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Pharmacoepidemiology & Pharmacogenomics Resources:
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Introduction to Pharmacoepidemiology & Pharmacogenomics Resources
Pharmacoepidemiology examines the benefit and risk of drugs used in populations and
analyzes the outcomes of drug therapies. This includes detection and evaluation of
drug-related adverse effects, assessment of risk vs. benefit ratios in drug therapy,
patterns of drug utilization, and the cost-effectiveness of specific drugs.
Pharmacogenomics examines genetic variation on drug response in patients by associating
gene expression or single-nucleotide polymorphisms with a drug's efficacy or toxicity.
Such approaches attempt to optimize drug response for each individual's unique genetic
make-up.
NCI has developed this website to assist clinicians and researchers who are
interested in investigating relationships between pharmaceutical agents,
genomic factors, and cancer prevention and treatment. This website
provides:
The intent of this website is to stimulate research to assess the magnitude to which
prescription drugs are associated with risk and/or benefit of cancer development; evaluate
the risk of serious adverse acute events and longer-term effects associated with cancer
drug therapies and drugs used to treat side-effects; and identify specific clinical and genomic
profiles that could enhance optimal response to cancer therapy and minimize toxicity.
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