National Toxicology Program

CASRN: 2489-77-2

Formula: C4 H10 N2 S

Synonyms/Common Names:

• 1,1,3-TRIMETHYL-2-THIOUREA

Known Uses:

VULCANIZATION; ADHESIVES; POLYETHYLENE FILM; CHEMICAL INTERMEDIATE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C02186) Completed 
  • NTIS No. PB288802  (Peer Review 08/31/1978)
    Citation: Bioassay of Trimethylthiourea for Possible Carcinogenicity (CAS No. 2489-77-2)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C02186) Completed 
  • NTIS No. PB288802  (Peer Review 08/31/1978)
    Citation: Bioassay of Trimethylthiourea for Possible Carcinogenicity (CAS No. 2489-77-2)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,315,6800, M: 0,370,5500 PPM/10 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C02186) Report Complete 
  • TR-129 (NTIS No. PB288802)  (Peer Review 08/31/1978)
    Bioassay of Trimethylthiourea for Possible Carcinogenicity (CAS No. 2489-77-2)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Negative 
  • Female Rats Positive 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: R: 0,250,500, M: 0,500,1000 PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (652396) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Not Tested 
• In Vitro Cytogenetics (CA/SCE)  (724688) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Drosophila  (572931) Completed 
  • Citation: Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
  • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Inconclusive 
• Mouse Lymphoma  (360906) Completed 
  • Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154
  •  Positive 
• Salmonella  (526337) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative