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Person Details

Superfund Basic Research Program

Bruce D. Hammock

University of California-Davis
Department of Entomology
Office: 90 Briggs Hall
One Shields Avenue
Davis, CA 95616
Phone: 530-752-7519
Fax: 530-752-1537
Email:

Projects

Research Briefs

Patents

  • Linoleic acid diol and glucuronide conjugate levels as diagnostic markers of disorders of abnormal regulation of cytochrome P450 metabolism of unsaturated fatty acids
  • Epoxide hydrolase inhibitor methods
  • Epoxide hydrolase complexes and methods therewith
  • Enzyme amplified, complex linked, competitive and non-competitive assays for the detection of metal ions
  • Compact assay system with digital information
  • Cyanohydrin ethers and esters as high-sensitivity enzyme substrates
  • Diagnostic microarray apparatus
  • Recombinant soluble epoxide hydrolase
  • Inhibitors of epoxide hydrolases for the treatment of hypertension
  • Inhibition of glutathione transferase by haloenol lactones
  • Inhibition of glutathione transferase by haloenol lactones

Superfund Sites

Frontier Fertilizer

  • University of California-Davis: Development and Implementation of Immunoassays for Human and Environmental Monitoring

Sulphur Bank Mercury Mine

  • University of California-Davis: Development and Implementation of Immunoassays for Human and Environmental Monitoring

Publications

2008
  • Aronov, Pavel A., Laura M. Hall, Katja Dettmer, Charles B. Stephensen, and Bruce D. Hammock. 2008. Metabolic profiling of major vitamin D metabolites using Diels-Alder derivatization and ultra-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry. (http://www.springer.com/chemistry/analytical/ journal/216) Exit NIEHS Website doi:10.1007/s00216-008-2095-8 (http://dx.doi.org/10.1007/s00216-008-2095-8) Exit NIEHS Website391(5):1917-30.
  • Aronova, S., K. Wedman, Pavel A. Aronov, K. Fontes, Bruce D. Hammock, and T. Powers. 2008. TOR complex 2 regulates sphingolipid biosynthesis at the conserved step of de novo ceramide formation via the AGC kinase Ypk2. Cell Metabolism. (in press)
  • Chawengsub, Yuttana, N. Aggarwal, Kasem Nithipatikom, K.M. Gauthier, Siddam Anjaiah, Bruce D. Hammock, John R. Falck, and William B. Campbell. 2008. Identification of 15-hydroxy-11,12-epoxyeicosatrienoic acid as a vasoactive 15-lipoxygenase metabolite in rabbit aorta. American Journal of Physiology-Heart and Circulatory Physiology. (http://ajpheart.physiology.org/) Exit NIEHS Website 294(3):1348-56.
  • Corenblum, Mandi J., Vance E. Wise, Katrin Georgi, Bruce D. Hammock, Peter A. Doris, and Myriam Fornage. 2008. Altered soluble epoxide hydrolase gene expression and function and vascular disease risk in the stroke-prone spontaneously hypertensive rat. Hypertension. (http://hyper.ahajournals.org/) Exit NIEHS Website 51(2):567-73.
  • Dreisbach, A.W., J.C. Rice, S. Japa, John W. Newman, A. Sigel, R. Gill, A.E. Hess, A.C. Cemo, J.P. Fonseca, Bruce D. Hammock, J.J. Lertora, and L.L. Hamm. 2008. Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects. Hypertension. (http://hyper.ahajournals.org/) Exit NIEHS Website 51:755-761.
  • Gonzalez-Techera, A., M. Umpierrez-Failache, S. Cardozo, G. Obal, Jerold A. Last, Shirley J. Gee, Bruce D. Hammock, Gualberto Gonzalez-Sapienza, and O. Pritsch. 2008. High-throughput method for ranking the affinity of peptide ligands selected from phage display libraries. Bioconjugate Chemistry. (http://pubs.acs.org/journals/bcches/index.htm l) Exit NIEHS Website doi:10.1021/bc700279y (http://dx.doi.org/10.1021/bc700279y) Exit NIEHS Website19(5):993-1000.
  • Gross, Garrett J., K.M. Gauthier, Jeannine Moore, John R. Falck, Bruce D. Hammock, William B. Campbell, and Kasem Nithipatikom. 2008. Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart. American Journal of Physiology-Heart and Circulatory Physiology. (http://ajpheart.physiology.org/) Exit NIEHS Website doi:10.1152/ajpheart.00186.2008 (http://dx.doi.org/10.1152/ajpheart.00186.2008) Exit NIEHS Website294(6):H2838-44.
  • Harris, Todd R., Pavel A. Aronov, and Bruce D. Hammock. 2008. Soluble epoxide hydrolase homologs in Strongylocentrotus purpuratus suggest a gene duplication event and subsequent divergence. DNA and Cell Biology. (http://www.liebertpub.com/publication.aspx?pu b_id=13) Exit NIEHS Website doi:10.1089/dna.2008.0751 (http://dx.doi.org/10.1089/dna.2008.0751) Exit NIEHS Website27(9):467-77.
  • Hwang, Hyun-Min, Eun-Kee Park, Thomas M. Young, and Bruce D. Hammock. 2008. Occurrence of endocrine-disrupting chemicals in indoor dust. Science of the Total Environment. (http://www.elsevier.com/wps/find/journaldescr iption.cws_home/503360/description#descriptio n) Exit NIEHS Website doi:10.1016/j.scitotenv.2008.05.031 (http://dx.doi.org/10.1016/j.scitotenv.2008.05 .031) Exit NIEHS Website404(1):26-35.
  • Jiang, H., Angela G. Zhu, Magdalena Mamczur, Christophe Morisseau, Bruce D. Hammock, John R. Falck, and John C. McGiff. 2008. Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells. Journal of Pharmacology and Experimental Therapeutics. (http://jpet.aspetjournals.org/) Exit NIEHS Website doi:10.1124/jpet.107.134858 (http://dx.doi.org/10.1124/jpet.107.134858) Exit NIEHS Website326(1):330-7.
  • Kim, H.J., A. Gonzalez-Techera, Gualberto Gonzalez-Sapienza, Ki Chang Ahn, Shirley J. Gee, and Bruce D. Hammock. 2008. Phage-borne peptidomimetics accelerate the development of polyclonal antibody-based heterologous immunoassays for the detection of pesticide metabolites. Environmental Science and Technology. (http://pubs.acs.org/journals/esthag/) Exit NIEHS Website doi:10.1021/es702219a (http://dx.doi.org/10.1021/es702219a) Exit NIEHS Website42(6):2047-53.
  • Morisseau, Christophe and Bruce D. Hammock. 2008. Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical. Pesticide Managment Science. (in press)
  • Morisseau, Christophe, John W. Newman, Craig E. Wheelock, Thomas Hill, Dexter Morin, Alan R. Buckpitt, and Bruce D. Hammock. 2008. Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website doi:10.1021/tx700446u (http://dx.doi.org/10.1021/tx700446u) Exit NIEHS Website21(4):951-7.
  • Pedersen, Theresa L., R.J. Grekin, Bruce D. Hammock, D.L. Ball, and A. Vollmer. 2008. Heparin, lipoproteins, and oxygenated fatty acids in blood: a cautionary note. Prostaglandins, Leukotrienes and Essential Fatty Acids. (in press)
  • Tanaka, Hiromasa, Shizou G. Kamita, Nicola M. Wolf, Todd R. Harris, Zaining Wu, Christophe Morisseau, and Bruce D. Hammock. 2008. Transcriptional regulation of the human soluble expoxide hydrolase gene EPHX2. Biochimica et Biophysica Acta. (http://www.elsevier.com/locate/bba) Exit NIEHS Website doi:10.1016/j.bbagrm.2007.11.005 (http://dx.doi.org/10.1016/j.bbagrm.2007.11.00 5) Exit NIEHS Website1779(1):17-27.
  • Van Emon, Jeanette M., Jane Chuang, Robert A. Lordo, Mary E. Schrock, Mikaela J. Nichkova, Shirley J. Gee, and Bruce D. Hammock. 2008. An enzyme-linked immunosorbent assay for the determination of dioxins in contaminated sediment and soil samples. Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) Exit NIEHS Website doi:10.1016/j.chemosphere.2008.01.012 (http://dx.doi.org/10.1016/j.chemosphere.2008. 01.012) Exit NIEHS Website72(1):95-103.
  • Wheelock, Craig E., J. Forshed, S. Goto, Bruce D. Hammock, and John W. Newman. 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website doi:10.1021/tx7002454 (http://dx.doi.org/10.1021/tx7002454) Exit NIEHS Website21(3):583-90.
  • Wheelock, Craig E., J. Forshed, S. Goto, Bruce D. Hammock, and John W. Newman. 2008. Effects of pyridine exposure upon structural lipid metabolism in Swiss Webster mice. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website (in press)
  • Wheelock, Craig E., Kosuke Nishi, Paul D. Jones, Michael E. Colvin, Marilyn M. Olmstead, and Bruce D. Hammock. 2008. Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH). Bioorganic & Medicinal Chemistry. (http://www.sciencedirect.com/science/journal/ 09680896) Exit NIEHS Website doi:10.1016/j.bmc.2007.10.081 (http://dx.doi.org/10.1016/j.bmc.2007.10.081) Exit NIEHS Website16(4):2114-30.
  • Wheelock, Craig E., Bryn M. Phillips, Jeff L. Miller, Marion G. Miller, and Bruce D. Hammock. 2008. Applications of carboxylesterase activity in environmental monitoring and Toxicity Identification Evaluations (TIEs). Reviews of Environmental Contamination and Toxicology. (in press)
2007
  • Ahn, Ki Chang, Pete N. Lohstroh, Shirley J. Gee, Nancy A. Gee, Bill L. Lasley, and Bruce D. Hammock. 2007. High-throughput automated luminescent magnetic particle-based immunoassay to monitor human exposure to pyrethroid insecticides. Analytical Chemistry. (http://pubs.acs.org/journals/ancham/index.htm l) Exit NIEHS Website 79(b):8883-90.
  • Ai, D., Y.C. Fu, D. Guo, Hiromasa Tanaka, N. Wang, C. Tang, Bruce D. Hammock, John Y-J Shyy, and Yi Zhu. 2007. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 104(21):9018-23.
  • Akatsuka, T., T. Ishikawa, N. Kobayashi, T. Saito, M. Shindo, M. Yamauchi, K. Kurokohchi, H. Miyazawa, H. Duan, T. Matsunaga, T. Komoda, Christophe Morisseau, and Bruce D. Hammock. 2007. Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A. Journal of Autoimmunology. 28:7-18.
  • Chen, Jiangang, Ki Chang Ahn, Nancy A. Gee, Shirley J. Gee, Bruce D. Hammock, Bill L. Lasley, M.I. Mohamed, A.J. Duleba, and L. Zhao. 2007. Triclocarban enhances testosterone action: A new type of endocrine disruptor?. Endocrinology. (http://endo.endojournals.org/) Exit NIEHS Website
  • Chen, Jiangang, Ki Chang Ahn, Shirley J. Gee, Nancy A. Gee, Bruce D. Hammock, and Bill L. Lasley. 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 221(a):278-284.
  • Chiamvimonvat, Nipavan, C-M Ho, Hsing-Ju Tsai, and Bruce D. Hammock. 2007. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. Journal of Cardiovascular Pharmacology. 50:225-237.
  • Chiappe, C., E. Leandri, Bruce D. Hammock, and Christophe Morisseau. 2007. Effect of ionic liquids on epoxide hydrolase-catalyzed synthesis of chiral 1,2-diols. Green Chemistry. (http://www.rsc.org/is/journals/current/green/ greenpub.htm) Exit NIEHS Website 9:162-168.
  • Dettmer, Katja, Pavel A. Aronov, and Bruce D. Hammock. 2007. Mass spectrometry-based metabolomics. Mass Spectrometry Review. (http://www3.interscience.wiley.com/cgi-bin/jt oc/49879) Exit NIEHS Website 26(1):51-78.
  • Dettmer, Katja, D. Hanna, Paul Whetstone, R. Hansen, and Bruce D. Hammock. 2007. Autism and urinary exogenous neuropeptides: development of an on-line SPE-HPLC-tandem mass spectrometry method to test the opioid excess theory. Analytical and Bioanalytical Chemistry. (http://www.springer.com/chemistry/analytical/ journal/216) Exit NIEHS Website 388:1643-1651.
  • Devonshire, A.L., R. Heidari, Huazhang Huang, Bruce D. Hammock, Robyn J. Russell, and John G. Oakeshott. 2007. Hydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterases from Lucilia cuprina. Insect Biochemistry and Molecular Biology. 37:891-902.
  • Dosev, Dosi, Mikaela J. Nichkova, Randy K. Dumas, Shirley J. Gee, Bruce D. Hammock, Kai Liu, and Ian M. Kennedy. 2007. Magnetic/luminescent core/shell particles synthesized by spray pyrolysis and their application in immunoassays with internal standard. Nanotechnology. (http://www.iop.org/EJ/journal/Nano) Exit NIEHS Website 18(5):055102(6pp).
  • Endsley, Michael P., N. Aggarwal, Margaret A. Isbell, Craig E. Wheelock, Bruce D. Hammock, J.R. Flack, William B. Campbell, and Kasem Nithipatikom. 2007. Diverse roles of 2-arachidonoylglycerol in invasion of prostate carcinoma cells: location, hydrolysis and 12-lipoxygenase metabolism. International Journal of Cancer. (http://www3.interscience.wiley.com/cgi-bin/jt oc?ID=29331) Exit NIEHS Website 121:984-991.
  • Fleming, Ingrid, Alexandria Rueben, Rudiger Popp, Beate Fisslthaler, Anna Sander, Judith Haendeler, John R. Falck, Christophe Morisseau, Bruce D. Hammock, and Rudi Busse. 2007. Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. Arteriosclerosis, Thrombosis and Vascular Biology. (http://atvb.ahajournals.org/) Exit NIEHS Website 27(12):2612-8.
  • Gonzalez-Techera, A., L. Vanrell, Jerold A. Last, Bruce D. Hammock, and Gualberto Gonzalez-Sapienza. 2007. Phage anti-immune complex assay: general strategy for noncompetitive immunodetection of small molecules. Analytical Chemistry. (http://pubs.acs.org/journals/ancham/index.htm l) Exit NIEHS Website 79(20):7799-806.
  • Hillard, C.J., W.S. Ho, J. Thompson, K.M. Gauthier, Craig E. Wheelock, H. Huang, and Bruce D. Hammock. 2007. Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619. British Journal of Pharmacology. (http://www.nature.com/bjp/index.html) Exit NIEHS Website 152(5):691-8.
  • Huang, Huazhang, Kosuke Nishi, Hsing-Ju Tsai, and Bruce D. Hammock. 2007. Development of highly sensitive fluorescent assays for fatty acid amide hydrolase. Analytical Biochemistry. (http://www.sciencedirect.com/science/journal/ 00032697) Exit NIEHS Website 363(1):12-21.
  • Hwang, Sung Hee, Hsing-Ju Tsai, Jennifer Liu, Christophe Morisseau, and Bruce D. Hammock. 2007. Orally bioavailable potent soluble epoxide hydrolase inhibitors. Journal Of Medicinal Chemistry. 50:3825-3840.
  • Inceoglu, Bora, Kara R. Schmelzer, Christophe Morisseau, Steven L. Jinks, and Bruce D. Hammock. 2007. Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins & Other Lipid Mediators. 82(1-4):42-49.
  • Inceoglu, Bora, Kara R. Schmelzer, Christophe Morisseau, Steven L. Jinks, and Bruce D. Hammock. 2007. Soluble epoxide hydrolase inhibition reveals novel biological functions of epoxyeicosatrienoic acids (EETs). Prostaglandins & Other Lipid Mediators. 82(1-4):42-9.
  • Kim, H.J., Ki Chang Ahn, Seung Jin Ma, Shirley J. Gee, and Bruce D. Hammock. 2007. Development of sensitive immunoassays for the detection of the glucuronide conjugate of 3-phenoxybenzyl alcohol, a putative human urinary biomarker for pyrethroid exposure. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 55(10):3750-7.
  • Kim, In Hae, Hsing-Ju Tsai, Kosuke Nishi, T. Kasagami, Christophe Morisseau, and Bruce D. Hammock. 2007. 1,3-Disubstituted ureas functionalized with ether groups and potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties. Journal Of Medicinal Chemistry. 50:5217-5226.
  • Kim, In-Hae, Kosuke Nishi, Hsing-Ju Tsai, Tanya Bradford, Yasuko Koda, Takaho Watanabe, Christophe Morisseau, Joanne Blanchfield, Istvan Toth, and Bruce D. Hammock. 2007. Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry. (http://www.sciencedirect.com/science/journal/ 09680896) Exit NIEHS Website 15(1):312-23.
  • Loch, D., A. Hoey, Christophe Morisseau, Bruce D. Hammock, and L. Brown. 2007. Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase. Cellular Biochemistry and Biophysiology. 47:87-97.
  • Luria, Ayala, S.M. Weldon, A.K. Kabcenell, R.H. Ingraham, D. Matera, H. Jiang, R. Gill, Christophe Morisseau, John W. Newman, and Bruce D. Hammock. 2007. Compensatory mechanism for homeostatic blood pressure regulation in Ephx2 gene-disrupted mice. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 282(5):2891-8.
  • Newman, John W., George A. Kaysen, Bruce D. Hammock, and Gregory C. Shearer. 2007. Proteinuria increases oxylipid concentrations in VLDL and HDL, but not LDL particles in the rat. Journal of Lipid Research. (http://www.jlr.org/) Exit NIEHS Website 48:1792-1800.
  • Nichkova, Mikaela J., Dosi Dosev, A. Davies, Shirley J. Gee, Ian M. Kennedy, and Bruce D. Hammock. 2007. Multiplexed immunoassays for biomonitoring of exposure to agrochemicals using quantum dots as fluorescent reporters. Proceedings of SPIE. 6448:644817-1.
  • Nichkova, Mikaela J., Dosi Dosev, A. Davies, Shirley J. Gee, Ian M. Kennedy, and Bruce D. Hammock. 2007. Quantum dots as reporters in multiplexed immunoassays for biomarkers of exposure to agrochemicals. Analytical Letters. 40(7):1423-1433.
  • Nichkova, Mikaela J., Dosi Dosev, Shirley J. Gee, Bruce D. Hammock, and Ian M. Kennedy. 2007. Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration. Analytical Biochemistry. (http://www.sciencedirect.com/science/journal/ 00032697) Exit NIEHS Website 369(a):34-40.
  • Park, Eun-Kee, Sally K. Mak, Bruce D. Hammock, and Dietmar Kultz. 2007. Evaluation of cytotoxicity attributed to thimerosal on murine and human kidney cells. Journal of Toxicology and Environmental Health, Part A. (http://www.tandf.co.uk/journals/titles/152873 94.asp) Exit NIEHS Website 70(24):2092-5.
  • Park, Eun-Kee, Sally K. Mak, Dietmar Kultz, and Bruce D. Hammock. 2007. Determination of cytotoxicity of nephrotoxins on murine and human kidney cell lines. Journal of Environmental Science and Health, Part B. (http://www.informaworld.com/smpp/title~conten t=t713597269~db=all) Exit NIEHS Website 43:71-74.
  • Thompson, David A. and Bruce D. Hammock. 2007. Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst. Journal of Bioscience. 32:279-291.
  • Wadkins, Randy M., Janice L. Hyatt, Carol C. Edwards, Lyudmila Tsurkan, Matthew R. Redinbo, Craig E. Wheelock, Paul D. Jones, Bruce D. Hammock, and Philip M. Potter. 2007. Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds. Molecular Pharmacology. (http://molpharm.aspetjournals.org/) Exit NIEHS Website 71(3):713-723.
  • Wheelock, Craig E., S. Goto, Bruce D. Hammock, and John W. Newman. 2007. Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster mice. Metabolomics. (http://www.springerlink.com/content/1573-3890 /) Exit NIEHS Website 3:137-145.
  • Yuan, W., Joyce S. Chung, Shirley J. Gee, Bruce D. Hammock, and Jiang Zheng. 2007. Development of polyclonal antibodies for detection of styrene oxide modified proteins. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 20:316-321.
  • Zhang, Wenri, Ines P. Koerner, Ruediger Noppens, Marjorie Grafe, Hsing-Ju Tsai, Christophe Morisseau, Ayala Luria, Bruce D. Hammock, John R. Falck, and Nabil J. Alkayed. 2007. Soluble epoxide hydrolase: a novel therapeutic target in stroke. Journal of Cerebral Blood Flow & Metabolism. 27(12):1931-40.
2006
  • Ahn, Ki Chang, Seung Jin Ma, Hsing-Ju Tsai, Shirley J. Gee, and Bruce D. Hammock. 2006. An immunoassay for a urinary metabolite as a biomarker of human exposure to the pyrethroid insecticide permethrin. Analytical and Bioanalytical Chemistry. (http://www.springer.com/chemistry/analytical/ journal/216) Exit NIEHS Website 384(3):713-722.
  • Carkeet, Colleen, Stephen R. Dueker, Jozsef Lango, Bruce A. Buchholz, Joshua W. Miller, Ralph Green, Bruce D. Hammock, John R. Roth, and Peter J. Anderson. 2006. Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled 14C-cobalamin. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 103(15):5694-5699.
  • Cummins, C.M., Marja E. Koivunen, Ara Stephanian, Shirley J. Gee, Bruce D. Hammock, and Ian M. Kennedy. 2006. Application of europium(III) chelate-dyed nanoparticle labels in a competitive atrazine fluoroimmunoassay on an ITO waveguide. Biosensors & Bioelectronics. (http://www.sciencedirect.com/science/journal/ 09565663) Exit NIEHS Website 21(7):1077-1085.
  • Davis, Benjamin B., Christophe Morisseau, John W. Newman, Theresa L. Pedersen, Bruce D. Hammock, and Robert H. Weiss. 2006. Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition. Journal of Pharmacology and Experimental Therapeutics. (http://jpet.aspetjournals.org/) Exit NIEHS Website 316(2):815-821.
  • Dettmer, Katja, Pavel A. Aronov, and Bruce D. Hammock. 2006. Mass spectrometry-based metabolomics. Mass Spectrometry Review. (http://www3.interscience.wiley.com/cgi-bin/jt oc/49879) Exit NIEHS Website 26(1):51-78.
  • Gomez, German A., Christophe Morisseau, Bruce D. Hammock, and David W. Christianson. 2006. Human soluble epoxide hydrolase: Structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids. Protein Science. (http://www.proteinscience.org/) Exit NIEHS Website 15(1):58-64.
  • Harris, Todd R., Christophe Morisseau, Rosemary L. Walzem, Seung Jin Ma, and Bruce D. Hammock. 2006. The cloning and characterization of a soluble epoxide hydrolase in chicken. Poultry Science. (http://ps.fass.org/) Exit NIEHS Website 82(2):278-287.
  • Huang, Huazhang, Kosuke Nishi, Shirley J. Gee, and Bruce D. Hammock. 2006. Evaluation of chiral -cyanoesters as general fluorescent substrates for screening enantioselective esterases. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 54(3):694-699.
  • Hwang, Sung Hee, Christophe Morisseau, Zung N. Do, and Bruce D. Hammock. 2006. Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 16(22):5773-7.
  • Inceoglu, Bora, Steven L. Jinks, Kara R. Schmelzer, Troy Waite, In Hae Kim, and Bruce D. Hammock. 2006. Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain. Life Sciences. (http://www.sciencedirect.com/science?_ob=Jour nalURL&_cdi=5109&_auth=y&_acct=C000050221&_ve rsion=1&_urlVersion=0&_userid=10&md5=04401ec8 8e88172e95fa3d07c90d39e9) Exit NIEHS Website 79(24):2311-2319.
  • Inceoglu, Bora, Jozsef Lango, Paul Whetstone, and Bruce D. Hammock. 2006. The neutralizing effect of a polyclonal antibody raised against the N-terminal eighteen-aminoacid residues of birtoxin towards the whole venom of Parabuthus transvaalicus. Toxicology. (http://www.sciencedirect.com/science/journal/ 0300483X) Exit NIEHS Website 47(2):144-149.
  • Jones, Paul D., Hsing-Ju Tsai, Zung N. Do, Christophe Morisseau, and Bruce D. Hammock. 2006. Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase. Bioorganic & Medicinal Chemistry Letters. 16(19):5212-5216.
  • Koivunen, Marja E., Katja Dettmer, Roel Vermeulen, Berit Bakke, Shirley J. Gee, and Bruce D. Hammock. 2006. Improved methods for urinary atrazine mercapturate analysisAssessment of an enzyme-linked immunosorbent assay (ELISA) and a novel liquid chromatographymass spectrometry (LCMS) method utilizing online solid phase extraction (SPE). Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 572(2):180-189.
  • Larsen, Brandon T., Hiroto Miura, Ossama A. Hatoum, William B. Campbell, Bruce D. Hammock, Darryl C. Zeldin, John R. Falck, and David D. Gutterman. 2006. Epoxyeicosatrienoic and dihydroxyeicosatrienoic acids dilate human coronary arterioles via BKCa channels: implications for soluble epoxide hydrolase inhibition. American Journal of Pathology. (http://ajp.amjpathol.org/) Exit NIEHS Website 290(2):H491-H499.
  • Lee, Craig R., Kari E. North, Molly S. Bray, Myriam Fornage, John M. Seubert, John W. Newman, Bruce D. Hammock, David J. Couper, Gerardo Heiss, and Darryl C. Zeldin. 2006. Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Human Molecular Genetics. (http://hmg.oupjournals.org/) Exit NIEHS Website 15(10):1640-1649.
  • Morisseau, Christophe, John W. Newman, Hsing-Ju Tsai, Preston A. Baecker, and Bruce D. Hammock. 2006. Peptidyl-urea based inhibitors of soluble epoxide hydrolases. Bioorganic & Medicinal Chemistry Letters. 16(20):5439-5444.
  • Ng, Valerie Y., Christophe Morisseau, John R. Falck, Bruce D. Hammock, and Deanna L. Kroetz. 2006. Inhibition of Smooth Muscle Proliferation by Urea-Based Alkanoic Acids via Peroxisome Proliferator-Activated Receptor {alpha}Dependent Repression of Cyclin D1. Arteriosclerosis, Thrombosis and Vascular Biology. (http://atvb.ahajournals.org/) Exit NIEHS Website 26(11):4262.
  • Nichkova, Mikaela J., Dosi Dosev, Richard Perron, Shirley J. Gee, Bruce D. Hammock, and Ian M. Kennedy. 2006. Eu3+-doped Gd2O3 nanoparticles as reporters for optical detection and visualization of antibodies patterned by microcontact printing. Analytical and Bioanalytical Chemistry. (http://www.springer.com/chemistry/analytical/ journal/216) Exit NIEHS Website 384(3):631-637.
  • Nishi, Kosuke, Huazhang Huang, Shizou G. Kamita, In Hae Kim, Christophe Morisseau, and Bruce D. Hammock. 2006. Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 445(1):115-123.
  • Nording, Malin, Mikaela J. Nichkova, Erik Spinnel, Ylva Persson, Shirley J. Gee, Bruce D. Hammock, and Peter Haglund. 2006. Rapid screening of dioxin-contaminated soil by accelerated solvent extraction/purification followed by immunochemical detection. Analytical and Bioanalytical Chemistry. (http://www.springer.com/chemistry/analytical/ journal/216) Exit NIEHS Website 385(2):357-366.
  • Olearczyk, Jeffery J., Mary B. Field, In-Hae Kim, Christophe Morisseau, Bruce D. Hammock, and John D. Imig. 2006. Substituted adamantyl-urea inhibitors of the soluble epoxide hydrolase dilate mesenteric resistance vessels. Journal of Pharmacology and Experimental Therapeutics. (http://jpet.aspetjournals.org/) Exit NIEHS Website 318(3):1307-1314.
  • Pokreisz, Peter, Ingrid Fleming, Ladislau Kiss, Eduardo Barbosa-Sicard, Beate Fisslthaler, John R. Falck, Bruce D. Hammock, In Hae Kim, Zsolt Szelid, Pieter Vermeersch, Hilde Gillijns, Marijke Pellens, Friedrich Grimminger, Anton-Jan van Zonneveld, Desire Collen, Rudi Busse, and Stefan Janssens. 2006. Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling. Hypertension. (http://hyper.ahajournals.org/) Exit NIEHS Website 47(4):762-770.
  • Schmelzer, Kara R., Bora Inceoglu, Lukas Kubala, In Hae Kim, Steven L. Jinks, Jason P. Eiserich, and Bruce D. Hammock. 2006. Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 103(37):13646-13651.
  • Schmelzer, Kara R., Asa M. Wheelock, Katja Dettmer, Dexter Morin, and Bruce D. Hammock. 2006. The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways. Environmental Health Perspectives. 114(9):1354-1360.
  • Seubert, John M., Christopher J. Sinal, Joan Graves, Laura M. Degraff, J. Alyce Bradbury, Craig R. Lee, Kerry Goralski, Michelle A. Carey, Ayala Luria, John W. Newman, Bruce D. Hammock, John R. Falck, Holly Roberts, Howard A. Rockman, Elizabeth Murphy, and Darryl C. Zeldin. 2006. Role of soluble epoxide hydrolase in postischemic recovery of heart contractile function. Circulation Research. (http://circres.ahajournals.org/) Exit NIEHS Website 99(4):442-450.
  • Watanabe, Takaho, Daniel Schulz, Christophe Morisseau, and Bruce D. Hammock. 2006. High-throughput pharmacokinetic method: Cassette dosing in mice. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 559(1):37-44.
  • Wheelock, Asa M., Jeff L. Miller, Mike J. Miller, Bryn M. Phillips, Sarah A. Huntley, Shirley J. Gee, Ronald S. Tjeerdema, and Bruce D. Hammock. 2006. Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations. Environmental Toxicology and Chemistry. (http://etc.allenpress.com/entconline/?request =index-html) Exit NIEHS Website 25(4):973-984.
  • Wolf, Nicola M., Christophe Morisseau, Paul D. Jones, Bertold Hock, and Bruce D. Hammock. 2006. Development of a high-throughput screen for soluble epoxide hydrolase inhibition. Analytical Biochemistry. (http://www.sciencedirect.com/science/journal/ 00032697) Exit NIEHS Website 355(1):71-80.
  • Xu, Danyan, Ning Li, Yuxia He, Valeriy Timofeyev, Ling Lu, Hsing-Ju Tsai, In Hae Kim, Dipika Tuteja, Robertino Karlo P. Mateo, Anil Singapuri, Benjamin B. Davis, Reginald Low, Bruce D. Hammock, and Nipavan Chiamvimonvat. 2006. Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 103(49):18733-18738.
  • Zhao, Bin, David S. Baston, Bruce D. Hammock, and Michael S. Denison. 2006. Interaction of diuron and related substituted phenylureas with the Ah receptor pathway. Journal of Biochemical and Molecular Toxicology. (http://www.interscience.wiley.com/jpages/1095 -6670/) Exit NIEHS Website 20(3):103-113.
2005
  • Ahn, Ki Chang, Shirley J. Gee, H.J. Kim, Mikaela J. Nichkova, and Bruce D. Hammock. 2005. Progress in the development of biosensors for environmental and human monitoring of agrochemicals. Proceedings of the American Chemical Society Pacifichem. 966:138-154.
  • Aronov, Pavel A., Katja Dettmer, Julie A. Christiansen, Anthony J. Cornel, and Bruce D. Hammock. 2005. Development of a HPLC/tandem-MS method for the analysis of the larvicides methoprene, hydroprene and kinoprene at trace levels using Diels-Alder derivatization. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 53(9):3306-3312.
  • Dorrance, Ann M., Nicole Rupp, David M. Pollock, John W. Newman, Bruce D. Hammock, and John D. Imig. 2005. An epoxide hydrolase inhibitor, 12-(3-Adamantan-1-yl-ureido)dodecanoic acid (AUDA) reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology. 46(6):842-848.
  • Dosev, Dosi, Mikaela J. Nichkova, Maozi Liu, Bing Guo, Gang-yu Liu, Bruce D. Hammock, and Ian M. Kennedy. 2005. Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns. Journal of Biomedical Optics. 10(6):1-7.
  • Dosev, Dosi, Mikaela J. Nichkova, Maozi Liu, Bing Guo, Gang-yu Liu, Younan Xia, Bruce D. Hammock, and Ian M. Kennedy. 2005. Application of fluorescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns. Chapter 5699 in: Imaging, Manipulation, and Analysis of Biomolecules and Cells: Fundamentals and Applications: III (Proceedings of SPIE). SPIE Society of Photo-Optical Instrumentation Engineering, San Jose, CA. pp.473-481.
  • Fang, Xianx, Shanming Hu, Takaho Watanabe, Neal L. Weintraub, Gary D. Snyder, Jianrong Yao, Yi Liu, John Y-J Shyy, Bruce D. Hammock, and Author A. Spector. 2005. Activation of Peroxisome Proliferator-Activated Receptor by Substituted Urea-Derived Soluble Epoxide Hydrolase Inhibitors. Journal of Pharmacology and Experimental Therapeutics. (http://jpet.aspetjournals.org/) Exit NIEHS Website 314(1):260-270.
  • German, J.Bruce, Bruce D. Hammock, and Steven M. Watkins. 2005. Metabolomics: building on a century of biochemistry to guide human health. Metabolomics. (http://www.springerlink.com/content/1573-3890 /) Exit NIEHS Website 1(1):3-9.
  • Hennebold, Jon D., Kuni Mah, Wilma Perez, Jessica E. Vance, Richard L. Stouffer, Christophe Morisseau, Bruce D. Hammock, and Eli Y. Adashi. 2005. Identification and characterization of an ovary-selective isoform of epoxide hydrolase. Biology of Reproduction. (http://www.biolreprod.org/) Exit NIEHS Website 72(4):968-975.
  • Huang, Huazhang, Christopher D. Fleming, Kosuke Nishi, Matthew R. Redinbo, and Bruce D. Hammock. 2005. Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 18(9):1371-1377.
  • Huang, Huazhang, Jeanette E. Stok, Donald W. Stoutamire, Shirley J. Gee, and Bruce D. Hammock. 2005. Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 18(3):516-527.
  • Imig, John D., Xueying Zhao, Constantine Z. Zaharis, Jeffery J. Olearczyk, David M. Pollock, John W. Newman, In-Hae Kim, Takaho Watanabe, and Bruce D. Hammock. 2005. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension. (http://hyper.ahajournals.org/) Exit NIEHS Website 46(4):975-981.
  • Inceoglu, Bora, Jozsef Lango, Isaac N. Pessah, and Bruce D. Hammock. 2005. Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus possess divergent biological activity. Toxicon. 45(6):727-733.
  • Jones, Paul D., Nicola M. Wolf, Christophe Morisseau, Paul Whetstone, Bertold Hock, and Bruce D. Hammock. 2005. Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies. Analytical Biochemistry. (http://www.sciencedirect.com/science/journal/ 00032697) Exit NIEHS Website 343(1):66-75.
  • Jung, Oliver, Ralf P. Brandes, In-Hae Kim, Frank Schweda, Ronald Schmidt, Bruce D. Hammock, Rudi Busse, and Ingrid Fleming. 2005. Soluble epoxide hydrolase is a main effector of angiotensin ll-induced hypertension. Hypertension. (http://hyper.ahajournals.org/) Exit NIEHS Website 45(4):759-765.
  • Kang, Kyung-Don, Paul D. Jones, Huazhang Huang, Rong Zhang, Lyudmila A. Mostovich, Craig E. Wheelock, Takaho Watanabe, Lyudmila F. Gulyaeva, and Bruce D. Hammock. 2005. Evaluation of a-cyano ethers as fluorescent substrates for assay of cytochrome P450 enyzme activity. Analytical Biochemistry. (http://www.sciencedirect.com/science/journal/ 00032697) Exit NIEHS Website 344(2):183-192.
  • Kim, In-Hae, Fenton R. Heirtzler, Christophe Morisseau, Kosuke Nishi, Hsing-Ju Tsai, and Bruce D. Hammock. 2005. Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility. Journal Of Medicinal Chemistry. 48(10):3621-3629.
  • Koivunen, Marja E., Shirley J. Gee, Eun-Kee Park, K. Lee, Marc B. Schenker, and Bruce D. Hammock. 2005. Application of an enzyme-linked immunosorbent assay for the analysis of paraquat in human exposure samples. Archives of Environmental Contamination and Toxicology. (http://link.springer.de/link/service/journals /00244/tocs.html) Exit NIEHS Website 48(2):184-190.
  • Liu, Yi, Yingjia Zhang, Kara R. Schmelzer, Tzong-Shyuan Lee, Xianx Fang, Yi Zhu, Author A. Spector, Sarjeet Gill, Christophe Morisseau, Bruce D. Hammock, and John Y-J Shyy. 2005. The antiinflammatory effect of laminar flow: The role of PPAR, epoxyeicosatrienoic acids, and soluble epoxide hydrolase. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 102(46):16747-16752.
  • Mak, Sally K., Guomin Shan, Hu-Jang Lee, Takaho Watanabe, Donald W. Stoutamire, Shirley J. Gee, and Bruce D. Hammock. 2005. Development of a class selective immunoassay for the type II pyrethroid insecticides. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 534:109-120.
  • Morisseau, Christophe and Bruce D. Hammock. 2005. Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles. Annual Review of Pharmacology and Toxicology. (http://pharmtox.annualreviews.org/) Exit NIEHS Website 45:311-333.
  • Newman, John W., Christophe Morisseau, and Bruce D. Hammock. 2005. Epoxide hydrolases: their roles and interactions with lipid metabolism. Progress in Lipid Research. 44(1):1-50.
  • Nichkova, Mikaela J., Dosi Dosev, Shirley J. Gee, Bruce D. Hammock, and Ian M. Kennedy. 2005. Microarray of immunoassay for phenoxybenzoic acid using polymer encapsulated Eu:Gd2O3 nanoparticles as fluorescent labels. Analytical Chemistry. (http://pubs.acs.org/journals/ancham/index.htm l) Exit NIEHS Website 77(21):6864-6873.
  • Nithipatikom, Kasem, Michael P. Endsley, Marilyn A. Isbell, Craig E. Wheelock, Bruce D. Hammock, and William B. Campbell. 2005. A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. Biochemical and Biophysical Research Communications. (http://www.sciencedirect.com/science/journal/ 0006291X) Exit NIEHS Website 332(4):1028-1033.
  • Schmelzer, Kara R., Lukas Kubala, John W. Newman, In-Hae Kim, Jason P. Eiserich, and Bruce D. Hammock. 2005. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 102(28):9772-9777.
  • Sellers, Kathleen W., Chengwen Sun, Carlos Diez-Freire, Hidefumi Waki, Christophe Morisseau, John R. Falck, Bruce D. Hammock, Julian F. Paton, and Mohan K. Raizada. 2005. Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat. FASEB Journal. (http://www.fasebj.org/) Exit NIEHS Website 19:626-628.
  • Shearer, Gregory C., John W. Newman, Bruce D. Hammock, and George A. Kaysen. 2005. Graded effects of proteinuria on HDL structure in nephrotic rats. Journal of the American Society of Nephrology. 16(5):1309-1319.
  • Smith, Kevin R., Kent E. Pinkerton, Takaho Watanabe, Theresa L. Pedersen, Seung Jin Ma, and Bruce D. Hammock. 2005. Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 102(6):2186-2191.
  • Tran, Katherine L., Pavel A. Aronov, Hiromasa Tanaka, John W. Newman, Bruce D. Hammock, and Christophe Morisseau. 2005. Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase. Biochemistry. (http://pubs.acs.org/journals/bichaw/index.htm l) Exit NIEHS Website 44(36):12179-12187.
  • Wheelock, Craig E., Kai J. Eder, Ingeborg Werner, Huazhang Huang, Paul D. Jones, Benjamin F. Brammell, Adria A. Elskus, and Bruce D. Hammock. 2005. Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 74(2):172-192.
  • Wheelock, Craig E., Jeff L. Miller, Mike J. Miller, Bryn M. Phillips, Shirley J. Gee, Ronald S. Tjeerdema, and Bruce D. Hammock. 2005. Influence of container adsorption upon observed pyrethroid toxicity to Ceriodaphnia dubia and Hyalella azteca. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) Exit NIEHS Website 74(1):47-52.
2004
  • Ahn, Ki Chang, Takaho Watanabe, Shirley J. Gee, and Bruce D. Hammock. 2004. Hapten and antibody production for a sensitive immunoassay determinining a human urinary metabolite of the pyrethroid insecticide permethrin. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 52(15):4583-4594.
  • Dey, Aparajita, Rogers S. Williams, David M. Pollock, David W. Stepp, John W. Newman, Bruce D. Hammock, and John D. Imig. 2004. Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obesity Research. (http://www.obesityresearch.org/) Exit NIEHS Website 12(8):1278-89.
  • Dey, Aparajita, Rogers S. Williams, David M. Pollock, David W. Stepp, John W. Newman, Bruce D. Hammock, and John D. Imig. 2004. Promiscuous ligand-dependent activation of the Ah receptor: chemicals in crude extracts from commercial and consumer products bind to and activate the Ah receptor and Ah receptor-dependent gene expression. Obesity Research. (http://www.obesityresearch.org/) Exit NIEHS Website 12(8):1278-1289.
  • DuTeaux, Shelley Brown, John W. Newman, Christophe Morisseau, Elise A. Fairbairn, Karen Jelks, Bruce D. Hammock, and Marion G. Miller. 2004. Epoxide hydrolases in the rat epididymis: possible roles in xenobiotic and endogenous fatty acid metabolism. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 78(2):187-195.
  • Fang, Xianx, Neal L. Weintraub, Ryan B. McCaw, Shanming Hu, Shawn Harmon, James B. Rice, Bruce D. Hammock, and Author A. Spector. 2004. Effect of soluble epoxide hydrolase inhibition on epoxyeicosatrienoic acid metabolism in human blood vessels. American Journal of Physiology-Cell Physiology. 287:H2412-H2420.
  • Gomez, German A., Christophe Morisseau, Bruce D. Hammock, and David W. Christianson. 2004. Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis. Biochemistry. (http://pubs.acs.org/journals/bichaw/index.htm l) Exit NIEHS Website 43(16):4716-4723.
  • Kennedy, Ian M., Marja E. Koivunen, Shirley J. Gee, C.M. Cummins, Richard Perron, Dosi Dosev, and Bruce D. Hammock. 2004. Nanoscale fluoro-immuno assays with lanthanide oxide nanoparticles. Chapter 5593 in: Nanosensing: Materials and Devices (Proceedings of SPIE). SPIE Society of Photo-Optical Instrumentation Engineering, Bellingham, WA. pp.329-339.
  • Kim, In-Hae, Christophe Morisseau, Takaho Watanabe, and Bruce D. Hammock. 2004. Design, Synthesis, and Biological Activity of 1,3-Disubstituted Ureas as Potent Inhibitors of the Soluble Epoxide Hydrolase of Increased Water Solubility. Journal Of Medicinal Chemistry. 47(8):759-765.
  • Lee, Hu-Jang, Guomin Shan, Ki Chang Ahn, Eun-Kee Park, Takaho Watanabe, Shirley J. Gee, and Bruce D. Hammock. 2004. Development of an enzyme-linked Immunosorbent assay for the pyrethroid cypermethrin. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 52(2):1039-1043.
  • Newman, John W., Jeanette E. Stok, J.D. Vidal, C.J. Corbin, Qihung Huang, Bruce D. Hammock, and A.J. Conley. 2004. Cytochrome P450-dependent lipid metabolism in preovulatory follicles. Endocrinology. (http://endo.endojournals.org/) Exit NIEHS Website 145(11):5097-5105.
  • Nichkova, Mikaela J., Eun-Kee Park, Marja E. Koivunen, Shizou G. Kamita, Shirley J. Gee, Jane Chuang, Jeanette M. Van Emon, and Bruce D. Hammock. 2004. Immunochemical determination of dioxins in environmental and biological samples. Talanta. (http://www.sciencedirect.com/science/journal/ 00399140) Exit NIEHS Website 63:1213-1223.
  • Park, Eun-Kee, Jung-Hyun Kim, Shirley J. Gee, Takaho Watanabe, Ki Chang Ahn, and Bruce D. Hammock. 2004. Determination of pyrethroid residues in agricultural products by an enzyme-linked immunosorbent assay. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 52(18):5572-5576.
  • Rufo, Caterina, Bruce D. Hammock, Shirley J. Gee, Jerold A. Last, and Gualberto Gonzalez-Sapienza. 2004. Robust and sensitive monoclonal enzyme-linked immunosorbent assay for the herbicide molinate. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 52(2):182-187.
  • Seubert, John M., Baichun Yang, J. Alyce Bradbury, Joan Graves, Laura M. Degraff, Scott Gabel, Rebecca Gooch, Julie Foley, John W. Newman, Lan Mao, Howard A. Rockman, Bruce D. Hammock, Elizabeth Murphy, and Darryl C. Zeldin. 2004. Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K+ Channels and p42/p44 MAPK Pathway. Circulation Research. (http://circres.ahajournals.org/) Exit NIEHS Website 95(5):506-514.
  • Shan, Guomin, Huazhang Huang, Donald W. Stoutamire, Shirley J. Gee, Gabriele Leng, and Bruce D. Hammock. 2004. A sensitive class specific immunoassay for the detection of pyrethroid metabolites in human urine. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 17(2):218-225.
  • Stok, Jeanette E., Andrey Goloshchapov, Cheng Song, Craig E. Wheelock, Maher Derbel, Christophe Morisseau, and Bruce D. Hammock. 2004. Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 430(2):247-255.
  • Stok, Jeanette E., Huazhang Huang, Paul D. Jones, Craig E. Wheelock, Christophe Morisseau, and Bruce D. Hammock. 2004. Identification, expression and purification of a pyrethroid hydrolyzing carboxylesterase from mouse liver microsomes. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 279(28):29863-29869.
  • Wheelock, Craig E., Jeff L. Miller, Mike J. Miller, Shirley J. Gee, Guomin Shan, and Bruce D. Hammock. 2004. Development of toxicity identification evaluation procedures for pyrethroid detection using esterase activity. Environmental Toxicology and Chemistry. (http://etc.allenpress.com/entconline/?request =index-html) Exit NIEHS Website 23(11):2699-2708.
  • Yu, Zhigang, Benjamin B. Davis, Christophe Morisseau, Bruce D. Hammock, Jean L. Olson, Deanna L. Kroetz, and Robert H. Weiss. 2004. Vascular localization of soluble epoxide hydrolase in the human kidney. American Journal of Physiology Renal-Physiology. 286(4):F720-F726.
  • Zhao, Xueying, Tatsuo Yamamoto, John W. Newman, In-Hae Kim, Takaho Watanabe, Bruce D. Hammock, Janet Stewart, and John D. Imig. 2004. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. Journal of the American Society of Nephrology. 15(5):1244-53.
2003
  • Chen, Shi-Che, P. Yuen, S. Collins, R. Smith, Marja E. Koivunen, and Bruce D. Hammock. 2003. Time gated detection of europium nanoparticles in a microchannel-based environmental immunoassay. In: Proceedings of SPIE (The International Society for Optical Engineering).
  • Cho, Young Ae, Yoo Jung Kim, Bruce D. Hammock, Yong Tae Lee, and Hye-Sung Lee. 2003. Development of a microtiter plate ELISA and a dipstick ELISA for the determination of the organophosphorus insecticide fenthion. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 51(27):7854-7860.
  • Denton, Debra L., Craig E. Wheelock, Shauna A. Murray, Linda A. Deanovic, Bruce D. Hammock, and David E. Hinton. 2003. Joint acute toxicity of esfenvalerate and diazinon to fathead minnow (Pimephales promelas) larvae. Environmental Toxicology and Chemistry. (http://etc.allenpress.com/entconline/?request =index-html) Exit NIEHS Website 22(2):336-341.
  • Feng, Jun, J.S. Mack, Guomin Shan, and Bruce D. Hammock. 2003. C60 nanoparticle quenching used as a biological label. In: Proceedings of SPIE (The International Society for Optical Engineering). pp.156-163.
  • Feng, Jun, Guomin Shan, Bruce D. Hammock, and Ian M. Kennedy. 2003. Fluorescence quenching competitive immunoassay in micro droplets. Biosensors & Bioelectronics. (http://www.sciencedirect.com/science/journal/ 09565663) Exit NIEHS Website 18(8):1055-1063.
  • Feng, Jun, Guomin Shan, Angel Maquieira, Marja E. Koivunen, Bing Guo, and Bruce D. Hammock. 2003. Functionalized Europium Oxide Nanoparticles Used as a Fluorescent Label in an Immunoassay for Atrazine. Analytical Chemistry. (http://pubs.acs.org/journals/ancham/index.htm l) Exit NIEHS Website 75(19):5282-5286.
  • Inceoglu, Bora, Jozsef Lango, Jie Jing, Lili Chen, Fuat Doymaz, Isaac N. Pessah, and Bruce D. Hammock. 2003. One scorpion, two venoms: Prevenom of Parabuthus transvaalicus acts as an alternative type of venom with distinct mechanism of action. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 100(3):922-927.
  • Kim, Yoo Jung, Young Ae Cho, Hye-Sung Lee, Yong Tae Lee, Shirley J. Gee, and Bruce D. Hammock. 2003. Synthesis of haptens for immunoassay of organophosphorus pesticides and effect of heterology in hapten spacer arm length of immunoassay sensitivity. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 475(1-2):85-96.
  • Koivunen, Marja E., Christophe Morisseau, John W. Newman, William R. Horwath, and Bruce D. Hammock. 2003. Purification and characterization of a methylene urea-hydrolyzing enzyme from Rhizobium radiobacter (Agrobacterium tumefaciens). Soil Biology and Biochemistry. (http://www.sciencedirect.com/science/journal/ 00380717) Exit NIEHS Website 35(11):1433-1442.
  • Lee, Hu-Jang, Takaho Watanabe, Shirley J. Gee, and Bruce D. Hammock. 2003. Application of an Enzyme-Linked Immunosorbent Assay (ELISA) to Determine Deltamethrin Residues in Milk. Bulletin of Environmental Contamination and Toxicology. (http://link.springer.de/link/service/journals /00128/tocs.html) Exit NIEHS Website 71(1):14-20.
  • Lee, Jae Koo, Ki Chang Ahn, Donald W. Stoutamire, Shirley J. Gee, and Bruce D. Hammock. 2003. Development of an Enzyme-Linked Immunosorbent Assay for the Detection of the Organophosphorus Insecticide Acephate. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 51(13):3695-3703.
  • McElroy, Nathan R., Peter C. Jurs, Christophe Morisseau, and Bruce D. Hammock. 2003. QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds. Journal Of Medicinal Chemistry. 46(6):1066-1080.
  • Morisseau, Christophe and Bruce D. Hammock. 2003. Measurements of soluble epoxide hydrolase (sEH) activity. Chapter 4 in: Current Protocals in Toxicology. John Wiley & Sons, NY. pp.1-4.
  • Newman, John W., Christophe Morisseau, Todd R. Harris, and Bruce D. Hammock. 2003. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 100(4):1558-1563.
  • Nichkova, Mikaela J., Jun Feng, Francisco Sanchez-Baeza, Maria-Pilar Marco, Bruce D. Hammock, and Ian M. Kennedy. 2003. Competitive quenching fluorescence immunoassy for chlorophenols based on laser-induced fluorescence detection in microdroplets. Analytical Chemistry. (http://pubs.acs.org/journals/ancham/index.htm l) Exit NIEHS Website 75(1):83-90.
  • Przybyla-Zawislak, Beata D., Punit K. Srivastava, Johana Vazquez-Matias, Harvey W. Mohrenweiser, Joseph E. Maxwell, Bruce D. Hammock, J. Alyce Bradbury, Ahmed E. Enayetallah, Darryl C. Zeldin, and David F. Grant. 2003. Polymorphisms in human soluble epoxide hydrolase. Molecular Pharmacology. (http://molpharm.aspetjournals.org/) Exit NIEHS Website 64(2):482-490.
  • Szekacs, Andras, Hong M. Le, Ferenc Szurdoki, and Bruce D. Hammock. 2003. Optimization and validation of an enzyme immunoassay for the insect growth regulator fenoxycarb. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 487(1):15-29.
  • Taniai, Kiyoko, Ahmet B. Inceoglu, Kenji Yukuhiro, and Bruce D. Hammock. 2003. Characterization and cDNA cloning of a clofibrate-inducible microsomal epoxide hydrolase in Drosophila melanogaster. European Journal of Biochemistry. 270(23):4696-4705.
  • Viswanathan, Saraswathi, Bruce D. Hammock, John W. Newman, Purushothaman Meerarani, Michal Toborek, and Bernhard Hennig. 2003. Involvement of CYP 2C9 in Mediating the Proinflammatory Effects of Linoleic Acid in Vascular Endothelial Cells. Journal of the American College of Nutrition. (http://www.jacn.org/) Exit NIEHS Website 22(6):502-510.
  • Viswanathan, Saraswathi, Bruce D. Hammock, John W. Newman, Michal Toborek, and Bernhard Hennig. 2003. Involvement of CYP2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells. Journal of the American College of Nutrition. (http://www.jacn.org/) Exit NIEHS Website 22(6):502-510.
  • Watanabe, Takaho, Christophe Morisseau, John W. Newman, and Bruce D. Hammock. 2003. In vitro metabolism of the mammalian soluble epoxide hydrolase inhibitor, 1-cyclohexyl-3-dodecy1-urea. Drug Metabolism and Disposition. (http://dmd.aspetjournals.org/) Exit NIEHS Website 31(7):846-853.
  • Wheelock, Craig E., Yoshiaki Nakagawa, Miki Akamatsu, and Bruce D. Hammock. 2003. Use of classical and 3-D QSAR to examine the hydration state of juvenile hormone esterase inhibitors. Bioorganic & Medicinal Chemistry. (http://www.sciencedirect.com/science/journal/ 09680896) Exit NIEHS Website 11(23):5101-5116.
  • Wheelock, Craig E., Asa M. Wheelock, Rebecca H. Zhang, Jeanette E. Stok, Christophe Morisseau, Susanna E. Le Valley, Carol E. Green, and Bruce D. Hammock. 2003. Evaluation of alpha-cyanoesters as fluorescent substrates for examining interindividual variation in general and pyrethroid-selective esterases in human liver microsomes. Analytical Biochemistry. (http://www.sciencedirect.com/science/journal/ 00032697) Exit NIEHS Website 315(2):208-222.
  • Zhang, Rebecca H., Kyung-Don Kang, Guomin Shan, and Bruce D. Hammock. 2003. Design, synthesis and evaluation of novel P450 fluorescent probes bearing -cyanoether. Tetrahedron Letters. 44(23):4331-4334.
2002
  • Cho, Young Ae, Hye-Sung Lee, Eun Young Park, Yong Tae Lee, Bruce D. Hammock, Ki Chang Ahn, and Jae Koo Lee. 2002. Development of an ELISA for the organophosphorus insecticide chlorpyrifos. Bulletin of the Korean Chemical Society. 23(3):481-487.
  • Davis, Benjamin B., David A. Thompson, Laura L. Howard, Christophe Morisseau, Bruce D. Hammock, and Robert H. Weiss. 2002. Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 99(4):2222-2227.
  • Dedos, S.G., Ferenc Szurdoki, Andras Szekacs, T. Shiotsuki, Bruce D. Hammock, J. Shimada, and H. Fugo. 2002. Fenoxycarb levels and their effects on general and juvenile hormone esterase activity in the hemolymph of the silkworm, Bombyx mori. Pesticide Biochemistry and Physiology. 73(3):174-187.
  • Denison, Michael S., Scott R. Nagy, Michael H. Ziccardi, George C. Clark, Michael D. Chu, David J. Brown, Guomin Shan, Yukio Sugawara, Shirley J. Gee, James R. Sanborn, and Bruce D. Hammock. 2002. Bioanalytical approaches for the detection of dioxin and related halogenated aromatic hydrocarbons. In: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives (http://www.amazon.com/exec/obidos/tg/detail/- /1566705967/qid=1125592445/sr=1-1/ref=sr_1_1/ 102-5267823-2464935?v=glance&s=books) Exit NIEHS Website. CRC Press Company, Boca Raton, FL. pp.483-494.
  • Fang, Xianx, Neal L. Weintraub, Christine L. Oltman, Lynn L. Stoll, Terry L. Kaduce, Shawn Harmon, Kevin C. Dellsperger, Christophe Morisseau, Bruce D. Hammock, and Author A. Spector. 2002. Human coronary endothelial cells convert 14, 15-EET to a biologically active chain-shortened epoxide. American Journal of Physiology-Heart and Circulatory Physiology. (http://ajpheart.physiology.org/) Exit NIEHS Website 283(6):H2306-H2314.
  • Feng, Jun, Guomin Shan, Bruce D. Hammock, and Ian M. Kennedy. 2002. Fluorescence quenching competitive fluoroimmunoassay in micro droplets. In: Methods for Ultrasensitive Detection II, Proceedings of the International Society for Optical Engineering. SPIE, Bellingham, WA. pp.118-127.
  • Fornage, Myriam, Cruz A. Hinojos, Barbara W. Nurowska, Eric Boerwinkle, Bruce D. Hammock, Christophe Morisseau, and Peter A. Doris. 2002. Polymorphism in soluble epoxide hydrolase and blood pressure in spontaneously hypertensive rats. Hypertension. (http://hyper.ahajournals.org/) Exit NIEHS Website 40(4):485-490.
  • Harcourt, Rebecca L., Irene Horne, Tara D. Sutherland, Bruce D. Hammock, Robyn J. Russell, and John G. Oakeshott. 2002. Development of a simple and sensitive fluorimetric method for isolation or coumaphos-hydrolysing bacteria. Letters in Applied Microbiology. 34(4):263-268.
  • Hennig, Bernhard, Bruce D. Hammock, Rabih M. Slim, Michal Toborek, Saraswathi Viswanathan, and Larry W. Robertson. 2002. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. International Journal of Hygiene and Environmental Health. (http://www.elsevier.de/ijheh) Exit NIEHS Website 205:95-102.
  • Hennig, Bernhard, Bruce D. Hammock, Rabih M. Slim, Michal Toborek, Saraswathi Viswanathan, and Larry W. Robertson. 2002. PCB-induced oxidative stress in endothelial cells: modulation by nutrients. International Journal of Hygiene and Environmental Health. (http://www.elsevier.de/ijheh) Exit NIEHS Website 205(1-2):95-102.
  • Imig, John D., Xueying Zhao, Jorge H. Capdevila, Christophe Morisseau, and Bruce D. Hammock. 2002. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension. Hypertension. (http://hyper.ahajournals.org/) Exit NIEHS Website 39(2):690-694.
  • Inceoglu, Bora, Yuki Hayashida, Jozsef Lango, Andrew T. Ishida, and Bruce D. Hammock. 2002. A single charged surface residue modifies the activity of ikitoxin, a beta-type Na+ channel toxin from Parabuthus transvaalicus. European Journal of Biochemistry. 269(22):5369-5376.
  • Kim, Kwang-Ok, Yoo Jung Kim, Yong Tae Lee, Bruce D. Hammock, and Hye-Sung Lee. 2002. Development of an enzyme-linked immunosorbent assay for the organophosphorus insecticide bromophos-ethyl. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 50(23):6675-6682.
  • Lee, Hu-Jang, Guomin Shan, Takaho Watanabe, Donald W. Stoutamire, Shirley J. Gee, and Bruce D. Hammock. 2002. Enzyme-linked immunosorbent assay for the pyrethroid deltamethrin. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 50(20):5526-5532.
  • Leppert, Valerie J., Ashley S. Harvey, Geoff D. McCool, Forest T. Quinlan, Jun Feng, Guomin Shan, Pieter Stroeve, Subhash H. Risbud, Bruce D. Hammock, and Ian M. Kennedy. 2002. Long-wavelength emitting nanocrystals for bioassay applications. In: Nanoscale Optics and Applications. Proceedings of SPIE, pp.110-121.
  • Morisseau, Christophe and Bruce D. Hammock. 2002. Epoxide Hydrolases. In: Wiley Encyclopedia of Molecular Medicine. Medicine John Wiley & Sons Inc., New York, NY. pp.1194-1197.
  • Morisseau, Christophe, Marvin H. Goodrow, John W. Newman, Craig E. Wheelock, Deanna L. Dowdy, and Bruce D. Hammock. 2002. Structural refinement of inhibitors of urea based soluble epoxide hydrolases. Biochemical Pharmacology. (http://www.elsevier.com/wps/find/journaldescr iption.cws_home/525454/description#descriptio n) Exit NIEHS Website 63(9):1599-1608.
  • Nagy, Scott R., James R. Sanborn, Bruce D. Hammock, and Michael S. Denison. 2002. Development of a green fluorescent protein based cell bioassay for the rapid and inexpensive detection and characterization of AhR agonists. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 65(2):200-210.
  • Newman, John W., Takaho Watanabe, and Bruce D. Hammock. 2002. The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. Journal of Lipid Research. (http://www.jlr.org/) Exit NIEHS Website 43(9):1563-1578.
  • Park, Won Chul, Young Ae Cho, Yoo Jung Kim, Bruce D. Hammock, Yong Tae Lee, and Hye-Sung Lee. 2002. Development of an enzyme-linked immunosorbent assay for the organophosphorus insecticide bromophos. Bulletin of the Korean Chemical Society. 23(10):1399-1403.
  • Severson, Tonya, Marvin H. Goodrow, Christophe Morisseau, Deanna L. Dowdy, and Bruce D. Hammock. 2002. Urea and amide-based inhibitors of the juvenile hormone epoxide hydrolase of the tobacco hornworm(Manduca sexta: Sphingidae). Insect Biochemistry and Molecular Biology. 32:1741-1756.
  • Shelver, Weilin L., Guomin Shan, Shirley J. Gee, Larry H. Stanker, and Bruce D. Hammock. 2002. Comparison of immunoaffinity column recovery patterns of polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans on columns generated with different monoclonal antibody clones and polyclonal antibodies. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 457:199-209.
  • Sugawara, Yukio, Koichi Saito, Masahiko Ogawa, Susumu Kobayashi, Guomin Shan, James R. Sanborn, Bruce D. Hammock, Hiroyuki Nakazawa, and Yasuhiko Matsuki. 2002. Development of dioxin toxicity evaluation method in human milk by enzyme-linked immunosorbent assay--assay validation for human milk. Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) Exit NIEHS Website 46(9-10):1471-1476.
  • Szurdoki, Ferenc, Andras Szekacs, Hong M. Le, and Bruce D. Hammock. 2002. Synthesis of haptens and protein conjugates for the development of immunoassays for the insect growth regulator fenoxycarb. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 50(1):29-40.
  • Viswanathan, Saraswathi, Bruce D. Hammock, Purushothaman Meerarani, Michal Toborek, and Bernhard Hennig. 2002. Mechanisms of linoleic acid-induced endothelial activation: possible involvement of epoxide metabolites in mediating the inflammatory response. FASEB Journal. (http://www.fasebj.org/) Exit NIEHS Website 16:A157.
  • Wheelock, Craig E., Michael E. Colvin, Ippei Uemura, Marilyn M. Olmstead, James R. Sanborn, Yoshiaki Nakagawa, A. Daniel Jones, and Bruce D. Hammock. 2002. Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors. Journal Of Medicinal Chemistry. 45(25):5576-5593.
  • Zurek, Gabriela, Shirley J. Gee, and Bruce D. Hammock. 2002. Development of an enzyme immunoassay for linoleic acid diols in urine. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 466(2):247-256.
2001
  • Buchholz, Bruce A., John S. Vogel, Douglas S. Gilman, Shirley J. Gee, Bruce D. Hammock, Xiaoying Hui, Ronald C. Wester, and Howard I. Maibach. 2001. Determining an occupational dermal exposure biomarker for atrazine through measurement of metabolites in human urine by HPLC-accelerator mass spectrometry. In: Toxicology of Skin. Taylor & Francis, Philadelphia, PA. pp.145-157.
  • Fang, Xianx, Terry L. Kaduce, Neal L. Weintraub, Shawn Harmon, Lynn M. Teesch, Christophe Morisseau, David A. Thompson, Bruce D. Hammock, and Author A. Spector. 2001. Pathways of epoxyeicosatrienoic acid metabolism in endothelial cells: Implications for the vascular effects of soluble epoxide hydrolase inhibition. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 276(18):14867-14874.
  • Hennig, Bernhard, Rabih M. Slim, Michal Toborek, Bruce D. Hammock, and Larry W. Robertson. 2001. Cardiovascular disease: endothelial cells as a target for PCB toxicity. In: PCBs: Recent Advances in Environmental Toxicology and Health Effects. University Kentucky Press, Lexington, KY. pp.211-220.
  • Hennig, Bernhard, Saraswathi Viswanathan, Michal Toborek, and Bruce D. Hammock. 2001. Mechanisms of fatty-acid mediated endothelial cell activation. Journal of the American College of Nutrition. (http://www.jacn.org/) Exit NIEHS Website 20:574.
  • Huang, Qihung, Quinn L. Deveraux, Shin Maeda, Henning R. Stennicke, Bruce D. Hammock, and John C. Reed. 2001. Cloning and characterization of an inhibitor of apoptosis protein (IAP) from Bombyx mori. Biochimica et Biophysica Acta. (http://www.elsevier.com/locate/bba) Exit NIEHS Website 1499(3):191-198.
  • Inceoglu, Bora, Jozsef Lango, Jennifer Wu, Pauline Hawkins, James Southern, and Bruce D. Hammock. 2001. Isolation and characterization of a novel type of neurotoxic peptide from the venom of the South African scorpion Parabuthus transvaalicus (Buthidae). European Journal of Biochemistry. 268(20):5407-5413.
  • Lee, Jae Koo, Ki Chang Ahn, Oee Suk Park, Shin Young Kang, and Bruce D. Hammock. 2001. Development of an ELISA for the detection of the residues of the insecticide imidacloprid in agricultural and environmental samples. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 49(5):2159-2167.
  • Matveeva, Evgenia G., Elena V. Gribkova, James R. Sanborn, Shirley J. Gee, Bruce D. Hammock, and Alexander P. Savitsky. 2001. Development of a homogeneous phosphorescent immunoassay for the detection of polychlorinated dibenzo-p-dioxins. Analytical Letters. 34(13):2311-2320.
  • Matveeva, Evgenia G., Guomin Shan, Ian M. Kennedy, Shirley J. Gee, and Bruce D. Hammock. 2001. Homogeneous fluoroimmunoassay of a pyrethroid metabolite in urine. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 444:103-117.
  • Miyashita, Masahiro, Jack M. Presley, Bruce A. Buchholz, Kit S. Lam, Young Moo Lee, John S. Vogel, and Bruce D. Hammock. 2001. Attomole level protein sequencing by Edman degradation coupled with accelerator mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 98(8):4403-4408.
  • Morisseau, Christophe, John W. Newman, Deanna L. Dowdy, Marvin H. Goodrow, and Bruce D. Hammock. 2001. Inhibition of microsomal epoxide hydrolases by ureas, amides and amines. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 14(4):409-415.
  • Newman, John W. and Bruce D. Hammock. 2001. Optimized thiol derivatizing reagent for the mass spectral analysis of disubstituted epoxy fatty acids. Journal of Chromatography A. (http://www.sciencedirect.com/science/journal/ 00219673) Exit NIEHS Website 925(1-2):223-240.
  • Newman, John W., Debra L. Denton, Christophe Morisseau, Cory S. Koger, Craig E. Wheelock, David E. Hinton, and Bruce D. Hammock. 2001. Evaluation of fish models of soluble epoxide hydrolase inhibition. Environmental Health Perspectives. 109(1):61-66.
  • Shan, Guomin and Bruce D. Hammock. 2001. Development of sensitive esterase assays based on alpha-cyano-containing esters. Analytical Biochemistry. (http://www.sciencedirect.com/science/journal/ 00032697) Exit NIEHS Website 299(1):54-62.
  • Shan, Guomin, Whitney R. Leeman, Shirley J. Gee, James R. Sanborn, A. Daniel Jones, Daniel PY Chang, and Bruce D. Hammock. 2001. Highly sensitive dioxin immunoassay and its application to soil and biota samples. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 444:169-178.
  • Sisemore, Marlene F., Jiang Zheng, Joy C. Yang, David A. Thompson, Charles G. Plopper, Gino A. Cortopassi, and Bruce D. Hammock. 2001. Cellular characterization of leukotoxin diol-induced mitochondrial dysfunction. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 392(1):32-37.
  • Slim, Rabih M., Bruce D. Hammock, Michal Toborek, and Larry W. Robertson. 2001. The role of methyl linoleic acid epoxide and diol metabolites in the synergistic toxicity of linoleic acid and PCBs to vascular endothelial cells. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 60:13.
  • Slim, Rabih M., Bruce D. Hammock, Michal Toborek, Larry W. Robertson, John W. Newman, Christophe Morisseau, Bruce A. Watkins, Saraswathi Viswanathan, and Bernhard Hennig. 2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 171(3):184-193.
  • Slim, Rabih M., Bruce D. Hammock, Michal Toborek, Larry W. Robertson, John W. Newman, Christophe Morisseau, Bruce A. Watkins, Saraswathi Viswanathan, and Bernhard Hennig. 2001. The role of methyl-linoleic acid epoxide and diol metabolites in the amplified toxicity of linoleic acid and polychlorinated biphenyls to vascular endothelial cells. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 171(3):184-193.
  • Staimer, Norbert, Shirley J. Gee, and Bruce D. Hammock. 2001. Development of a class-selective enzyme immunoassay for urinary phenolic glucuronides. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 444:27-36.
  • Staimer, Norbert, Shirley J. Gee, and Bruce D. Hammock. 2001. Development of a sensitive enzyme immunoassay for the detection of phenyl-b-D-thioglucuronide in human urine. Fresenius Journal of Analytical Chemistry. (http://link.springer.de/link/service/journals /00216/index_fresenius.htm) Exit NIEHS Website 369(3-4):273-279.
  • Viswanathan, Saraswathi, P. Narayan, Bruce D. Hammock, Purushothaman Meerarani, Michal Toborek, and Bernhard Hennig. 2001. Linoleic acid-derived epoxides alter calcium and nitric oxide metabolism in endothelial cells. FASEB Journal. (http://www.fasebj.org/) Exit NIEHS Website 15:A190.
  • Watanabe, Takaho and Bruce D. Hammock. 2001. Rapid determination of soluble epoxide hydrolase inhibitors in rat hepatic microsomes by high performance liquid chromatography with electrospray tandem mass spectrometry. Analytical Biochemistry. (http://www.sciencedirect.com/science/journal/ 00032697) Exit NIEHS Website 299(2):227-234.
  • Watanabe, Takaho, Guomin Shan, Donald W. Stoutamire, Shirley J. Gee, and Bruce D. Hammock. 2001. Development of a class-specific immunoassay for the type I pyrethroid insecticides. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 444:119-129.
  • Watkins, Steven M., Bruce D. Hammock, John W. Newman, and J. Bruce German. 2001. Individual metabolism should guide agriculture toward foods for improved health and nutrition. American Journal of Clinical Nutrition. (http://www.ajcn.org/) Exit NIEHS Website 74(3):283-286.
  • Wheelock, Craig E., Tonya Severson, and Bruce D. Hammock. 2001. Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 14(12):1563-1572.
  • Wudayagiri, Rajendra, Bora Inceoglu, Rafael Herrmann, Maher Derbel, Prabahakara Choudary, and Bruce D. Hammock. 2001. Isolation and characterization of a novel lepidopteran-selective toxin from the venom of South Indian red scorpion, Mesobuthus tamulus. BMC Biochemistry. (http://www.biomedcentral.com/bmcbiochem) Exit NIEHS Website 2:16.
  • Zheng, Jiang, Charles G. Plopper, Jeffery Lakritz, David H. Storms, and Bruce D. Hammock. 2001. Leukotoxin-diol - A putative toxic mediator involved in acute respiratory distress syndrome. American Journal of Respiratory Cell and Molecular Biology. (http://ajrcmb.atsjournals.org/) Exit NIEHS Website 25(4):434-438.
2000
  • Argiriadi, Maria A., Christophe Morisseau, Marvin H. Goodrow, Deanna L. Dowdy, Bruce D. Hammock, and David W. Christianson. 2000. Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 275(20):15265-15270.
  • Draper, Alison J. and Bruce D. Hammock. 2000. Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 376(1):199-205.
  • Fanucchi, Michelle V., Alan R. Buckpitt, M. Murphy, David H. Storms, Bruce D. Hammock, and Charles G. Plopper. 2000. Development of phase II xenobiotic metabolizing enzymes in differentiating murine Clara cells. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) Exit NIEHS Website 168(3):253-267.
  • Greene, Jessica F., John W. Newman, Kenneth Williamson, and Bruce D. Hammock. 2000. Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 13(4):217-226.
  • Greene, Jessica F., Kenneth Williamson, John W. Newman, Christophe Morisseau, and Bruce D. Hammock. 2000. Metabolism of monoepoxides of methyl linoleate: bioactivation and detoxification. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 376(2):420-432.
  • Greene, Jessica F., Jiang Zheng, David F. Grant, and Bruce D. Hammock. 2000. Cytotoxicity of 1,2-epoxynaphthalene is correlated with protein binding and in situ glutathione depletion in cytochrome P4501A1 expressing Sf-21 cells. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 53(2):352-360.
  • Huang, Qihung, Quinn L. Deveraux, Susumu Maeda, Guy S. Salvesen, Henning R. Stennicke, Bruce D. Hammock, and John C. Reed. 2000. Evolutionary conservation of apoptosis mechanisms: Lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 97:1427-1432.
  • Kido, Horacio, Angel Maquieira, and Bruce D. Hammock. 2000. Disc-based immunoassay microarrays. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 411(1-2):1-11.
  • Lakritz, Jeffery, Bruce S. Winder, Jaffar Noorouz-Zadeh, Tien L. Huang, Alan R. Buckpitt, Bruce D. Hammock, and Charles G. Plopper. 2000. Hepatic and pulmonary enzyme activities in horses. American Journal of Veterinary Research. (http://www.avma.org/publications/default.asp) Exit NIEHS Website 61(2):152-157.
  • Lohse, Christian, Lynn L. Jaeger, Norbert Staimer, James R. Sanborn, A. Daniel Jones, Jozsef Lango, Shirley J. Gee, and Bruce D. Hammock. 2000. Development of a class selective enzyme-linked immunosorbent assay for mercapturic acids in human urine. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 48(12):5913-5923.
  • Morisseau, Christophe, Jeffrey K. Beetham, Frank Pinot, Stephane Debernard, John W. Newman, and Bruce D. Hammock. 2000. Cress and potato soluble epoxide hydrolases: Purification, biochemical characterization, and comparison to mammalian enzymes. Archives of Biochemistry and Biophysics. (http://www.elsevier.com/locate/issn/0003-9861) Exit NIEHS Website 378(2):321-332.
  • Nakagawa, Yoshiaki, Craig E. Wheelock, Christophe Morisseau, Marvin H. Goodrow, Bruce G. Hammock, and Bruce D. Hammock. 2000. 3-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues. Bioorganic & Medicinal Chemistry. (http://www.sciencedirect.com/science/journal/ 09680896) Exit NIEHS Website 8(11):2663-2673.
  • Shan, Guomin, Wei Huang, Shirley J. Gee, Bruce A. Buchholz, John S. Vogel, and Bruce D. Hammock. 2000. Isotope-labeled immunoassays without radiation waste. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 97(6):2445-2449.
  • Shan, Guomin, Whitney R. Leeman, Donald W. Stoutamire, Shirley J. Gee, Daniel PY Chang, and Bruce D. Hammock. 2000. Enzyme-linked immunosorbent assay for the pyrethroid permethrin. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 48(9):4032-4040.
  • Shan, Guomin, James R. Sanborn, Douglas S. Gilman, Scott R. Nagy, Shirley J. Gee, Donald W. Stoutamire, Roger S. Mercer, A. Daniel Jones, Larry H. Stanker, Michael S. Denison, and Bruce D. Hammock. 2000. Surrogates for dioxin analyses: analytical, ELISA and toxicological aspects. Organohalogen Compounds. 45:188-191.
  • Williamson, Kenneth, Christophe Morisseau, Joseph E. Maxwell, and Bruce D. Hammock. 2000. Regio- and enantioselective hydrolysis of phenyloxiranes catalyzed by soluble epoxide hydrolase. Tetrahedron-Symmetry. 11:4451-4462.
  • Yamada, Takashi, Christophe Morisseau, Joseph E. Maxwell, Maria A. Argiriadi, David W. Christianson, and Bruce D. Hammock. 2000. Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 275(30):23082-23088.
  • Yu, Zhigang, Fengyun Xu, Linn M. Huse, Christophe Morisseau, Alison J. Draper, John W. Newman, Carol Parker, LeRae Graham, Marguerite M. Engler, Bruce D. Hammock, Darryl C. Zeldin, and Deanna L. Kroetz. 2000. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circulation Research. (http://circres.ahajournals.org/) Exit NIEHS Website 87(11):992-998.
1999
  • Argiriadi, Maria A., Christophe Morisseau, Bruce D. Hammock, and David W. Christianson. 1999. Detoxification of environmental mutagens and carcinogens: Structure, mechanism, and evolution of liver epoxide hydrolase. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 96:10637-10642.
  • Buchholz, Bruce A., Ester Fultz, Kurt W. Haack, John S. Vogel, Douglas S. Gilman, Shirley J. Gee, Bruce D. Hammock, Xiaoying Hui, Ronald C. Wester, and Howard I. Maibach. 1999. HPLC-accelerator MS measurement of atrazine metabolites in human urine after dermal exposure. Analytical Chemistry. (http://pubs.acs.org/journals/ancham/index.htm l) Exit NIEHS Website 71(16):3519-3525.
  • Draper, Alison J. and Bruce D. Hammock. 1999. Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 52:26-32.
  • Draper, Alison J. and Bruce D. Hammock. 1999. Soluble epoxide hydrolase in rat inflammatory cells is indistinguishable from soluble epoxide hydrolase in rat liver. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 50:30-35.
  • Kido, Horacio, Ferenc Szurdoki, M.S. Gustin, and Bruce D. Hammock. 1999. Chelate sensor method for mercury. In: Metals and Genetics. Kluwer Academic/Plenum Press, NY. pp.235-259.
  • Morisseau, Christophe, Maher Derbel, Terry R. Lane, Donald W. Stoutamire, and Bruce D. Hammock. 1999. Differential induction of hepatic drug-metabolizing enzymes by fenvaleric acid in male rats. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) Exit NIEHS Website 52(2):148-153.
  • Morisseau, Christophe, Marvin H. Goodrow, Deanna L. Dowdy, Jiang Zheng, Jessica F. Greene, James R. Sanborn, and Bruce D. Hammock. 1999. Potent urea and carbamate inhibitors of soluble epoxide hydrolases. Proceedings of the National Academy of Sciences of the United States of America (PNAS). (http://www.pnas.org/) Exit NIEHS Website 96(16):8849-8854.
  • Morisseau, Christophe, Barney L. Ward, David G. Gilchrist, and Bruce D. Hammock. 1999. Multiple epoxide hydrolases in Alternaria alternata f. sp. lycopersici and their relationship to medium composition and host-specific toxin production. Applied and Environmental Microbiology. (http://aem.asm.org/) Exit NIEHS Website 65(6):2388-2395.
  • Mullen, Robert T., Richard N. Trelease, Heike Duerk, Michael Arand, Bruce D. Hammock, Franz Oesch, and David F. Grant. 1999. Differential subcellular localization of endogenous and transfected soluble epoxide hydrolase in mammalian cells: evidence for isozyme variants. FEBS Letters. (http://www.sciencedirect.com/science/journal/ 00145793) Exit NIEHS Website 445(2-3):301-305.
  • Shan, Guomin, Donald W. Stoutamire, Shirley J. Gee, Ingrid Wengatz, and Bruce D. Hammock. 1999. Development of an immunoassay for the pyrethroid insecticide esfenvalerate. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 47(5):2145-2155.
  • Shan, Guomin, Ingrid Wengatz, Donald W. Stoutamire, Shirley J. Gee, and Bruce D. Hammock. 1999. An enzyme-linked immunosorbent assay for the detection of esfenvalerate metabolites in human urine. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 12(11):1033-1041.
  • Thomas, Beth Ann, W. Bret Church, Terry R. Lane, and Bruce D. Hammock. 1999. Homology model of juvenile hormone esterase from the crop pest, Heliothis virescens. Proteins. 34(2):184-196.
  • Yazynina, Elena V., Anatoliy V. Zherdev, Boris B. Dzantiev, Vladimir A. Izumrudov, Shirley J. Gee, and Bruce D. Hammock. 1999. Immunoassay techniques for detection of the herbicide simazine based on use of oppositely charged water-soluble polyelectrolytes. Analytical Chemistry. (http://pubs.acs.org/journals/ancham/index.htm l) Exit NIEHS Website 71(16):3538-3543.
  • Yazynina, Elena V., Anatoliy V. Zherdev, Boris B. Dzantiev, Vladimir A. Izumrudov, Shirley J. Gee, and Bruce D. Hammock. 1999. Microplate immunoassay technique using polyelectrolyte carriers: kinetic studies and application to detection of the herbicide atrazine. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 399(1-2):151-160.
1998
  • Gilman, Douglas S., Shirley J. Gee, Bruce D. Hammock, John S. Vogel, Kurt W. Haack, Bruce A. Buchholz, Stewart PHT Freeman, Ronald C. Wester, Xiaoying Hui, and Howard I. Maibach. 1998. Analytical performance of accelerator mass spectrometry and liquid scintillation counting for detection of 14C-labeled atrazine metabolites in human urine. Analytical Chemistry. (http://pubs.acs.org/journals/ancham/index.htm l) Exit NIEHS Website 70(16):3463-3469.
  • Goodrow, Marvin H. and Bruce D. Hammock. 1998. Hapten design for compound-selective antibodies: ELISA's for environmentally deleterious small molecules. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 376(1):83-91.
  • Harris, Adam S., Ingrid Wengatz, Monika Wortberg, Sabine B. Kreissig, Shirley J. Gee, and Bruce D. Hammock. 1998. Development and application of immunoassays for biological and environmental monitoring. In: Effects of Multiple Impacts on Ecosystems. Lewis Publishers, Chelsea, MI. pp.135-153.
  • Jaeger, Lynn L., A. Daniel Jones, and Bruce D. Hammock. 1998. Development of an enzyme-linked immunosorbent assay for atrazine mercapturic acid in human urine. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 11(4):342-352.
  • Marco, Maria-Pilar, Shirley J. Gee, and Bruce D. Hammock. 1998. Determination of 1-naphthol in well water samples by ELISA. In: Current Protocols in Field Analytical Chemistry. (V. Lopez-Avila, ed.) John Wiley & Sons, New York, NY. pp.2C.9.1-2C.9.11.
  • Marco, Maria-Pilar, Shirley J. Gee, and Bruce D. Hammock. 1998. Determination of carbaryl in well water samples by ELISA. In: Current Protocols in Field Analytical Chemistry. (V. Lopez-Avila, ed.) John Wiley & Sons, New York, NY. pp.2C8.1-2C8.15.
  • Mitchell, Alyson E., Jiang Zheng, Bruce D. Hammock, Mario Lo Bello, and A. Daniel Jones. 1998. Structural and functional consequences of haloenol lactone inactivation of murine and human glutathione S-transferase. Biochemistry. (http://pubs.acs.org/journals/bichaw/index.htm l) Exit NIEHS Website 37(19):6752-6759.
  • Reimer, Gerry J., Shirley J. Gee, and Bruce D. Hammock. 1998. Comparison of a time-resolved fluorescence immunoassay and an enzyme-linked immunosorbent assay for the analysis of atrazine in water. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 46(8):3353-3358.
  • Sanborn, James R., Shirley J. Gee, Douglas S. Gilman, Yukio Sugawara, A. Daniel Jones, J. Rogers, Ferenc Szurdoki, Larry H. Stanker, Donald W. Stoutamire, and Bruce D. Hammock. 1998. Hapten synthesis and antibody development for polychlorinated dibenzo-p-dioxin immunoassays. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 46:2407-2416.
  • Sugawara, Yukio, Shirley J. Gee, James R. Sanborn, Douglas S. Gilman, and Bruce D. Hammock. 1998. Development of a highly sensitive enzyme-linked immunosorbent assay based on polyclonal antibodies for the detection of polychlorinated dibenzo-p-dioxins. Analytical Chemistry. (http://pubs.acs.org/journals/ancham/index.htm l) Exit NIEHS Website 70(6):1092-1099.
  • Wengatz, Ingrid, Donald W. Stoutamire, Shirley J. Gee, and Bruce D. Hammock. 1998. Development of an enzymelinked immunosorbent assay for the detection of the pyrethroid insecticide fenpropathrin. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 46(6):2211-2221.
1997
  • Jones, Geoffrey, Monika Wortberg, David M. Rocke, and Bruce D. Hammock. 1997. Immunoassay of cross-reacting analytes. In: Immunochemical Technology for Environmental Applications (ACS Symposium Series No. 657). American Chemical Society, Washington, DC. pp.331-342.
  • Kido, Horacio, Marvin H. Goodrow, Valerie Griffeth, Ann D. Lucas, Shirley J. Gee, and Bruce D. Hammock. 1997. Development of an enzyme-linked immunosorbent assay for the detection of hydroxytriazines. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 45(2):414-424.
  • Moghaddam, Mehran F., David F. Grant, Jeffrey M. Cheek, Jessica F. Greene, Kenneth Williamson, and Bruce D. Hammock. 1997. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase. Nature Medicine. (http://www.nature.com/nm/) Exit NIEHS Website 3(5):562-566.
  • Schutz, S., Ingrid Wengatz, Marvin H. Goodrow, Shirley J. Gee, Hans E. Hummel, and Bruce D. Hammock. 1997. Development of an enzyme-linked-immunosorbent assay for azadirachtins. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 45(6):2363-2368.
  • Swamy, Anand R., M.I. Danesvar, L. Evans, III, L. Strekowski, N. Narayanan, Ferenc Szurdoki, Ingrid Wengatz, Bruce D. Hammock, and Gabor Patonay. 1997. Near-infrared fluorescent immunoassays: A novel approach to environmental analysis. In: Immunochemical Technology for Environmental Applications (ACS Symposium Series No. 657). American Chemical Society, Washington, DC. pp.141-161.
  • Szurdoki, Ferenc, Horacio Kido, and Bruce D. Hammock. 1997. Rapid mercury assays. In: Immunochemical Technology for Environmental Applications (ACS Symposium Series No. 657). American Chemical Society, Washington, DC. pp.38-48.
  • Zheng, Jiang, Myung Cho, A. Daniel Jones, and Bruce D. Hammock. 1997. Evidence of quinone metabolites of naphthalene covalently bound to sulfur nucleophiles of proteins of murine clara cells after exposure to naphthalene. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 10(9):1008-1014.
1996
  • Grant, David F., Jessica F. Greene, Frank Pinot, Babak Borhan, Mehran F. Moghaddam, Bruce D. Hammock, Bill McCutchen, Hideo Ohkawa, Gang Luo, and Thomas M. Guenthner. 1996. Development of an in situ toxicity assay system using recombinant baculoviruses. Biochemical Pharmacology. (http://www.elsevier.com/wps/find/journaldescr iption.cws_home/525454/description#descriptio n) Exit NIEHS Website 51(4):503-515.
  • Jones, Geoffrey, Monika Wortberg, Bruce D. Hammock, and David M. Rocke. 1996. A procedure for the immunoanalysis of samples containing one or more members of a group of cross-reacting analytes. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 336(1-3):175-183.
  • Jones, Geoffrey, Monika Wortberg, Sabine B. Kreissig, Bruce D. Hammock, and David M. Rocke. 1996. Application of the bootstrap to calibration experiments. Analytical Chemistry. (http://pubs.acs.org/journals/ancham/index.htm l) Exit NIEHS Website 68(5):763-770.
  • Linde, C.D., Shirley J. Gee, Kean S. Goh, Jean C. Hsu, Bruce D. Hammock, Terrell A. Barry, and Don J. Weaver. 1996. Regulatory application of ELISA: Compliance monitoring of bromacil in soil. Bulletin of Environmental Contamination and Toxicology. (http://link.springer.de/link/service/journals /00128/tocs.html) Exit NIEHS Website 57(2):264-269.
  • Szurdoki, Ferenc, Lynn L. Jaeger, Adam S. Harris, Horacio Kido, Ingrid Wengatz, Marvin H. Goodrow, Andras Szekacs, Monika Wortberg, Jiang Zheng, Donald W. Stoutamire, James R. Sanborn, Douglas S. Gilman, A. Daniel Jones, Shirley J. Gee, Prabahakara Choudary, and Bruce D. Hammock. 1996. Rapid assays for environmental and biological monitoring. Journal of Environmental Science and Health. (http://www.informaworld.com/smpp/title~conten t=t713597268) Exit NIEHS Website 31(3):451-458.
  • Wengatz, Ingrid, Adam S. Harris, Douglas S. Gilman, Monika Wortberg, Horacio Kido, Ferenc Szurdoki, Marvin H. Goodrow, L. Jaeger, Donald W. Stoutamire, James R. Sanborn, Shirley J. Gee, and Bruce D. Hammock. 1996. Recent developments in immunoassays and related methods for the detection of xenobiotics. In: Environmental Immunochemical Methods, Perspectives and Applications. ACS Symposium Series No. 646, American Chemical Society, Washington, DC. pp.110-126.
  • Wortberg, Monika, Marvin H. Goodrow, Shirley J. Gee, and Bruce D. Hammock. 1996. Immunoassay for simazine and atrazine with low cross-reactivity for propazine. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 44(8):2210-2219.
  • Wortberg, Monika, Geoffrey Jones, Sabine B. Kreissig, David M. Rocke, Shirley J. Gee, and Bruce D. Hammock. 1996. An approach to the construction of an immunoarray for differentiating and quantitating cross reacting analytes. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 319(3):291-303.
  • Zheng, Jiang and Bruce D. Hammock. 1996. Development of polyclonal antibodies for detection of protein modification by 1,2-naphthoquinone. Chemical Research in Toxicology. (http://pubs.acs.org/journals/crtoec/index.htm l) Exit NIEHS Website 9(5):904-909.
  • Zheng, Jiang, Alyson E. Mitchell, A. Daniel Jones, and Bruce D. Hammock. 1996. Haloenol lactone is a new isozyme-selective and active site-directed inactivator of glutathione S-transferase. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 271(34):20421-20425.
1995
  • Borhan, Babak, A. Daniel Jones, Frank Pinot, David F. Grant, Mark Kurth, and Bruce D. Hammock. 1995. Mechanism of soluble epoxide hydrolase. Formation of An a-hydroxy ester-enzyme intermediate through Asp-333. Journal of Biological Chemistry. (http://www.jbc.org/) Exit NIEHS Website 270(45):26923-26930.
  • Choudary, Prabahakara, Heather A. Lee, Bruce D. Hammock, and Michael RA Morgan. 1995. Recombinant antibodies: New tools for immunoassays. Chapter 13 in: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.171-185.
  • Gee, Shirley J., Bruce D. Hammock, and John H. Skerritt. 1995. Diagnostics for plant agrochemicals--a meeting of chemistry and immunoassay. In: New Diagnostics in Crop Sciences. CAB International, Oxon, United Kingdom. pp.243-276.
  • Gee, Shirley J., Ann D. Lucas, and Bruce D. Hammock. 1995. Using immunochemical methods to analyze for biomarkers of exposure. In: Proceedings of the NATO (North Atlantic Treaty Organisation) Workshop on Methods of Pesticide Exposure Assessment. Ottawa, Canada.
  • Gee, Shirley J., Ann D. Lucas, and Bruce D. Hammock. 1995. Using immunochemical methods to analyze for biomarkers of exposure. In: Methods of Pesticide Exposure Assessment. Plenum Press, NY. pp.143-155.
  • Goodrow, Marvin H., James R. Sanborn, Donald W. Stoutamire, Shirley J. Gee, and Bruce D. Hammock. 1995. Strategies for immunoassay hapten design. In: Immunoanalysis of Agrochemicals: Emerging Technologies (ACS Symposium Series 586). American Chemical Society, Washington, DC. pp.119-139.
  • Hammock, Bruce D. and Shirley J. Gee. 1995. Impact of emerging technologies on immunochemical methods for environmental analysis. In: Immunoanalysis of Agrochemicals: Emerging Technologies (ACS Symposium Series 586). American Chemical Society, Washington, DC. pp.1-19.
  • Harris, Adam S., Ann D. Lucas, Petra M. Kramer, Maria-Pilar Marco, Shirley J. Gee, and Bruce D. Hammock. 1995. Use of immunoassay for the detection of urinary biomarkers of exposure. In: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.217-235.
  • Jones, Geoffrey, Monika Wortberg, Sabine B. Kreissig, Bruce D. Hammock, and David M. Rocke. 1995. Sources of experimental variation in calibration curves for enzyme-linked immunosorbent assay. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 313:197-207.
  • Kreissig, Sabine B., Vernon K. Ward, Bruce D. Hammock, and Prabahakara Choudary. 1995. Nucleotide sequence of the variable region of the heavy and light chains of a monoclonal lgG antibody reactive to herbicides, terbutryn and prometryn. DNA Sequence. (http://www.business-magazines.com/product.php ?prd=108135) Exit NIEHS Website 6:51-54.
  • Kreissig, Sabine B., Vernon K. Ward, Bruce D. Hammock, and Prabahakara Choudary. 1995. Sequence analysis of individual chains of antibodies to triazine herbicides. In: Immunoanalysis of Agrochemicals: Emerging Technologies (ACS Symposium Series 586). American Chemical Society, Washington, DC. pp.31-49.
  • Lucas, Ann D., Shirley J. Gee, Bruce D. Hammock, and James N. Seiber. 1995. Integration of immunochemical methods with other analytical techniques for pesticide residue determination. Journal of AOAC International. (http://www.aoac.org/pubs/pubjaoac.html) Exit NIEHS Website 78(3):585-591.
  • Lucas, Ann D., Marvin H. Goodrow, James N. Seiber, and Bruce D. Hammock. 1995. Development of an ELISA for the N-dealkylated s-triazines: Application to environmental and biological samples. Food & Agricultural Immunology. (http://www.gbhap.com/journals/titles/09540105 .asp) Exit NIEHS Website 7:227-241.
  • Marco, Maria-Pilar, Serge Chiron, Jordi Gascon, Bruce D. Hammock, and Damia Barcelo. 1995. Validation of two immunoassay methods for environmental monitoring of carbaryl and 1-naphthol in ground water samples. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 311(3):319-329.
  • Schneider, P., Shirley J. Gee, Sabine B. Kreissig, Adam S. Harris, Petra M. Kramer, Maria-Pilar Marco, Ann D. Lucas, and Bruce D. Hammock. 1995. Troubleshooting during the development and use of immunoassays for environmental monitoring. In: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.103-122.
  • Sundaram, K.MS, A. Sundaram, Shirley J. Gee, R.O. Harrison, and Bruce D. Hammock. 1995. Enzyme-linked immunosorb and assay for quantification of Bacillus thuringiensis var. kurstaki crystaline protein in commerical formulations, in relation to total protein content and insecticidal activity. In: Pesticide Formulations and Applicaiton Systems, 14th Volume. American Society for Testing and Materials, Philadelphia, PA.
  • Szekacs, Andras and Bruce D. Hammock. 1995. Development of an enzyme-linked immunosorbent assay for the detection of the triazole fungicide myclobutanil. Journal of Agricultural and Food Chemistry. (http://pubs.acs.org/journals/jafcau/) Exit NIEHS Website 43(8):2083-2091.
  • Szekacs, Andras, F. Jung, and Bruce D. Hammock. 1995. Chemical modification of haptens: Selective amino group protection by chromophores for an immunoassay for aminotriazoles. In: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.65-75.
  • Szurdoki, Ferenc, Hassan KM Bekheit, Maria-Pilar Marco, Marvin H. Goodrow, and Bruce D. Hammock. 1995. Important factors in hapten design and enzyme-linked immunosorbent assay development. In: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.39-63.
  • Szurdoki, Ferenc, Horacio Kido, and Bruce D. Hammock. 1995. Development of assay for analysis of Hg2+ based on sulfur-containing ligands. In: Immunoanalysis of Agrochemicals: Emerging Technologies (ACS Symposium Series 586). American Chemical Society, Washington, DC. pp.248-264.
  • Szurdoki, Ferenc, Horacio Kido, and Bruce D. Hammock. 1995. Development of rapid mercury assays. Synthesis of sulfur-and mercury-containing conjugates. Bioconjugate Chemistry. (http://pubs.acs.org/journals/bcches/index.htm l) Exit NIEHS Website 6(2):145-149.
  • Ward, Vernon K., Bruce D. Hammock, Shin Maeda, and Prabahakara Choudary. 1995. Development and application of recombinant antibodies to pesticide residue analysis. In: New Frontiers in Agrochemical Immunoassay. AOAC International, Arlington, VA. pp.197-216.
  • Ward, Vernon K., Sabine B. Kreissig, Bruce D. Hammock, and Prabahakara Choudary. 1995. Generation of an expression library in the baculovirus expression vector system. Journal of Virological Methods. (http://www.sciencedirect.com/science/journal/ 01660934) Exit NIEHS Website 53(2-3):263-272.
  • Wengatz, Ingrid, Ferenc Szurdoki, Anand R. Swamy, Lawrence Evans, Gabor Patonay, Eric Stimman, Michael Delwiche, Donald W. Stoutamire, Shirley J. Gee, and Bruce D. Hammock. 1995. Immunoassays for pesticide monitoring. SPIE Proceedings, San Jose, CA. 408-416.
  • Wortberg, Monika, Sabine B. Kreissig, Geoffrey Jones, David M. Rocke, and Bruce D. Hammock. 1995. An immunoarray for the simultaneous determination of multiple triazine herbicides. Analytica Chimica Acta. (http://www.sciencedirect.com/science/journal/ 00032670) Exit NIEHS Website 304:339-352.
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