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2000 Case DefinitionClinical case definitionAn acute illness with a) discrete onset of symptoms (such as nausea, vomiting, abdominal pain and diarrhea) and b) jaundice or abnormal serum aminotransferase levels Laboratory criteria for diagnosis Serum alanine aminotransferase levels greater than 7 times the upper limit of normal, and IgM antibody to hepatitis A virus (IgM anti-HAV) negative (if done) and IgM antibody to hepatitis B core antigen (IgM anti-HBc) negative, or if not done, hepatitis B surface antigen (HBsAg) negative, and Antibody to hepatitis C virus (anti-HCV) positive, verified by an additional more specific assay. Case classification: Confirmed: a case that meets the clinical case definition and is laboratory confirmed Comment:
See also: References 6. Kuo G, Choo Q-L, Alter HJ, et al. An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science 1989;244:362-4. |
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