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Joel B. Mason, M.D.

Joel B. Mason Scientist I and Director
Vitamins and Carcinogenesis Laboratory
Jean Mayer USDA HNRCA at Tufts University
711 Washington Street
Boston, MA 02111-1524
Phone: (617) 556-3194
Fax: (617) 556-3234
E-mail: joel.mason@tufts.edu
Education M.D., University of Chicago
Pritzker School of Medicine
Research Focus Folate and carcinogenesis, intestinal metabolism of folate
Academic Appointments Associate Professor, Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy at Tufts University
Associate Professor, Tufts University School of Medicine
Selected Professional Affiliations Member, Professional Education Committee, American Society for Nutritional Sciences
Editorial Board, JPEN - Journal of Parenteral and Enteral Nutrition
Board Certification Internal Medicine
Gastroenterology
Nutrition

 

Featured HNRCA Research Publications

Mason, J.B., Cole, B.F., Baron, J.A., Kim, Y., Refsum, H., Selhub, J., Smith, A. Folic acid fortification and cancer risk: plea for objective evaluation of the evidence. Lancet. 2008;371:1335-1336.

van den Donk M, Pellis L, Crott JW, van Engeland M, Friederich P, Nagengast FM, van Bergeijk JD, de Boer SY, Mason JB, Kok FJ, Keijer J, Kampman E. Folic Acid and Vitamin B-12 Supplementation Does Not Favorably Influence Uracil Incorporation and Promoter Methylation in Rectal Mucosa DNA of Subjects with Previous Colorectal Adenomas. J Nutr. 2007;137(9):2114-2120.

Crott JW, Liu Z, Keyes MK, Choi SW, Jang H, Moyer MP, Mason JB. Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines. J Nutr Biochem. 2007;19(5):328-335.

Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, Rosenberg IH. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomarkers Prev. 2007;16(7):1325-9.

Keyes MK, Jang H, Mason JB, Liu Z, Crott JW, Smith DE, Friso S, Choi SW. Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon. J Nutr. 2007;137(7):1713-7.

Other Recent Publications

Liu, Z., Choi, S., Crott, J.W., Smith, D., Mason, J.B. Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2. International Journal of Cancer. 2008;123(3):519-525.

Crott JW, Liu Z, Choi SW, Mason JB. Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene. Mutat Res. 2007;626(1-2):171-9.

Liu, Z., Choi, S., Crott, J.W., Keyes, M.K., Jang, H., Smith, D., Kim, M., Laird, P.W., Bronson, R., Mason, J.B. Mild depletion of dietary folate combined with other B-vitamins alters multiple components of the Wnt pathway in the mouse colon. Journal of Nutrition. 2007;137(12):2701-08.

Keyes, M.K., Jang, H., Mason, J.B., Liu, Z., Crott, J.W., Smith, D., Friso, S., Choi, S. Genomic and p16-specific DNA methylation of the mouse colon: elder age and dietary folate as interactive determinants. Journal of Nutrition. 2007;137(7):1713-1717.

Mason, J.B.  Gastrointestinal Cancer: Nutritional Support. In: Kelsen, D.P. Principles and Practice of Gastrointestinal Oncology, 2nd Edition. Lippincott Williams & Wilikins. 2007: 87-101.

Mason, J.B. 2007. Vitamins, Trace Minerals, and Other Micronutrients. In: Goldman, L., Ausiello, D. Cecil Medicine, 23rd Edition. Philadelphia, PA: Saunders Elsevier. 2007:1626-1639.

Yang AS, Doshi KD, Choi SW, Mason JB, Mannari RK, Gharybian V, Luna R, Rashid A, Shen L, Estecio MR, Kantarjian HM, Garcia-Manero G, Issa JP. DNA methylation changes after 5-aza-2' deoxycytidine therapy in patients with leukemia. Cancer Res. 2006;66(10):5495-503.

Gabriel HE, Liu Z, Crott JW, Choi SW, Song BC, Mason JB, Johnson EJ. A comparison of carotenoids, retinoids, and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus nonsmokers. Cancer Epidemiol Biomarkers Prev. 2006;15(5):993-9.

Gabriel-Woodward, H.E., Crott, J.W., Ghandour, H., Choi, S., Dallal, G.E., Keyes, M.K., Jang, H., Liu, Z., Nadeau, M., Johnston, A., Mager, D., Mason, J.B. Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults. American Journal of Clinical Nutrition. 2006;83(4):835-841.

Mason, J.B., Jacques, P.F., Rosenberg, I.H.  Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. American Journal of Clinical Nutrition. 2005;82(4):806-812.

To see more of Dr. Joel B. Mason's publications, please visit PubMed and search for "Mason JB."