Current Projects
- To identify nutrients from supplement or foods that can diminish risk for age-related cataract and maculopathy.
- Determination of the intake levels from supplements or food sources and duration of intake for specific nutrients as a means to diminish risk for age-related cataract and maculopathy.
- To identify other behavioral or physical parameters, i.e., obesity, insulinemia, which are related to risk for cataract and age-related macular degeneration.
- To determine whether oxidized proteins are more readily ubiquitinated than native proteins.
- Identification of proteins that are most susceptible to oxidation and ubiquitination in lens and retina.
- To identify rate-limiting enzymes in the ubiquitin proteolytic pathway of lens and retina models.
- Modeling age- or oxidation-related stress in cell culture and animal experiments.
- To examine whether nutritional factors alleviate age- or oxidation-related stress induced damage.
- To identify the mechanisms and roles of specific genes and/or proteins by which calorie restricted diets extend youthful function.
- Correlation of ubiquitin-dependent protein turnover and control of cell proliferation and differentiation.
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