Current Projects

Effect of retinoic acid homeostasis on the regulation of both mitogen-activated protein kinase and retinoid signaling pathways.
Regulatory effect of lycopene and its metabolites on the insulin-like growth factor-I (IGF-I)/IGF binding proteins (IGFBPs) system.
Transactivation of peroxisome proliferator-activated receptors (PPARs)/retinoic acid receptors (RARs) response elements by carotenoids and their metabolites.
Molecular cloning and characterization of carotene excentric cleavage enzyme-monoxygenase and its regulation of carotenoid metabolism.
Mechanisms of alteration of carotenoid/retinoid metabolism by excessive alcohol intake and cigarette smoking exposure.
Modulation of lung molecular biomarkers by carotenoids (beta-carotene and beta-cryptoxanthin) in ferret model and in the human subjects (Physicians' Health Study).
Anti-inflammatory effects of lutein in dextran sulfate sodium-induced colitis in mouse model and in human colon cancer cells.
Combined chemopreventive agents of vitamin A (9-cis retinoic acid), vitamin D (1,25(OH)2 vitamin D3) and fish oil against lung cancer in AJ mouse model.
Effect of cytochrome p4502E1 inhibitors on alcoholic steatohepatitis (ASH) and alcohol-promoted hepatic carcinogenesis.
Anti-inflammatory effect of carotenoids against high fat-induced non-alcoholic steatohepatitis (NASH) in rat model and in human liver cancer cells.