL-C level is under the recommended goal level based upon CV risk, the patient will be at low-risk for lipid-related events over a one to two-year period and thus, should be reevaluated for dyslipidemia in one to two years.

Follow-up of Therapy Algorithm

19. Address Adherence to Therapy

    Objective

    Identify causes of inadequate response to therapy following dose or stepwise titration.

    Recommendations

    1. Adherence to therapy should be assessed at every visit, through history, pill count, and/or administrative records especially if therapeutic goals have not been reached [I]
    2. Adherence to lipid-lowering medication regimens may be improved by a multi-pronged approach [I] including:
       1. Evaluation of medication side effects
       2. Simplifying medication regimens to incorporate patient preference
       3. Addressing barriers for obtaining the medications (administrative, economic, etc.)
       4. Coordination with other healthcare team members to improve monitoring of adherence with prescriptions of pharmacological and lifestyle modification
       5. Patient and family education about their disease/treatment regimens
       6. Evaluation for depression

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

20. Does The Patient Have Elevated TG Level, or Low HDL-C Level, or Metabolic Syndrome?

    The goal of dyslipidemia management is ultimately to decrease CV risk, and the evidence is best at reducing such risk through LDL-C lowering therapies. LDL-C remains the treatment priority, and should be addressed regardless of the TG level. Once the LDL-C goal has been reached, treatment attention may shift to obtain optimal lipoprotein profiles.

21. Evaluation and Treatment of High Triglycerides

    Objective

    Evaluate and treat TG levels above 200 mg/dL.

    Treatment for Hypertriglyceridemia
    TG >200 to 499 mg/dL	TG >500 mg/dL	TG >1000 mg/dL
    Lifestyle management Weight loss Alcohol cessation Secondary causes	Very low fat diet Low concentrated carbohydrate diet Alcohol cessation Secondary causes Consider drugs, if no response to above Consider referral	Strict MNT (avoidance of alcohol, fat, and restrict calories) Secondary causes Drug therapy, if no response to above Consider referral

    Recommendations

    1. Patients with elevated TG (>200 mg/dL) should have a repeat fasting lipid profile and, if persistent, receive intensive MNT, an appropriate exercise program, and be screened for underlying causes. [B]
    2. Drug therapy may be considered in patients with very high TG levels (> 500 mg/dL) that do not respond to lifestyle interventions and the treatment of underlying causes of elevated TG, for the purpose of preventing pancreatitis. [I]
    3. Effective drugs for lowering hypertriglyceridemia include fibrates, niacin, and fish oil. [B]

    Table. Drug Treatment for Hypertriglyceridemia

    TG 500 to 1000 mg/dL
    	Drug	Efficacy (Expected % Reduction in TG)
    Initial	Fibrates	-20 to -50
    Alternate	Niacin	-20 to -35
    	n-3 PUFA Supplements, Omega-3 Fatty Acids/Fish Oils	-20 to -30

    • Fibrates are contraindicated in severe renal disease.
    • Niacin is contraindicated in hepatic disease and relatively contraindicated in DM, gout, and history of complicated/active peptic ulcer disease (PUD).

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

22. Evaluation and Treatment of Low HDL-C

    Objective

    Reduce risk of CVD through raising the level of HDL-C.

    Recommendations

    1. Patients with CVD who have low HDL-C (<40 mg/dL), TG >200 mg/dL, and normal levels of LDL-C may benefit from gemfibrozil therapy. [A]
    2. Lifestyle modifications, including weight loss, exercise, and smoking cessation should be given high priority in the therapeutic plan for patients with low HDL-C. [B]
    3. CVD patients with low HDL-C (<40 mg/dL) may be considered for treatment with niacin. [B]

    Table. Drug Treatment for Isolated Low HDL-C

    LDL-C <130 and Low HDL-C
    Drug	Efficacy (Expected % Reduction in TG)
    Gemfibrozil	LDL-C +10 to –35	HDL-C +2 to 34

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

23. Evaluation and Treatment of Metabolic Syndrome

    Objective

    Identify therapeutic treatment options for individuals with metabolic syndrome.

    Recommendations

    1. TLC should be initiated for patients diagnosed with metabolic syndrome. [B]
    2. Lifestyle modification for weight reduction through diet and increased physical activity is indicated for patients diagnosed with metabolic syndrome. [B]
    3. Drug therapy to alter insulin resistance or low HDL-C or elevated TG has not been demonstrated to improve CVD outcomes in patients with metabolic syndrome and as such, clinicians will have to individualize therapy. [I]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

24. Reschedule Lipids Evaluation at Appropriate Time and Follow Up to Maintain Goals

    Objective

    Measure the efficacy of prescribed therapy for hyperlipidemia after allowing sufficient time to reach a new steady state.

    Recommendations

    1. Lipid profiles should be reevaluated after at least 6 to 12 weeks of drug therapy or change in dose or after at least three to six months of dietary therapy to document efficacy, identify adverse effects, and to titrate medication dose. [I]
    2. Follow-up visits should [I] include:
       • Patient history
       • Physical exam
       • Laboratory tests
       • Documentation of adverse events
    3. Once the goal is achieved, therapy for dyslipidemia should be continued to maintain the goal. Treatment of dyslipidemia is a lifelong process; however, adjustments may be necessary if the patient develops medical conditions that affect the severity of comorbidity or life expectancy.

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

25. Follow Up, Repeat Lipid Evaluation At Least Annually

    Objective

    Ensure that patients initially treated for dyslipidemia receive periodic reassessment of the efficacy of treatment.

    Recommendations

    1. Lipid evaluations should be repeated at least annually. [I]

QE = Quality of Evidence; R = Strength of Recommendation (see Appendix A in the original guideline document)

Definitions:

Strength of the Recommendations

A: A strong recommendation that the clinicians provide the intervention to eligible patients.
Good evidence was found that the intervention improves important health outcomes and concludes that benefits substantially outweigh harm.

B: A recommendation that clinicians provide (the service) to eligible patients.
At least fair evidence was found that the intervention improves health outcomes and concludes that benefits outweigh harm.

C: No recommendation for or against the routine provision of the intervention is made.
At least fair evidence was found that the intervention can improve health outcomes but concludes that the balance of benefits and harms is too close to justify a general recommendation.

D: Recommendation is made against routinely providing the intervention to asymptomatic patients.
At least fair evidence was found that the intervention is ineffective or that harms outweigh benefits.

I: The conclusion is that the evidence is insufficient to recommend for or against routinely providing the intervention.
Evidence that the intervention is effective is lacking, or poor quality, or conflicting and the balance of benefits and harms cannot be determined.

Quality of Evidence

I: At least one properly done randomized controlled trial

II-1: Well designed controlled trails without randomization

II-2: Well designed cohort or case-control analytic study, preferably from more than one source

II-3: Multiple time series evidence with/without intervention; dramatic results of uncontrolled experiment

III: Opinion of respected authorities, descriptive studies, case reports, and expert committees

Overall Quality

Good: High grade evidence (I or II-1) directly linked to health outcome

Fair: High grade evidence (I or II-1) linked to intermediate outcome; or moderate grade evidence (II-2 or II-3) directly linked to health outcome

Poor: Level III evidence or no linkage of evidence to health outcome.

Net Effect of Intervention

Substantial:

• More than a small relative impact on a frequent condition with a substantial burden of suffering, or
• A large impact on an infrequent condition with a significant impact on the individual patient level

Moderate:

• A small relative impact on a frequent condition with a substantial burden of suffering, or
• A moderate impact on an infrequent condition with a significant impact on the individual patient level

Small:

• A negligible relative impact on a frequent condition with a substantial burden of suffering, or
• A small impact on an infrequent condition with a significant impact on the individual patient level

Zero or Negative:

• Negative impact on patients, or
• No relative impact on either a frequent condition with a substantial burden of suffering, or
• An infrequent condition with a significant impact on the individual patient level

Abbreviations and Acronyms List

ACS – acute coronary syndrome

AIDS – acquired immune deficiency syndrome

ALT – alanine aminotransferase

AST– aspartate aminotransferase

AMI– acute myocardial infarction

BMI – body mass index

CAD – coronary artery disease

CHD – coronary heart disease

CK – creatine kinase

CV – cardiovascular

CVA – cerebrovascular accident

CVD – cardiovascular disease

DM – diabetes mellitus

HbAlc – glycosylated hemoglobin A1C

HDL-C – high density lipoprotein cholesterol

HIV – human immunodeficiency virus

HsCRP – high sensitive C-reactive protein

HTN – hypertension

LDL-C – low density lipoprotein cholesterol

LFT – liver function tests

MI – myocardial infarction

MNT – Medical Nutrition Therapy

PUD – peptic ulcer disease

SCr – serum creatine

TC – total cholesterol

TG – triglycerides

TLC – therapeutic lifestyle change

TSH – thyroid-stimulating hormone

References open in a new window

Electronic copies: Available from the Department of Veterans Affairs (VA) Web site.

Print copies: Available from the Department of Veterans Affairs, Veterans Health Administration (VHA), Office of Quality and Performance (10Q), 810 Vermont Ave. NW, Washington, DC 20420.

• Diagnosis and management of dyslipidemia guideline summary – update 2006. Washington (DC): Department of Veterans Affairs (U.S.); 2006. 25 p.
• Diagnosis and management of dyslipidemia pocket guide – update 2006. Washington (DC): Department of Veterans Affairs (U.S.); 2006. 2 p. See the related QualityTool summary on the Health Care Innovations Exchange Web site.
• Diagnosis and management of dyslipidemia key points card – update 2006. Washington (DC): Department of Veterans Affairs (U.S.); 2006. 2 p. See the related QualityTool summary on the Health Care Innovations Exchange Web site.

Electronic copies: Available from the Department of Veterans Affairs (VA) Web site.

Print copies: Available from the Department of Veterans Affairs, Veterans Health Administration (VHA), Office of Quality and Performance (10Q), 810 Vermont Ave. NW, Washington, DC 20420.

The following is also available:

• Putting clinical practice guidelines to work [online tutorial]. Available from the Department of Veterans Affairs Web site.

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