National Toxicology Program

CASRN: 8001-30-7

Formula: N/F

Synonyms/Common Names:

• MAZOLA OIL

Known Uses:

SALAD AND COOKING OIL, MARGARINE PRODUCTION, PHARMACEUTICAL PREPARATIONS, IN NONYELLOWING ENAMEL PAINT, DEFOAMING AGENT IN PAPER/PAPERBOARD MANUFACTURING, VEHICLE FOR EXPERI. DIETS AND TEST COMPDS.

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C00577) Report Complete 
  • TR-426 (NTIS No. PB95-103958)  (Peer Review 12/01/1992)
    Comparative Toxicology Studies of Corn Oil, Safflower Oil, and Tricaprylin (CAS Nos. 8001-30-7, 8001-23-8, and 538-23-8) in Male F344/N Rats as Vehicles for Gavage
  • Rats: F344/N
  • Dose: RATS ONLY: 0, 2.5, 5, 10 ML CORN OIL/KG FOR 103 WEEKS./50 PER GROUP

Genetic Toxicology

• Salmonella  (655449) Completed 
  •  Negative 

Organ Systems Toxicity

• Dominant Lethal (Female)  (DLF015) Completed 
  • Citation: Generoso, W.M., Cain, K.T., Hoskins, J.A., Washington, W.J., and Rutledge, J.C. Pseudo dominant-lethal response in female mice treated with plant oils. Mutation Res. 129:235-241 (1984).
  • F Mice: C3H X C57BL
  • Mice Female Negative 
• Dominant Lethal (Female)  (DLF016) Completed 
  • Citation: Generoso, W.M., Cain, K.T., Hoskins, J.A., Washington, W.J., and Rutledge, J.C. Pseudo dominant-lethal response in female mice treated with plant oils. Mutation Res. 129:235-241 (1984).
  • F Mice: C3H X 101
  • Mice Female Negative 
• Dominant Lethal (Female)  (DLF017) Completed 
  • Citation: Generoso, W.M., Cain, K.T., Hoskins, J.A., Washington, W.J., and Rutledge, J.C. Pseudo dominant-lethal response in female mice treated with plant oils. Mutation Res. 129:235-241 (1984).
  • F Mice: SEC X C57BL
  • Mice Female Negative 
• GD 6-15 Conventional Teratology (Gavage)  (TER87118) Completed 
  • NTIS No. PB89-165401
    Citation: Teratologic Evaluation of Corn Oil or Distilled Water Administered to CD Rats on Gestational Days 6 through 15
  • F Rats: Sprague Dawley
  • Rats Maternal Negative 
  • Rats Fetal Negative 
  • Dose: 5 ML/KG/DAY
• GD 6-15 Conventional Teratology (Gavage)  (TER87119) Completed 
  • NTIS No. PB89-122246
    Citation: Teratologic Evaluation of Corn Oil or Distilled Water Administered by Gavage to CD-1 Mice on Gestational Days 6 through 15
  • F Mice: Swiss
  • Mice Maternal Negative 
  • Mice Fetal Negative 
  • Dose: 0,3, 10 MIC.O./KG OR 0,5 ML DIS.W/KG
• Total Reproductive Capacity  (TRC98029) Completed 
  • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns ofFemale Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
  • F Mice
  • - CONTROL