Fu Shang, Ph.D.

Featured HNRCA Research Publications
	Scientist I Laboratory for Nutrition and Vision Research Jean Mayer USDA HNRCA at Tufts University 711 Washington Street Boston, MA 02111-1524 Phone: (617) 556-3158 Fax: (617) 556-3132 E-mail: fu.shang@tufts.edu
Education	Ph.D., Biochemistry Beijing Medical University
Research Focus	Effects of nutrition, oxidation, and aging on protein turnover in the lens; lens development and differentiation; developing models of age-and diabetes-related cataract
Selected Professional Affiliations	The Association for Research in Vision and Ophthalmology American Society for Mass Spectrometry Board
Zhang X, Dudek EJ, Liu B, Ding L, Fernandes AF, Liang JJ, Horwitz J, Taylor A, Shang F. Degradation of C-terminal Truncated {alpha}A-crystallins by the Ubiquitin Proteasome Pathway. Invest Ophthalmol Vis Sci. 2007;48(9):4200-8. Fernandes AF, Guo W, Zhang X, Gallagher M, Ivan M, Taylor A, Pereira P, Shang F. Proteasome-dependent regulation of signal transduction in retinal pigment epithelial cells. Exp Eye Res. 2006;83(6):1472-81. Liu Q, Shang F, Zhang X, Li W, Taylor A. Expression of K6W-ubiquitin inhibits proliferation of human lens epithelial cells. Mol Vis. 2006;12:931-6.
Other Recent Publications Zetterberg M, Zhang X, Taylor A, Liu B, Liang JJ, Shang F. Glutathiolation enhances the degradation of gammaC-crystallin in lens and reticulocyte lysates, partially via the ubiquitin-proteasome pathway. Invest Ophthalmol Vis Sci. 2006;47(8):3467-73. Guo W, Shang F, Liu Q, Urim L, Zhang M, Taylor A. Ubiquitin-proteasome pathway function is required for lens cell proliferation and differentiation. Invest Ophthalmol Vis Sci. 2006;47(6):2569-75. Marques C, Guo W, Pereira P, Taylor A, Patterson C, Evans PC, Shang F. The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones. FASEB J. 2006;20(6):741-3. Liu Q, Shang F, Whitcomb E, Guo W, Li W, Taylor A. Ubiquitin-conjugating enzyme 3 delays human lens epithelial cells in metaphase. Invest Ophthalmol Vis Sci. 2006;47(4):1302-9. Dudek EJ, Shang F, Valverde P, Liu Q, Hobbs M, Taylor A. Selectivity of the ubiquitin pathway for oxidatively modified proteins: relevance to protein precipitation diseases. FASEB J. 2005;19(12):1707-9. Shang F, Deng G, Liu Q, Guo W, Haas AL, Crosas B, Finley D, Taylor A. Lys6-modified ubiquitin inhibits ubiquitin-dependent protein degradation. J Biol Chem. 2005;280(21):20365-74. Girao H, Pereira P, Taylor A, Shang F. Subcellular redistribution of components of the ubiquitin-proteasome pathway during lens differentiation and maturation. Invest Ophthalmol Vis Sci. 2005;46(4):1386-92. Marques C, Pereira P, Taylor A, Liang JN, Reddy VN, Szweda LI, Shang F.Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells. FASEB J. 2004; 18(12):1424-6. Guo W, Shang F, Liu Q, Urim L, West-Mays J, Taylor A. Differential regulation of components of the ubiquitin-proteasome pathway during lens cell differentiation. Invest Ophthalmol Vis Sci. 2004;45(4):1194-201. Liu Q, Shang F, Guo W, Hobbs M, Valverde P, Reddy V, Taylor A. Regulation of the ubiquitin proteasome pathway in human lens epithelial cells during the cell cycle. Exp Eye Res. 2004;78(2):197-205. To see more of Dr. Fu Shang's publications, please visit PubMed and search for "Shang F."