Current Projects
- Effect of folate status on p53 and APC tumor suppressor gene expression in the development of colon cancer in animals.
- Exploration of a possible connection between folate supplementation in human subjects with colonic adenomas and the reversal of intermediary markers of colon cancer.
- Examining two-way interactions between SNPs in DNA repair enzymes and one-carbon nutrient status in determining cancer risk.
- Using transplanted murine colonocytes in node mice to dissect the molecular pathways by which folate modulates carcinogenesis.
- Mechanisms by which alterations in folate status effect the cell cycle and DNA repair in the colonocyte.
- Effects of folate depletion on biochemical and molecular features of the human colon.
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