Current Projects
- Characterize and quantify multiple forms of vitamin K in food samples representative of the US food supply.
- To develop stable isotope techniques using liquid chromatography mass spectrometry (LC/MS) to measure vitamin K absorption and transport.
- To relate the dietary intakes of various forms of vitamin K to physiological outcomes, such as bone health, in the Framingham Heart Study.
- To determine the impact of vitamin K supplementation, in an amount that is expected to be nutritionally optimal and safe, on bone, joint and vascular health in elderly men and women.
- To conduct a bioavailability study in younger and older men and women to examine the role of age, lipid profile and current vitamin K status on absorption and relative bioavailability of vitamin K from a vegetable.
- To examine the roles of apolipoprotein E, vitamin K epoxide reductase, and vitamin K-dependent gamma carboxylase genotypes in modulating vitamin K status among participants in a vitamin K supplementation trial.
- To determine the impact of vitamin K supplementation on measures of inflammation, as they relate to bone and vascular health.
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