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Current Projects

  • Mechanisms of Vitamin E-induced enhancement of T cell function in the aged with focus on early activation signaling and membrane related events.
  • Determining age-related change in T cell signalosomes using proteomic and lipidomic methods.
  • Contribution of polymorphisms at cytokine genes to heterogeneity of vitamin E-induced effects on cytokine production and resistance to respiratory infections in the elderly.
  • Effect of reducing caloric intake on immune response of humans.
  • Effect of age and vitamin E on gene expression profile of immune cells.
  • Impact of age on host resistance to food born pathogens and effect of nutritional modulation.
  • Effect of probiotics on immune function and resistance to infections in mouse model.
  • Effect of mushrooms on immune functions and resistance to infections in mouse model.
  • Modulation of T cell response by green tea EGCG and mechanisms.
  • Altered macrophage functions with age and the underlying mechanisms.
  • Age-related inflammatory state in adipose tissue and the underlying mechanisms