Testing Status of Agents at NTP
p-Benzoquinone dioxime
CASRN: 105-11-3
Related: P-BENZOQUINONE MONOOXIME (CAS 637-62-7)
Formula: C6-H6-N2-O2
Synonyms/Common Names:
- 2,5-CYCLOHEXADIENE-1,4-DIONE, DIOXIME (9CI)
- P-QUINONE DIOXIME
Known Uses:
VULCANIZATION OF RUBBER
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C03850) Completed
- NTIS No. PB291501
(Peer Review 10/25/1978)
Citation: Bioassay of p-Quinone Dioxime for Possible Carcinogenicity (CAS No. 105-11-3) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB291501
(Peer Review 10/25/1978)
- 13-Week (Dosed-Feed)
(C03850) Completed
- NTIS No. PB291501
(Peer Review 10/25/1978)
Citation: Bioassay of p-Quinone Dioxime for Possible Carcinogenicity (CAS No. 105-11-3) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 0,680,10000, M: 0,680,14700 PPM/10 PER GROUP
- NTIS No. PB291501
(Peer Review 10/25/1978)
Long-Term Carcinogenicity
- 2-Year (Dosed-Feed)
(C03850) Report Complete
- TR-179 (NTIS No. PB291501)
(Peer Review 10/25/1978)
Bioassay of p-Quinone Dioxime for Possible Carcinogenicity (CAS No. 105-11-3) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Negative
- Female Rats Positive
- Male Mice Negative
- Female Mice Negative
- Dose: R: 0,375,750, M: 0,750,1500 PPM/50 PER GROUP
- TR-179 (NTIS No. PB291501)
(Peer Review 10/25/1978)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(233313) Completed
- Chromosome Aberation Positive
- Sister Chromatid Exchange Positive
- Drosophila
(922553) Completed
- Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
- Reciprocal Translocation/Sex-Linked Recessive Lethal Negative
- Mouse Lymphoma
(034164) Completed
- Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
- Positive
- Salmonella (NCI)
(N-9297) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
- Salmonella-NCI Positive
- Salmonella
(604471) Completed
- Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Positive
- Salmonella
(960242) Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
- Positive
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