()I,'I 'I S,l ().@\7 At its Sopteii)j'.),-r 21, 1970 on Cei-cbro- vascular I)i-soase, the fol.1.01-11'.1.1'11, resolution Several s'L-tiair-,s of aiitili),,,)ert(-@risix@c d-.ct,(,s ill YcduciP,,-, t'l- frcclu- c o' stroke, and to a lesser deoi-co, coro,,I.-).-ry disease. Study of a of stil)j,-,,--Ls to Over 500 risen for i-ip to yc,,z,,rs aTI)oitli--- 20 iri,--)iitlis) In tl-ios,-- pp@ysons iij-tli very h@--@"i blood I)rc,,ssi..ir-- , the, -results 4-1 favored the treatr,.,,c,--ot (,-coup so Ci-i-zlillia-L:'Lca)-i-y investioators col-isidc,,red tfiit t]-ic,,)r ii,.,ust teli@,dn,-t-Le the for reasons of i-,---dical In the crc)ul) rich r,,,oiest blood T.-)-rc;ssurl-, the s col@.1r@'le -;b ),i 1-d@ci results s-@,-roll(,Iy StLicl@y w@-i-s all-o@ to r-Lin -i. t cl al- C, l 4C], in favor o@ c treated --Coup BlObrl pro-@uro TeducL- i-ois aC]IIC@Ve d I,,7ere 'I'hc.,, disease c@ite-. gories ij-,o-q-t niarl.@e(jiv affected tl3(@, coi-ic,,estive heart failure, accelerated icc,@iial and sti,ol-le. Ili-- re- eciliivocal- but par]-iaps sults I,,Iit'll corollary artery disease are sl,.ovi a gejiuinc reduction in sudden d - a -Ll@s. ThO results for stroke are sLir,-,Tari.zed as follo-t,,rs: Treated Control All events 5 20 lvlost serious events 12 -ited arbup have stroke events, but those -Thus, not only did t@6 troc e., that occurred i@ere n@,acil less likely to be seirere. Since this represents a dramatic and extrc@ricl.y hopeful develop"q"c-,]-It in t]16 control of stroke, the Joint Coil,-icil Subcoly!iii,'Lttc-,@e on Corebrovasciil.ar Dis- ease, @,I]LI-NIXDS, stronal rocoji--.,,,,.eiids tlict fi@rtl?c-r Steps shoz@Zd be y as Bass ,as e=eeitiovsl..u o,-, d ibze; n ti'?at a b,-, co@v--i.ed -t',-O de,3ion te@sive, t'nero-o?@ on e Joint Council SubcoiTmttee recolf2liended that the above resolution be for- rded to the National Advisory flea-rt and Lunc, Council, the National @%dvi.so-ry urol6,2ical Di.,,easr-@s and Stroke Council, and the I\Iational Advisory Council Oil gional I,!--dical Proa@anis. t4 A') I A L I i,: E@ I I l'Ul j- @7 I.' ,11: I iA L'I'l -1 c 0, j@ Drf@,: Nc)vero@,Dc3r 24, 1970 *I"/,Iy to F4 E@, I - OD ,@t@ljcct: Council Rc@@3ol.ution on Aii@@-ihypocL-leii@;ivc, and St)-oke- Preve-.n-c@ Dircc'L-.or, NIII --,7 L De ',?u Di)---c.,c-or, I\'Tlj At its iriec@IL--j.ijg c),,-i 1970, t--.!-ic N@iti.on@.11- Nc---@urolc)cji.cFil Str(-)3,,(@ C(-)i-iici.1 cc)nc-@i-dc-@rc@0,. the rc-,soliiti-o- of the ic)-i-i-)t Cc)-;-,,)ici-I. !7,u!Dc,c)-Ir.,i-ri-I. -(-?c on Disease, I\TINDE) and resc)].-u-IL--'.'t-0i'l urcje-.(.i L, L- ste,Ds be as ci,-iCi ,.gg-cessi.vc,,I.y as poss-i.','Dl-e, n,-,r@-.c tl-i a L'- a co,-,,Lrii-ttc.-3 be conv(--@--r)e,,.t -Lc) dc@si@fn, study and i-ii@plemerit the appl ication of aii'L-Iiliyp,@r'L-c,-iisivc,-.. @thci-Eipy on community IDases.11 Aftel' czirc--,41-u.1 c)" 'L--)-jc-,, research ii)forpjiEtion a-,.-ailab-",c,- and of tl-,Ic-, iiLii-)-I-ica-Lli-c)nF; of as one effec-@(----': C)" in @tro"'(:,l n, -I-, Y'@dvi.sory Council ii L-h rc-coiiijcienclc,d -Iiis resolution be to the Re,-,fj@c).nal @@c.@i. Prc"grzlras Sel.-N7icc-@ for and h l,',Tll,'k,fDS CoLinci-i asked wc,, urgc.@ t]-ic Aivif@ory Council ol- consider taking active steps to i-i-nplc.,i,.ic@n-'c. further and expa-nO, activities on L,.tro3@c cori'L-.rol-; ac-(--i-\7itiec, might include @L-h6 organization 0-ic c@trefull planned, co-,Rinun-i-ty based field trials, y designed to test the effect on a co-.Qilnuni-Ly basis of stroke control through adequate antiliyperteiisj-\70, T4d Advisory Council and staff of -the NINDS are prparecl o be ol-- whatever assistance necessary to aid R-%IPS as required and apprbbri Eldon L. Eagles, M.D., C.M., Dr. P.I-I.. A,Cting Director lq8tional in8tituL--e'of Neurologi.cal Diseases :@nd S-L-rol-,e Encloi3ure A;\]D D,tc: 2, 1-970 to Nill,"-OD cl-It of I-IypErtensioll T clation re NIII T] TIIRO'kiGII.- 1) e r-) uy Di-rec.@L'O:c, aj- its 7.,,dviso3--y @).i-d iiing@ Council t- tllc, to it by Jo-iiit Co,,),ri@il on Cc-2i,-cbrc)@y@iscular Disease of the I.,,Iati-on@-13- of and Strol,.e and -@lic- .-Fns-Li.tu-te. j-@ copy of this resolution concerning the trc.,atriic-,nt of hy,p,@r- tension is attached. 2. Pascal upon recei-%!-- cl-irii-(,al- of tlic, effectiveness d flrec,,tienc-- of- st).-oke o z:t Y,, I-) -r:zicj s3-1-1 C, @7 (an(3., in trati.bn C6oi.:,,cra-Live J-04.]-)t cokiic-i-1 SubcorL-@.iiiittee be to.]-1cri as c-,,xpo.(ai- tiously and aggressively as possi.-)Dl,o, coll-Lillit---@ IL-ee be, convened to design a stud@7 and i.ii,,pl.eiiien-L the api-)licEl- tion of aiitihyi-erL@-ei-iFive on bases." 3. The Na't-ional Advisory I-iczirt and ]'lung Council dis@ussed this recoiir.--@iendz,,,@-.-Lon ill do-tail and at coiiF3.i.dcrabl-c- I.engtl-i. The council acce,-)tc@d and endorsed staterL@t(-nt in principle and i-tLr,iunity-basc-,,@i stu.,-i:i.es desi@ as agreed that co 3@ecl p) iyiiarily demonstration progra,-n.7; c;ho@ild be uiadertzi-Y,(:,@n by the Region -71 1 4- edi.cal -rro rairLs. th Cc,-.-,nci,l noted JL--ha@ there --Ls O@- .1 i d need f additional controlled clinical trial-, to determine the effectiveness of anjL--il-i@,,per-'L-lc.,,nsivc tlic@i-apy in the general C population and in defined population grougs. Efforts to accom- pli@SI-i the latter are already underplay wi--Lliiri this Institute. The l,,Tatio-nal-lic-@z,,rt'and lui-ig Institute has established an ad hoc n linic--3- trials in hi la blood pressure and wc, have panel o c ct received their recommendations. r@'-Lirtlieri-nore, the Institute is preparing a Request Lror Proposals for controlled cl.in cal trials of the therapy of hypertension in the general population. 4. We vieNv these developments as one of the major oppc)r- tuni.ti-&s to reduce the'mortality and morbidity attributable to hypertension. Theodore Cooper, M.D. Director