Current Projects

Effect of folate status on p53 and APC tumor suppressor gene expression in the development of colon cancer in animals.
Exploration of a possible connection between folate supplementation in human subjects with colonic adenomas and the reversal of intermediary markers of colon cancer.
Examining two-way interactions between SNPs in DNA repair enzymes and one-carbon nutrient status in determining cancer risk.
Using transplanted murine colonocytes in node mice to dissect the molecular pathways by which folate modulates carcinogenesis.
Mechanisms by which alterations in folate status effect the cell cycle and DNA repair in the colonocyte.
Effects of folate depletion on biochemical and molecular features of the human colon.

For more information about the Vitamins & Carcinogenesis Laboratory, please visit the USDA, Agricultural Research Service.

Smoking & Cancer
Folates may play role in oral cancer

Questioning Folic Acid Fortification
Colorectal cancer rates went up just as folic acid was added to enriched grains, researchers say