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Boston University: Details

Superfund Basic Research Program

Superfund Basic Research Program at Boston University

Program Director: David M. Ozonoff
Grant Number: P42ES07381
Funding Period: 1995-2010
Grantee Website (http://www.busbrp.org/) Exit NIEHS Website

Publications

2008
  • Bagchi, G. and David J. Waxman. 2008. Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression. International Journal of Andrology. (http://www.blackwellpublishing.com/journal.as p?ref=0105-6263&site=1) Exit NIEHS Website (in press)
  • Evans, Brad R., Sibel I. Karchner, Lenka L. Allan, R.S. Pollenz, R.L. Tanguay, David H. Sherr, and Mark E. Hahn. 2008. Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator. Molecular Pharmacology. (http://molpharm.aspetjournals.org/) Exit NIEHS Website 73(2):387-98.
  • Hansson, M.C. and Mark E. Hahn. 2008. Functional properties of the four Atlantic salmon (Salmo salar) aryl hydrocarbon receptor type 2 (AHR2) isoforms. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 86(2):121-30.
  • Janulewicz, Patricia A., Roberta F. White, Michael R. Winter, Janice Weinberg, Lisa G. Gallagher, Veronica Vieira, Thomas Webster, and Ann Aschengrau. 2008. Risk of learning and behavioral disorders following prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water. Neurotoxicology and Teratology. (http://www.sciencedirect.com/science/journal/ 08920362) Exit NIEHS Website doi:10.1016/j.ntt.2008.01.007 (http://dx.doi.org/10.1016/j.ntt.2008.01.007) Exit NIEHS Website30(3):175-85.
  • Johnston, Thomas P. and David J. Waxman. 2008. The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARalpha. Journal of Pharmacy and Pharmacology. (http://www.ingentaconnect.com/content/rpsgb/j pp) Exit NIEHS Website doi:10.1211/jpp.60.6.0011 (http://dx.doi.org/10.1211/jpp.60.6.0011) Exit NIEHS Website60(6):753-9.
  • Kitana, Noppadon and Ian P. Callard. 2008. Effect of cadmium on gonadal development in freshwater turtle (Trachemys scripta, Chrysemys picta) embryos. Journal of Environmental Science and Health, Part A. (http://www.informaworld.com/smpp/title~conten t=t713597268) Exit NIEHS Website 43(3):262-71.
  • Lutton, B.V. and Ian P. Callard. 2008. Influence of reproductive activity, sex steroids, and seasonality on epigonal organ cellular proliferation in the skate (Leucoraja erinacea). General and Comparative Endocrinology. 155(1):116-25.
  • Webster, Thomas, K. Hoffman, Janice Weinberg, Veronica Vieira, and Ann Aschengrau. 2008. Community and Individual-Level Socioeconomic Status and Breast Cancer Risk: Multi-level Modeling on Cape Cod, MA. Environmental Health Perspectives. (in press)
2007
  • Burnett, K.G., L.J. Bain, W.S. Baldwin, Gloria V. Callard, S. Cohen, Richard T. Di Giulio, D.H. Evans, M. Gomez-Chiarri, Mark E. Hahn, C.A. Hoover, Sibel I. Karchner, F. Katoh, D.L. MacLatchy, W.S. Marshall, J.N. Meyer, D.E. Nacci, M.F. Oleksiak, B.B. Rees, T.P. Singer, John J. Stegeman, D.W. Towle, P. A V Veld, W.K. Vogelbein, A. Whitehead, R.N. Winn, and D.L. Crawford. 2007. Fundulus as the Premier Teleost Model in Environmental Biology: Opportunities for New Insights Using Genomics. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics. (http://www.sciencedirect.com/science/journal/ 1744117X) Exit NIEHS Website 2:257-286.
  • Carvan, M.J., Evan P. Gallagher, A. Goksoyr, Mark E. Hahn, and D.G. Joakim. 2007. Fish models in toxicology. Zebrafish. (http://www.liebertpub.com/publication.aspx?pu b_id=122) Exit NIEHS Website 4:9-20.
  • Celenligil-Cetin, Remle, Patrina Paraskevopoulou, Rupam Dinda, N. Lalioti, Y. Sanakis, A. Rawashdeh, Richard J. Staples, E. Sinn, and P. Stavropoulos. 2007. Oxidative ligand rearrangement due to incipient aminyl radicals in the oxidation of iron(ll) species with dioxygen. European Journal of Inorganic Chemistry. (http://www.wiley.com/WileyCDA/WileyTitle/prod uctCd-2005.html) Exit NIEHS Website (in press)
  • Celenligil-Cetin, Remle, Patrina Paraskevopoulou, Rupam Dinda, Y. Sanakis, Richard J. Staples, E. Sinn, N.P. Rath, and P. Stavropoulos. 2007. Synthesis, characterization, and reactivity of iron trisamido-amine complexes that undergo both metal- and ligand-centered oxidative transformations. Inorganic Chemistry. (http://pubs.acs.org/journals/inocaj/index.htm l) Exit NIEHS Website (in press)
  • Clodfelter, Karl H., G.D. Miles, V. Wauthier, M.G. Holloway, X. Zhang, P. Hodor, W.J. Ray, and David J. Waxman. 2007. Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis. Physiological Genomics. (http://physiolgenomics.physiology.org/) Exit NIEHS Website 31:63-74.
  • Goldstone, Jared V. and John J. Stegeman. 2007. Gene Structure of the Novel Cytochrome P4501D1 Genes in Stickleback (Gasterosteus aculeatus) and Medaka (Oryzias latipes). Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) Exit NIEHS Website (in press)
  • Goldstone, Jared V., Heather M. Handley-Goldstone, A.M. Morrison, A. Tarrant, S.E. Kern, Bruce R. Woodin, and John J. Stegeman. 2007. Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family. Molecular Biology and Evolution. (http://mbe.oxfordjournals.org/) Exit NIEHS Website 24(12):2619-31.
  • Greytak, Sarah R. and Gloria V. Callard. 2007. Cloning of three estrogen receptors (ER) from killifish (Fundulus heteroclitus): differences in populations from polluted and reference environments. General and Comparative Endocrinology. 150(1):174-88.
  • Hahn, Mark E. and E.V. Hestermann. 2007. Receptor-mediated mechanisms of toxicity. In: The Toxicology of Fishes (http://www.nhbs.com/title.php?tefno=123130) Exit NIEHS Website. Taylor & Francis, Boca Raton, FL.
  • Howard, Gregory, Jennifer J. Schlezinger, and Thomas Webster. 2007. Interactions of TCDD with AhR partial agonists and a competitive antagonist: implications for TEFs. Organohalogen Compounds. 69:1065-1068.
  • Jonsson, M.E., M.J. Jenny, Bruce R. Woodin, Mark E. Hahn, and John J. Stegeman. 2007. Role of AHR2 in the expression of novel cytochrome P450 1 family genes, cell cycle genes, and morphological defects in developing zebra fish exposed to 3,3',4,4',5-pentachlorobiphenyl or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 100(1):180-93.
  • Jonsson, M.E., R. Orrego, Bruce R. Woodin, Jared V. Goldstone, and John J. Stegeman. 2007. Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 221(1):29-41.
  • Kitana, Noppadon, Seung-Jae Won, and Ian P. Callard. 2007. Reproductive deficits in male freshwater turtle Chrysemys picta from Cape Cod, Massachusetts. Biology of Reproduction. (http://www.biolreprod.org/) Exit NIEHS Website 76(3):346-52.
  • Lutton, B.V. and Ian P. Callard. 2007. Effects of reproductive activity and sex hormones on apoptosis in the epigonal organ of the skate (Leucoraja erinacea). General and Comparative Endocrinology. 154(1-3):75-84.
  • Ma, X., J.R. Idle, Michael A. Malfatti, K.W. Krausz, D.W. Nebert, Chong S. Chen, James S. Felton, David J. Waxman, and Frank J. Gonzalez. 2007. Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis. (http://carcin.oupjournals.org/) Exit NIEHS Website 28(3):732-7.
  • Pinnapareddy, Devender. 2007. Synthesis and characterization of metal reagents mediating C-X Activation (X = Cl, H) of hydrocarbon. .
  • Prasad, Jahnavi C., Jared V. Goldstone, Carlos J. Camacho, Sandor Vajda, and John J. Stegeman. 2007. Ensemble modeling of substrate binding to cytochromes P450: Analysis of catalytic differences between CYP1A orthologues. Biochemistry. (http://pubs.acs.org/journals/bichaw/index.htm l) Exit NIEHS Website 46(10):2640-2654.
  • Reddy, C.M., John J. Stegeman, and Mark E. Hahn. 2007. Organic Pollutants: Presence and Effects in Humans and Marine Animals. Chapter 6 in: Oceans and Human Health: Risks and Remedies from the Seas. (in press)
  • Schlezinger, Jennifer J., Jessica K. Emberley, David H. Sherr, and S.L. Bissonnette. 2007. An L-tyrosine derivative and PPARγ agonist, GW7845, activates a multi-faceted capase cascade in bone marrow B cells. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 98(1):125-36.
  • Silberstein, Michael, Jiri Damborsky, and Sandor Vajda. 2007. Exploring the binding sites of the haloalkane dehalogenase DhlA from Xanthobacter autotrophicus GJ10. Biochemistry. (http://pubs.acs.org/journals/bichaw/index.htm l) Exit NIEHS Website 46(32):9239-49.
  • Sun, L., C.S. Chen, David J. Waxman, H. Liu, James R. Halpert, and S. Kumar. 2007. Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 458(2):167-74.
  • Wilson, Joanna Y., R. Wells, A.A. Aguilar, A. Borrell, V. Tornero, P. Reijnders, M. Moore, and John J. Stegeman. 2007. Correlates of cytochrome P450 1A1 expression in bottlenose dolphin (Tursiops truncatus) integument biopsies. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 97(1):111-9.
2006
  • Abello, James and Graham Cormode, eds. 2006. Discrete Methods in Epidemiology, DIMACS: Series in Discrete Mathematics and Theoretical Computer Science. American Mathematical Society, Providence, RI.
  • Allan, Lenka L., Jennifer J. Schlezinger, Maryam Shansab, and David H. Sherr. 2006. CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression. Biochemical and Biophysical Research Communications. (http://www.sciencedirect.com/science/journal/ 0006291X) Exit NIEHS Website 342(1):227-235.
  • Bradbury, Brian D., Jemma B. Wilk, Ann Aschengrau, and Timothy L. Lash. 2006. Departure from multiplicative interaction for catechol-O-methyltransferase genotype and active/passive exposure to tobacco smoke among women with breast cancer. Journal of Carcinogenesis. 5:3.
  • Brody, Julia Green, Ann Aschengrau, Christopher H. Swartz, Wendy McKelvey, and Ruthann A. Rudel. 2006. Breast cancer risk and drinking water contaminated by wastewater: a case control study. Environmental Health: A Global Access Science Source. 5:28.
  • Chang, Thomas K H and David J. Waxman. 2006. Catalytic assays for human cytochrome P450. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.73-83.
  • Chang, Thomas K H and David J. Waxman. 2006. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2 and CYP1B1 with 7-ethoxyresorufin as substrate. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.85-90.
  • Chang, Thomas K H and David J. Waxman. 2006. Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR). Drug Metabolism Reviews. 38(1-2):51-73.
  • Chang, Thomas K H, Charles L. Crespi, and David J. Waxman. 2006. Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.127-131.
  • Clodfelter, Karl H., M.G. Holloway, P. Hodor, S-H Park, W.J. Ray, and David J. Waxman. 2006. Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Molecular Endocrinology. (http://mend.endojournals.org/cgi/content/full /14/9/1462) Exit NIEHS Website 20(6):1333-51.
  • Clodfelter, Karl H., David J. Waxman, and Sandor Vajda. 2006. Computational solvent mapping reveals the importance of local conformational changes for broad substrate specificity in mammalian cytochromes P450. Biochemistry. (http://pubs.acs.org/journals/bichaw/index.htm l) Exit NIEHS Website 45(31):9393-407.
  • Crespi, Charles L., Thomas K H Chang, and David J. Waxman. 2006. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high performance liquid chromatography with fluorescence detection. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.121-125.
  • Dong, Wu, Wakana Muramoto, Y. Nagai, Kazusnige Takehana, John J. Stegeman, Hiroki Teraoka, and Takeo Hiraga. 2006. Retinal neuronal cell is a toxicological target of tributyltin in developing zebrafish. Journal of Veterinary Medical Sciences. 68(6):573-9.
  • Dong, Wu, Wakana Muramoto, Kazusnige Takehana, John J. Stegeman, Hiroki Teraoka, and Takeo Hiraga. 2006. Oxidative stress and apoptosis induced by tributyltin in retinal neuronal cells of developing zebrafish. Japanese Journal of Veterinary Science.
  • Garrick, Rita Anne, Bruce R. Woodin, Joanna Y. Wilson, Bobby L. Middlebrooks, and John J. Stegeman. 2006. Cytochrome P4501A is induced in endothelial cell lines from the kidney and lung of the bottlenose dolphin, Tursiops truncatus. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 76(3-4):295-305.
  • Goldstone, Jared V., A. Hamdoun, B.J. Cole, M. Howard-Ashby, D.W. Nebert, M. Scally, M. Dean, Mark E. Hahn, and John J. Stegeman. 2006. The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. Developmental Biology. 300(1):366-84.
  • Hahn, Mark E., Sibel I. Karchner, Brad R. Evans, Diana G. Franks, Rebeka R. Merson, and J.M. Lapseritis. 2006. Unexpected diversity of aryl hydrocarbon receptors in non-mammalian vertebrates: insights from comparative genomic. Journal of Experimental Zoology. 305(9):693-706.
  • Handley-Goldstone, Heather M. and John J. Stegeman. 2006. A revised evolutionary history of the CYP1A subfamily: Gene duplication, gene conversion, and positive selection. Journal of Molecular Evolution. 62(6):708-717.
  • Handley-Goldstone, Heather M. and John J. Stegeman. 2006. Molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin cardiovascular embryotoxicity. Drug Metabolism Reviews. 38(1-2):261-289.
  • Kaya, Taner, S.C. Mohr, David J. Waxman, and Sandor Vajda. 2006. Computational screening of phthalate monoesters for binding to PPARgamma. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 19(8):999-1009.
  • Kitana, Noppadon, W. Khonsue, Seung-Jae Won, V.A. Lance, and Ian P. Callard. 2006. Gonadotropin and estrogen responses in freshwater turtle (Chrysemys picta) from Cape Cod, Massachusetts. General and Comparative Endocrinology. 149(1):49-57.
  • Kubota, A., Hisato Iwata, Heather M. Handley-Goldstone, E.Y. Kim, John J. Stegeman, and S. Tanabe. 2006. Cytochrome P450 1A4 and 1A5 in Common Cormorant (Phalacrocorax carbo): Evolutionary relationships and functional implications associated with dioxin and related compounds. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 92(2):394-408.
  • Landon, Melissa R., David R. Lancia, Karl H. Clodfelter, and Sandor Vajda. 2006. Clustering of domains of functionally related enzymes in the interaction database PRECISE by the generation of primary sequence patterns. Journal of Molecular Graphics and Modelling. 24(6):426-433.
  • Malins, Donald C., Katie M. Anderson, John J. Stegeman, Pawel Jaruga, Virgina M. Green, Naomi K. Gilman, and Miral Dizdaroglu. 2006. Biomarkers signal contaminant effects on the organs of English sole (Parophrys vetulus) from Puget Sound. Environmental Health Perspectives. 114(6):823-829.
  • Matsuo, A.Y., Bruce R. Woodin, C.M. Reddy, A.L. Val, and John J. Stegeman. 2006. Humic substances and crude oil induce cytochrome P450 1A expression in the Amazonian fish species Colossoma macropomum (Tambaqui). Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) Exit NIEHS Website 40(8):2851-8.
  • Merson, Rebeka R., Diana G. Franks, Sibel I. Karchner, and Mark E. Hahn. 2006. Development and characterization of polyclonal antibodies against the aryl hydrocarbon receptor protein family (AHR1, AHR2, and AHR repressor) of Atlantic killifish Fundulus heteroclitus. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. (http://www.sciencedirect.com/science/journal/ 15320456) Exit NIEHS Website 142:85-94.
  • Novillo, Apolonia, Noppadon Kitana, Seung-Jae Won, and Ian P. Callard. 2006. Comparative environmental endocrinology, genomics and endocrine disruption. In: Proceedings of the 5th Intercongress Symposium of the Asia and Oceania Society for Comparative Endocrinology. Bangkok, pp.77-82.
  • Ozonoff, David M., A. Pogel, and T. Hannan. 2006. Generalized contingency tables and concept lattices. In: Discrete Methods in Epidemiology, DIMACS: Series in Discrete Mathematics and Theoretical Computer Science. American Mathematical Society, Providence, RI. pp.93.
  • Puinean, A.M., P. Labadie, E.M. Hill, Makoto Osada, Mitsuyo Kishida, Apolonia Novillo, Ian P. Callard, and J.M. Rotchell. 2006. Laboratory exposure to 17beta-estradiol fails to induce vitellogenin and estrogen receptor gene expression in the marine invertebrate Mytilus edulis. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 79(4):376-383.
  • Sawyer, S.J., K.A. Gerstner, and Gloria V. Callard. 2006. Development of a real time PCR assay for the differential detection and quantification of cytochrome P450 aromatase isoforms in zebrafish: tissue distribution, sex differences, developmental programming, and estrogen regulation. General and Comparative Endocrinology. 147(2):108-117.
  • Sawyer, S.J., K.A. Gerstner, and Gloria V. Callard. 2006. Real-time PCR analysis of cytochrome P450 aromatase expression in zebrafish: gene specific tissue distribution, sex differences, developmental programming, and estrogen regulation. General and Comparative Endocrinology. 147(2):108-17.
  • Schlezinger, Jennifer J., Jessica K. Emberley, and David H. Sherr. 2006. Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 92(2):433-44.
  • Schlezinger, Jennifer J., W. DJ Struntz, Jared V. Goldstone, and John J. Stegeman. 2006. Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 77(4):422-432.
  • Sea Urchin Genome Sequencing Consortium, , E. Sodergren, G.M. Weinstock, E.H. Davidson, R.A. Cameron, R.A. Gibbs, and et al. 2006. The genome of the sea urchin Strongylocentrotus purpuratus. Science. (http://www.sciencemag.org/) Exit NIEHS Website 314(5801):941-52.
  • Shipley, Jonathan M. and David J. Waxman. 2006. Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methycholanthrene. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 213(2):87-97.
  • Stavropoulous, Pericles, Remle Celenligil-Cetin, Salma Kiani, Amy E. Tapper, Devender Pinnapareddy, and Patrina Paraskevopoulou. 2006. lron,bis(pyridine)bis(2-pyridinecarboxylato-N1,O2. In: Encyclopedia of Reagents for Organic Synthesis. John Wiley & Sons, Inc.,
  • Stavropoulous, Pericles, R. Qelenligil-Qetin, Salma Kiani, Amy E. Tapper, Devender Pinnapareddy, and Patrina Paraskevopoulou. 2006. lron,bis(pyridine)bis(2-pyridinecarboxylato-N1,02). In: Encyclopedia of Reagents for Organic Synthesis. John Wiley & Sons, Inc., pp.414-15.
  • Stuchal, Leah, Kevin M. Kleinow, John J. Stegeman, and Margaret O. James. 2006. Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes. Drug Metabolism and Disposition. (http://dmd.aspetjournals.org/) Exit NIEHS Website 34(6):932-8.
  • Tarrant, A.M., Sarah R. Greytak, Gloria V. Callard, and Mark E. Hahn. 2006. Estrogen receptor-related receptors in the killifish Fundulus heteroclitus: diversity, expression, and estrogen responsiveness. Journal of Molecular Endocrinology. (http://jme.endocrinology-journals.org/) Exit NIEHS Website 37(1):105-20.
  • Teraoka, Hiroki, S. Urakawa, S. Nanba, Y. Nagai, Wu Dong, T. Imagawa, Robert L. Tanguay, K. Svoboda, Heather M. Handley-Goldstone, John J. Stegeman, and Takeo Hiraga. 2006. Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 212(1):24-34.
  • Verslycke, T., Jared V. Goldstone, and John J. Stegeman. 2006. Isolation and phylogeny of novel cytochrome P450 genes from tunicates (Ciona spp.): a CYP3 line in early deuterostomes?. Molecular Phylogenetics and Evolution. 40(3):760-771.
  • Vieira, Veronica, Thomas Webster, Janice Weinberg, and Ann Aschengrau. 2006. Temporal-Spatial analysis of breast cancer on upper Cape Cod, Massachusetts. In: Proceedings of the Spatial Epidemiology Conference, 2006 (http://www.spatepiconf.org/) Exit NIEHS Website. London, pp.115-119.
  • Vieira, Veronica, Thomas Webster, Janice Weinberg, and Ann Aschengrau. 2006. Temporal-spatial analysis of breast cancer risk on upper Cape Cod, Massachusetts, USA. Epidemiology. (http://www.epidem.com/) Exit NIEHS Website 19:S484.
  • Waxman, David J. and Thomas K H Chang. 2006. Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2 and CYP3 families. In: Methods in Molecular Biology, Vol 320. Humana Press, Inc, Louisville, KY. pp.153-156.
  • Webster, Thomas. 2006. Cross-level bias in partially ecologic studies. In: Proceedings of the Spatial Epidemiology Conference, 2006 (http://www.spatepiconf.org/) Exit NIEHS Website. London, pp.127-132.
  • Webster, Thomas, Veronica Vieira, Janice Weinberg, and Ann Aschengrau. 2006. Method for mapping population-based case-control studies: an application using generalized additive models. International Journal of Health Geographics. (http://www.ij-healthgeographics.com/home/) Exit NIEHS Website 5:26.
  • Webster, Thomas, Janice Weinberg, Veronica Vieira, K. Hoffman, and Ann Aschengrau. 2006. The impact of community and individual-level socioeconomic status on the risk of breast cancer: Multi-level modeling in Massachusetts. Epidemiology. (http://www.epidem.com/) Exit NIEHS Website 19:S210.
2005
  • Callard, Ian P., Joseph St George, and Thomas J. Koob. 2005. Endocrine Control of the Female Reproductive Tract. Chapter 9 in: The Reproductive Biology and Phylogeny of Chondrichthyes: sharks, batoids and chimaeras (http://www.scipub.net/index.html) Exit NIEHS Website. Science Publishers, Enfield, NH. pp.283-300.
  • Chang, Thomas K H and David J. Waxman. 2005. Pregnane X receptor-mediated transcription. Methods in Enzymology. (http://www.sciencedirect.com/science/bookseri es/00766879) Exit NIEHS Website 400:588-598.
  • Custodia-Lora, Noemi, Apolonia Novillo, and Ian P. Callard. 2005. Synergistic role for pituitary growth hormone in the regulation of hepatic estrogen and progesterone receptors and vitellogenesis in female freshwater turtles, Chrysemys picta. General and Comparative Endocrinology. 140:25-32.
  • Evans, Brad R., Sibel I. Karchner, Diana G. Franks, and Mark E. Hahn. 2005. Duplicate aryl hydrocarbon receptor repressor genes (ahrr1 and ahrr2) in the zebrafish Danio rerio: Structure, function, evolution, and AHR-dependent regulation in vivo. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 441(2):151-167.
  • Garrick, Rita Anne, Bruce R. Woodin, and John J. Stegeman. 2005. Cytochrome p4501a induced differentially in endothelial cells cultured from different organs of Anguilla rostrata. In Vitro Cellular & Developmental Biology - Animal. 41(1):57-63.
  • Godard, Celine AJ, Jared V. Goldstone, Maya R. Said, Richard L. Dickerson, Bruce R. Woodin, and John J. Stegeman. 2005. The new vertebrate CYP1C family: Cloning of new subfamily members and phylogenetic analysis. Biochemical and Biophysical Research Communications. (http://www.sciencedirect.com/science/journal/ 0006291X) Exit NIEHS Website 331(4):1016-1024.
  • Greytak, Sarah R., Denise Champlin, and Gloria V. Callard. 2005. Isolation and characterization of two cytochrome P450 aromatase forms in killifish (Fundulus heteroclitus): differential expression in fish from polluted and unpolluted environments. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 71(4):371-389.
  • Handley-Goldstone, Heather M., Matthew W. Grow, and John J. Stegeman. 2005. Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 85(1):683-693.
  • Hurst, Christopher H. and David J. Waxman. 2005. Interactions of endocrine-active environmental chemicals with the nuclear receptor PXR. Toxicological and Environmental Chemistry. (http://www.informaworld.com/smpp/title~conten t=t713653210) Exit NIEHS Website 87:299-311.
  • Kumar, Santosh, Chong S. Chen, David J. Waxman, and James R. Halpert. 2005. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates including the anticancer prodrugs cyclophosphamide and ifosfamide. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 280(20):19569-19575.
  • Lash, Timothy L., Brian D. Bradbury, Jemma B. Wilk, and Ann Aschengrau. 2005. A case-only analysis of the interaction between N-acetyltransferase 2 haplotypes and tobacco smoke in breast cancer etiology. Breast Cancer Research. (http://breast-cancer-research.com/) Exit NIEHS Website 7(3):R385-R393.
  • Lutton, B.V., Joseph St George, C.R. Murrin, L.A. Fileti, and Ian P. Callard. 2005. The Elasmobranch Ovary. Chapter 8 in: The Reproductive Biology and Phylogeny of Chondrichthyes: sharks, batoids and chimaeras (http://www.scipub.net/index.html) Exit NIEHS Website. Science Publishers, Enfield, NH. pp.237-82.
  • Malins, Donald C., John J. Stegeman, Virgina M. Green, Naomi K. Gilman, and Katie M. Anderson. 2005. Spectral Models for Assessing Exposure of Fish to Contaminants. In: Techniques in Aquatic Toxicology. CRC Press, Inc., Boca Raton, FL. pp.537-545.
  • Novillo, Apolonia, Noppadon Kitana, Emily Marquez, and Ian P. Callard. 2005. Genotoxicity in repiles. In: New Perspectives: Toxicology and the Environment. Taylor and Francis, London, England. pp.241-166.
  • Novillo, Apolonia, Seung-Jae Won, Christine Li, and Ian P. Callard. 2005. Changes in nuclear receptor and vitellogenin gene expression in response to steroids and heavy metal in Caenorhabditis elegans. Integrative and Comparative Biology. 45:61-71.
  • Ozonoff, Al, Thomas Webster, Veronica Vieira, Janice Weinberg, David M. Ozonoff, and Ann Aschengrau. 2005. Cluster detection methods applied to the Upper Cape Cod cancer data. Environmental Health: A Global Access Science Source. 4:19.
  • Ozonoff, David M. 2005. On being careful what we wish for: Some difficulties with operationalizing the precautionary principle (Reprinted from the European Journal of Oncology Library, vol 2, 2003). Human and Ecological Risk Assessment. (http://www.sciencedirect.com/science/journal/ 10807039) Exit NIEHS Website 11(1):53-62.
  • Rie, Melanie T., Noppadon Kitana, Katherine A. Lendas, Seung-Jae Won, and Ian P. Callard. 2005. Reproductive endocrine disruption in a sentinel species (Chrysemys picta) on Cape Cod, Massachusetts. Archives of Environmental Contamination and Toxicology. (http://link.springer.de/link/service/journals /00244/tocs.html) Exit NIEHS Website 48(2):217-224.
  • Ryu, Heui-Young, Jessica K. Emberley, Jennifer J. Schlezinger, Lenka L. Allan, Songqing Na, and David H. Sherr. 2005. Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology. (http://molpharm.aspetjournals.org/) Exit NIEHS Website 68(4):1087-1096.
  • Scammell, Madeleine Kangsen. 2005. Roots of Community Research: Primer on the Legacy of Participatory Research Partnerships. Race, Poverty & The Environment. XINo.2:
  • Sheu, Shu-Hsien, Taner Kaya, David J. Waxman, and Sandor Vajda. 2005. Exploring the binding site structure of the PPAR gamma ligand-binding domain by computational solvent mapping. Biochemistry. (http://pubs.acs.org/journals/bichaw/index.htm l) Exit NIEHS Website 44(4):1193-1209.
  • Sheu, Shu-Hsien, David R. Lancia, Karl H. Clodfelter, Melissa R. Landon, and Sandor Vajda. 2005. PRECISE: a Database of Predicted and Consensus Interaction Sites in Enzymes. Nucleic Acids Research. (http://www3.oup.co.uk/nar/contents/) Exit NIEHS Website 33:D206-D211.
  • Stavropoulous, Pericles, Remle Celenligil-Cetin, Salma Kiani, Amy E. Tapper, Devender Pinnapareddy, and Patrina Paraskevopoulou. 2005. Gif Reactions. Chapter 2.1.1 in: Handbook of C-H Transformations: Applications in Organic Synthesis, Two Volumes. Wiley-VCH, Weinheim, Germany. pp.497-507.
  • Timme-Laragy, Alicia R., Joel N. Meyer, Robert A. Waterland, and Richard T. Di Giulio. 2005. Analysis of CpG methylation in the killifish CYP1A promoter. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 141(4):406-411.
  • Vieira, Veronica, Ann Aschengrau, and David M. Ozonoff. 2005. Impact of tetrachloroethylene-contaminated drinking water on the risk of breast cancer: Using a dose model to assess exposure in a case-control study. doi:10.1186/1476-069X-4-3. Environmental Health: A Global Access Science Source. 4(1):3.
  • Vieira, Veronica, Thomas Webster, Janice Weinberg, and Ann Aschengrau. 2005. Spatial analysis of low birth weight on Cape Cod, MA using generalized additive modeling. Epidemiology. (http://www.epidem.com/) Exit NIEHS Website 16(5):S104.
  • Vieira, Veronica, Thomas Webster, Janice Weinberg, Ann Aschengrau, and David M. Ozonoff. 2005. Spatial analysis of lung, colorectal, and breast cancer on Cape Cod: An application of generalized additive models to case-control data. Environmental Health: A Global Access Science Source. 4(1):11.
  • Webster, Thomas and Veronica Vieira. 2005. Negative confounding in spatial epidemiology: An example from breast cancer. Epidemiology. (http://www.epidem.com/) Exit NIEHS Website 16(5):S105-S106.
  • Won, Seung-Jae, Apolonia Novillo, Noemi Custodia, Melanie T. Rie, Kelly Fitzgerald, Makoto Osada, and Ian P. Callard. 2005. The fresh water mussel (Elliptic complanata) as a sentinel species: vitellogenin and steroid receptors. Integrative and Comparative Biology. 45:72-80.
  • Yang, Xinhai, Donghui Liu, Tessa J. Murray, Geoffrey C. Mitchell, Eli V. Hesterman, Sibel I. Karchner, Rebeka R. Merson, Mark E. Hahn, and David H. Sherr. 2005. The aryl hydrocarbon receptor constitutively represses c-myc transcription in human mammary tumor cells. Oncogene. (http://www.nature.com/onc/) Exit NIEHS Website 24(53):7869-7881.
2004
  • Ahluwalia, A., Karl H. Clodfelter, and David J. Waxman. 2004. Sexual dimorphism of rat liver gene expression: Regulatory role of growth hormone revealed by deoxyribonucleic acid microarray analysis. Molecular Endocrinology. (http://mend.endojournals.org/cgi/content/full /14/9/1462) Exit NIEHS Website 18(3):747-760.
  • Brody, Julia Green, Ann Aschengrau, Wendy McKelvey, Ruthann A. Rudel, Christopher H. Swartz, and Theresa Kennedy. 2004. Breast Cancer Risk and Historical Exposure to Pesticides from Wide-Area Applications Assessed with GIS. Environmental Health Perspectives. 112(8):889-897.
  • Clodfelter, Karl H. and David J. Waxman. 2004. Computational solvent mapping reveals major differences in substrate binding between bacterial and mammalian cytochrome. In: Proceedings of the New England Member Enzyme Conference.
  • Comeau, Stephen R., David W. Gatchell, S. Vajda, and Carlos J. Camacho. 2004. ClusPro: a fully automated algorithm for protein-protein docking. Nucleic Acids Research. (http://www3.oup.co.uk/nar/contents/) Exit NIEHS Website 32:W96-W99.
  • Comeau, Stephen R., David W. Gatchell, Sandor Vajda, and Carlos J. Camacho. 2004. ClusPro: An automated docking and discrimination method for the prediction of protein complexes. Bioinformatics. (http://bioinformatics.oupjournals.org/) Exit NIEHS Website 20(1):45-50.
  • Custodia-Lora, Noemi, Apolonia Novillo, and Ian P. Callard. 2004. Effect of gonadal steroids on progesterone receptor, estrogen receptor, and vitellogenin expression in male turtles (Chrysemys picta). Journal of Experimental Zoology. 301A(1):15-25.
  • Custodia-Lora, Noemi, Apolonia Novillo, and Ian P. Callard. 2004. Regulation of hepatic progesterone and estrogen receptors in the female turtle, Chrysemys picta: relationship to vitellogenesis. General and Comparative Endocrinology. 136(2):232-240.
  • Dong, Wu, Hiroki Teraoka, Yoshikazu Tsujimoto, John J. Stegeman, and Takeo Hiraga. 2004. Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 77(1):109-116.
  • Hahn, Mark E., Sibel I. Karchner, Diana G. Franks, and Rebeka R. Merson. 2004. Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus). Pharmacogenetics. (http://www.jpharmacogenetics.com/) Exit NIEHS Website 14(2):131-143.
  • Hurst, Christopher H. and David J. Waxman. 2004. Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 199(3):266-274.
  • Malins, Donald C., John J. Stegeman, Jack W. Anderson, Paul M. Johnson, Jordan Gold, and Katie M. Anderson. 2004. Structural Changes in Gill DNA Reveal the Effects of Contaminants on Puget Sound Fish. Environmental Health Perspectives. 112(5):511-515.
  • Powell, Wade H., Hilary G. Morrison, E. Jennifer Weil, Sibel I. Karchner, Mitchell L. Sogin, John J. Stegeman, and Mark E. Hahn. 2004. Cloning and analysis of the CYP1A promoter from the atlantic killifish (Fundulus heteroclitus). Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) Exit NIEHS Website 58(2-5):119-124.
  • Prasad, Jahnavi C., Sandor Vajda, and Carlos J. Camacho. 2004. Consensus alignment server for reliable comparative modeling with distant templates. Nucleic Acids Research. (http://www3.oup.co.uk/nar/contents/) Exit NIEHS Website 32:W50-W54.
  • Schlezinger, Jennifer J., Gregory Howard, Christopher H. Hurst, Jessica K. Emberley, David J. Waxman, Thomas Webster, and David H. Sherr. 2004. Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: Interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-Deoxy-Delta(12,14)-prostaglandin J(2). Journal of Immunology. (http://www.jimmunol.org/) Exit NIEHS Website 173(5):3165-3177.
  • Sheu, Shu-Hsien, Taner Kaya, David J. Waxman, and Sandor Vajda. 2004. Exploring the Binding Site Structure of the PPARg Ligand-Binding Domain by Computational Solvent Mapping. Biochemistry. (http://pubs.acs.org/journals/bichaw/index.htm l) Exit NIEHS Website 44:1193-1209.
  • Shipley, Jonathan M. and David J. Waxman. 2004. Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 199(3):275-284.
  • Su, Ting and David J. Waxman. 2004. Impact of dimethyl sulfoxide on expression of nuclear receptors and drug-inducible cytochromes P450 in primary rat hepatocytes. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 424(2):226-234.
  • Zodrow, Jeanmarie M., John J. Stegeman, and Robert L. Tanguay. 2004. Histological analysis of acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in zebrafish. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 66(1):25-38.
2003
  • Abriola, Linda. 2003. The long (LINEs) and the short (SINEs) of it: altered methylation as a precursor to toxicity. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 65:229-235.
  • Ahluwalia, A. 2003. Trichloroethylene effects on gene expression during cardiac development. Birth Defects Research Part A: Clinical and Molecular Teratology. (http://www3.interscience.wiley.com/cgi-bin/jh ome/102526943) Exit NIEHS Website 67(7):488-495.
  • Ahmed, Kazi Matin. 2003. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiation Research. (http://www.radres.org/ECOMradres/timssnet/com mon/tnt_InstructionsforAuthors.cfm) Exit NIEHS Website 160:512-516.
  • Allan, Lenka L., Koren K. Mann, Raymond A. Matulka, Heui-Young Ryu, Jennifer J. Schlezinger, and David H. Sherr. 2003. Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 76(2):357-365.
  • Aschengrau, Ann, Sarah Rogers, and David M. Ozonoff. 2003. Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA. Environmental Health Perspectives. 111(2):167-173.
  • Carnell, A.N. and Jay I. Goodman. 2003. The long (LINEs) and the short (SINEs) of it: altered methylation as a precursor to toxicity. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 65:229-235.
  • Chen, Y.C., H.J. Su, Yue-Liang Leon Guo, Y.M. Hsueh, T.J. Smith, L.M. Ryan, M.S. Lee, and David C. Christiani. 2003. Arsenic methylation and bladder cancer risk in Taiwan. Cancer Causes and Control. (http://www.ovid.com/site/catalog/Journal/1462 .jsp) Exit NIEHS Website 14(4):303-310.
  • Collier, J.M., Ornella Selmin, P.D. Johnson, and R.B. Runyan. 2003. Trichloroethylene effects on gene expression during cardiac development. Birth Defects Research Part A: Clinical and Molecular Teratology. (http://www3.interscience.wiley.com/cgi-bin/jh ome/102526943) Exit NIEHS Website 67(7):488-495.
  • Collier, J.M., Ornella Selmin, P.D. Johnson, and R.B. Runyan. 2003. Trichloroethylene effects on gene expression during cardiac development. Birth Defects Research Part A: Clinical and Molecular Teratology. (http://www3.interscience.wiley.com/cgi-bin/jh ome/102526943) Exit NIEHS Website 67(7):488-495.
  • Custodia-Lora, Noemi and Ian P. Callard. 2003. Effects of gonadal steroids on progesterone receptor mRNA and progesterone receptor, estrogen receptor mRNA and vitellogenin mRNA and vitellogenin. General and Comparative Endocrinology.
  • Goldstone, Jared V. and John J. Stegeman. 2003. Quantification of ROS Production and Enzyme Inactivation of CYP 1A by Polychlorinated Biphenyls and by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • Henderson, P.T., J.C. Delaney, J.G. Muller, W.L. Neeley, S.R. Tannenbaum, C.J. Burrows, and J.M. Essigmann. 2003. The hydantoin lesions formed from oxidation if 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry. (http://pubs.acs.org/journals/bichaw/index.htm l) Exit NIEHS Website 42:9257-9262.
  • Henderson, P.T., J.C. Delaney, J.G. Muller, W.L. Neeley, S.R. Tannenbaum, C.J. Burrows, and J.M. Essigmann. 2003. he hydantoin lesions formed from oxidation if 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry. (http://pubs.acs.org/journals/bichaw/index.htm l) Exit NIEHS Website 42:9257-9262.
  • Hurst, Christopher H. and David J. Waxman. 2003. Activation of PPARalpha and PPARgamma by Environmental Phthalate Monoesters. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 74(2):297-308.
  • Jahnavi, C. and Jahnavi C. Prasad. 2003. Differences in Substrate Binding Between Mammalian and Fish Cytochrome P450 1As Predicted by Comparative Modeling and Flexible Docking. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • Kortvelyesi, Tamas, Sheldon Dennis, S. Silberstein, Lawerence Brown, and Sandor Vajda. 2003. Algorithms for computational solvent mapping of proteins. Proteins. 51(3):340-351.
  • Kortvelyesi, Tamas, Michael Silberstein, Sheldon Dennis, and S. Vajda. 2003. Improved mapping of protein binding sites. Journal of Computer-Aided Molecular Design. 17(2):173-186.
  • McArthur, A.G., Tove Hegelund, Rachel L. Cox, John J. Stegeman, M. Liljenberg, U. Olsson, P. Sundberg, and M.C. Celander. 2003. Phylogenetic analysis of the cytochrome P450 (CYP3) gene family. Journal of Molecular Evolution. 57(2):200-211.
  • Meyer, Joel N., Deena M. Wassenberg, Sibel I. Karchner, Mark E. Hahn, and Richard T. Di Giulio. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environmental Toxicology and Chemistry. (http://etc.allenpress.com/entconline/?request =index-html) Exit NIEHS Website 22(10):2337-2343.
  • Morrison, Ann and John J. Stegeman. 2003. In Vitro Assessment of CYP51 Azole Sensitivity in Fish: Dos Upregulation of CYP1A Protect the CYP51?. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • Oleksiak, Marjorie, Shu Wu, Carol Parker, Wei Qu, Rachel L. Cox, Darryl C. Zeldin, and John J. Stegeman. 2003. Identification and regulation of a new vertebrate cytochrome P450 subfamily, the CYP2Ps and functional characterization of CYP2P3, a conserved arachidonic acid epoxygenase/19-hydroxylase. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 411(2):223-234.
  • Ozonoff, David M. 2003. Superfund Basic Research Program: A model for contemporary research programs. Environmental Health Perspectives. 111(3):A140-A141.
  • Prasad, Jahnavi C. 2003. Identification of substrate binding sites in enzymes by computational solvent mapping. Drug Metabolism Reviews. 35:331Suppl.2.
  • Prasad, Jahnavi C., Stephen R. Comeau, Sandor Vajda, and Carlos J. Camacho. 2003. Consensus alignment for reliable framework prediction in homology modeling. Bioinformatics. (http://bioinformatics.oupjournals.org/) Exit NIEHS Website 19(13):1682-1691.
  • Prasad, Jahnavi C., Michael Silberstein, Carlos J. Camacho, and Sandor Vajda. 2003. Homology modeling of proteins using multiple models and consensus sequence alignment. Lecture Notes in Bioinformatics. (http://www.springeronline.com/sgw/cda/frontpa ge/0,11855,4-164-2-73658-0,00.html) Exit NIEHS Website 2812:389-401.
  • Prasad, Jahnavi C., Sandor Vajda, and Carlos J. Camacho. 2003. Identification of substrate binding sites in enzymes by computational solvent mapping. Drug Metabolism Reviews. 35:331Suppl.2.
  • Prasad, Jahnavi C., Sandor Vajda, Jared V. Goldstone, Carlos J. Camacho, and John J. Stegeman. 2003. Differences in Substrate Binding Between Mammalian and Fish Cytochrome P450 1As Predicted by Comparative Modeling and Flexible Docking. In: Presented at the International Society for the study of Xenobiotics, October. Providence, RI.
  • Prasad, Jahnavi C., Sandor Vajda, Jared V. Goldstone, Carlos J. Camacho, and John J. Stegeman. 2003. Identification of substrate binding sites in enzymes by computational solvent mapping. Drug Metabolism Reviews. 35:331Suppl.2.
  • Prasch, Amy L., Hiroki Teraoka, Sara A. Carney, Wu Dong, Takeo Hiraga, John J. Stegeman, Warren Heideman, and Richard E. Peterson. 2003. Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 76(1):138-150.
  • Rice, Robert H. and Michael S. Denison. 2003. Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 419:158-169.
  • Ryu, Heui-Young, Koren K. Mann, Jennifer J. Schlezinger, Brenda Jensen, and David H. Sherr. 2003. Environmental chemical-induced Pro/Pre-B cell apoptosis: Analysis of c-Myc, p27(Kipl), and p21(WAF1) reveals a death pathway distinct from clonal deletion. Journal of Immunology. (http://www.jimmunol.org/) Exit NIEHS Website 170(10):4897-4907.
  • Shipley, J.M. and David J. Waxman. 2003. Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) alpha and PPAR gamma. Molecular Pharmacology. (http://molpharm.aspetjournals.org/) Exit NIEHS Website 64(2):355-364.
  • Silberstein, Michael, Sheldon Dennis, Lawerence Brown, Tamas Kortvelyesi, Karl H. Clodfelter, and Sandor Vajda. 2003. Identification of substrate binding sites in enzymes by computational solvent mapping. Journal of Molecular Biology. 332(5):1095-1113.
  • Su, Ting and David J. Waxman. 2003. Impact of dimethyl sulphoxide on expression of nuclear receptors and drug-inducible cytochromes P450 (CYPs) in primary rat hepatocytes. FASEB Journal. (http://www.fasebj.org/) Exit NIEHS Website 17(4):A240-A240Part1Suppl..
  • Takai, Yasushi, Jacqueline Canning, Gloria I. Perez, James K. Pru, Jennifer J. Schlezinger, David H. Sherr, Richard N. Kolesnick, Junying Yuan, Richard A. Flavell, Stanley J. Korsmeyer, and Jonathan L. Tilly. 2003. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology. (http://endo.endojournals.org/) Exit NIEHS Website 144(1):69-74.
  • Teraoka, Hiroki, Wu Dong, Yoshikazu Tsujimoto, Hiroyuki Iwasa, Daiji Endoh, Naoto Ueno, John J. Stegeman, R.E. Peterson, and Takeo Hiraga. 2003. Induction of cytochrome P450 1A is required for circulation failure and edema by 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish. Biochemical and Biophysical Research Communications. (http://www.sciencedirect.com/science/journal/ 0006291X) Exit NIEHS Website 304(2):223-228.
  • Waxman, David J. 2003. Nuclear receptor regulation of drug-metzbolizing P450 enzymes. In: Encyclopedia Reference of Molecular Pharmacology. Springer-Verlag Press,
  • Webster, Thomas and David H. Sherr. 2003. Types of AhREs and their Implications. Organohalogen Compounds. 65:106-109.
  • Webster, Thomas, Veronica Vieira, Janice Weinberg, and Ann Aschengrau. 2003. Spatial Analysis of Lung, Breast and Colorectal Cancer Using Generalized Additive Models. In: Proceedings of the EUROHEIS-SAHSU (European Health and Environment Information System-Small Area Health Statistics Unit) Conference 2003. Small Area Health Statistics Unit. Imperial College, London, England.
  • Zhang, Qunwei, Konstantin Salnikow, Thomas Kluz, Lung Chi Chen, Weichen Su, and Max Costa. 2003. Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 192(3):201-211.
2002
  • Ahluwalia, A. and David J. Waxman. 2002. Global gene expression profiling in rat liver using oligonucleotide microarrays: evaluation of the regulatory role of hormones and xenobiotics. In: New England Drug Metabolism Discussion Group Summer Symposium. Worcester, MA.
  • Andreasen, Eric A., Jan M. Spitsbergen, Robert L. Tanguay, John J. Stegeman, Warren Heideman, and Richard E. Peterson. 2002. Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 68(2):403-419.
  • Baader, Manuel, Carmela Gnerre, John J. Stegeman, and Urs A. Meyer. 2002. Transcriptional activation of cytochrome P-450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor CXR interacting with a phenobarbital-response enhancer unit. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 277(18):15647-15653.
  • Bard, Shannon Mala, Susan M. Bello, Mark E. Hahn, and John J. Stegeman. 2002. Expression of P-glycoprotein in killifish (Fundulus heteroclitus) exposed to environmental xenobiotics. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 59(3-4):237-251.
  • Bard, Shannon Mala, Bruce R. Woodin, and John J. Stegeman. 2002. Expression of P-glycoprotein and cytochrome p450 1A in intertidal fish (Anoplarchus purpurescens) exposed to environmental contaminants. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 60(1-2):17-32.
  • Custodia-Lora, Noemi and Ian P. Callard. 2002. Progesterone and progesterone receptors in reptiles. General and Comparative Endocrinology. 127:1-7.
  • Custodia-Lora, Noemi and Ian P. Callard. 2002. Seasonal changes in hepatic progesterone receptor mRNA, estrogen receptor mRNA, and vitellogenin mRNA in the painted turtle, Chrysemys picta. General and Comparative Endocrinology. 128:193-204.
  • Dennis, Sheldon, Tamas Kortvelyesi, and Sandor Vajda. 2002. Computational mapping identifies the binding sites of organic solvents on proteins. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 99(7):4290-4295.
  • Dennis, Sheldon, Tamas Kortvelyesi, and Sandor Vajda. 2002. Computational solvent mapping for the analysis of enzyme active sites. Abstracts of Papers - American Chemical Society. (http://www.cas.org/) Exit NIEHS Website 224:221-COMPPart1.
  • Duggan, Annemarie E., Ronald Ste Marie, and Ian P. Callard. 2002. Expression of SR-BI (Scavenger Receptor Class B Type I) in turtle (Chrysemys picta) tissues and other nonmammalian vertebrates. Journal of Experimental Zoology. 292(5):430-434.
  • Goss, Kendrick Alan, Karl H. Clodfelter, and David J. Waxman. 2002. Understanding P450 structure-function relationships using DNA shuffling mutagenesis. In: Boston University-Humboldt University Bioinformatics Workshop, Boston, MA.
  • Hahn, Mark E., Sibel I. Karchner, and Diana G. Franks. 2002. Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus). Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) Exit NIEHS Website 54:409.
  • Hoyer, Annette Pernille, Anne Marie Gerdes, Torben Jorgensen, Fritz Rank, and Helle Boggild Hartvig. 2002. Organochlorines, p53 mutations in relation to breast cancer risk and survival. A Danish cohort-nested case-controls study. Breast Cancer Research and Treatment. 71(1):59-65.
  • Iwata, Hisato, Kouichi Yoshinari, Masahiko Negishi, and John J. Stegeman. 2002. Species-specific responses of constitutively active receptor (CAR)-CYP2B coupling: lack of CYP2B inducer-responsive nuclear translocation of CAR in marine teleost, scup (Stenotomus chrysops). Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. (http://www.sciencedirect.com/science/journal/ 15320456) Exit NIEHS Website 131(4):501-510.
  • Karchner, Sibel I., Diana G. Franks, Wade H. Powell, and Mark E. Hahn. 2002. Regulatory interactions among three members of the vertebrate aryl hydrocarbon receptor family: AHR repressor, AHR1, and AHR2. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 277:6949-6959.
  • Lash, Timothy L. and Ann Aschengrau. 2002. A Null Association between Active or Passive Cigarette Smoking and Breast Cancer Risk. Breast Cancer Research and Treatment. 75(2):181-184.
  • Nicholls, Jill, Bill L. Lasley, Steven T. Nakajima, Kenneth DR Setchell, and Barbara O. Schneeman. 2002. Effect of soy consumption on gonadotropin secretion and acute pituitary response to GnRH in women. Journal of Nutrition. (http://jn.nutrition.org/) Exit NIEHS Website 132:708-714.
  • Paulu, Christopher, Ann Aschengrau, and David M. Ozonoff. 2002. Exploring associations between residential location and breast cancer incidence in a case-control study. Environmental Health Perspectives. 110(5):471-478.
  • Powell, Wade H. and Mark E. Hahn. 2002. Identification and functional characterization of hypoxia-inducible factor 2alpha from the estuarine teleost, Fundulus heteroclitus: interaction of HIF-2alpha with two ARNT2 splice variants. Journal of Experimental Zoology. 294(1):17-29.
  • Schlezinger, Jennifer J., Brenda Jensen, Koren K. Mann, Heui-Young Ryu, and David H. Sherr. 2002. Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells. Journal of Immunology. (http://www.jimmunol.org/) Exit NIEHS Website 169(12):6831-6841.
  • Sturup, Stefan. 2002. Review of Plasma Source Mass Spectrometry - The New Millennium. (Edited by, Grenville Holland and Scott D. Tanner). Journal of Analytical Atomic Spectrometry. (http://www.rsc.org/Publishing/Journals/JA/ind ex.asp) Exit NIEHS Website 17:7N-8N.
  • Vieira, Veronica, Thomas Webster, Ann Aschengrau, and David M. Ozonoff. 2002. A method for spatial analysis of risk in a population-based case-control study. International Journal of Hygiene and Environmental Health. (http://www.elsevier.de/ijheh) Exit NIEHS Website 205(1-2):115-120.
  • Webster, Thomas. 2002. Commentary: Does the specter of ecologic bias haunt epidemiology?. International Journal of Epidemiology. (http://ije.oupjournals.org/) Exit NIEHS Website 31:161-162.
  • Yamazaki, K., Hiroki Teraoka, Wu Dong, John J. Stegeman, and Takeo Hiraga. 2002. cDNA cloning and expressions of cytochrome P450 1A in zebrafish embryos. Journal of Veterinary Medical Sciences. 64(9):829-833.
  • Zhou, Yunshu, Helen W. Davey, Michael J. McLachlan, Tao Xie, and David J. Waxman. 2002. Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 182(1):1-10.
2001
  • Bello, Susan M., Diana G. Franks, John J. Stegeman, and Mark E. Hahn. 2001. Acquired resistance to Ah receptor agonists in a population of Atlantic killifish (Fundulus heteroclitus) inhabiting a marine Superfund site: In vivo and in vitro studies on the inducibility of xenobiotic-metabolizing enzymes. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 60(1):77-91.
  • Callard, Gloria V., Anna V. Tchoudakova, Mitsuyo Kishida, and Elizebeth Wood. 2001. Differential tissue distribution, developmental programming, estrogen regulation and promoter characteristics of cyp19 genes in teleost fish. Journal of Steroid Biochemistry and Molecular Biology. (http://www.sciencedirect.com/science/journal/ 09600760) Exit NIEHS Website 79(1-5):305-314.
  • Custodia, Noemi, Seung-Jae Won, Apolonia Novillo, M. Wieland, Christine Li, and Ian P. Callard. 2001. Caenorhabditis elegans as an environmental monitor using DNA microarray analysis. Annals of the New York Academy of Science. (http://www.nyas.org/) Exit NIEHS Website 948:32-42.
  • Duggan, Annemarie E., Marina Paolucci, Ann Tercyak, Michael Gigliotti, Donald Small, and Ian P. Callard. 2001. Seasonal variation in plasma lipids, lipoproteins, apolipoprotein A-I and vitellogenin in the freshwater turtle, Chrysemys picta. Comparative Biochemistry and Physiology. (http://www.sciencedirect.com/science/journal/ 10956433) Exit NIEHS Website 130(2):253-269.
  • Hahn, Mark E. 2001. Dioxin toxicology and the aryl hydrocarbon receptor: insights from fish and other non-traditional models. Marine Biotechnology. 3:S224-S238.
  • Handley, Heather, Matthew W. Grow, M.C. Fishman, and John J. Stegeman. 2001. Broad-scale characterization of gene expression patterns associated with embryonic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 60(1):1604S.
  • Huang, Y-W, John J. Stegeman, Bruce R. Woodin, and William H. Karasov. 2001. Immunohistochemical localization of cytochrome P450 1A induced by 3,3',4,4',5-pentachlorobiphenyl (PCB126) in multiple organs of the northern leopard frog Rana pipiens. Environmental Toxicology and Chemistry. (http://etc.allenpress.com/entconline/?request =index-html) Exit NIEHS Website 20(1):191-197.
  • Kishida, Mitsuyo and Gloria V. Callard. 2001. Distinct cytochrome P450 aromatase isoforms in zebrafish (Danio rerio) brain and ovary are differentially programmed and estrogen regulated during early development. Endocrinology. (http://endo.endojournals.org/) Exit NIEHS Website 142(2):740-750.
  • Kishida, Mitsuyo, Megan McLellan, Jason A. Miranda, and Gloria V. Callard. 2001. Estrogen and xenoestrogens upregulate the brain aromatase isoform (P450aromB) and perturb markers of early development in zebrafish (Danio rerio). Comparative Biochemistry and Physiology. (http://www.sciencedirect.com/science/journal/ 10956433) Exit NIEHS Website 129(2-3):261-268.
  • Mann, Koren K., Stefan Doerre, Jennifer J. Schlezinger, David H. Sherr, and Shafat A. Quadri. 2001. The role of NF-kB as a survival factor in environmental chemical-induced preB cell apoptosis. Molecular Pharmacology. (http://molpharm.aspetjournals.org/) Exit NIEHS Website 59(2):302-309.
  • Matikainen, Tiina, Gloria I. Perez, Andrea Jurisicova, James K. Pru, Jennifer J. Schlezinger, Heui-Young Ryu, Jarmo Laine, Toshiyuki Sakai, Stanley J. Korsmeyer, Robert F. Casper, David H. Sherr, and Jonathan L. Tilly. 2001. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nature Genetics. (http://www.nature.com/ng/) Exit NIEHS Website 28(4):355-360.
  • Morabia, A., Timothy L. Lash, and Ann Aschengrau. 2001. Passive cigarette smoking and breast cancer. In: Environmental tobacco smoke: toxicity, treatment and prevention. CRC Press, Boca Raton, FL.
  • Rie, Melanie T., Katherine A. Lendas, and Ian P. Callard. 2001. Cadmium: Tissue distribution and binding protein induction in the painted turtle, Chrysemys picta. Comparative Biochemistry and Physiology. (http://www.sciencedirect.com/science/journal/ 10956433) Exit NIEHS Website 130(1):41-51.
  • Rie, Melanie T., Katherine A. Lendas, Bruce R. Woodin, John J. Stegeman, and Ian P. Callard. 2001. Hepatic biotransformation enzymes in a sentinel species, the turtle Chrysemys picta, from Cape Cod, Massachusetts: Seasonal, sex and location related differences. Biomarkers. (http://tandf.catchword.com/titles/1354750x.ht m) Exit NIEHS Website 5(5):382-394.
  • Shideler, Susan E., Nancy A. Gee, Lisa S. Laughlin, and Bill L. Lasley. 2001. Estrogen and progesterone metabolites and follicle-stimulating hormone in the aged macaque female. Biology of Reproduction. (http://www.biolreprod.org/) Exit NIEHS Website 65(6a0:1718-1725.
  • Stavropoulos, Pericles, Remle Celenligil-Cetin, and Amy E. Tapper. 2001. The gif paradox. Accounts of Chemical Research. (http://pubs.acs.org/journals/achre4/index.htm l) Exit NIEHS Website 34(9):745-752.
  • Tchoudakova, Anna V., Mitsuyo Kishida, Elizebeth Wood, and Gloria V. Callard. 2001. Promoter characterisitcs of two cyp19 genes differentially expressed in the brain and ovary of the teleost fish. Journal of Steroid Biochemistry and Molecular Biology. (http://www.sciencedirect.com/science/journal/ 09600760) Exit NIEHS Website 78(5):427-439.
  • Toomey, Barbara H., Susan M. Bello, Mark E. Hahn, Susannah Cantrell, Peggy Wright, Donald E. Tillitt, and Richard T. Di Giulio. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 53(2):127-138.
  • Verbrugge, Lori A., J.P. Giesy, D. Verbrugge, and Bruce R. Woodin. 2001. Catalytic and immunochemical properties of hepatic cytochrome P450 1A in three avian species treated with beta-naphthoflavone or isosafrole. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. (http://www.sciencedirect.com/science/journal/ 15320456) Exit NIEHS Website 130(1):67-83.
  • Xie, Wen, Anna Radominska-Pandya, Yanhong Shi, Cynthia M. Simon, Michael C. Nelson, Erwin S. Ong, David J. Waxman, and Ronald M. Evans. 2001. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 98(6):3375-3380.
  • Zhao, Jin, Paul Mak, Anna V. Tchoudakova, Gloria V. Callard, and Shiuan Chen. 2001. Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatatase isozymes. General and Comparative Endocrinology. 123(2):180-191.
2000
  • Betka, Marlies, Alice Welenc, Diana G. Franks, Mark E. Hahn, and Gloria V. Callard. 2000. Characterization of two aryl hydrocarbon receptor (AHR) mRNA forms in Squalus acanthias and stage-dependent expression during spermatogenesis. The Bulletin: Mount Desert Island Biological Laboratory. (http://www.bio.georgiasouthern.edu/Bull-MDIBL /Bull-MDIBL.html) Exit NIEHS Website 39:65-67.
  • Callard, Gloria V. and C. Wang. 2000. PCR-Differential display identifies a subset of stage-dependent and cadmium-regulated mitochondrial genes during spermatogenesis. In: Proceedings of the International Symposium on Hormones & Endocrine Disruptors in Food and Water: Possible Effects on Human Health. Copenhagen, Denmark.
  • Callard, Ian P. 2000. C.elegans as a model for environmental change. In: Proceedings of "e. hormone 2000". New Orleans, LA.
  • Callard, Ian P. 2000. Field and laboratory studies of endocrine disruption by heavy metals in wildlife species. In: Proceedings of the Gordon Research Conference on "Environmental Endocrine Disrupters".
  • Callard, Ian P. and Melanie T. Rie. 2000. Assessment of the effects of groundwater pollution on a sentinel species, Chrysemys picta, on Cape Cod: tissue contaminant levels and hepatic and reproductive bioindicators. In: Proceedings of the Workshop on "Endocrine Disrupters in Food and Water: Possible impact on human health". Copenhagen, Denmark. pp.29.
  • Callard, Ian P., Christine Li, and Seung-Jae Won. 2000. Caenorhabditis elegans as a potential bioindicator species for xenobiotics. In: Proceedings of the Workshop on "Endocrine Disrupters in Food and Water: Possible impact on human health". Copenhagen, Denmark. pp.30.
  • Celenligil-Cetin, Remle, Richard J. Staples, and Pericles Stavropoulos. 2000. Synthesis, characterization, and reactivity of ferrous and ferric oxo/peroxo pivalate complexes in relation to Gif-type oxygenation of substrates. Inorganic Chemistry. (http://pubs.acs.org/journals/inocaj/index.htm l) Exit NIEHS Website 39(25):5838-5846.
  • Custodia, Noemi and Ian P. Callard. 2000. The turtle hepatic progesterone receptor: expression and potential role in the regulation of vitellogenin gene expression. In: Proceedings of the 11th International Congress of Endocrinology, 2000.
  • Custodia, Noemi, Seung-Jae Won, Apolonia Novillo, Christine Li, and Ian P. Callard. 2000. Potential use of cultured C. elegans as a test system for xenobiotics. In: Proceedings of the Superfund Basic Research Program Conference: "Oxidative Processes: Stress to Remediation". Chapel Hill, NC. pp.18.
  • Godard, Celine AJ, Michael J. Leaver, Maya R. Said, Richard L. Dickerson, Sarah George, and John J. Stegeman. 2000. Identification of cytochrome P450 1B-like sequences in two teleost fish species (scup, Stenotomus chrysops and plaice, Pleuronectes platessa) and in a cetacean (striped dolphin, Stenella coeruleoalba). Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) Exit NIEHS Website 50(1-5):7-10.
  • Hoyer, Annette Pernille, Philippe Grandjean, Torben Jorgensen, John W. Brock, and Helle Boggild Hartvig. 2000. Organochlorine exposure and breast cancer (in Danish). Ugeskr Laeger. 162:922-926.
  • Hoyer, Annette Pernille, Torben Jorgensen, John W. Brock, and Philippe Grandjean. 2000. Organochlorine exposure and breast cancer survival. Journal of Clinical Epidemiology. (http://www.sciencedirect.com/science/journal/ 08954356) Exit NIEHS Website 53(3):323-330.
  • Iwata, Hisato and John J. Stegeman. 2000. In situ RT-PCR detection of CYP1A mRNA in pharyngeal epithelium and chondroid cells from chemically untreated fish: Involvement in vertebrate craniofacial skeletal development. Biochemical and Biophysical Research Communications. (http://www.sciencedirect.com/science/journal/ 0006291X) Exit NIEHS Website 271(1):130-137.
  • Karchner, Sibel I., Sean W. Kennedy, Suzanne Trudeau, and Mark E. Hahn. 2000. Towards molecular understanding of species differences in dioxin sensitivity: initial characterization of Ah receptor cDNAs in birds and an amphibian. Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) Exit NIEHS Website 50(1-5):51-56.
  • Kiani, Salma, Amy E. Tapper, Richard J. Staples, and Pericles Stavropoulos. 2000. Functional aspects of Gif-type oxidation of hydrocarbons mediated by iron picolinate H2O2-dependent systems: Evidence for the generation of carbon- and oxygen-centered radicals. Journal of the American Chemical Society. (http://pubs.acs.org/journals/jacsat/index.htm l) Exit NIEHS Website 122(31):7503-7517.
  • Kim, Dong W., Lee Gazourian, Shafat A. Quadri, Raphaëlle Romieu-Mourez, David H. Sherr, and Gail E. Sonenshein. 2000. The RelA NF-kappaB subunit and the aryl hydrocarbon receptor (AhR) cooperate to transactivate the c-myc promoter in mammary cells. Oncogene. (http://www.nature.com/onc/) Exit NIEHS Website 19(48):5498.
  • Lash, Timothy L. and Ann Aschengrau. 2000. Alcohol drinking and the risk of breast cancer. The Breast Journal. (http://www.blackwellpublishing.com/journal.as p?ref=1075-122X&site=1) Exit NIEHS Website 6(6):396-399.
  • Novak, Colleen M. and Antonio A. Nunez. 2000. A sparse projection from the suprachiasmatic nucleus to the sleep active ventrolateral preoptic area in the rat. NeuroReport. (http://www.neuroreport.com/) Exit NIEHS Website 11(1):93-96.
  • Novak, Colleen M., Laura Smale, and Antonio A. Nunez. 2000. Rhythms in Fos expression in brain areas related to the sleep-wake cycle in the diurnal Arvicanthis niloticus. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 278(5):R1267-R1274.
  • Oleksiak, Marjorie, Shu Wu, Carol Parker, and Darryl C. Zeldin. 2000. Identification, functional characterization, and regulation of a new cytochrome P450 subfamily, the CYP2Ns. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 275(4):2312-2321.
  • Powell, Wade H. and Mark E. Hahn. 2000. The evolution of aryl hydrocarbon signaling proteins: Diversity of ARNT isoforms among fish species. Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) Exit NIEHS Website 50(1-5):39-44.
  • Powell, Wade H., Rachel Bright, Susan M. Bello, and Mark E. Hahn. 2000. Developmental and Tissue-specific Expression of AHR1, AHR2, and ARNT2 in Dioxin-sensitive and -resistant Populations of the Marine Fish, Fundulus heteroclitus. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 57(2):229-239.
  • Quadri, Shafat A., Ariful N. Qadri, Mark E. Hahn, Koren K. Mann, and David H. Sherr. 2000. The Bioflavonoid Galangin Blocks Aryl Hydrocarbon Receptor (AhR) Activation and Polycyclic Aromatic Hydrocarbon-induced Pre-B cell Apoptosis. Molecular Pharmacology. (http://molpharm.aspetjournals.org/) Exit NIEHS Website 58:515-525.
  • Rie, Melanie T., Katherine A. Lendas, Bruce R. Woodin, John J. Stegeman, and Ian P. Callard. 2000. Hepatic biotransformation enzymes in a sentinel species, the painted turtle (Chrysemys picta), from Cape Cod, MA: Seasonal, sex and location related differences. Biomarkers. (http://tandf.catchword.com/titles/1354750x.ht m) Exit NIEHS Website 5(5):382-394.
  • Rie, Melanie T., Katherine A. Lendas, Bruce R. Woodin, John J. Stegeman, and Ian P. Callard. 2000. Multiple bioindicators of environmental pollution in a sentinel species, Chrysemys picta, on Cape Cod,MA. Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) Exit NIEHS Website 50(1):436-437.
  • Robles, Rodolfo, Yutaka Morita, Koren K. Mann, Gloria I. Perez, Shi Yang, Tiina Matikainen, David H. Sherr, and Jonathan L. Tilly. 2000. The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse. Endocrinology. (http://endo.endojournals.org/) Exit NIEHS Website 141(1):450-453.
  • Schlezinger, Jennifer J. and John J. Stegeman. 2000. Dose and Inducer-Dependent Induction of Cytochrome P450 1A in Endothelia of the Eel, including in the Swimbladder Rete Mirabile, a Model Microvascular Structure. Drug Metabolism and Disposition. (http://dmd.aspetjournals.org/) Exit NIEHS Website 28(6):701-708.
  • Schlezinger, Jennifer J. and John J. Stegeman. 2000. Induction cytochrome P450 1A in the American eel by model halogenated and non-halogenated aryl hydrocarbon receptor agonists. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 50:375-386.
  • Schlezinger, Jennifer J., Courtnery E. Blickarz, Koren K. Mann, Stefan Doerre, and John J. Stegeman. 2000. Identification of NF-kB in the Marine Fish Stenotomus chrysops and Examination of Its Activation by Aryl Hydrocarbon Receptor Agonists. Chemico-Biological Interactions. (http://www.sciencedirect.com/science/journal/ 00092797) Exit NIEHS Website 126(2):137-157.
  • Schlezinger, Jennifer J., Jennifer Keller, Lori A. Verbrugge, and John J. Stegeman. 2000. 3,3',4,4'-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. (http://www.sciencedirect.com/science/journal/ 15320456) Exit NIEHS Website 125(3):273-286.
  • Tapper, Amy E., Jeffrey R. Long, Richard J. Staples, and Pericles Stavropoulos. 2000. Oxygenation of Hydrocarbons Mediated by Mixed-Valent Basic Iron Trifluoroacetate and Valence-Separated Component Species under Gif-Type Conditions Involves Carbon- and Oxygen-Centered Radicals. Angewandte Chemie-International Edition. 39(13):2343-2346.
  • Toomey, Barbara H., Susan M. Bello, Mark E. Hahn, Susannah Cantrell, Peggy Wright, Donald E. Tillitt, and Richard T. Di Giulio. 2000. TCDD induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website
  • Trombino, Anthony F., Richard I. Near, Raymond A. Matulka, Shi Yang, L.F. Hafer, Paul Toselli, Dong W. Kim, Adrianne E. Rogers, Gail E. Sonenshein, and David H. Sherr. 2000. Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1 gene transcription in a rat model of mammary tumorigenesis. Breast Cancer Research and Treatment. 63(2):117-131.
  • Waxman, David J. 2000. Receptor-mediated signaling events in cytochrome P450 gene regulation. In: Proceedings of the Early Toxicity Screening in Drug Discovery Conference.
  • Webster, Thomas. 2000. Bias in ecologic and semi-individual studies. D.Sc. Thesis. Boston University.
  • Webster, Thomas. 2000. Bias magnification in ecologic studies. In: Proceedings of the International Society for Environmental Epidemiology. Buffalo, NY.
  • Webster, Thomas. 2000. Can semi-individual studies have ecologic bias?. In: Proceedings of the International Society for Environmental Epidemiology. Buffalo, NY.
1999
  • Bello, Susan M. 1999. Characterization of resistance to halogenated aromatic hydrocarbons in a population of Fundulus heteroclitus from a marine Superfund site. Ph.D. Thesis, Woods Hole Oceanographic Institution / Massachusetts Institute of Technology.
  • Betka, Marlies and Gloria V. Callard. 1999. Stage-dependent accumulation of cadmium and induction of metallothionein-like binding activity in the testis of the dogfish shark Squalus acanthias. Biology of Reproduction. (http://www.biolreprod.org/) Exit NIEHS Website 60(1):14-22.
  • Betka, Marlies, Alice Welenc, Mark E. Hahn, and Gloria V. Callard. 1999. Stage-related distribution of two arylhydrocarbon receptor (AhR) mRNA variants and differential effects of Ah ligands on cell proliferation and death during spermatogenesis in the spiny dogfish shark (Squalus acanthias). In: Proceedings of the 1999 SETAC (Society of Environmental Toxcology and Chemistry) Annual Meeting.
  • Black, Virginia H., P.M. Shaw, Sibel I. Karchner, Wade H. Powell, and Mark E. Hahn. 1999. Differential expression of CYP1A1 and CYP1A2, but not AHR or ARNT, in guinea pig adrenal and liver. Endocrine Research. 24:631-632.
  • Callard, Gloria V. and Ian P. Callard. 1999. Spermatogenesis in subavian vertebrates. In: Encyclopedia of Reproduction, Vol 4. Academic Press, pp.563-570.
  • Callard, Gloria V., Leo M. McClusky, and Marlies Betka. 1999. Stage-specific effects of hormones and spermatotoxicants on germ cell proliferation and death: the shark testis model. In: Proceedings of the Symposium on Endocrine Disruptors. 5th International Congress Physiology Biochemistry Calgary. Calgary, Canada.
  • Callard, Gloria V., C. Wang, R. Sikora, and Marlies Betka. 1999. In vivo effects of cadmium on the estrogen signaling pathway during spermatogenesis. In: Proceedings of the Symposium on Estrogens in the Environment. New Orleans, LA.
  • Custodia, Noemi, Seung-Jae Won, and Ian P. Callard. 1999. A cDNA from the freshwater mussel (Elliptio complanata) with homology to vertebrate steroid receptors. In: Proceedings of the Symposium on Environmental Hormones. Tulane University, New Orleans, LA.
  • Elskus, Adria A., Emily Monosson, Anne E. McElroy, John J. Stegeman, and Dana S. Woltering. 1999. Altered CYP1A expression in Fundulus heteroclitus adults and larvae: a sign of pollutant resistance?. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 45(2-3):99-113.
  • Gensemer, Robert W., D. George Dixon, and Bruce M. Greenberg. 1999. Using chlorophyll fluorescence induction to detect the onset of anthracene photoinduced toxicity in Lemna gibba, and the mitigating effects of humic acid. Limnology and Oceanography. (http://www.aslo.org/lo/index.html) Exit NIEHS Website 44(3,Part2):878-888.
  • Karchner, Sibel I., Wade H. Powell, and Mark E. Hahn. 1999. Structural and Functional Characterization of Two Highly Divergent Aryl Hydrocarbon Receptors (AHR1 and AHR2) in the teleost Fundulus heteroclitus. Evidence for a novel class of ligand-binding basic helix-loop-helix Per-ARNT-Sim (bHLH-PAS) factors. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 274:33814-33824.
  • Kleinow, Kevin M., Adriana M. Doi, and A.A. Smith. 1999. Distribution of C219 detectable P-glycoprotein transporter in the catfish. In: Proceedings of the PRIMO Meeting.
  • Ma, Wanli, Pascal Kamdem, Paul R. Loconto, Yanlyang Pan, Douglas M. Gage, and Benjamin E. Dawson-Andoh. 1999. Characterization and bioremediation of birch condensate. Wood and Fiber Science. (http://www1.fpl.fs.fed.us/swst/journal.html) Exit NIEHS Website 31(4):370-375.
  • Maloney, Erin K. and David J. Waxman. 1999. trans-Activation of PPARalpha and PPARgamma by structurally diverse environmental chemicals. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 161(2):209-218.
  • Mann, Koren K., Mark E. Hahn, Anthony F. Trombino, B. Paige Lawrence, Nancy I. Kerkvliet, and David H. Sherr. 1999. The Role of DMBA Metabolites in PreB Cell Apoptosis. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 48(1-S):
  • Mann, Koren K., Raymond A. Matulka, Mark E. Hahn, Anthony F. Trombino, B. Paige Lawrence, Nancy I. Kerkvliet, and David H. Sherr. 1999. The Role of polycyclic aromatic hydrocarbon metabolism in dimethylbenzanthracene-induced Pre-B Cell Apoptosis. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 161:10-22.
  • Mann, Koren K., Raymond A. Matulka, B. Paige Lawrence, Nancy I. Kerkvliet, and David H. Sherr. 1999. The role of cytochrome P-450 enzymes in 7,12-dimethylbenz[a]anthracene-induced apoptosis. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 161:10.
  • Nunez, Antonio A., Abel Bult, Teresa L. McElhinny, and Laura Smale. 1999. Daily rhythms of Fos expression in hypothalamic targets of the suprachiasmatic nucleus in diurnal and nocturnal rodents. Journal of Biological Rhythms. (http://www.sagepub.com/journal.aspx?pid=183) Exit NIEHS Website 14(4):300-306.
  • Paulu, Christopher, Ann Aschengrau, and David M. Ozonoff. 1999. Tetrachloroethylene-contaminated drinking water in Massachusetts and the risk of colon-rectum, lung, and other cancers. Environmental Health Perspectives. 107(4):265-271.
  • Powell, Wade H. and Rachel Bright. 1999. Functional diversity of vertebrate ARNT proteins: Identification of ARNT2 as the predominant form of ARNT in the marine teleost, Fundulus heteroelitus. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 361(1):156-163.
  • Powell, Wade H., Sibel I. Karchner, Rachel Bright, and Mark E. Hahn. 1999. Functional diversity of vertebrate ARNT proteins: Identification of ARNT2 as the predominant form of ARNT in the marine teleost, Fundulus heteroclitus. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 361:156-163.
  • Rie, Melanie T. and Ian P. Callard. 1999. Changes in bioindicators of environmental pollution in sentinel species, Chrysemys picta and Elliptio complanata, on Cape Cod, MA. In: Proceedings of the Keystone Symposium. Keystone, CO. pp.225.
  • Rie, Melanie T., Katherine A. Lendas, and Ian P. Callard. 1999. Reproductive changes in the turtle, Chrysemys picta, on Cape Cod, MA: Indices of Endocrine Disruption?. Biology of Reproduction. (http://www.biolreprod.org/) Exit NIEHS Website 60:194.
  • Rie, Melanie T., Katherine A. Lendas, Bruce R. Woodin, John J. Stegeman, and Ian P. Callard. 1999. Multiple bioindicators of environmental pollution, Chrysemys picta, on Cape Cod, MA. In: Proceedings of the PRIMO Meeting. pp.58.
  • Schlezinger, Jennifer J., Renee D. White, and John J. Stegeman. 1999. Oxidative Inactivation of Cytochrome P450 1A Stimulated by 3,3',4,4'-Tetrachlorobiphenyl: Production of Reactive Oxygen by Vertebrate CYP1As. Molecular Pharmacology. (http://molpharm.aspetjournals.org/) Exit NIEHS Website 56(3):588-597.
  • Waxman, David J. 1999. P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR and PPAR. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 369(1):11-23.
  • Won, Seung-Jae, Ashley Flynn, Michelle Ammerman, and Ian P. Callard. 1999. Putative vitellogenins in the freshwater mussel, Elliptio complanata. Soc. Study of Reproduction Abs. 60(Suppl1):293.
  • Zhou, Yunshu and David J. Waxman. 1999. Inhibitory cross-talk between JAK2/STAT5b and PPARa. In: Proceedings of the 81st Annual Endocrine Society Meeting. pp.108.
  • Zhou, Yunshu and David J. Waxman. 1999. STAT5b down-regulates peroxisome proliferator-activated receptor alpha transcription by inhibition of ligand-independent activation function region-1 trans-activation domain. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 274(42):29874-29882.
1998
  • Aschengrau, Ann, Christopher Paulu, and David M. Ozonoff. 1998. Tetrachloroethylene-contaminated drinking water and the risk of breast cancer. Environmental Health Perspectives. 106:947-953.
  • Bello, Susan M., Diana G. Franks, John J. Stegeman, and Mark E. Hahn. 1998. Dioxin Resistance in Killifish (Fundulus heteroclitus) from the New Bedford Harbor Superfund Site: In Vivo and In Vitro studies of CYP1A1 Inducibility. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19th Annual Meeting. Charlotte, NC. pp.168.
  • Besselink, Harrie T., Michael S. Denison, Mark E. Hahn, Sibel I. Karchner, A. Dick Vethaak, Jan H. Koeman, and Abraham Brouwer. 1998. Low inducibility of CYPIA activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): Characterization of the Ah receptor and the role of CYPIA inhibition. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 43(2):161-171.
  • Betka, Marlies and Gloria V. Callard. 1998. Cloning of an androgen receptor cDNA from Squalus acanthias testis. The Bulletin: Mount Desert Island Biological Laboratory. (http://www.bio.georgiasouthern.edu/Bull-MDIBL /Bull-MDIBL.html) Exit NIEHS Website 37:111.
  • Betka, Marlies and Gloria V. Callard. 1998. Negative feedback control of the spermatogenic progression by testicular estrogen synthesis: insights from the shark testis model. Acta Physiologica Scandinavica. (http://www.blackwell-synergy.com/Journals/iss uelist.asp?journal=aps) Exit NIEHS Website 106(1):252-258.
  • Callard, Gloria V., Leo M. McClusky, and Marlies Betka. 1998. Apoptosis as a normal mechanism of growth control and target of toxicant actions during spermatogenesis: insights using the shark testis model. In: New Developments in Marine Biotechnology (http://www.bookhq.com/compare/0306459078.html) Exit NIEHS Website. Kluwer Academic Publishers, pp.125-128.
  • Chang, Thomas K H and David J. Waxman. 1998. Catalytic assays for human cytochrome P450. Methods Mol Biol. 107:95-102.
  • Chang, Thomas K H and David J. Waxman. 1998. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods Mol Biol. 107:103-109.
  • Chang, Thomas K H, Charles L. Crespi, and David J. Waxman. 1998. Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. Methods Mol Biol. 107:147-152.
  • Crespi, Charles L., Thomas K H Chang, and David J. Waxman. 1998. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high-performance liquid chromatography with fluorescence detection. Methods Mol Biol. 107:141-145.
  • Hahn, Mark E. 1998. Mechanisms of innate and acquired resistance to dioxin-like compounds. Reviews in Toxicology: Series B - Environmental Toxicology. 2:395-443.
  • Hahn, Mark E. 1998. The Aryl Hydrocarbon Receptor: A Comparative Perspective. Comparative Biochemistry and Physiology. (http://www.sciencedirect.com/science/journal/ 10956433) Exit NIEHS Website 121(1-3):23-53.
  • Hahn, Mark E., Sibel I. Karchner, Miriam A. Shapiro, and Samanthi A. Perera. 1998. The aryl hydrocarbon receptor in early vertebrates. Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) Exit NIEHS Website 46(1-5):41-44.
  • Hoyer, Annette Pernille, Philippe Grandjean, Torben Jorgensen, John W. Brock, and Helle Boggild Hartvig. 1998. Organochlorine exposure and risk of breast cancer. Lancet. (http://www.thelancet.com) Exit NIEHS Website 352(9143):1816-1820.
  • Mann, Koren K., Shafat A. Quadri, Ariful N. Qadri, Alexander M. Shneider, and David H. Sherr. 1998. Involvement of NF-ÇB and c-myc in DMBA-induced preB lymphocyte apoptosis. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 42:89.
  • Marsh, D.E., J. Prystupa, and Robert W. Gensemer. 1998. Development of photosynthetic assays for the toxicity of organics and metals using submerged rooted macrophytes. In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA.
  • Matulka, Raymond A., Koren K. Mann, and David H. Sherr. 1998. DMBA (7,12-dimethlbenzanthracene) induces preB cell death via a soluble stromal cell factor. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 42:190.
  • McClusky, Leo M. 1998. In vitro analysis of cadmium actions during spermatogenesis. In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA.
  • McClusky, Leo M., Marlies Betka, and Gloria V. Callard. 1998. Stage-specific actions of cadmium on apoptosis during spermatogenesis. In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA.
  • Morrison, Hilary G., E. Jennifer Weil, Sibel I. Karchner, Mitchell L. Sogin, and John J. Stegeman. 1998. Molecular cloning of CYP1A from the estuarine fish Fundulus heteroclitus and phylogenetic analysis of CYP1A genes: Update with new sequences. Comparative Biochemistry and Physiology. (http://www.sciencedirect.com/science/journal/ 10956433) Exit NIEHS Website 121C:231-240.
  • Ozonoff, David M. 1998. Assessing uncertainty in decision processes. In: Setting Priorities for Drinking Water Contaminants, National Research Council. National Academy Press,
  • Ozonoff, David M. and T. Webster. 1998. The Lattice Diagram and 2x2 Tables. In: Hazardous Waste: Impacts on Human and Ecological Health (Proceedings of the 2nd International Congress on Hazardous Waste). Princeton Scientific, Princeton, NJ. pp.441-458.
  • Paulu, Christopher. 1998. Cancer Risk and Tetrachloroethylene-Contaminated Drinking Water in Massachusetts: Colorectal, Lung, and Other Cancers. In: Proceedings of the Joint Conference of the International Society for Environmental Epidemiology and International Society for Exposure Assessment.
  • Paulu, Christopher and David M. Ozonoff. 1998. Exploring associations between residential history and breast cancer risk in a case-control study. In: Proceedings of the Joint Conference of the International Society for Environmental Epidemiology and International Society for Exposure Assessment.
  • Powell, Wade H., Sibel I. Karchner, and Mark E. Hahn. 1998. Aryl Hydrocarbon Signaling Components in Fundulus heteroclitus: A Phylogenetic Perspective. In: Proceedings of the Society of Environmental Toxicology and Chemistry (SETC) 19th Annual Meeting. Charlotte, NC.
  • Quadri, Shafat A., Ariful N. Qadri, and David H. Sherr. 1998. Inhibition of polyaromatic hydrocarbon-induced apoptosis in murine pre-B cells by a dietary flavonoid, galangin. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 42:189.
  • Rie, M.T. 1998. Reproductive and hepatic parameters as bioindicators of xenobiotic exposure in fresh water turtles. In: Proceedings of Gordon Conference on Endocrine Disruptors.
  • Rie, Melanie T., Katherine A. Lendas, Bruce R. Woodin, John J. Stegeman, and Ian P. Callard. 1998. Seasonal, sex-related and habitat differences in hepatic CYP1A and glutathione-s-transferase in field-trapped turtles (Chrysemys picta). In: Proceedings of the Superfund Basic Research Program (SBRP) Conference, 1998. Boston, MA. pp.45.
  • Rie, Melanie T., Katherine A. Lendas, Bruce R. Woodin, John J. Stegeman, and Ian P. Callard. 1998. Seasonal, sex-related and habitat differences in hepatic CYP1A and glutathione-s-transferase in field-trapped turtles (Chrysemys picta). Biology of Reproduction. (http://www.biolreprod.org/) Exit NIEHS Website 58(1):351.
  • Schlezinger, Jennifer J., Carol Parker, Darryl C. Zeldin, and John J. Stegeman. 1998. Arachidonic Acid Metabolism in the Marine Fish Stenotomus chrysops (scup) and the Effects of Cytochrome P4501A Inducers. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 353(2):265-275.
  • Schlezinger, Jennifer J., W. DJ Struntz, and John J. Stegeman. 1998. Cytochrome P4501A (CYP1A) and planar halogenated hydrocarbons (pHAH): Oxidative inactivation and reactive oxygen production. In: Proceedings of the 37th Society of Toxicology Annual Meeting, March 1-5. Seattle, WA.
  • Trombino, Anthony F., Raymond A. Matulka, Shi Yang, L.F. Hafer, Adrianne E. Rogers, and David H. Sherr. 1998. Nuclear expression of the aryl hydrocarbon receptor (AhR) in 7,12-dimethylbenz[a]anthracene (DMBA)- induced rat mammary tumors and human breast cancer cell lines. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 42:316.
  • Waxman, David J. and Thomas K H Chang. 1998. Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families. Methods Mol Biol. 107:175-179.
  • Webster, T., C. Poole, and David M. Ozonoff. 1998. Moving the cutpoint: What does it tell us about dose-response?. In: Proceedings of the Joint Conference of the International Society for Environmental Epidemiology and International Society for Exposure Assessment.
  • Yawetz, Aminadav, Bruce R. Woodin, and John J. Stegeman. 1998. Cytochromes P450 (CYP) in liver of the turtle, Chrysemes picta picta and the induction and partial purification of CYP1A-like proteins. Biochimica et Biophysica Acta. (http://www.elsevier.com/locate/bba) Exit NIEHS Website 1381(1):12-26.
  • Zhou, Y.C. 1998. JAK-STAT interaction with PPARα. In: Proceedings of the 80th Annual Endocrine Society Meeting.
  • Zhou, Yunshu and David J. Waxman. 1998. Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids. Environmental Health Perspectives. 106Suppl.4:983-988.
  • Zhou, Yunshu and David J. Waxman. 1998. Cross-talk between JAK-STAT and PPARα signaling pathways: Growth hormone (GH) inhibition of PPARα activity mediated by STAT5b. In: Proceedings of the 12th International Symposium on Microsomes and Drug Oxidations. pp.123.
1997
  • Bello, Susan M., John J. Stegeman, and Mark E. Hahn. 1997. Lack of cytochrome P450-1A inducibility in Fundulus heteroclitus from New Bedford Harbor: A case of dioxin resistance?. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
  • Betka, Marlies. 1997. Cadmium accumulation in cardiac and skeletal muscle of Squalus acanthias. The Bulletin: Mount Desert Island Biological Laboratory. (http://www.bio.georgiasouthern.edu/Bull-MDIBL /Bull-MDIBL.html) Exit NIEHS Website 36:89.
  • Callard, Gloria V. 1997. Unconventional models for toxicology research. In: Comprehensive Toxicology, Vol. 10, Reproductive and Endocrine Toxicology. Section I. Male Reproductive Toxicology. Elsevier, NY. pp.235-247.
  • Chang, Thomas K H. 1997. Catalytic assays for human cytochrome P450. Chapter 9 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.95-102.
  • Chang, Thomas K H. 1997. Enzymatic Analysis of cDNA-expressed human CYP1A1,CYP1A2 and CYP1B1 with 7-ethoxyresorufin as substrate. Chapter 10 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.103-110.
  • Chang, Thomas K H, Charles L. Crespi, and David J. Waxman. 1997. Spectrophotometric Analysis of Human CY P2El -Catalyzed pNitrophenol Hydroxylation. Chapter 17 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.147-152.
  • Crespi, Charles L., Thomas K H Chang, and David J. Waxman. 1997. CYP2D6-dependent bufuralol 1'-hydroxylation assayed by reversed-phase ion-pair high performance liquid chromatography with fluorescence detection. Chapter 16 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.141-146.
  • Guiney, Patrick D., Roxanna M. Smolowitz, Richard E. Peterson, and John J. Stegeman. 1997. Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction of cytochrome P450 1A in vascular endothelium with toxicity in early life stages of lake trout. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 143(2):256-273.
  • Hahn, Mark E., Sibel I. Karchner, Samanthi A. Perera, and Miriam A. Shapiro. 1997. Evolution of the Ah Receptor: Evidence for two AhR genes in early vertebrates. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website 36:242.
  • Hahn, Mark E., Sibel I. Karchner, Miriam A. Shapiro, and Samanthi A. Perera. 1997. Molecular evolution of two vertebrate aryl hydrocarbon (dioxin) receptors (AHRI and AHR2) and the PAS family. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 94(25):13743-13748.
  • Karchner, Sibel I. and Mark E. Hahn. 1997. Molecular Characterization of Two Aryl Hydrocarbon (Ah) Receptors in the Mummichog Fundulus heteroclitus. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA. pp.426.
  • Mann, Koren K., Nancy I. Kerkvliet, B. Paige Lawrence, David H. Sherr, and Anthony F. Trombino. 1997. DMBA-induced pre-B cell apoptosis is both stromal and AhR-dependent, but not P-4501A mediated. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website
  • Marsh, D.E. and Robert W. Gensemer. 1997. Photosynthetic endpoints for the toxicity of organics and heavy metals using freshwater phytoplankton. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
  • McClusky, Leo M. and Gloria V. Callard. 1997. In situ end-labeling of fragmented DNA in apoptotic germ cells in the spiny dogfish (Squalus acanthias) testis. The Bulletin: Mount Desert Island Biological Laboratory. (http://www.bio.georgiasouthern.edu/Bull-MDIBL /Bull-MDIBL.html) Exit NIEHS Website 36:106-107.
  • McClusky, Leo M., Marlies Betka, and Gloria V. Callard. 1997. Preferential accumulation of cadmium and effects on apoptosis during premiotic stages of spermatogenesis. In: Proceedings of the XIVth Testis Workshop: Germ cell development, division, disruption and death. Serono Symposium. Baltimore, MD.
  • Ozonoff, David M. 1997. Environmental Epidemiology: A natural application for discrete mathematics. In: Proceedings of the DIMACS (Discrete Mathematics and Theoretical Computer Science ) Miniworkshop exploring large data sets using classification, consensus, and pattern recognition techniques. Piscataway, NJ.
  • Ozonoff, David M. and Thomas Webster. 1997. The lattice diagram and 2 x 2 tables. Toxicology and Industrial Health. (http://tih.sagepub.com/) Exit NIEHS Website 13(2-3):339-355.
  • Ozonoff, David M., Christopher Paulu, and Thomas Webster. 1997. New methods for analyzing disease clusters in relation to environmental features. In: Silent Spring Institute, Breast Cancer and Environmental Features of Cape Cod. Massachusetts Department of Public Health, Boston, MA.
  • Rie, Melanie T. and Ian P. Callard. 1997. Tissue heavy metal content in a freshwater species, the turtle, Chrsemys picta, on Cape Cod, Massachusetts: Habitat, tissue and sex related differences. Biology of Reproduction. (http://www.biolreprod.org/) Exit NIEHS Website 56(1):97.
  • Schlezinger, Jennifer J., Renee D. White, and John J. Stegeman. 1997. Inactivation of cytochrome P4501A1 by 3,3',4,4'-tetrachlorobiphenyl and the formation of reactive oxygen species. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.
  • Shneider, Alexander M. and David H. Sherr. 1997. Benzo(a)pyrene induces NF-χB in mouse hepatoma cells. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website
  • Trombino, Anthony F., Shi Yang, L.F. Hafer, Ariful N. Qadri, Adrianne E. Rogers, and David H. Sherr. 1997. Modulation of aromatic hydrocarbon receptor expression in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors. The Toxicologist. (http://www.toxicology.org/ai/pub/journals.asp #toxicologist) Exit NIEHS Website
  • Waxman, David J. and Thomas K H Chang. 1997. Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYPI, CYP2, and CYP3 Families. Chapter 21 in: Methods in Molecular Biology series: Cytochrome P450 Protocols. Humana Press, Inc., pp.175-180.
  • White, Renee D., Damian Shea, and John J. Stegeman. 1997. Metabolism of the Aromatic Hydrocarbon Receptor Agonist 3,3',4,4'-Tetrachlorobiphenyl by the Marine Fish Scup (Stenotomus chrysops) in vivo and in vitro. Drug Metabolism and Disposition. (http://dmd.aspetjournals.org/) Exit NIEHS Website 25(5):564-572.
  • Yamaguchi, Koichi, Raymond A. Matulka, Alexander M. Shneider, Paul Toselli, Anthony F. Trombino, Shi Yang, Laurie J. Hafer, Koren K. Mann, Xiao-Jing Tao, Jonathan L. Tilly, Richard I. Near, and David H. Sherr. 1997. Induction of preB cell apoptosis by 7,12 dimethylbenz[a]anthracene in long term primary bone marrow cultures. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 147(2):190-203.
  • Yamaguchi, Koichi, Richard I. Near, Raymond A. Matulka, Alexander M. Shneider, Paul Toselli, Anthony F. Trombino, and David H. Sherr. 1997. Activation of the aryl hydrocarbon receptor/transcription factor and bone marrow stromal cell-dependent preB cell apoptosis. Journal of Immunology. (http://www.jimmunol.org/) Exit NIEHS Website 158(5):2165-2173.
  • Zhou, Yunshu and David J. Waxman. 1997. Cross-talk between PPAR and JAK-STAT signaling pathways regulating liver P450 expression. In: Proceedings of the 15th New England Membrane Enzyme Conference.
1996
  • Betka, Marlies. 1996. Metallothionein induction during spermatogenesis. The Bulletin: Mount Desert Island Biological Laboratory. (http://www.bio.georgiasouthern.edu/Bull-MDIBL /Bull-MDIBL.html) Exit NIEHS Website 35:93.
  • Callard, Gloria V. 1996. Endocrinology of Leydig cells in nonmammalian vertebrates. In: The Leydig Cell. Cache River Press, Clearwater, FL. pp.307-332.
  • Cui, H., S-T Ju, and David H. Sherr. 1996. Functional expression of Fas (CD95) protein in autoimmune lpr mice. Cellular Immunology. (http://www.elsevier.com/wps/find/journaldescr iption.cws_home/622804/description#descriptio n) Exit NIEHS Website 174:35-41.
  • Engel, K.B. and Gloria V. Callard. 1996. Endocrinology of Leydig cells in nonmammalian vertebrates. Chapter 15 in: The Leydig Cell in Health and Disease (http://www.springer.com/humana+press/book/978 -1-58829-754-9?detailsPage=toc) Exit NIEHS Website. Humana Press, pp.207-224.
  • Gillett, James W. and R.N. Ram. 1996. Mobilization of Sediment Contamination from the Lake Erie-Lake Ontario-St. Lawrence River basin: The Critical Role of the Food Webs. In: Proceedings of the International Symposium on the St. Lawrence Ecosystem. Cornwall, Ontario, Canada. pp.735.
  • Hahn, Mark E., Sibel I. Karchner, and Samanthi A. Perera. 1996. Molecular studies on the Ah receptor (AhR) in early vertebrates (bony and cartilaginous fish) and evidence for a second vertebrate AhR gene. In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.232.
  • McClusky, Leo M., Marlies Betka, D. Miller, and Gloria V. Callard. 1996. Analysis of the apoptotic form of programmed cell death (PCD) during spermatogenesis in spiny dogfish (Squalus acanthias). The Bulletin: Mount Desert Island Biological Laboratory. (http://www.bio.georgiasouthern.edu/Bull-MDIBL /Bull-MDIBL.html) Exit NIEHS Website 35:96-97.
  • Peters, Jeffrey M., Yunshu Zhou, P.A. Ram, S. ST Lee, Frank J. Gonzalez, and David J. Waxman. 1996. Peroxisome proliferator-activated receptor a required for gene induction by dehydroepiandrosterone 3b-sulfate. Molecular Pharmacology. (http://molpharm.aspetjournals.org/) Exit NIEHS Website 50(1):67-74.
  • Schlezinger, Jennifer J., Renee D. White, and John J. Stegeman. 1996. 3,3',4,4'-tetrachlorobiphenyl stimulates release of active oxygen from hepatic microsomes and the oxidative inactivation of cytochrome P4501A1. In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.192.
  • Waxman, David J. 1996. Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator. Journal of Endocrinology. (http://joe.endocrinology-journals.org/) Exit NIEHS Website 150:S129-S147.
  • Wu, Min, M. Arsura, R.E. Bellas, M.J. Fitzgerald, H. Lee, S.L. Schauer, David H. Sherr, and Gail E. Sonenshein. 1996. Inhibition of c-myc expression induces apoptosis of WEHI 231 murine B cells. Molecular and Cellular Biology. (http://mcb.asm.org/) Exit NIEHS Website 16(9):5015-5025.
  • Yamaguchi, Koichi, Richard I. Near, Alexander M. Shneider, H. Cui, S-T Ju, and David H. Sherr. 1996. Fluoranthene-induced apoptosis in murine T cell hybridomas is independent of the aromatic hydrocarbon receptor. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 139(1):144-152.
  • Zhou, Yunshu, Jeffrey M. Peters, P.A. Ram, S. ST Lee, Frank J. Gonzalez, and David J. Waxman. 1996. Peroxisome proliferator-activated receptor a (PPARa) mediates gene induction by dehydroepiandrosterone 3b-sulfate (DHEA-S). In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.209.
1995
  • Roberts, Mattew A. and Richard A. Durst. 1995. Detection of polychlorinated biphenyls by liposome-based immunomigration assays. In: Proceedings of the Pacific Basin Conference on Hazardous Waste, Edmonton, Alberta, Canada, 7-12 May, 1995. Edmonton, Alberta, Canada.
  • Roberts, Mattew A. and Richard A. Durst. 1995. Investigation of liposome-based immunomigration sensors for the detection of polychlorinated biphenyls. Analytical Chemistry. (http://pubs.acs.org/journals/ancham/index.htm l) Exit NIEHS Website 67:482-491.
  • Siebert, S.TA, S.G. Reeves, Mattew A. Roberts, and Richard A. Durst. 1995. Improved liposome immunomigration strip assay for alachlor determination. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 311(3):309-318.
  • Waxman, David J. 1995. Metabolism of DHEA and related steroids: interaction with liver cytochromes P450 (CYPs). In: Proceedings of the International Symposium on DHEA (Dehydroepiandrosterone) Transformation. pp.29.
1994
  • Neilson, Julia W., Karen L. Josephson, Ian L. Pepper, Robert G. Arnold, G.D. DiGiovanni, and N.A. Sinclair. 1994. Frequency of Horizontal Gene Transfer of a Large Catabolic Plasmid (pJP4) in Soil. Applied and Environmental Microbiology. (http://aem.asm.org/) Exit NIEHS Website 60:4053-4058.
1993
  • Dawson, Brenda V., Paula D. Johnson, Stanley J. Goldberg, and J.B. Ulreich. 1993. Cardiac Teratogenesis of Halogenated Hydrocarbon-Contaminated Drinking Water. Journal of the American College of Cardiology. (http://content.onlinejacc.org/) Exit NIEHS Website 21:1466-1472.
  • Lowe, Timothy P., Quan Chen, Quintus Fernando, Rodney L. Keith, and A. Jay Gandolfi. 1993. Elemental Analysis of Renal Slices by Proton-Induced X-Ray Emission. Environmental Health Perspectives. 101:302.
1992
  • Neilson, Julia W., Karen L. Josephson, S.D. Pillai, and Ian L. Pepper. 1992. Polymerase Chain Reaction and Gene Probe Detection of the 2,4-Dichlorophenoxyacetic Acid Degradation Plasmid pJP4. Applied and Environmental Microbiology. (http://aem.asm.org/) Exit NIEHS Website 58:1271-1275.
1991
  • Grosser, Robert J., David Warshawsky, and J. Robbie Vestal. 1991. Indigenous and enhanced mineralization of pyrene, benzo(a)-pyrene and carbazole in soils. Applied and Environmental Microbiology. (http://aem.asm.org/) Exit NIEHS Website 57:3462-3469.
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