Validation of Test Methods for Assessing Neurodevelopment in Children1
Specific Aims
This investigation proposed to determine the sensitivity and specificity of a
battery of neurodevelopmental tests in detecting the anticipated subtle effects
of exposure to low dosages of developmental neurotoxicants. The study was
designed to answer the question: What is the capacity of selected tests and
tasks to detect a subtle effect of prenatal or postnatal environmental exposures
on children’s specific behaviors and skills during neurodevelopment?
The current project was funded under a public-private partnership organized by
the Agency for Toxic Substances and Disease Registry (ATSDR), US Centers for
Disease Control and Prevention. Funding partners included the ATSDR, the
National Institute of Environmental Health Sciences (NIEHS), the US
Environmental Protection Agency (EPA), the US Food and Drug Administration
(FDA), and the Electric Power Research Institute (EPRI). Philip W. Davidson
served as principal investigator. The study was supported in part by a General
Clinical; Research Center (GCRC) Grant 5 M01 RR00044 from the National Center
for Research Resources, NIH. The pilot study was funded by two grants, one to
Bernard Weiss from EPRI, and the other from the University of Maryland’s Joint
Institute on Food Safety and Nutrition (JIFSAN) to Philip Davidson. The JIFSAN
is a joint venture of the University of Maryland and the US Food and Drug
Administration. The grant to Dr. Davidson was funded under a cooperative
agreement mechanism. The University of Maryland received funds for the project
from the FDA, EPRI, ATSDR, and the NIEHS.
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