|
Acronym | Definition |
---|---|
Act | "The Act", i.e., Federal Food, Drug, and Cosmetic Act |
ABS | chromosome aberration(s) |
ADI | acceptable daily intake |
A/G | albumin-to-globulin |
ANOVA | analysis of variance |
B-cells | B lymphocytes |
B/T | ratio of B to T lymphocytes |
CAC | Cancer Assessment Committee |
CAS | Chemical Abstract Service |
CCFAC | Codex Committee for Food Additives and Contaminants |
CFR | Code of Federal Regulations |
CFSAN | Center for Food Safety and Applied Nutrition |
CHO | Chinese hamster ovary [cell(s)] |
CMI | cell mediated immunity |
CSO | consumer safety officer |
DNA | deoxyribonucleic acid |
DTH | delayed type hypersensitivity |
EAFUS | Everything Added to Food in the United States (database) |
ECVAM | European Centre for the Validation of Alternative Methods |
EDI | estimated daily intake |
ELISA | enzyme-linked immunosorbent assay |
EPA | Environmental Protection Agency (United States) |
FAP | food additive petition |
FASEB | Federation of American Societies for Experimental Biology |
FASP | food additive safety profile |
FCS | food contact substance |
FCN | Food Contact (Substance) Notification |
FDA | Food and Drug Administration |
GLP | good laboratory practices |
GMPs | good manufacturing practices |
GRAS | generally recognized as safe |
HGPRT | hypoxanthineguanine phosphoribosyl transferase activity |
HTD | highest treatment dose |
IARC | International Agency for Research on Cancer |
ICH | International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use |
Ig | immunoglobulin |
JECFA | Joint (FAO/WHO) Expert Committee on Food Additives |
LOEL | lowest observed effect level |
LPS | lipopolysaccharide |
LSD | least significant difference (refers to statistical test) |
MFO | mixed function oxidase |
ML | L5178Y mouse lymphoma cell |
MLA | mouse lymphoma assay |
MLR | mixed lymphocyte response |
MTD | maximum tolerated dose |
OECD | Organization for Economic Cooperation and Development |
OFAS | Office of Food Additive Safety (CFSAN) |
PAFA | Priority-Based Assessment of Food Additives (database) |
PALS | periarteriolar lymphocyte sheath |
PB-PK | physiologically based pharmacokinetic model |
PHA | phytohemagglutinin |
PWM | pokeweed mitogen |
QAU | Quality Assurance Unit |
QRAC | Quantitative Risk Assessment Committee |
QRAs | quantitative risk assessments |
RBC | red blood cells |
Redbook I | Toxicological Principles for the Safety Assessment of Direct Food Food Additives and Color Additives Used in Food (1982) |
Redbook II | draft Toxicological Principles for the Safety Assessment of Direct Food Food Additives and Color Additives Used in Food (1993) |
Redbook 2000 | Toxicological Principles for the Safety Assessment of Food Ingredients (2000, additions and updates in 2001, 2003, 2004) |
RIA | radio immunoassay |
RNA | ribonucleic acid |
SAR | structure activity relationship |
SCE | sister chromatid exchange |
SHE | Syrian hamster embryo cell |
SOP | standard operating procedure |
SRBC | sheep red blood cells |
T-cells | T-lymphocytes, or thymus derived cells |
TK | thymidine kinase |
UDS | unscheduled DNA synthesis |
WBC | white blood cells |
WBA | whole body autoradiography |