National Cancer Institute
U.S. National Institutes of Health | www.cancer.gov

NCI Home
Cancer Topics
Clinical Trials
Cancer Statistics
Research & Funding
News
About NCI
Understanding Cervical Changes: A Health Guide for Women
    Posted: 01/28/2005



Introduction






What Is the Cervix?






What Should I Know About HPV Infection?






Finding Abnormal Cells






What Do My Pap Test Results Mean?






Questions To Ask Your Health Care Provider






Finding the Support You Need






Table 1






Table 2






Table 3






Table 4






Resources



Page Options
Print This Page
Print This Document
View Entire Document
E-Mail This Document
View/Print PDF
Quick Links
Director's Corner

Dictionary of Cancer Terms

NCI Drug Dictionary

Funding Opportunities

NCI Publications

Advisory Boards and Groups

Science Serving People

Español
Quit Smoking Today
NCI Highlights
Report to Nation Finds Declines in Cancer Incidence, Death Rates

High Dose Chemotherapy Prolongs Survival for Leukemia

Prostate Cancer Study Shows No Benefit for Selenium, Vitamin E

The Nation's Investment in Cancer Research FY 2009

Past Highlights
Table 1: What Your Pap Test/HPV Test Results Mean and Follow-Up

Possible Result What It Means to You What Your Health Care Provider May Recommend Possible Outcomes
Normal Normal Only normal cells were seen on the Pap test. Make sure to continue receiving Pap tests at least once every 3 years. A False Negative (Looks Normal, But May Not Be)
The Pap test is a very good screening test, but it is not perfect. A single Pap test may miss up to 20 percent of abnormalities. Changes that are missed once are usually found the next time. This is why it is important to get a Pap test at least once every 3 years.
Abnormal Unclear

ASC-US

ASC-US (atypical squamous cells-- of undetermined significance)
  • Some cells from the lining of the outer cervix (also called squamous cells) do not appear normal.
  • The health care provider will need to do additional tests to clarify the results.
  • Follow up with repeat Pap tests every 4-6 months.
  • HPV testing
  • Immediate colposcopy (a test that can be done in the doctor's office to get a magnified view of your cervix)

Abnormal Pap Test Result
If a repeat Pap test is abnormal, your health care provider will probably recommend a colposcopy.

Positive HPV Test Result
If your HPV test is positive, your health care provider will probably recommend a colposcopy.

Negative HPV Test Result
If your HPV test is negative, your health care provider may recommend a repeat screening in 1 year.

Abnormal Colposcopy Result
If your colposcopy is abnormal, your health care provider may do a biopsy, endocervical curettage, or both.

Abnormal Unclear

ASC-H

AGC

ASC-H (atypical squamous cells-- cannot exclude HSIL)

  • Cervical cells do not appear normal.
  • A high-grade lesion may be present, but the cell changes are too minor to be sure.

AGC (atypical glandular cells)

  • Some glandular cells in the lining of your cervix appear abnormal.
Colposcopy

Normal Colposcopy Result
If cervical tissue looks healthy, your health care provider may not need to do any further testing or treatment right away, but may recommend a repeat Pap test or HPV test in 6-12 months.

Abnormal Colposcopy Result
If your colposcopy is abnormal, your health care provider may do a biopsy, endocervical curettage, or both.

Abnormal LSIL

LSIL (low-grade squamous intraepithelial lesion)

  • Squamous cells are abnormal, but are usually not precancerous.
Colposcopy

Normal Colposcopy Result
If cervical tissue looks healthy, your health care provider may not need to do any further testing or treatment right away, but may recommend a repeat Pap test or HPV test in 6-12 months.

Abnormal Colposcopy Result
If your colposcopy is abnormal, your health care provider may do a biopsy, endocervical curettage, or both.

Abnormal Precancer

HSIL

AIS

If you have one of the results below, it is very important that you get the necessary tests and treatments.

HSIL (high-grade squamous intraepithelial lesion)

  • The lesion is precancerous; without treatment, it may turn into invasive cancer.

AIS (adenocarcinoma in situ)

  • A precancerous lesion is found in the glandular tissue of the cervix.
Colposcopy

Normal Colposcopy Result
If cervical tissue looks healthy, your health care provider may still need to do further testing or treatment.

Abnormal Colposcopy Result
If your colposcopy is abnormal, your health care provider will probably do a biopsy, endocervical curettage, or both.

Abnormal Cancer Cancer cells are present in the cervix.

Colposcopy

Your health care provider will probably refer you to a gynecologic oncologist.

Abnormal Colposcopy Result
If your colposcopy is abnormal, your health care provider will probably do a biopsy, endocervical curettage, or both.

This table is based on the American Society for Colposcopy and Cervical Pathology (ASCCP) consensus guidelines.

For more information on cells of the cervix, see the What is the Cervix in this booklet.

Back to Top

< Previous Section  |  Next Section >


A Service of the National Cancer Institute
Department of Health and Human Services National Institutes of Health USA.gov