|
CFSAN/Office of Food Additive Safety
December 2008
The summary tables that are immediately below provide the following information about GRAS notices received within each year since 1998, when FDA received its first GRAS notice:
Detailed yearly tables provide additional links to information corresponding to the proposed "GRAS exemption claim" (proposed 21 CFR 170.36(c)(1)), including the following information, which FDA proposed to make readily accessible to the public:
Persons interested in obtaining additional data and information in the notice may obtain a copy of those data and information that are disclosable by requesting the information under the Freedom of Information Act (see FDA's document entitled "How to Request Information or Make a Freedom of Information Request").
These tables are current as of December 17, 2008, and therefore, do not show any new notices filed by FDA, or response letters issued by FDA, after that date. These tables will be updated approximately monthly.
For further information about the GRAS notification program, telephone Dr. Paulette Gaynor at (301) 436-1192 or send a question by electronic mail to
| Details about Notices Received in 2008 (GRN No. 239-271) | ||
| GRN No. | Substance | FDA's Letter |
|---|---|---|
| 271 | Ferrous ammonium phosphate | Pending |
| 270 | Polyglycerol polyricinoleic acid | Pending |
| 269 | Polyglycerol fatty acid esters | Pending |
| 268 | Bifidobacterium longum BB536 | Pending |
| 267 | Protein-glutaminase enzyme preparation derived from Chryseobacterium proteolyticum | Pending |
| 266 | Polyglycerol polyricinoleate | Pending |
| 265 | Glycerophospholipid cholesterol acyltransferase (GCAT) enzyme preparation produced by Bacillus licheniformis expressing the gene encoding GCAT enzyme from Aeromonas salmonicida subsp. salmonicida | Pending |
| 264 | Sweet lupin flour | Pending |
| 263 | Sweet lupin fiber | Pending |
| 262 | Sweet lupin protein | Pending |
| 261 | Oat hull fiber | Pending |
| 260 | High-selenium yeast | Pending |
| 259 | Catechins from green tea extract | Pending |
| 258 | Sucromalt | Pending |
| 257 | gamma-Amino butyric acid | Pending |
| 256 | Flaxseed oil | Pending |
| 255 | Bovine globulin | Pending |
| 254 | Lactobacillus reuteri strain DSM 17938 | FDA has no questions |
| 253 | Rebaudioside A purified from Stevia rebaudiana (Bertoni) Bertoni | FDA has no questions |
| 252 | Rebaudioside A purified from Stevia rebaudiana (Bertoni) Bertoni | FDA has no questions |
| 251 | Carbon monoxide | Pending |
| 250 | Pine tree phytosterols | Pending |
| 249 | Capsiate | Pending |
| 248 | Sucrose fatty acid esters (i.e., sucrose monoesters of lauric acid, palmitic acid, and stearic acid) manufactured by reaction of sucrose with vinyl esters of lauric, palmitic, and stearic acids | FDA has no questions |
| 247 | Modified gum acacia | FDA has no questions |
| 246 | Isomalto-oligosaccharides | Pending |
| 245 | Menaquinone-7 | At notifier's request, FDA ceased to evaluate the notice |
| 244 | Glutathione | At notifier's request, FDA ceased to evaluate the notice |
| 243 | D-Ribose | FDA has no questions |
| 242 | Krill oil | FDA has no questions |
| 241 | High-selenium yeast | At notifier's request, FDA ceased to evaluate the notice Resubmitted as GRN No. 260 |
| 240 | Corn, cane, or beet sugar cultured with Lactobacillus paracasei subsp. paracasei, Bacillus coagulans LA-1, or Propionibacterium freudenreichii subsp. shermanii, or mixtures of these microorganisms | FDA has no questions |
| 239 | Bakers yeast beta-glucan | FDA has no questions |
| Details about Notices Received in 2007 (GRN No. 219-238) | ||
| GRN No. | Substance | FDA's Letter |
|---|---|---|
| 238 | Lipase enzyme preparation derived from Hansenula polymorpha expressing a gene encoding a lipase from Fusarium heterosporum | FDA has no questions |
| 237 | Alkyl polyglycosides | FDA has no questions |
| 236 | Galacto-oligosaccharides | FDA has no questions |
| 235 | Lactoferrin (human) purified from rice | Pending |
| 234 | Bovine globulin | At notifier's request, FDA ceased to evaluate the notice Resubmitted as GRN No. 255 |
| 233 | Galactooligosaccharides and polydextrose | Pending |
| 232 | Conjugated linoleic acid isomers | FDA has no questions |
| 231 | Lactobacillus casei subsp. rhamnosus strain GG | FDA has no questions |
| 230 | Chymosin enzyme preparation from Trichoderma reesei expressing the bovine prochymosin B gene | FDA has no questions |
| 229 | Methylsulfonylmethane | FDA has no questions |
| 228 | Sodium nitrite | Pending |
| 227 | Olestra | FDA has no questions |
| 226 | Lecithin derived from krill | FDA has no questions |
| 225 | Catechins from green tea extract | At notifier's request, FDA ceased to evaluate the notice Resubmitted as GRN No. 259 |
| 224 | trans-Resveratrol | At notifier's request, FDA ceased to evaluate the notice |
| 223 | Phosphatidylserine | FDA has no questions |
| 222 | Citric acid esters of mono- and diglycerides | FDA has no questions |
| 221 | Suspended lutein | FDA has no questions |
| 220 | alpha-Glycosyl isoquercitrin | FDA has no questions |
| 219 | Ammonium phosphatide | FDA has no questions |
| Details about Notices Received in 2006 (GRN No. 189-218) | ||
| GRN No. | Substance | FDA's Letter |
|---|---|---|
| 218 | Bacteriophage P100 preparation from Listeria innocua | FDA has no questions |
| 217 | Tailored tryglycerides containing approximately 12 percent medium-chain fatty acids | FDA has no questions |
| 216 | Lipase enzyme preparation from Rhizopus oryzae | FDA has no questions |
| 215 | Actinidia arguta extract | FDA has no questions |
| 214 | Asparaginase enzyme preparation from Aspergillus niger expressing the asparaginase gene from A. niger | FDA has no questions |
| 213 | Hydroxypropyl methylcellulose - expanded substitution pattern (HPMC-ESP) | FDA has no questions |
| 212 | Phospholipase A2 enzyme preparation from Streptomyces violaceruber expressing a gene encoding phospholipase A2 from the same species | FDA has no questions |
| 211 | Xanthan gum (lower pyruvate levels) | FDA has no questions |
| 210 | Water soluble tomato concentrate | FDA has no questions; some uses may require a color additive listing |
| 209 | L-theanine | FDA has no questions |
| 208 | Erythritol | FDA has no questions Corrected letter issued Nov. 20, 2007 |
| 207 | Barley fiber | FDA has no questions |
| 206 | Phytosterol esters and diglycerides resulting from transesterification of vegetable oils/fats with soy phytosterols | FDA has no questions |
| 205 | Pullulanase enzyme preparation from Bacillus subtilis expressing the pullulanase gene from B. acidopullulyticus | FDA has no questions |
| 204 | Phospholipase C enzyme preparation from Pichia pastoris expressing a heterologous phospholipase C gene | FDA has no questions |
| 203 | Erythritol fatty acid esters | At notifier's request, FDA ceased to evaluate the notice |
| 202 | Polyoxyethanyl-alpha-tocopheryl sebacate (PTS) | FDA has no questions |
| 201 | Asparaginase enzyme preparation from Aspergillus oryzae expressing the asparaginase gene from A. oryzae | FDA has no questions |
| 200 | Tailored triglycerides enriched in omega-3 fatty acids from fish oil | FDA has no questions |
| 199 | Concentrated hydrolyzed milk protein | FDA has no questions |
| Additional correspondence about intended uses | ||
| 198 | Bacteriophage P100 Preparation from Listeria innocua | FDA has no questions |
| 197 | Phosphatidylserine | FDA has no questions |
| 196 | Bovine milk basic protein fraction | FDA has no questions |
| 195 | Mixed beta-Glucanase and xylanase enzyme preparation from Humicola insolens | FDA has no questions |
| 194 | Carbon monoxide | Pending |
| 193 | Fish oil (predominantly sardine and anchovy); tuna oil | FDA has no questions |
| 192 | High 2-palmitic vegetable oil | FDA has no questions |
| 191 | Lysozyme (human) purified from rice | Pending |
| 190 | Hydroxypropyl methylcellulose | At notifier's request, FDA ceased to evaluate the notice Resubmitted as GRN No. 213 |
| 189 | Lactoferrin (human) purified from bovine milk | Pending |
| Details about Notices Received in 2005 (GRN No. 163-188) | ||
| GRN No. | Substance | FDA's Letter |
|---|---|---|
| 188 | Carbon monoxide | At notifier's request, FDA ceased to evaluate the notice |
| 187 | L(+) Tartaric acid (alternative method of manufacture) | FDA has no questions |
| 186 | Soy lecithin enzymatically modified to have increased phosphatidylserine | FDA has no questions |
| 185 | Concentrated tomato lycopene extract | FDA has no questions |
| 184 | Isomaltulose | FDA has no questions |
| 183 | Phospholipase A2 enzyme preparation from Aspergillus niger expressing a gene encoding a porcine phospholipase A2 | FDA has no questions |
| 182 | Hydrolyzed wheat gluten isolate; pea protein isolate | FDA has no questions |
| 181 | Phytosterols | FDA has no questions |
| 180 | Allyl isothiocyanate | FDA has no questions |
| 179 | Polyglycerol polyricinoleic acid | FDA has no questions |
| 178 | Sodium iron EDTA | FDA has no questions |
| 177 | Plant sterol esters | FDA has no questions |
| 176 | Plant sterols and plant sterol esters from vegetable oils or sterols/stanols from tall oil | FDA has no questions |
| 175 | Saccharomyces cerevisiae strain ECMo01 with enhanced expression of urea amidolyase | FDA has no questions |
| 174 | Lysozyme (human) enzyme preparation from rice | At notifier's request, FDA ceased to evaluate the notice. |
| 173 | Lycopene from Blakeslea trispora | FDA has no questions; some uses may require a color additive listing |
| 172 | Isomalto-oligosaccharide | At notifier's request, FDA ceased to evaluate the notice. Resubmitted as GRN No. 246 |
| 171 | Lactobacillus acidophilus, Lactobacillus lactis, and Pediococcus acidilactici | FDA has no questions |
| Additional correspondence about intended uses | ||
| 170 | Shrimp-derived chitosan | At notifier's request, FDA ceased to evaluate the notice. |
| 169 | Bovine globulin | At notifier's request, FDA ceased to evaluate the notice. Resubmitted as GRN No. 234 |
| 168 | Poultry protein | FDA has no questions |
| 167 | Carbon monoxide | FDA has no questions |
| 166 | Carbon monoxide | At notifier's request, FDA ceased to evaluate the notice. |
| 165 | Quillaia extract type 1 | FDA has no questions |
| 164 | Lauramide arginine ethyl ester | FDA has no questions |
| Additional correspondence about intended uses | ||
| 163 | Tomato pulp powder | FDA has no questions |
| Additional correspondence about intended uses | ||
| Details about Notices Received in 2004 (GRN No. 143-162) | ||
| GRN No. | Substance | FDA's Letter |
|---|---|---|
| 162 | Lactoferrin (human) purified from rice | At notifier's request, FDA ceased to evaluate the notice. |
| 161 | Chlorine dioxide, generated using sodium chlorite in calcined or sulfated kaolin clay | FDA has no questions |
| 160 | Micro-algal oil (Ulkenia sp.) | At notifier's request, FDA ceased to evaluate the notice. |
| 159 | Carnobacterium maltaromaticum strain CB1 | FDA has no questions |
| 158 | Lipase preparation from Aspergillus niger expressing a gene encoding a lipase from Candida antartica | FDA has no questions |
| 157 | Calcium propionate (alternative method of manufacture) | FDA has no questions |
| 156 | Tomato lycopene extract 6 percent, tomato lycopene extract 1.5 percent, and crystallized tomato lycopene extract | FDA has no questions; some uses may require a color additive listing |
| 155 | alpha-Cyclodextrin | FDA has no questions |
| 154 | Dried orange pulp | FDA has no questions |
| 153 | Conjugated linoleic acid | At notifier's request, FDA ceased to evaluate the notice. Resubmitted as GRN No. 232 |
| 152 | Sodium iron EDTA | FDA has no questions |
| 151 | Ethanol (ethyl alcohol) | FDA has no questions |
| 150 | Glucosamine hydrochloride prepared from chitin obtained from Aspergillus niger | At notifier's request, FDA ceased to evaluate the notice. |
| 149 | Beta-glucanase enzyme preparation from Trichoderma harzianum | FDA has no questions |
| 148 | Vegetable oil conjugated linoleic acid preparation | At notifier's request, FDA ceased to evaluate the notice. Resubmitted as GRN No. 232 |
| 147 | Extracted "seafood species" protein | FDA has no questions |
| Additional correspondence clarifying the subject of the notice | ||
| Additional correspondence about intended uses | ||
| 146 | Salmon oil | FDA has no questions |
| 145 | Phospholipase A2 enzyme preparation from Streptomyces violaceoruber | FDA has no questions |
| 144 | Adenosine 5'-monophosphoric acid and its monosodium and disodium salts | FDA has no questions |
| 143 | Carbon monoxide | FDA has no questions |
| Details about Notices Received in 2003 (GRN Nos. 120 - 142) | ||
| GRN No. | Substance | FDA's Letter |
|---|---|---|
| 142 | Phospholipase enzyme preparation from Aspergillus oryzae expressing the gene encoding a phospholipase A1 from Fusarium venenatum | FDA has no questions |
| 141 | Polyvinyl alcohol | FDA has no questions |
| 140 | Crystalline lutein | FDA has no questions; some uses may require a color additive listing |
| 139 | Cassia gum | At notifier's request, FDA ceased to evaluate the notice. |
| 138 | Fish oil | FDA has no questions |
| 137 | Algal oil (Schizochytrium sp.) | FDA has no questions |
| 136 | Calcium gluconate | FDA has no questions |
| 135 | ε-Polylysine | FDA has no questions |
| 134 | Soy protein hydrolyzate with enzyme-modified lecithin | FDA has no questions |
| 133 | Volatile oil of mustard | FDA has no questions |
| 132 | Lactase enzyme preparation from Aspergillus niger | FDA has no questions |
| 131 | High 2-palmitic vegetable oil | FDA has no questions |
| Additional correspondence | ||
| 130 | Bovine milk-derived lactoferrin | FDA has no questions |
| Additional correspondence | ||
| 129 | Sucrose fatty acid esters | FDA has no questions |
| 128 | Skim milk or dextrose cultured with Propionibacterium freudenreichii subsp. shermanii | FDA has no questions |
| 127 | Spirulina, the dried biomass of Arthrospira platensis | FDA has no questions; some uses may require a color additive listing |
| 126 | Alpha-amylase enzyme preparation from Pseudomonas fluorescens Biovar I expressing a gene encoding a hybrid alpha-amylase derived from three microorganisms within the order Thermococcales | FDA has no questions |
| 125 | Grape seed extract and grape pomace extract | FDA has no questions; some uses may require a color additive listing |
| 124 | Grape seed extract | FDA has no questions |
| 123 | Laminaria japonica broth and extract powder | FDA has no questions |
| 122 | Laccase enzyme preparation produced by Aspergillus oryzae expressing the gene encoding a laccase from Myceliophthora thermophila | FDA has no questions |
| 121 | Xanthan gum | FDA has no questions |
| 120 | Saccharomyces cerevisiae strain ML01 carrying a gene encoding the malolactic enzyme from Oenococcus oeni and a gene encoding malate permease from Schizosaccharomyces pombe | FDA has no questions |
| Details about Notices Received in 2002 (GRN Nos. 94 - 119) | ||
| GRN No. | Substance | FDA's Letter |
|---|---|---|
| 119 | Synthetic lycopene | FDA has no questions; some uses may require a color additive listing Corrected letter issued April 7, 2005 |
| 118 | Inulin | FDA has no questions |
| Additional correspondence about intended uses | ||
| 117 | Ice structuring protein preparation | FDA has no questions |
| 116 | Carrot fiber | FDA has no questions |
| 115 | Diacylglycerol oil | FDA has no questions |
| 114 | Pectate lyase enzyme preparation from Bacillus subtilis | FDA has no questions |
| 113 | Lipase enzyme preparation from Aspergillus oryzae | FDA has no questions |
| 112 | Phytosterols | FDA has no questions |
| 111 | Lipase enzyme preparation from Aspergillus niger | FDA has no questions |
| 110 | Lutein esters | FDA has no questions; some uses may require a color additive listing |
| 109 | Tuna oil | FDA has no questions |
| 108 | Glycerol ester of gum rosin | Notice does not provide a basis for a GRAS determination |
| 107 | Polydextrose | At notifier's request, FDA ceased to evaluate the notice |
| 106 | Glucose oxidase enzyme preparation from Aspergillus oryzae carrying a gene encoding a glucose oxidase from Aspergillus niger | FDA has no questions |
| 105 | Fish oil concentrate | FDA has no questions |
| 104 | Sucrose acetate isobutyrate | FDA has no questions |
| 103 | Lipase enzyme preparation from Aspergillus oryzae carrying a gene constructed from a modified Thermomyces lanuginosus lipase gene and a portion of the Fusarium oxysporum lipase gene | FDA has no questions |
| 102 | Small planktivorous pelagic fish body oil | FDA has no questions |
| 101 | Spirulina | At notifier's request, FDA ceased to evaluate the notice. Resubmitted as GRN No. 127 |
| 100 | D-Ribose | Notice does not provide a basis for a GRAS determination Resubmitted as GRN No. 243 |
| 99 | Pullulan | FDA has no questions |
| 98 | Small planktivorous pelagic fish body oil | At notifier's request, FDA ceased to evaluate the notice. Resubmitted as GRN No. 102 |
| 97 | Tuna oil | At notifier's request, FDA ceased to evaluate the notice. Resubmitted as GRN No. 109 |
| 96 | Silk protein food powder | Notice does not provide a basis for a GRAS determination |
| 95 | Transglutaminase from Streptoverticillium mobaraense | FDA has no questions |
| 94 | Docosahexaenoic acid-rich oil from tuna (DHA-rich tuna oil) and arachidonic acid-rich oil from Mortierella alpina (AA-rich fungal oil) | FDA has no questions |
| Details about Notices Received in 2001 (GRN Nos. 66 - 93) | ||
| GRN No. | Substance | FDA's Letter |
|---|---|---|
| 93 | Grape seed extract and grape skin extract | Notice does not provide a basis for a GRAS determination. Resubmitted as GRN No. 125 |
| 92 | Sucrose fatty acid esters | Notice does not provide a basis for a GRAS determination. Follow-up submitted as GRN No. 129 |
| 91 | Mycoprotein | FDA has no questions |
| 90 | Carbohydrase enzyme preparation from Aspergillus oryzae, protease enzyme preparation from Aspergillus oryzae, and carbohydrase enzyme preparation from Rhizopus oryzae | FDA has no questions |
| Additional correspondence | ||
| 89 | Five enzyme preparations from Aspergillus niger: Carbohydrase enzyme preparation, catalase enzyme preparation, glucose oxidase enzyme preparation, pectinase enzyme preparation, and protease enzyme preparation | FDA has no questions |
| Additional correspondence | ||
| 88 | Invertase enzyme preparation from Saccharomyces cerevisiae and lactase enzyme preparation from Kluyveromyces marxianus | FDA has no questions |
| 87 | Composite filtration media (diatomaceous earth and perlite) | FDA has no questions |
| 86 | Coagulated potato protein, hydrolyzed potato protein, or clarified hydrolyzed potato protein | FDA has no questions |
| 85 | Isoamylase from Pseudomonas amyloderamosa | FDA has no questions |
| 84 | Arabinogalactan from Eastern Larch (Larix laricina) | FDA has no questions |
| 83 | Carbon monoxide | FDA has no questions |
| 82 | 1,1,1,2-Tetrafluoroethane (HFC-134a) | FDA has no questions |
| 81 | Lipase from Candida rugosa | FDA has no questions |
| 80 | ARASCO (arachidonic acid-rich single-cell oil) | FDA has no questions |
| 79 | Alpha-amylase derived from Bacillus licheniformis carrying a gene encoding a modified alpha-amylase from Bacillus licheniformis | FDA has no questions |
| 78 | D-Tagatose | FDA has no questions |
| 77 | Milk-derived lactoferrin | FDA has no questions |
| 76 | Erythritol | FDA has no questions |
| 75 | Lipase derived from Aspergillus oryzae carrying a gene encoding lipase from Fusarium oxysporum | FDA has no questions |
| 74 | Beta-cyclodextrin | FDA has no questions |
| 73 | Shrimp-derived chitosan | At notifier's request, FDA ceased to evaluate the notice |
| 72 | Pullulanase derived from Bacillus licheniformis carrying a gene encoding pullulanase from B. deramificans | FDA has no questions |
| 71 | White mineral oil, USP (viscosity ISO 100 ) | FDA has no questions |
| 70 | Stearyl alcohol | FDA has no questions |
| 69 | Behenic acid | FDA has no questions |
| 68 | Lipase from Penicillium camembertii | FDA has no questions |
| 67 | Milk-derived lactoferrin | FDA has no questions |
| 66 | Milk thistle extract | Notice does not provide a basis for a GRAS determination |
| Details about Notices Received in 2000 (GRN Nos. 36 - 65) | ||
| GRN No. | Substance | FDA's Letter |
|---|---|---|
| 65 | Nisin | FDA has no questions |
| 64 | Egg white lysozyme | FDA has no questions |
| 63 | Hops beta acids | FDA has no questions |
| 62 | Chlorine dioxide generated from particles (<30µm) composed of sodium polyphosphate, magnesium sulfate, sodium silicate and sodium chlorite that are incorporated into low density polyethylene (LDPE) food-packaging films, at levels not exceeding 17.5 µg chlorite/in2 of finished package film | FDA has no questions |
| Additional correspondence about intended uses | ||
| 61 | Plant sterols/Plant sterol esters | FDA has no questions |
| 60 | Potassium bisulfate | FDA has no questions |
| 59 | Hydrogenated starch hydrolysate | At notifier's request, FDA ceased to evaluate the notice |
| 58 | Gum arabic | At notifier's request, FDA ceased to evaluate the notice |
| 57 | Argon gas | FDA has no questions |
| 56 | Diacylglycerol oil | FDA has no questions |
| 55 | Transglutaminase from Streptoverticillium mobaraense | FDA has no questions |
| 54 | Xylanase derived from Fusarium venenatum carrying a gene encoding xylanase from Thermomyces lanuginosus | FDA has no questions |
| 53 | Phytosterol esters | FDA has no questions |
| 52 | Whey mineral concentrate | FDA has no questions |
| 51 | Cassia gum from Cassia tora/obtusifolia | At notifier's request, FDA ceased to evaluate the notice. Resubmitted as GRN No. 139 |
| 50 | Bohenin | FDA has no questions |
| 49 | Bifidobacterium lactis strain Bb12 and Streptococcus thermophilus strain Th4 | FDA has no questions |
| Additional correspondence regarding new information about B. lactis strain Bb12 | ||
| 48 | Vegetable oil phytosterol esters | FDA has no questions |
| 47 | Arabinogalactan from Larix occidentalis | FDA has no questions |
| 46 | Gamma cyclodextrin | FDA has no questions |
| 45 | Trehalose | FDA has no questions |
| 44 | Fructooligosaccharide | FDA has no questions |
| Additional correspondence about intended uses | ||
| 43 | Lipase derived from Aspergillus oryzae carrying a gene encoding lipase from Thermomyces lanuginosus | FDA has no questions |
| 42 | Milk-derived lactoferrin | Notice does not provide a basis for a GRAS determination. Resubmitted as GRN No. 77 |
| Additional correspondence clarifying the appropriate mechanism to "supplement" a notice after FDA has responded to that notice | ||
| 41 | DHASCO (docosahexaenoic acid-rich single-cell oil) and ARASCO (arachidonic acid-rich single-cell oil) | FDA has no questions |
| 40 | Mineral oil | Notice does not provide a basis for a GRAS determination. Resubmitted as GRN No. 71 |
| 39 | Tall oil phytosterols | FDA has no questions |
| Additional correspondence clarifying intended use | ||
| 38 | Cetylpyridinium chloride | Notice does not provide a basis for a GRAS determination |
| 37 | Whey protein isolate and dairy product solids | FDA has no questions |
| Additional correspondence clarifying the term "dairy product solids" | ||
| 36 | Chromium picolinate; Ginkgo biloba leaf extract; and Ginseng extract | At notifier's request, FDA ceased to evaluate the notice |
| Details about Notices Received in 1999 (GRN Nos. 13 - 35) | ||
| GRN No. | Substance | FDA's Letter |
|---|---|---|
| 35 | Hempseed oil | Notice does not provide a basis for a GRAS determination |
| 34 | Aspartic proteinase derived from Aspergillus oryzae carrying a gene encoding aspartic proteinase from Rhizomucor miehei | FDA has no questions |
| 33 | Low erucic acid oil derived from Brassica juncea | FDA has no questions |
| 32 | Pectin lyase derived from Trichoderma reesei carrying a gene encoding pectin lyase from Aspergillus niger | FDA has no questions |
| 31 | Cetylpyridinium chloride | At notifier's request, FDA ceased to evaluate the notice.
Resubmitted as GRN No. 38 |
| 30 | Crospovidone-cranberry juice extract | Notice does not provide a basis for a GRAS determination |
| Additional correspondence that does not provide a basis for a GRAS determination | ||
| 29 | Transglutaminase from Streptoverticillium mobaraense | FDA has no questions |
| 28 | Seaweed-derived calcium | FDA has no questions |
| Additional correspondence about intended uses | ||
| 27 | Dextranase from Chaetomium gracile | FDA has no questions |
| 26 | Isolated wheat protein | FDA has no questions |
| 25 | Extract of Garcinia kola seed ("bitter cola") | Notice does not provide a basis for a GRAS determination |
| 24 | alpha-Amylase derived from Bacillus licheniformis carrying a gene encoding alpha-amylase from Bacillus stearothermophilus | FDA has no questions |
| 23 | Protein preparation from animal blood | At notifier's request, FDA ceased to evaluate the notice |
| 22 | alpha-Amylase derived from Bacillus licheniformis carrying a gene encoding a modified alpha-amylase derived from Bacillus lichenformis and Bacillus amyloliquefaciens | FDA has no questions |
| 21 | Pork collagen | FDA has no questions |
| 20 | Pullulanase derived from Bacillus subtilis carrying a gene encoding pullulanase from Bacillus naganoensis | FDA has no questions |
| 19 | Ferrous bisglycinate chelate | FDA has no questions |
| 18 | Mesquite (Prosopis spp.) wood alcoholic extract | FDA has no questions |
| 17 | Arabinogalactan | At notifier's request, FDA ceased to evaluate the notice. Resubmitted as GRN No. 47 |
| 16 | Menhaden oil | At notifier's request, FDA ceased to evaluate the notice |
| 15 | Tasteless smoke | FDA has no questions |
| 14 | Hydrogen peroxide | Notice does not provide a basis for a GRAS determination |
| 13 | Botanicals: Chrysanthemum; Licorice; Jellywort | FDA has no questions |
| Botanicals: Honeysuckle; Lophatherum; Mulberry leaf; Frangipani; Selfheal; Sophora flower bud | Notice does not provide a basis for a GRAS determination | |
| Details about Notices Received in 1998 (GRN Nos. 1 - 12) | ||
| GRN No. | Substance | FDA's Letter |
|---|---|---|
| 12 | Mesquite wood alcoholic extract | At notifier's request, FDA ceased to evaluate the notice. Resubmitted as GRN No. 18 |
| 11 | Calcium casein peptone-calcium phosphate | FDA has no questions |
| 10 | Exopeptidase derived from Aspergillus oryzae carrying a gene encoding a leucine aminopeptidase from Aspergillus sojae | Notice does not provide a basis for a GRAS determination |
| 9 | Polyglycerol polyricinoleic acid | FDA has no questions |
| 8 | Pectin esterase derived from Aspergillus oryzae carrying a gene encoding pectin esterase from Aspergillus aculeatus | FDA has no questions |
| 7 | ARASCO (arachidonic acid-rich single-cell oil) and DHASCO (docosahexaenoic acid-rich single-cell oil) as sources of the fatty acids ARA (arachidonic acid) and DHA (docosahexaenoic acid) | Notice does not provide a basis for a GRAS determination. Resubmitted as GRN No. 41 |
| 6 | Dioctyl sodium sulfosuccinate | FDA has no questions |
| 5 | Tasteless smoke | At notifier's request, FDA ceased to evaluate the notice. Resubmitted as GRN No. 15 |
| 4 | Transglutaminase from Streptoverticillium mobaraense | FDA has no questions |
| 3 | Sodium bisulfate | FDA has no questions |
| 2 | Solin oil (low linolenic acid flaxseed oil or low linolenic acid linseed oil) | FDA has no questions |
| 1 | Soy isoflavone extract | At notifier's request, FDA ceased to evaluate the notice |
