| NCTR Centers of Excellence | Center for Phototoxicology |  National Toxicology Program |

Publications
 

2005

Xia, Q., Yin, J.J., Cherng, S.H., Wamer, W.G., Boudreau, M., Howard, P.C., and Fu, P.P. UVA photoirradiation of retinyl palmitate-formation of singlet oxygen and superoxide, and their role in induction of lipid peroxidation. 2005. Toxicology Letters, , in press.

Tsuji, J.S., Maynard, A.D., Howard, P.C., James, J.T., Lam, C.W., Warheit, D.B., and Santamaria, A.B. 2005. Research Strategies for safety evaluation of nanomaterials, part IV: risk assessment of nanoparticles. Toxicological Sciences, 89, 42-50.

Yan, J., Xia, Q., Cherng, S.H., Wamer, W.G., Howard, P.C., Yu, H., and Fu, P.P. 2005. Photo-induced DNA damage and photocytotoxicity of retinyl palmitate and its photodecomposition products. Toxicol. Industrial Health, 21, 167-175.

Cui, Y., Churchwell, M.I., Couch, L.H., Doerge, D.R., and Howard, P.C. 2005. Metabolism of pigment yellow 74 by rat and human microsomal proteins. Drug. Metabol. Disposition, 33, 1459-1465.

Gopee, N.V., Cui, Y., Olson, G., Warbritton, A.R., Miller, B.J., Couch, L.H., Wamer, W.G., and Howard, P.C. 2005. Response of mouse skin to tattooing: use of SKH-1 mice as a surrogate model for human tattooing. Toxicol. Appl. Pharmacol., 209, 145-158.

Cheng, S.-H., Xia, Q., Blakenship, L.R., Freeman, J.P., Wamer, W.G., Howard, P.C., and Fu, P.P. 2005. Photodecomposition of retinyl palmitate in ethanol by UVA light – formation of photodecomposition products, reactive oxygen species, and lipid peroxides. Chemical Research in Toxicology, 18, 129-138.

Verkler, T.L., Couch, L.H., Howard, P.C., and Parsons, B.L. 2005. Quantifying levels of p53 mutation in mouse skin tumors. Environ. Mol. Mutagen., 45, 427-434.

Tolleson, W.H., Doss, J.C., Latendresse, J., Warbritton, A.R., Melchior, W.B., Chin, L., Dubielzig, R.R., and Albert, D.M. 2005. Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf -/- mice. Arch. Ophthalmol. 123, 1088-1094.

2004

Cheng, S.-H., Xia, Q., Blakenship, L.R., Freeman, J.P., Wamer, W.G., Howard, P.C., and Fu, P.P. Photodecomposition of retinyl palmitate in ethanol by UVA light – formation of photodecomposition products, reactive oxygen species, and lipid peroxides. Chemical Research in Toxicology, in press.

Cui, Y., Spann, A.P., Couch L.H., Gopee, N.V., Evans, F.E., Churchwell, M.I., Williams, L.D., Doerge, D.R., and Howard, P.C. Photodecomposition of pigment yellow 74, a pigment used in tattoo inks. Photochemistry and Photobiology, in press.

Tolleson, W.H., S.-H. Cherng, Q. Xia, J.J. Yin, W.G. Wamer, P.C. Howard, H. Yu, and P.P. Fu. Photoreaction, phototoxicity, and photocarcinogenicity of retinoids. Int. J. Environ. Res. Public Health, in press

Molefe, D., J.J. Chen, P.C. Howard, B.J. Miller, C.P. Sambuco, P.D. Forbes, and R.L. Kodell. 2004. Tests for effects on tumor frequency and latency in multiple dosing photococarcinogenicity experiments. J. Statistical Planning and Inference, in press.

2003

Fu, P.P., Cheng, S.-H., Coop, L., Xia, Q., Culp, S.J., Tolleson, W.H., Wamer, W.G., and Howard, P.C. 2003. Photoreaction, phototoxicity and photocarcinogenicity of retinoids. Environ. Carcinogen. Ecotoxicol. Rev, C21, 165-197.

Couch. L.H., and P.C. Howard. 2002. Quantification of glycolic acid in cosmetic products using reversed phase high performance liquid chromatography. International Journal of Cosmetic Science, 24, 89-95.

Sams, R.L., II, L.H. Couch, B.J. Miller, C.V. Okerberg, A.R. Warbritton, W.G. Wamer, J.Z. Beer, and P.C. Howard. 2002. The effects of alpha- and beta-hydroxy acids on the edemal response induced in female SKH-1 mice by simulated solar light. Toxicology and Applied Pharmacology, 184, 136-143.

Fu, P., P.C. Howard, S.J. Culp, Q. Xia, P.J. Webb, L.R. Blankenship, W.G. Wamer, and J.R. Bucher. 2002. Do topically applied skin creams containing retinyl palmitate affect the photocarcinogenicity of simulated solar light? J. Food Drug Analysis, 10, 262-268.

Howard, P.C., R.L. Sams II, D.A. Dennis, and W.G. Wamer. 2002. Alpha-hydroxy acids: consideration of the biological effects and possible role in photococarcinogenesis. J. Food Drug Analysis, 10, 258-261.

Howard, P.C., R.L. Sams II, J.R. Bucher, and W.T. Allaben. 2002. Phototoxicology and photocarcinogenesis at the U.S. Food and Drug Administration’s National Center for Toxicological Research. J. Food Drug Analysis, 10, 252-257.

Sams, R.L. II, L.H. Couch, B.J. Miller, C.V. Okerberg, A. Warbritton, W.G. Wamer, J.Z. Beer, and P.C. Howard. 2001. Basal cell proliferation in female SKH-1 mice treated with alpha- and beta-hydroxy acids. Toxicology and Applied Pharmacology, 175, 76-82.
 

Couch, L.H., Cui, Y., Spann, A., Gopee, N.V., Evans, F.E., Churchwell, M.I., Williams, L., Doerge, D.R., and Howard, P.C. Photodecomposition of pigment yellow 74, a primary color chemical in tattoo inks. The Toxicologist, 58, 1609, 2004.

Cui, Y.Y., Gopee, N.V., Evans, F.E., Couch, L.H., Churchwell, M.I., Doerge, D.R., and Howard, P.C. Metabolism of tattoo pigment yellow 74 using rat liver microsomal protein or xanthine oxidase. The Toxicologist, 58, 671, 2004.

Howard, P.C., Gopee, N.V., Cui, Y.Y., Evans, F.E., Couch, L.H., Churchwell, M.I., and Doerge, D.R. Photochemical decomposition of the dichlorobenzidine-based tattoo pigment orange 13 in simulated solar light. The Toxicologist, 58, 1610, 2004.

Gopee, N.V., Cui, Y.Y., Olson, G., Warbritton, A., Miller, B.J., Couch, L.H., Wamer, W.G., and Howard, P.C. Response of SKH-1 mouse skin following the acute injury of tattooing. The Toxicologist, 58, 1602, 2004.

Verkler, T.L., Couch, L.H., Miller, B.J., Howard, P.C., and Parsons, B.L. ACB-PCR measurement of p53 mutation: a potential biomarker of skin cancer development. The Toxicologist, 58, 861, 2004.

P.P. Fu, Q. Xia, L.G. Blankenship, P.J. Webb, W.G. Wamer, and P.C. Howard, Photostability and photogenotoxicity of retinyl palmitate. The Toxicologist, 57, 1007, 2003.

Verkler TL, Delongchamp RR, Warbritton A, Couch LH, Miller BJ, Howard PC, Parsons BL.  2004.  Accumulation of simulated solar light-induced mouse p53 codon 270 CGT to TGT mutation during skin tumor development.  35th Annual Meeting of the Environmental Mutagen Society, Pittsburgh, PA.  Environmental and Molecular Mutagenesis 44:234.

Xia, Q., S.-H. Cherng, L.R. Blankenship, W.G. Wamer, J.R. Bucher, P.C. Howard, and P.P. Fu. Formation of reactive oxygen species and lipid peroxides from photoirradiation of retinyl palmitate and its photodecomposition products. The 32nd Annual Meeting of the American Society for Photobiology, Abstract #164, 2004.

Yan, J., S.-H. Cherng, Q. Xia, W.G. Wamer, J.R. Bucher, P.C. Howard, H. Yu, and P.P. Fu. Photoclastogenicity of retinyl palmitate and its photodecomposition products. The 32nd Annual Meeting of the American Society for Photobiology, Abstract #165, 2004.

Cheng, S.H., Q. Xia, J. P. Freeman, W. G. Wamer, P. C. Howard and P. P. Fu. Mechanism of retinyl palmitate photodecomposition. Abstract #187, the 31st Annual Meeting American Society for Photobiology, p. 58, 2003.

Others

Fu, P.P. Photodecomposition and phototoxicity of retinoids, First International Symposium on Recent Advances in Environmental Health Research, Abstract #O-11, 2004.

Fu, P.P., Cheng, S.H., Q. Xia, J. P. Freeman, W. G. Wamer, and P. C. Howard. Mechanism of retinyl palmitate photodecomposition. Abstract #P120, the 10th Congress of the European Society for Photobiology, p. 58, September 6-11, 2003.