Sang-Woon Choi, M.D., Ph.D.

Featured HNRCA Research Publications
	Scientist I Vitamins and Carcinogenesis Laboratory Jean Mayer USDA HNRCA at Tufts University 711 Washington Street Boston, MA 02111-1524 Phone: (617) 556-3007 Fax: (617) 556-3234 E-mail: sang.choi@tufts.edu
Education	M.D., Seoul National University Ph.D., Medical Science, Seoul National University
Research Focus	Mechanisms underlying the modulation of carcinogenesis by one-carbon metabolism, aging, and epigenetics
Selected Professional Affiliations	Associate Professor at the Friedman School of Nutrition Science and Policy at Tufts University
Board Certification	Korean Board of Gastroenterology Korean Board of Internal Medicine
Keyes MK, Jang H, Mason JB, Liu Z, Crott JW, Smith DE, Friso S, Choi SW. Aging reduces genomic DNA methylation and increases p16 promoter methylation in the mice colon and dietary folate modifies this effect. Journal of Nutrition. 2007;137:1713-1717. Friso S, Lamon-Fava S, Jang H, Schaefer EJ, Corrocher R, Choi SW. Estrogen replacement therapy reduces total plasma homocysteine and concurrently enhances genomic DNA methylation in postmenopausal women. British Journal of Nutrition. 2007;97:617-621. Friso S, Girelli D, Trabetti E, Olivieri O, Guarini P, Pignatti P, Corrocher R, Choi SW. TheMTHFR1298A>C polymorphism and genomic DNA methylation in human lymphocytes. Cancer Epidemiology, Biomarkers, & Prevention. 2005;14(4):938-943. Choi SW, Friso S, Keyes MK, Mason JB. Folate supplementation increases genomic DNA methylation in the liver of elder rats. British Journal of Nutrition. 2005;93(1):31-35. Choi SW, Friso S, Ghandour H, Bagley PJ, Selhub J, Mason JB. Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium. Journal of Nutrition. 2004;134(4):750-755.
Other Recent Publications Crott JW, Liu Z, Keyes MK, Choi SW, Jang H, Moyer MP, Mason JB. Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines. Journal of Nutritional Biochemistry. 2008; 19(5):328-35. Kim Y, Lian F, Yeum KJ, Chongviriyaphan N, Choi SW, Russell RM, Wang XD. The effects of combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single-strand breaks and levels of insulin-like growth factor-1/IGF-binding protein 3 in the ferret model of lung cancer. International Journal of Cancer. 2007;120(9):1847-54. Crott JW, Liu Z, Choi SW, Mason JB. Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene. Mutation Research. 2007;626(1-2):171-9. Choi SW, Keyes MK, Horrocks P. LC/ESI-MS demonstrates the absence of 5-methyl-2'-deoxycytosine in Plasmodium falciparum genomic DNA. Molecular and Biochemical Parasitology. 2006;150(2):350-2. Gabriel HE, Liu Z, Crott JW, Choi SW, Song BC, Mason JB, Johnson EJ. A comparison of carotenoids, retinoids, and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus nonsmokers. Cancer Epidemiology Biomarkers & Prevention. 2006;15(5):993-9. Yang AS, Doshi KD, Choi SW, Mason JB, Mannari RK, Gharybian V, Luna R, Rashid A, Shen L, Estecio MR, Kantarjian HM, Garcia-Manero G, Issa JP. DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Research. 2006;66(10):5495-503. Gabriel HE, Crott JW, Ghandour H, Dallal GE, Choi SW, Keyes MK, Jang H, Liu Z, Nadeau M, Johnston A, Mager D, Mason JB. Chronic cigarette smoking is associated with diminished folate status, altered folate form distribution, and increased genetic damage in the buccal mucosa of healthy adults. American Journal of Clinical Nutrition. 2006;83(4):835-41. Jang H, Mason JB, Choi SW. Genetic and epigenetic interactions between folate and aging in carcinogenesis. Journal of Nutrition. 2005;135(12 Suppl):2967S-2971S. To see more of Dr. Sang-Woon Choi's publications, please visit PubMed and search for "Choi SW."