Nutritional Genomics

Nutrigenomics is the study of how dietary constituents interact with genes, and their products, to regulate biochemical pathways and thus, the balance between health and disease states. Genetic variation and numerous environmental factors modulate these interactions and their understanding constitutes the basis for the future development of more personalized and successful dietary recommendations to prevent disease and achieve healthier aging. The Nutrition and Genomics Laboratory is a pioneer of the study of gene-diet interactions in the area of cardiovascular diseases, utilizing both genetic epidemiology approaches as well as controlled dietary intervention studies. This research involves the investigation of nutrient-gene interactions in large and diverse populations around the world with long-standing collaborations with investigators in Europe, Asia, Australia and the United States. Some highlights of this research include the elucidation of highly significant gene-diet interactions at several loci involved in lipid metabolism (e.g., APOE, LIPC, APOA1, APOA4, APOA5, PPARA) as well as in obesity (e.g., PLIN).

In addition, we seek to identify genes involved in longevity and healthy aging and to understand their regulation in response to dietary factors. For this research we use model organisms such as Drosophila and mouse. Further comprehension of the relation between genetic factors, nutrients and the rate of aging will provide better understanding of the pathology of age-related diseases and lead to improved strategies for their prevention.

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For more information about the Nutrition & Genomics Laboratory, please visit the USDA, Agricultural Research Service.

It's in the Genes
Working in what he calls "the lab of the future" at Tufts' Human Nutrition Research Center on Aging, senior scientist Jose Ordovas explores the ways in which the linkages between nutrition, behavior and genetics impact human health.

Benefits of Eating Fish Outweigh Risks
Despite the risk of consuming contaminants, eating fish is good for your health, according to a recent report by a committee of nutrition experts, including Tufts' Jose Ordovas

Genetic Variants Shown to Hoard Body Fat
Two variations of a gene associated with obesity and type 2 diabetes have been linked to storing excess fat in Caucasian women.

Risky gene
Research uncovers another cause of heart disease

USDA honors
Scientist recognized for work in genetics and nutrition