Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter
Current Clinical Trials
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic stratgegy. (Refer to the PDQ summary on Levels of Evidence for more information.)
The prognosis for any patient with metastatic or recurrent transitional cell
cancer is poor. The proper management of recurrence depends on the sites of
recurrence, extent of prior therapy, and individual patient considerations.
Chemotherapy regimens that have been shown effective for metastatic bladder
cancer have generally been applied to transitional cell cancers arising from
other sites. Patients with distant metastases have a poor prognosis, and can
be appropriately offered treatment on a clinical trial.
In patients with metastatic or recurrent transitional cell carcinoma of the
bladder, combination chemotherapy has produced high response rates and
occasional complete responses.[1,2] Results from a randomized trial that
compared methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) to
single-agent cisplatin in advanced bladder cancer show a significant advantage
with M-VAC in both response rate and median survival. The overall response
rate with M-VAC in this cooperative group trial was 39%.[3]
Other chemotherapy agents that have shown activity in metastatic transitional
cell cancer include the following:[4-8][Level of evidence: 3iiiDiv]
- Paclitaxel.
- Ifosfamide.
- Gallium nitrate.
- Gemcitabine.
- Pemetrexed.
Ifosfamide, gallium, and pemetrexed have shown limited activity in
patients previously treated with cisplatin.
Current Clinical Trials
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with recurrent transitional cell cancer of the renal pelvis and ureter. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
References
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Sternberg CN, Yagoda A, Scher HI, et al.: Methotrexate, vinblastine, doxorubicin, and cisplatin for advanced transitional cell carcinoma of the urothelium. Efficacy and patterns of response and relapse. Cancer 64 (12): 2448-58, 1989.
[PUBMED Abstract]
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Harker WG, Meyers FJ, Freiha FS, et al.: Cisplatin, methotrexate, and vinblastine (CMV): an effective chemotherapy regimen for metastatic transitional cell carcinoma of the urinary tract. A Northern California Oncology Group study. J Clin Oncol 3 (11): 1463-70, 1985.
[PUBMED Abstract]
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Loehrer PJ Sr, Einhorn LH, Elson PJ, et al.: A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study. J Clin Oncol 10 (7): 1066-73, 1992.
[PUBMED Abstract]
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Roth BJ: Preliminary experience with paclitaxel in advanced bladder cancer. Semin Oncol 22 (3 Suppl 6): 1-5, 1995.
[PUBMED Abstract]
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Witte RS, Elson P, Bono B, et al.: Eastern Cooperative Oncology Group phase II trial of ifosfamide in the treatment of previously treated advanced urothelial carcinoma. J Clin Oncol 15 (2): 589-93, 1997.
[PUBMED Abstract]
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Einhorn LH, Roth BJ, Ansari R, et al.: Phase II trial of vinblastine, ifosfamide, and gallium combination chemotherapy in metastatic urothelial carcinoma. J Clin Oncol 12 (11): 2271-6, 1994.
[PUBMED Abstract]
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Pollera CF, Ceribelli A, Crecco M, et al.: Weekly gemcitabine in advanced bladder cancer: a preliminary report from a phase I study. Ann Oncol 5 (2): 182-4, 1994.
[PUBMED Abstract]
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Sweeney CJ, Roth BJ, Kabbinavar FF, et al.: Phase II study of pemetrexed for second-line treatment of transitional cell cancer of the urothelium. J Clin Oncol 24 (21): 3451-7, 2006.
[PUBMED Abstract]
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