National Toxicology Program

CASRN: 532-27-4

Formula: C8-H7-CL-O

Synonyms/Common Names:

• 2-CHLORO-1-PHENYLETHANONE
• CN

Known Uses:

RIOT CONTROL AGENT. (TDB)

Short-Term Toxicity

• 2-WEEK (Inhalation)  (C55107) Completed 
  • NTIS No. PB90-256066  (Peer Review 11/20/1989)
    Citation: Toxicology and Carcinogenesis Studies of 2-Chloroacetophenone (CAS No. 532-27-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-WEEK (Inhalation)  (C55107) Completed 
  • NTIS No. PB90-256066  (Peer Review 11/20/1989)
    Citation: Toxicology and Carcinogenesis Studies of 2-Chloroacetophenone (CAS No. 532-27-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,0.25,4 MG/M3/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Inhalation)  (C55107) Report Complete 
  • TR-379 (NTIS No. PB90-256066)  (Peer Review 11/20/1989)
    Toxicology and Carcinogenesis Studies of 2-Chloroacetophenone (CAS No. 532-27-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0,1,2, M: 0,2,4 MG/M3/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (037856) Completed 
  • Chromosome Aberation Weakly Positive 
  • Sister Chromatid Exchange Negative 
• Salmonella  (961999) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
  •  Negative