HuGENet™ publications are articles related to the HuGENet™ movement written by our HuGENet™ collaborators.
If you would like to submit or recommend a publication, please contact us at huge@cdc.gov.
Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology (479KB) Paul R Burton, et al. International Journal of Epidemiology 2008; August
A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions Janssens AC, et al. Am J Hum Genet 2008 Mar;82(3):593-9
Required sample size and nonreplicability thresholds for heterogeneous genetic associations Moonesinghe R, et al. Proc Natl Acad Sci U S A. 2008; Jan 3
The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? (148KB) Muin J. Khoury, et al. Genetics in Medicine. 2007; October
Assessment of cumulative evidence on genetic associations: interim guidelines John PA Ioannidis, et al. International Journal of Epidemiology 2007; September
Reporting of systematic reviews: the challenge of genetic association studies Muin J. Khoury, Julian Little, Julian Higgins, John P. A. Ioannidis, Marta Gwinn PLoS Medicine 2007; 4(6):e211
Turning the Pump Handle: Evolving Methods for Integrating the Evidence on Gene-Disease Association Julian P. T. Higgins, et al. American Journal of Epidemiology 2007; 166(8): 863-866
Commentary: Rare alleles, modest genetic effects and the need for collaboration H Campbell, T Manolio International Journal of Epidemiology 2007; 36(2):445-8
Genetic and molecular epidemiology John P.A. Ioannidis Journal of Epidemiology and Community Health 2007;61:757-758
Predictive value of testing for multiple genetic variants in multifactorial diseases: implications for the discourse on ethical, legal and social issues (327KB) A. Cecile J.W. Janssens, Muin J. Khoury Italian Journal of Public Health 2007; 4(3):35-41
The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases Cecile J. W. Janssens, PhD, et al. Genetics In Medicine 2007; 9(8):528-35
Claims of Sex Differences: An Empirical Assessment in Genetic Associations Nikolaos A. Patsopoulos, MD, et al. JAMA 2007; 298(8):880-93
Online genetic databases informing human genome epidemiology Angela J Frodsham, Julian PT Higgins BMC Medical Research Methodology 2007 7:31
Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: a systematic review and annotated bibliography Simon Sanderson, et al. International Journal of Epidemiology (April 2007)
The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey John P.A. Ioannidis and Thomas A. Trikalinos Canadian Medical Association Journal, April 2007
Genetic Association Studies of Cancer: Where Do We Go from Here? Timothy R. Rebbeck, Muin J. Khoury, John D. Potter Cancer Epidemiol Biomarkers Prev 2007 May;16(5):864-5
The ESCI Award 2007: Molecular evidence-based medicine J.P.A. Ioannidis European Journal of Clinical Investigation (2007) 37:340-349
Meta-Analysis in Genome-Wide Association Datasets: Strategies and Application in Parkinson Disease Evangelos Evangelou, et al PLoS Medicine (April 2007)
HuGE Reviews and Meta-analysis of Gene Association Studies Hashem El–Serag, Associate Editor, Muin J. Khoury, Centers for Disease Control and Prevention and James D. Lewis, Associate Editor Gastroenterology 2007; 132(3):839-840
Most published research findings are false--but a little replication goes a long way (last accessed 2/2008) Ramal Moonesinghe, Muin J. Khoury, A. Cecile J. W. Janssens PLoS Medicine (February 2007)
Genomics and public health Marta Gwinn, Scott Bowen, Muin J. Khoury and the Centers for Disease Control and Prevention. MMWR Morb Mortal Wkly Rep. 2006 Dec 22;55 Suppl 2:20-1
The Emergence of Networks in Human Genome Epidemiology: Challenges and Opportunities Daniela Seminara, et al Epidemiology 2007; 18(1):1-8
On the synthesis and interpretation of consistent but weak gene–disease associations in the era of genome-wide association studies Muin J. Khoury, Julian Little, Marta Gwinn and John PA Ioannidis International Journal Epidemiology 2006 (December)
The integration of genomics into obstetrics and gynecology: A HuGE challenge Muin J. Khoury and Roberto Romero American Journal of Obstetrics and Gynecology 2006; 195:1503-5
Concordance of functional in vitro data and epidemiological associations in complex disease genetics Ioannidis JP, Kavvoura FK. Genetics in Medicine 2006; 8(9):583-593
What role for public health in genetics and vice versa? (60KB) Khoury MJ, Gwinn M. Community Genetics 2006; 9(4):282
Bayesian synthesis of epidemiological evidence with different combinations of exposure groups: application to a gene-gene-environment interaction (157KB) Salanti G, Higgins JP, White IR. Statistics in Medicine 2006; 25(24): 4147-4163
Genomics, Epidemiology and common complex diseases: let's not throw out the baby with the bathwater! Muin J. Khoury and Marta Gwinn International Journal of Epidemiology 2006; 35(5):1363-1364
Genes, environment and the value of prospective cohort studies Teri A. Manolio, et al. Nature 2006; 7:812-820
Genomics and Proteomics in Epidemiology: Treasure Trove or "High-Tech Stamp Collecting"? David J. Hunter Epidemiology 2006 Sep;17(5):487-489
Getting ready for the future: integration of genomics into public health research, policy and practice in Europe and globally Angela Brand et al. Community Genetics 2006; 9(1):67-71
Family-Based versus Unrelated Case-Control Designs for Genetic Associations Evangelou E, Trikalinos TA, Salanti G, Ioannidis JP PLoS Genetics 2006; 2(8):e123
Implications of Small Effect Sizes of Individual Genetic Variants on the Design and Interpretation of Genetic Association Studies of Complex Diseases John P. A. Ioannidis, Thomas A. Trikalinos and Muin J. Khoury American Journal of Epidemiology 2006; 164(7):609-614
Causal models in epidemiology: Past inheritance and genetic future Vineis P, Kriebel D. Environmental Health 2006; 5(1):21
Predictive testing for complex diseases using multiple genes: Fact or fiction? A. Cecile J. W. Janssens, et al. Genetics in Medicine 2006; 8(7):395-400
What is the clinical utility of genetic testing? Scott D. Grosse, Muin J. Khoury, et al. Genetics in Medicine 2006; 8(7):448-50
The path from genome-based research to population health: Development of an international public health genomics network Wylie Burke, Muin J. Khoury et al. Genetics in Medicine 2006; 8(7):451-58
Genetic epidemiological studies of preterm birth: Guidelines for research Pennell C, et al. American Journal of Obstetrics and Gynecology 2006 (June)
Bayesian meta-analysis and meta-regression for gene-disease associations and deviations from Hardy-Weinberg equilibrium Salanti G, et al. Statistics in Medicine 2007; 26(3): 553-567
Tracking the Epidemiology of Human Genes in the Literature: The HuGE Published Literature Database Bruce K. Lin, et al. American Journal of Epidemiology 2006; 164(1):1-4
Commentary: Grading the credibility of molecular evidence for complex diseases John P A Ioannidis International Journal of Epidemiology 2006; 35(3):572-578
Make it HuGE: human genome epidemiology reviews, population health, and the IJE Smith GD et al. International Journal of Epidemiology 2006; 35(3):507-510
Genomics and public health in the United States: signposts on the translation highway Gwinn M, Khoury MJ Community Genetics 2006; 9(1):21-6
Quantifying the health benefits of genetic tests: the importance of a population perspective Khoury MJ, Jones K, Grosse SD Genetics in Medicine 2006; 8(3):191-5
A road map for efficient and reliable human genome epidemiology John P A Ioannidis, Marta Gwinn, Julian Little, et al. Nature Genetics 38, 305 (2006)
Expanded publishing model for genetic association studies Gwinn M, Khoury MJ. Cancer Epidemiology Biomarkers & Prevention 2006;15(1):185
Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations Trikalinos TA, Salanti G, Khoury MJ, Ioannidis JP. American Journal of Epidemiology 2006;163(4):300-9.
Journals should publish all "null" results and should sparingly publish "positive" results Ioannidis JP. Cancer Epidemiology Biomarkers & Prevention 2006;15(1):186
Do We Need Genomic Research for the Prevention of Common Diseases with Environmental Causes? Muin J. Khoury, Robert Davis, Marta Gwinn, Mary Lou Lindegren and Paula Yoon American Journal of Epidemiology 2006; 161(9):799-805
The epidemiologic approach to pharmacogenomics (335KB) Little J, et al., American Journal of Pharmacogenomics 2005; 5(1):1-20
Genomic Epidemiology of Complex Disease: The Need for an Electronic Evidence-based Approach to Research Synthesis HuGE commentary by M. Bracken American Journal of Epidemiology 2005; 162(4):297-301
Obstacles and opportunities in meta-analysis of genetic association studies G. Salanti et al. Genetics in Medicine 2005; 7(1):13-20
The Case for a Global Human Genome Epidemiology Initiative Article by Muin J. Khoury, Sep (2004) Nature Genetics 2004;36(10):1027-8
The Emergence of Epidemiology in the Genomics Age Muin J Khoury, Robert Millikan, Julian Littleand Marta Gwinn International Journal of Epidemiology 2004; 33(5):936-944
Human Genome Epidemiology: A Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease Book edited by Muin J. Khoury, Julian Little, and Wylie Burke (2004)
Improving the Prediction of Complex Diseases by Testing for Multiple Disease‐Susceptibility Genes American Journal Human Genetics 2003 Mar;72(3):636-49
Mendelian Randomisation: A New Spin or Real Progress? A commentary by Julian Little and Muin J. Khoury Lancet 2003;362(9388):930-1
The Human Genome Project Is Now Complete. How Do We Develop a Handle for the Pump? Article by Julian Little et al. American Journal of Epidemiology 2003; 157:667-673
Reporting, Appraising, and Integrating Data On Genotype Prevalence and Gene-Disease Associations Article by Julian Little et al. American Journal of Epidemiology 2002; 156:300-310
Genetic Test Evaluation: Information Needs of Clinicians, Policy-Makers and the Public Article by Wylie Burke et al. American Journal of Epidemiology2002; 156:311-318
Human Genome Epidemiology Information (HuGE) on the Internet: Current Resources and Future Prospects Article by Adam Marks and Paula Yoon, (2002)
Human Genome Epidemiologic Reviews: the Beginning of Something HuGE Article by Muin J. Khoury and Julian Little American Journal of Epidemiology 2000; 151:2-3
Human Genome Epidemiology (HuGE): Translating Advances in Human Genetics into Population-based Data for Medicine and Public Health Article by Muin J. Khoury Genetics in Medicine, Mar (1999)
The Human Genome Epidemiology Network (HuGENet™) Editorial by Muin J. Khoury and Janice S. Dorman American Journal of Epidemiology 1998; 198:4