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Carotenoids & Health

Carotenoids and other phytonutrients seem to be health promoting when taken at the physiologic levels found in foods. However, there is a lack of data concerning key aspects of absorption, metabolism and biological functions of food carotenoids in humans. These areas include: 1) the bioavailability of carotenoids from different food matrices and the efficiency of carotenoid conversion to vitamin A; 2) the function of carotenoids and other phytonutrients as antioxidants in both lipid and aqueous compartments of biological matrices; and 3) determinants of the distribution of carotenoids, lutein and zeaxanthin, in the human macula.

This research team is studying the bioavailability, bioconversion, antioxidant function, and tissue distribution of dietary carotenoids and other phytonutrients. Our research studies have been designed to better define the relationship between phytonutrients and the prevention of major age-related diseases, including macular degeneration, night blindness, cardiovascular disease, and certain cancers, using advanced mass spectrometry, total antioxidant / oxidative stress measurements, and macular pigments determinations. The Carotenoids and Health Laboratory is fully equipped for automated high-performance liquid chromatography (HPLC) and accessible mass spectrometries (MS, LC/MS and GC/MS) for the analysis of carotenoids, retinoids, tocopherols in biological samples and diets, microplate reader for antioxidant capacity analysis, and heterochromatic flicker photometer for macular pigment measurement.