Cancer, Reproductive, and Cardiovascular Diseases
Outputs: Publications
Selected Publications
Cancer
Metals
Effect of stainless steel manual metal arc welding fume on free radical production, DNA damage, and apoptosis induction
Mol Cell Biochem 2005 Nov; 279(1-2):17-23
This publication summarizes the effects of a specific welding type on processes that are known to be related to lung disease and the development of cancer.
Metals, metalloids, and cancer
Phytopharmaceuticals in Cancer Chemoprevention
CRC Press 2004 Oct; 29-39
Because of their ability to produce free radicals, transition metals provide a unique means by which to study not only metal-related diseases but also the effects of free radicals on DNA damage, intracellular signaling, and cell-to-cell communication. These processes have been linked to the carcinogenic effects of these metals.
Arsenic
Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death
Mol Cell Biochem 2005 Nov; 279(1-2):123-131
The results from these studies indicate that the exposure of cells to NaAsO(2) resulted in cytotoxicity and cell death, at least in part, due to the inhibition of eIF4E gene expression leading to diminished cellular levels of critical genes such as cyclin D1.
Heat shock protein 70 as an indicator of early lung injury caused by exposure to arsenic
Mol Cell Biochem 2005 Sep; 277(1-2):153-164
The results from these studies suggest that cellular injury by arsenic is mediated through ROS generation resulting in the expression of Hsp70. It is possible that Hsp70 may prove to be a sensitive biomarker for arsenic exposure with other markers of oxidative stress in human serum.
Silica Exposure
Role of cyclinD1 and CDK4 in the carcinogenesis induced by silica
Biomed Environ Sci 2005 Oct; 18(5):286-296
During the progress of the malignant transformation of 2BS cells induced by silica CyclinD1 and CDK4 play an important role in maintaining transformed phenotype of the cancer cells.
Essential role of p53 in silica-induced apoptosis
Am J Physiol, Lung Cell Mol Physiol 2005 Mar; 288(3):L488-L496
Occupational exposure to mineral dusts, such as silica, has been associated with progressive pulmonary inflammation, lung cancer, and fibrosis. This study demonstrates for the first time that silica induces p53 transactivation via induction of p53 protein expression and phosphorylation of p53 protein and that p53 plays a crucial role in the signal transduction pathways of silica-induced apoptosis.
Other Occupational Exposures
Surface contamination of chemotherapy drug vials and evaluation of new vial-cleaning techniques: Results of three studies
Am J Health-System Pharmacy 2005. 62(5):475-484.
Transcriptional signatures of environmentally relevant exposures in normal human mammary epithelial cells: benzo(a)pyrene
Cancer Lett 2005 Apr; 221(2):201-211
These studies provide a complementary approach to molecular epidemiology for the investigation of differential susceptibility to chemical carcinogens, and specifically polycyclic aromatic hydrocarbons by investigating transcriptional signatures following relevant environmental exposures.
Pro/antioxidant status in murine skin following topical exposure to cumene hydroperoxide throughout the ontogeny of skin cancer
Biochemistry 2004 Jan; 69(1):30-40
Organic peroxides used in the chemical and pharmaceutical industries have a reputation for being potent skin tumor promoters and inducers of epidermal hyperplasia. These results suggest that COX-2-dependent oxidative metabolism is at least partially involved in Cum-OOH-induced inflammatory responses and thus tumor promotion.
Chemical carcinogenesis: recent advances and future directions
Rec Adv Res Upd 2003 Apr; 4(1):99-111
This article presents a perspective of the recent advancements in our knowledge of the process of chemical carcinogenesis.
Molecular Mechanisms
Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats
Mol Carcinog 2004 Jul; 40(3):150-159
These experiments indicate that the enhanced c-myc expression, common to all hepatic neoplasms in this system, coupled with enhanced expression of Igf2 in female TG+ rats, may be responsible for the increase in growth rate in hepatic neoplasms of female TG+ rats compared with that in livers of male TG+ rats and may contribute to neoplastic progression in the liver of this transgenic model.
Expression profile of eukaryotic translation factors in human cancer tissues and cell lines
Mol Carcinog 2004 Jul; 40(3):171-179
The results of these experiments indicate that human carcinogenesis is often associated with alterations in the expression of various translation factors especially the overexpression of eukaryotic translation elongation factor 1A2.
Genetic Studies
NAT2 slow acetylation and bladder cancer in workers exposed to benzidine
International Journal of Cancer, 2006; 118(1):161-168
This article expanded and updated an earlier NIOSH study on risk of bladder cancer from occupational exposures, and found that a particular type of metabolic activity in the body involving the enzyme NAT2 was associated with a decreased risk for bladder cancer from exposure to benzidine, even though the same activity is associated with an increased risk for bladder cancer from exposure to two other industrial chemicals, 2-naphthylamine and 4-aminobiphenyl. This finding suggests that the use of NAT2 as a signal for risk of occupational bladder cancer must be done in a "contextual" way that takes the type of chemical exposure into account. The potential use of such emerging knowledge for better identifying populations of at-risk workers represents an extraordinarily powerful tool for preventive occupational medicine.
Specific Chromosomal Aberrations in Mouse Lung Adenocarcinoma Cell Lines Detected by Spectral Karyotyping: A Comparison with Human Lung Adenocarcinoma
Cancer Res 2002 Feb; 62(4):1152-1157
This study utilizes spectral karyotyping to identify putative susceptibility genes for mouse lung adenocarcinoma. Chromosomal regions containing susceptibility genes linked to tumor size were frequently amplified, whereas regions with susceptibility loci linked to tumor multiplicity were deleted. Similar linkage groups are altered in human lung adenocarcinoma, implying that the mouse is a valid genetic model for the study of human lung adenocarcinoma susceptibility.
Detection of three novel translocation and specific common chromosomal break sites in malignant melanoma by spectral karyotyping
Genes Chromosomes Cancer 2001 Sep; 32(1):18-25
These studies identify three recurring translocations involving four of the most frequent chromosomal break points. The identification of recurring translocations and unique chromosome break points in melanoma will aid in the identification of the genes that are important in the neoplastic process.
Oxidative Stress
Signaling by carcinogenic metals and metal-induced reactive oxygen species
Mutat Res 2003 Dec; 533(1-2):183-200
This article reviews current literature on the effects of carcinogenic metals and metal-induced ROS on cancer-related signaling pathways. In addition, the mechanisms by which those changes occur and the role of those changes in carcinogenesis are discussed.
Generation of Reactive Oxygen Species in the Enzymatic Reduction of PbCrO4 and Related DNA Damage
Mol Cell Biochem 2002 May-Jun, 234-235(1-2):309-315
The reduction of insoluble PbCrO4 by glutathione reductase in the presence of NADPH as a cofactor generated hydroxyl radicals (OH) and caused DNA damage. The OH radicals generated by PbCrO4 caused DNA strand breakage.
Prevention
Inhibitory effect on activator protein-1, nuclear factor-kappaB, and cell transformation by extracts of strawberries (Fragaria xananassa Duch.)
J Agric Food Chem 2005 May; 53(10):4187-4193
The inhibitory effects of strawberry extracts on the proliferation and transformation of human and mouse cancer cells were evaluated. The strawberries may be highly effective as a chemopreventive agent that acts by targeting the down-regulation of AP-1 and NF-kappaB activities, blocking MAPK signaling, and suppressing cancer cell proliferation and transformation.
Suppressed NF-kB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-a induced apoptosis in human cancer cells
Carcinogenesis 2004 Nov; 25(11):2191-2199
These studies suggest that suppressed NF-kB activation and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-a-mediated cell death in human cancer cells.
Reproductive
An occupational reproductive research agenda for the third millennium
Environ Health Perspect 2003 Apr; 111(4):584-592
This article provides a review of the current knowledge about occupational exposure to toxic substances and potential reproductive outcomes, and focuses on recommendations for future directions in occupational reproductive health research.
Cardiovascular
Examining the brachial artery reactivity curve measured by B-Mode ultrasound in the Buffalo Cardio-Metabolic Occupational Police Stress Pilot Study
J Vasc Ultrasound 2005 Dec, 29(4):199-206
This study examines mean differences and correlations by gender for brachial reactivity and carotid artery wall thickness parameters among participants of the Buffalo Cardio-Metabolic Occupational Police Stress Pilot Study.
The Buffalo cardio-metabolic occupational police stress pilot study: methods and participant characteristics
Ann Epidemiol 2006 Feb,16(2):148-156
This publication describes the methods and general characteristics of police officers enrolled in the Buffalo Cardio-Metabolic Occupational Police Stress Pilot Study, a population-based study that assesses salivary cortisol as a physiologic measure of stress in relation to markers of subclinical cardiovascular diseases and metabolic abnormalities.
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