Jimmy Crott, Ph.D.

Selected HNRCA Research Publications
	Scientist II Vitamins and Carcinogenesis Laboratory Jean Mayer USDA HNRCA at Tufts University 711 Washington Street Boston, MA 02111-1524 Phone: (617) 556-3117 Fax: (617) 556-3234 E-mail: jimmy.crott@tufts.edu
Education	Ph.D., Physiology, Adelaide University, South Australia
Research Focus	The effects of folate deficiency on patterns of gene expression and the identification of novel intracellular endpoints of folate deficiency that may be of relevance to cancer and other diseases of old age.
DeVos, L., Chanson, A., Liu, Z., Ciappio, E.D., Parnell, L.D., Mason, J.B., Tucker, K.L., Crott, J.W. Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine and DNA uracil concentrations. American Journal of Clinical Nutrition. In Press. Crott, J.W., Liu, Z., Keyes, M.K., Choi, S.W. Jang, H., Moyer, M.P., Mason, J.B. Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signalling, and folate uptake in human colonic epithelial cell lines. Journal of Nutritional Biochemistry. 2008 May;19(5):328-35. Crott JW, Liu Z, Choi SW, Mason JB. Folate Depletion in human lyphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene. Mutation Research. 2006;626:171-179. Gabriel-Woodward HE, Crott JW, Ghandour H, Dallal GE, Choi SW, Keyes MK, Jang H, Liu Z, Nadeau M, Johnston A, Mager D, Mason JB. Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults. American Journal of Clinical Nutrition. 2006;83(4):853-41. Crott JW, Choi SW, Branda RF, Mason JB. Accumulation of mitochondrial DNA deletions is age, tissue and folate-dependent in rats. Mutation Research. 2005;579(1):63-70.
Other Recent Publications Liu, Z, Choi S, Crott JW, Mason JB. *Inadequate intake of multiple B-vitamins amplifies alterations in p53* expression and function induced by isolated folate depletion. International Journal of Cancer. 2008;123:519-525. van den Donk M, Pellis L, Crott JW, van Engeland M, Friederich P, Nagengast FM, van Bergeijk JD, de Boer SY, Mason JB, Kok FJ, Keijer J, Kampman E. Folic Acid and Vitamin B-12 Supplementation Does Not Favorably Influence Uracil Incorporation and Promoter Methylation in Rectal Mucosa DNA of Subjects with Previous Colorectal Adenomas. Journal of Nutrition. 2007;137(9):2114-2120. Keyes MK, Jang H, Mason JB, Liu Z, Crott JW, Smith DE, Friso S, Choi SW. Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon. Journal of Nutrition. 2007;137(7):1713-7. Liu, Z, Choi, S, Crott, JW, Keyes, MK, Jang, H, Smith, DE, Kim, M, Laird, PW, Bronson, R, Mason, JB. Mild depletion of dietary folate combined with other B-vitamins alters multiple components of the Wnt pathway in the mouse colon. Journal of Nutrition. 2007;137:2701-2708. Gabriel HE, Liu Z, Crott JW, Choi SW, Song BC, Mason JB, Johnson EJ. A comparison of carotenoids, retinoids, and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus nonsmokers. Cancer Epidemiology Biomarkers & Prevention. 2006;15(5):993-9. Crott JW, Mason JB. MTHFR polymorphisms and colorectal neoplasia.** In: Ueland PM, Rozen R, ed(s). MTHFR Polymorphisms and Disease. Georgetown, TX: Landes Bioscience (Eureka.com), 2004:1-18. Crott JW, Choi SW, Ordovas JM, Ditelberg JS, Mason JB. Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis. Carcinogenesis. 2004;25(1):69-76. To see more of Dr. Jimmy Crott's publications, please visit PubMed and search for "Crott JW."