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Hepatitis C Virus Infection (past or present)
2003 Case Definition
Clinical description
Most hepatitis C virus (HCV) infected persons are asymptomatic.
However, many have chronic liver disease, which can range from mild
to severe including cirrhosis and liver cancer.
Laboratory criteria for diagnosis
- Anti-HCV positive (repeat reactive) by EIA, verified
by an additional more specific assay (e.g. RIBA for anti-HCV or
nucleic acid testing for HCV RNA), OR
- HCV RIBA positive, OR
- Nucleic acid test for HCV RNA positive, OR
- Anti-HCV positive (repeat reactive) by EIA with
a signal to cut-off ratio >= 3.8 (as this becomes available).
Case classification
Probable: a case that is
anti-HCV positive (repeat reactive) by EIA and has alanine aminotranferase
(ALT or SGPT) values above the upper limit of normal, but the anti-HCV
EIA result has not been verified by an additional more specific assay
or the signal to cutoff ratio is unknown.
Confirmed: a case that is laboratory confirmed
and that does not meet the case definition for acute hepatitis C.
See also:
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