Duke University: Developmental Effects of Superfund Hydrocarbon Mixtures in Fundulus heteroclitus
Duke University: Microbial and Photolytic Transformations of Superfund Chemicals
FCX, Inc. (Washington Plant)
Duke University: Developmental Effects of Superfund Hydrocarbon Mixtures in Fundulus heteroclitus
Duke University: Microbial and Photolytic Transformations of Superfund Chemicals
Georgia-Pacific Corporation Hardwood Sawmill, Washington County
Duke University: Developmental Effects of Superfund Hydrocarbon Mixtures in Fundulus heteroclitus
Duke University: Microbial and Photolytic Transformations of Superfund Chemicals
Publications
2008
Billiard, Sonya M., Joel N. Meyer, Deena M. Wassenberg, Peter V. Hodson, and Richard T. Di Giulio. 2008. Nonadditive effects of PAHs on early vertebrate development: mechanisms and implications for risk assessment. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) doi:10.1093/toxsci/kfm303(http://dx.doi.org/10.1093/toxsci/kfm303) 105(1):5-23.
Matson, Cole W., Bryan W. Clark, M.J. Jenny, Carrie R. Fleming, Mark E. Hahn, and Richard T. Di Giulio. 2008. Development of the morpholino gene knockdown technique in Fundulus heteroclitus: a tool for studying molecular mechanisms in an established environmental model. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) doi:10.1016/j.aquatox.2008.02.010(http://dx.doi.org/10.1016/j.aquatox.2008.02.0 10) 87(4):289-95.
Timme-Laragy, Alicia R., Pamela D. Noyes, Donald R. Buhler, and Richard T. Di Giulio. 2008. CYP1B1 knockdown does not alter synergistic developmental toxicity of polycyclic aromatic hydrocarbons in zebrafish (Danio rerio). Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) doi:10.1016/j.marenvres.2008.02.030(http://dx.doi.org/10.1016/j.marenvres.2008.02 .030) 66(1):85-7.
2007
Burnett, K.G., L.J. Bain, W.S. Baldwin, Gloria V. Callard, S. Cohen, Richard T. Di Giulio, D.H. Evans, M. Gomez-Chiarri, Mark E. Hahn, C.A. Hoover, Sibel I. Karchner, F. Katoh, D.L. MacLatchy, W.S. Marshall, J.N. Meyer, D.E. Nacci, M.F. Oleksiak, B.B. Rees, T.P. Singer, John J. Stegeman, D.W. Towle, P. A V Veld, W.K. Vogelbein, A. Whitehead, R.N. Winn, and D.L. Crawford. 2007. Fundulus as the Premier Teleost Model in Environmental Biology: Opportunities for New Insights Using Genomics. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics. (http://www.sciencedirect.com/science/journal/ 1744117X) 2:257-286.
Ostrander, Gary K., Richard T. Di Giulio, David E. Hinton, M.R. Miller, and J.R. Rotchell. 2007. Chemical Carcinogensis. In: The Toxicology of Fishes(http://www.nhbs.com/title.php?tefno=123130) . Taylor & Francis, Boca Raton, FL.
Timme-Laragy, Alicia R., C. Cockman, Cole W. Matson, and Richard T. Di Giulio. 2007. Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) 85(4):241-50.
2006
Arzuaga, Xabier, Deena M. Wassenberg, Richard T. Di Giulio, and Adria A. Elskus. 2006. The chlorinated AHR ligand 3,32,4,42,5-pentachlorobiphenyl (PCB126) promotes reactive oxygen species (ROS) production during embryonic development in the killifish (Fundulus heteroclitus). Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) 76(1):13-23.
Billiard, Sonya M., Alicia R. Timme-Laragy, Deena M. Wassenberg, C. Cockman, and Richard T. Di Giulio. 2006. The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 92:526-536.
Embry, Michelle Rau, Sonya M. Billiard, and Richard T. Di Giulio. 2006. Lack of p53 induction in fish cells by model chemotherapeutics. Oncogene. (http://www.nature.com/onc/) 25(14):2004-2010.
Timme-Laragy, Alicia R., Edward D. Levin, and Richard T. Di Giulio. 2006. Developmental and behavioral effects of embryonic exposure to the polybrominated diphenylether mixture DE-71 in the killifish (Fundulus heteroclitus). Chemosphere. (http://www.sciencedirect.com/science/journal/ 00456535) 62(7):1097-1104.
2005
Meyer, Joel N., David C. Volz, Jonathan H. Freedman, and Richard T. Di Giulio. 2005. Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) 73(4):327-341.
Nacci, Diane E., L. Coiro, Deena M. Wassenberg, and Richard T. Di Giulio. 2005. A non-destructive technique to measure cytochrome P4501A enzyme activity in living embryos of the estuarine fish Fundulus heteroclitus. Chapter Vol. 2 in: Techniques in Aquatic Toxicology. CRC Press, Inc., Boca Raton, FL. pp.209-226.
Timme-Laragy, Alicia R., Joel N. Meyer, Robert A. Waterland, and Richard T. Di Giulio. 2005. Analysis of CpG methylation in the killifish CYP1A promoter. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 141(4):406-411.
Wassenberg, Deena M., Abby L. Nerlinger, Lauren P. Battle, and Richard T. Di Giulio. 2005. Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities. Environmental Toxicology and Chemistry. (http://etc.allenpress.com/entconline/?request =index-html) 24(10):2526-2532.
2004
Bacanskas, Lisa R., Julia Whitaker, and Richard T. Di Giulio. 2004. Oxidative stress in two populations of killifish (Fundulus heteroclitus) with differing contaminant exposure histories. Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) 58(2-5):597-601.
Craft, Elena S., Michelle Rau Embry, Richard T. Di Giulio, and Jonathan H. Freedman. 2004. Evidence for the role of p53 in metal-induced activation of metallothionein gene expression. In: Metal Ions in Biology and Medicine: Proceedings of the Eighth International Symposium on Metal Ions in Biology and Medicine. John Libbey Eurotext Publishers, Montrouge, France.
Embry, Michelle Rau, Julia Whitaker, Jonathan H. Freedman, and Richard T. Di Giulio. 2004. Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. (http://www.sciencedirect.com/science/journal/ 15320456) 137(4):335-342.
Wassenberg, Deena M. and Richard T. Di Giulio. 2004. Synergistic Embryotoxicity of Polycyclic Aromatic Hydrocarbon Aryl Hydrocarbon Receptor Agonists with Cytochrome P4501A Inhibitors in Fundulus heteroclitus. Environmental Health Perspectives. 112(17):1658-1664.
Wassenberg, Deena M. and Richard T. Di Giulio. 2004. Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors. Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) 58(2-5):163-168.
2003
Meyer, Armando, Jim D. Smith, Gary W. Winston, and Richard T. Di Giulio. 2003. Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) 65(4):377-395.
Meyer, Joel N. and Richard T. Di Giulio. 2003. Heritable adaptation and fitness costs in killifish (Fundulus heteroclitus) inhabiting a polluted estuary. Ecological Applications. (http://www.jstor.org/journals/10510761.html) 13(2):490-503.
Meyer, Joel N., Deena M. Wassenberg, Sibel I. Karchner, Mark E. Hahn, and Richard T. Di Giulio. 2003. Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories. Environmental Toxicology and Chemistry. (http://etc.allenpress.com/entconline/?request =index-html) 22(10):2337-2343.
2002
Meyer, Joel N. and Richard T. Di Giulio. 2002. Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) 54(3-5):621-626.
Meyer, Joel N., Diane E. Nacci, and Richard T. Di Giulio. 2002. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicological Sciences. (http://www3.oup.co.uk/toxsci/) 68(1):69-81.
Schlenk, Daniel R. and Richard T. Di Giulio. 2002. Biochemical responses as indicators of aquatic ecosystem health. In: Biological Indicators of Aquatic Ecosystem Stress. American Fisheries Society, Bethesda, MD. pp.13-422.
Wassenberg, Deena M., Erin E. Swails, and Richard T. Di Giulio. 2002. Effects of combined exposures to benzo[a]pyrene and 3,3',4,4',5-pentachlorobiphenyl on Fundulus heteroclitus. Marine Environmental Research. (http://www.sciencedirect.com/science/journal/ 01411136) 54(3-5):279-283.
2001
Toomey, Barbara H., Susan M. Bello, Mark E. Hahn, Susannah Cantrell, Peggy Wright, Donald E. Tillett, and Richard T. Di Giulio. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) 53(2):127-138.
Toomey, Barbara H., Susan M. Bello, Mark E. Hahn, Susannah Cantrell, Peggy Wright, Donald E. Tillitt, and Richard T. Di Giulio. 2001. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X) 53(2):127-138.
Willett, Kristine L., Laila Lienesch, William Reichert, and Richard T. Di Giulio. 2001. In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Toxicology and Applied Pharmacology. (http://www.academicpress.com/tap) 177(3):264-271.
2000
Toomey, Barbara H., Susan M. Bello, Mark E. Hahn, Susannah Cantrell, Peggy Wright, Donald E. Tillitt, and Richard T. Di Giulio. 2000. TCDD induces apoptotic cell death and cytochrome P4501A expression in developing Fundulus heteroclitus embryos. Aquatic Toxicology. (http://www.sciencedirect.com/science/journal/ 0166445X)
1998
Ploch, S.A., Jun Nakamura, James A. Swenberg, and Richard T. Di Giulio. 1998. Assessment of AP site formation in isolated hepatocytes from brown bullhead upon treatment with benzo(a)pyrene. Fundamental and Applied Toxicology. (http://www.sciencedirect.com/science/journal/ 02720590) 42:82.
1997
Gray, L.Earl, William R. Klece, Tom Wiese, Rochelle Tyl, Kevin Gaido, Jon Cook, Gary Klinefelter, Daniel Desaulniers, Elizabeth Wilson, Timothy R. Zacharewski, Chris Waller, Paul Foster, John Laskey, Jerry Reel, John P. Giesy, Susan Laws, John A. McLachlan, William Breslin, Ralph Cooper, Richard T. Di Giulio, Rodney Johnson, Richard Purdy, Ellen Mihaich, Stephen H. Safe, Carlos Sonnenschein, Wade Welshons, Ron Miller, Susan McMaster, and Theo Colborn. 1997. Endocrine screening methods workshop report: Detection of estrogenic and androgenic hormonal and antihormonal activity for chemicals that act via receptor or steroidogenic enzyme mechanisms. Reproductive Toxicology. (http://www.sciencedirect.com/science/journal/ 08906238) 11(5):719-750.
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