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Current Projects

  • Role of sphingomyelin and its metabolites in increased vulnerability to oxidative stress in aging assessed in cell lines and in synaptosomes isolated from rodents.
  • Neurotransmitter receptor properties that decrease resistance to oxidative stress and may account for the regional specificity of neuronal decline in aging.
  • Signaling properties in kinase cascades and subsequent activation of transcription factors in cells exposed to oxidative stress and antioxidants.
  • Role of monoamine oxidases in cellular dopamine toxicity.
  • Effects of reduction of endogenous antioxidants, such as glutathione and dopamine exposure, on cognitive and motor behavior in the rodent.
  • Effects of radiation- or oxygen-induced oxidative stress on accelerated brain aging and its retardation via intake of diets high in antioxidant fruits and vegetables.
  • Influence of diets high in antioxidant fruits and vegetables on the retardation and reversal of age-related declines in motor and cognitive function, G protein- mediated signal transduction, and calcium regulation.
  • Biophysical-lipid membrane interactions in aging and following oxidative stress.
  • Oxidative stress effects on receptor internalization.
  • Role of neuronal stimulation in subsequent protection against oxidative stress in cells.