| NCTR Centers
of Excellence |
Center for Phototoxicology | National Toxicology Program |
Publications
2005
Xia, Q., Yin, J.J., Cherng, S.H., Wamer, W.G., Boudreau, M., Howard,
P.C., and Fu, P.P. UVA photoirradiation of retinyl palmitate-formation
of singlet oxygen and superoxide, and their role in induction of lipid
peroxidation. 2005. Toxicology Letters, , in press.
Tsuji, J.S., Maynard, A.D., Howard, P.C., James, J.T., Lam, C.W.,
Warheit, D.B., and Santamaria, A.B. 2005. Research Strategies for safety
evaluation of nanomaterials, part IV: risk assessment of nanoparticles.
Toxicological Sciences, 89, 42-50.
Yan, J., Xia, Q., Cherng, S.H., Wamer, W.G., Howard, P.C., Yu, H.,
and Fu, P.P. 2005. Photo-induced DNA damage and photocytotoxicity of
retinyl palmitate and its photodecomposition products. Toxicol.
Industrial Health, 21, 167-175.
Cui, Y., Churchwell, M.I., Couch, L.H., Doerge, D.R., and Howard,
P.C. 2005. Metabolism of pigment yellow 74 by rat and human microsomal
proteins. Drug. Metabol. Disposition, 33, 1459-1465.
Gopee, N.V., Cui, Y., Olson, G., Warbritton, A.R., Miller, B.J.,
Couch, L.H., Wamer, W.G., and Howard, P.C. 2005. Response of mouse skin
to tattooing: use of SKH-1 mice as a surrogate model for human
tattooing. Toxicol. Appl. Pharmacol., 209, 145-158.
Cheng, S.-H., Xia, Q., Blakenship, L.R., Freeman, J.P., Wamer, W.G.,
Howard, P.C., and Fu, P.P. 2005. Photodecomposition of retinyl palmitate
in ethanol by UVA light – formation of photodecomposition products,
reactive oxygen species, and lipid peroxides. Chemical Research in
Toxicology, 18, 129-138.
Verkler, T.L., Couch, L.H., Howard, P.C., and Parsons, B.L. 2005.
Quantifying levels of p53 mutation in mouse skin tumors. Environ.
Mol. Mutagen., 45, 427-434.
Tolleson, W.H., Doss, J.C., Latendresse, J., Warbritton, A.R.,
Melchior, W.B., Chin, L., Dubielzig, R.R., and Albert, D.M. 2005.
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf
-/- mice. Arch. Ophthalmol. 123, 1088-1094.
2004
Cheng, S.-H., Xia, Q., Blakenship, L.R., Freeman, J.P., Wamer, W.G.,
Howard, P.C., and Fu, P.P. Photodecomposition of retinyl palmitate in
ethanol by UVA light – formation of photodecomposition products,
reactive oxygen species, and lipid peroxides. Chemical Research in
Toxicology, in press.
Cui, Y., Spann, A.P., Couch L.H., Gopee, N.V., Evans, F.E.,
Churchwell, M.I., Williams, L.D., Doerge, D.R., and Howard, P.C.
Photodecomposition of pigment yellow 74, a pigment used in tattoo inks.
Photochemistry and Photobiology, in press.
Tolleson, W.H., S.-H. Cherng, Q. Xia, J.J. Yin, W.G. Wamer, P.C.
Howard, H. Yu, and P.P. Fu. Photoreaction, phototoxicity, and
photocarcinogenicity of retinoids. Int. J. Environ. Res. Public
Health,
in press
Molefe, D., J.J. Chen, P.C. Howard, B.J. Miller, C.P. Sambuco, P.D.
Forbes, and R.L. Kodell. 2004. Tests for effects on tumor
frequency and latency in multiple dosing photococarcinogenicity
experiments. J. Statistical Planning and Inference, in
press.
2003
Fu, P.P., Cheng, S.-H., Coop, L., Xia, Q., Culp, S.J., Tolleson, W.H.,
Wamer, W.G., and Howard, P.C. 2003. Photoreaction, phototoxicity
and photocarcinogenicity of retinoids. Environ. Carcinogen. Ecotoxicol.
Rev, C21, 165-197.
2002
Couch. L.H., and P.C. Howard. 2002. Quantification of glycolic
acid in cosmetic products using reversed phase high performance liquid
chromatography. International Journal of Cosmetic Science,
24, 89-95.
Sams, R.L., II, L.H. Couch, B.J. Miller, C.V. Okerberg, A.R.
Warbritton, W.G. Wamer, J.Z. Beer, and P.C. Howard. 2002. The
effects of alpha- and beta-hydroxy acids on the edemal response induced
in female SKH-1 mice by simulated solar light. Toxicology and
Applied Pharmacology, 184, 136-143.
Fu, P., P.C. Howard, S.J. Culp, Q. Xia, P.J. Webb, L.R. Blankenship,
W.G. Wamer, and J.R. Bucher. 2002. Do topically applied skin
creams containing retinyl palmitate affect the photocarcinogenicity of
simulated solar light? J. Food Drug Analysis, 10, 262-268.
Howard, P.C., R.L. Sams II, D.A. Dennis, and W.G. Wamer. 2002.
Alpha-hydroxy acids: consideration of the biological effects and
possible role in photococarcinogenesis. J. Food Drug Analysis,
10, 258-261.
Howard, P.C., R.L. Sams II, J.R. Bucher, and W.T. Allaben. 2002.
Phototoxicology and photocarcinogenesis at the U.S. Food and Drug
Administration’s National Center for Toxicological Research. J.
Food Drug Analysis, 10, 252-257.
2001
Sams, R.L. II, L.H. Couch, B.J. Miller, C.V. Okerberg, A. Warbritton,
W.G. Wamer, J.Z. Beer, and P.C. Howard. 2001. Basal cell
proliferation in female SKH-1 mice treated with alpha- and beta-hydroxy
acids. Toxicology and Applied Pharmacology, 175, 76-82.
ABSTRACTS AT RECENT MEETINGS
Society of Toxicology
Couch, L.H., Cui, Y., Spann, A., Gopee, N.V.,
Evans, F.E., Churchwell, M.I., Williams, L., Doerge, D.R., and Howard,
P.C. Photodecomposition of pigment yellow 74, a primary color chemical
in tattoo inks. The Toxicologist, 58, 1609, 2004.
Cui, Y.Y., Gopee, N.V., Evans, F.E., Couch, L.H.,
Churchwell, M.I., Doerge, D.R., and Howard, P.C. Metabolism of tattoo
pigment yellow 74 using rat liver microsomal protein or xanthine oxidase.
The Toxicologist, 58, 671, 2004.
Howard, P.C., Gopee, N.V., Cui, Y.Y., Evans, F.E.,
Couch, L.H., Churchwell, M.I., and Doerge, D.R. Photochemical
decomposition of the dichlorobenzidine-based tattoo pigment
orange 13 in simulated solar light. The Toxicologist, 58,
1610, 2004.
Gopee, N.V., Cui, Y.Y., Olson, G., Warbritton, A., Miller, B.J.,
Couch, L.H., Wamer, W.G., and Howard, P.C. Response of SKH-1 mouse skin
following the acute injury of tattooing. The Toxicologist,
58, 1602, 2004.
Verkler, T.L., Couch, L.H., Miller, B.J., Howard, P.C., and Parsons,
B.L. ACB-PCR measurement of p53 mutation: a potential biomarker of skin
cancer development. The Toxicologist, 58, 861, 2004.
Verkler, T.L., R.R. Delongchamp, A. Warbritton, L.H. Couch, B.J.
Miller, P.C. Howard, and B.L. Parsons. 2004.
Induction of mouse p53 codon 270 CGT to TGT mutation by simulated
solar light during skin tumor development. 2004 Annual Meeting of
the South Central Chapter of the Society of Toxicology, Mississippi
State University, Starkville, MS.
P.P. Fu, Q. Xia, L.G. Blankenship, P.J. Webb, W.G.
Wamer, and P.C. Howard, Photostability and photogenotoxicity of retinyl
palmitate. The Toxicologist, 57, 1007, 2003.
Environmental Mutagen Society
Verkler TL, Delongchamp RR, Warbritton A, Couch LH, Miller BJ, Howard
PC, Parsons BL. 2004. Accumulation of simulated solar
light-induced mouse p53 codon 270 CGT to TGT mutation during skin tumor
development. 35 th Annual Meeting of
the Environmental Mutagen Society, Pittsburgh, PA. Environmental
and Molecular Mutagenesis 44:234.
Parsons BL, Couch LH, Miller BJ, Howard PC. 2002.
Development of an allele-specific amplification for mouse p53 CC to TT
mutation, a potential biomarker for estimating skin cancer risk.
33rd Annual Meeting of the Environmental Mutagen Society.
Anchorage, AK.
FDA Annual Science Forum
Verkler, T.L., L.H. Couch, B.J. Miller, P.C. Howard, B.L. Parsons.
2004. Measurement of mouse p53 codon 270 CGT to TGT
mutant fraction as a potential biomarker for estimating the
co-carcinogenicity of sunlight and FDA-regulated products. 10th
Annual FDA Science Forum, FDA Science: The Critical Path from Concept to
Consumer. Washington, DC.
American Society for Photobiology
Xia, Q., S.-H. Cherng, L.R. Blankenship, W.G. Wamer, J.R. Bucher,
P.C. Howard, and P.P. Fu. Formation of reactive oxygen species and lipid
peroxides from photoirradiation of retinyl palmitate and its
photodecomposition products. The 32nd Annual Meeting of the American
Society for Photobiology, Abstract #164, 2004.
Yan, J., S.-H. Cherng, Q. Xia, W.G. Wamer, J.R. Bucher, P.C. Howard,
H. Yu, and P.P. Fu. Photoclastogenicity of retinyl palmitate and its
photodecomposition products. The 32nd Annual Meeting of the American
Society for Photobiology, Abstract #165, 2004.
Cheng, S.H., Q. Xia, J. P. Freeman, W. G. Wamer, P. C. Howard and P.
P. Fu. Mechanism of retinyl palmitate photodecomposition. Abstract #187,
the 31st Annual Meeting American Society for Photobiology, p. 58,
2003.
Others
Fu, P.P. Photodecomposition and phototoxicity of retinoids, First
International Symposium on Recent Advances in Environmental Health
Research, Abstract #O-11, 2004.
Fu, P.P., Cheng, S.H., Q. Xia, J. P. Freeman, W. G. Wamer, and P. C.
Howard. Mechanism of retinyl palmitate photodecomposition. Abstract
#P120, the 10th Congress of the European Society for Photobiology, p.
58, September 6-11, 2003.
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