Premature infants and DHA

Researchers in Adelaide, Australia, have made a major breakthrough in treating premature babies at risk of developmental disorders.

A six-year study led by Dr. Maria Makrides from the Women's & Children's Health Research Institute (WCHRI) and Professor Robert Gibson from the University of Adelaide has demonstrated that high doses of fatty acids administered to pre-term infants via their mother's breast milk or infant formula can help their mental development.

The findings were published January 14 in the Journal of the American Medical Association (JAMA).

Researchers found that a major lipid in the brain--the omega-3 fatty acid known as docosahexaenoic acid (DHA)--is not developed sufficiently in babies born before 33 weeks' gestation, leading to possible impaired mental development.

To counter this, increased doses of DHA (1000 mg per day) were administered to lactating mothers with pre-term infants, in the form of tuna oil capsules. If required, infants were given supplementary formula with matching DHA levels.

Of 657 premature babies tested in a trial involving five Australian hospitals, about 50% fewer infants on high-DHA diets had significantly delayed mental development compared with low DHA diets.

Premature girls in particular who were exposed to DHA-rich diets showed much better mental development than girls fed the low DHA diet.

Professor Gibson said his team was at a loss to explain why premature male babies--who are more susceptible to cognitive problems--did not respond to the same extent, with no obvious differences in mental development between the control group and those administered high doses of DHA.

"Boys may have a faster metabolic rate than girls and need higher doses of DHA to make a difference," he said. "We need to do a lot more work in this area to find out why."

Infants weighing less than 1250 g (about a third of a full-term baby's weight) who were fed a high-DHA diet also scored better on the mental development scale, with a 40% reduction in the incidence of mild mental delay.

The project was primarily funded by the National Health and Medical Research Council, with the University of Adelaide and Women's and Children's Health Research Institute (WCHRI) now in the process of formalizing a joint venture agreement in the area of food, nutrition and health.

Dr, Makrides is the Deputy Director of the WCHRI and Professor of Nutrition at the University of Adelaide. Professor Gibson is a Professor of Functional Food Science in the School of Agriculture, Food & Wine.

Sources: http://www.adelaide.edu.au/news/news31381.html

Makrides, M., R.A. Gibson, A.J. McPhee, C.T. Collins, P.G. Davis, L.W. Doyle, K. Simmer, P.B. Colditz, S. Morris, L.G. Smithers, K. Willson, and P. Ryan, Neurodevelopmental Outcomes of Preterm Infants Fed High-Dose Docosahexaenoic Acid: A Randomized Controlled Trial, JAMA 301:175--182 (2009).