The Registry of Toxic Effects of Chemical Substances

Manganese

RTECS #: OO9275000

CAS #: 7439-96-5

UPDATE: May 2008 MW: 54.94 MF: Mn


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Colloidal manganese
  2. Magnacat
  3. Mangan (Polish)
  1. Mangan nitridovany (Czech)
  2. Manganese (ACGIH:OSHA)
  3. Tronamang


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 28ZPAK -,21,1972
skin
rabbit 		500 mg/24 hour mild 28ZPAK -,21,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
dominant lethal test intraperitoneal
rat 		25 mg/kg VCVN5* -,413,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 0.71 mg/m3 (15-16 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic NRTXDN 27,395,2006
inhalation
rat 		lowest published toxic concentration: 0.71 mg/m3 (multigeneration) Reproductive: Effects on newborn: Biochemical and metabolic NRTXDN 27,395,2006
oral
mouse 		lowest published toxic dose: 322.5 mg/kg (43 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 17,547,2003
oral
mouse 		lowest published toxic dose: 1,290 mg/kg (43 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct REPTED 17,547,2003
oral
rat 		lowest published toxic dose: 50 mg/kg (20 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral 		NRTXDN 23,635,2002
oral
rat 		lowest published toxic dose: 90 mg/kg (18 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects 		TOSCF2 92,516,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 400 mg/kg/1 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		NCIUS* PH43-64-886


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
man 		lowest published toxic concentration: 2,300 µg/m3 Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness 		AIHAAP 27,454,1966
oral
rat 		lethal dose (50 percent kill): 9 gm/kg N/R 28ZPAK -,21,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 250 mg/m3/1 year- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Irritability

Lung, Thorax, or Respiration: Other changes 		VCVN5* -,413,1989
inhalation
human 		lowest published toxic concentration: 0.5 mg/m3/39 week- intermittent Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Irritability 		VCVN5* -,413,1989
inhalation
man 		lowest published toxic concentration: 210 µg/m3/5 year- intermittent Endocrine: Other changes ACLSCP 26,10,1996
inhalation
monkey 		lowest published toxic concentration: 0.3 mg/m3/5 hour/26 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Immunological Including Allergic: Decrease in cellular immune response 		VCVN5* -,412,1989
inhalation
mouse 		lowest published toxic concentration: 0.7 mg/m3/24 hour/22 week- continuous Lung, Thorax, or Respiration: Fibrosis (interstitial)

Immunological Including Allergic: Decrease in cellular immune response 		VCVN5* -,412,1989
inhalation
rat 		lowest published toxic concentration: 3,709 mg/m3/6 hour/13 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes 		TOXID9 54,85,2000
inhalation
rat 		lowest published toxic concentration: 0.3 mg/m3/5 hour/26 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial)

Immunological Including Allergic: Decrease in cellular immune response 		VCVN5* -,412,1989
inhalation
rat 		lowest published toxic concentration: 0.7 mg/m3/24 hour/22 week- continuous Lung, Thorax, or Respiration: Fibrosis (interstitial)

Immunological Including Allergic: Decrease in cellular immune response 		VCVN5* -,412,1989
inhalation
rat 		: 0.71 mg/m3/2 hour/10 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins 		NRTXDN 27,395,2006
intraperitoneal
rat 		lowest published toxic dose: 180 mg/kg/30 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Other metals 		TOLED5 7,217,1981
intraperitoneal
rat 		lowest published toxic dose: 216 mg/kg/15 week- intermittent Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites TOXID9 44,122,2005
intraperitoneal
rat 		lowest published toxic dose: 144 mg/kg/5 week- intermittent Behavioral: Alteration of classical conditioning

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		TOXID9 44,122,2005
intraperitoneal
rat 		lowest published toxic dose: 57.6 mg/kg/4 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Change in psychophysiological tests 		TOXID9 66,205,2002
oral
rat 		lowest published toxic dose: 200 mg/kg/20 day- intermittent Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral 		NRTXDN 23,645,2002
oral
rat 		: 5.25 mg/kg/21 day- intermittent Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum 		NETEEC 28,323,2006
oral
rat 		lowest published toxic dose: 185 mg/kg/37 day- continuous Nutritional and Gross Metabolic: Changes in: Fe

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		TOSCF2 92,516,2006
unreported route
rat 		lowest published toxic dose: 24 mg/kg/5 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Ataxia

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) 		TOXID9 78,82,2004
unreported route
rat 		lowest published toxic dose: 72 mg/kg/5 week- intermittent Behavioral: Change in motor activity (specific assay) TOXID9 78,82,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
BCPCA6 66,1,2003
TOXICOLOGY REVIEW
ACLSCP 4,487,1974
TOXICOLOGY REVIEW
ADTEAS 5,51,1972
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
85DHAX Mn,1,1973
TOXICOLOGY REVIEW
PEXTAR 12,102,1969
TOXICOLOGY REVIEW
IMSUAI 24,1,1955
TOXICOLOGY REVIEW
CREOH* 42,25,2002
TOXICOLOGY REVIEW
TOLED5 134,17,2002
TOXICOLOGY REVIEW
MUREAV 613,103,2006
TOXICOLOGY REVIEW
NRTXDN 27,147,2006
TOXICOLOGY REVIEW
NRTXDN 27,304,2006
TOXICOLOGY REVIEW
NRTXDN 27,315,2006
TOXICOLOGY REVIEW
NRTXDN 27,333,2006
TOXICOLOGY REVIEW
NRTXDN 27,340,2006
TOXICOLOGY REVIEW
NRTXDN 27,347,2006
TOXICOLOGY REVIEW
NRTXDN 27,350,2006
TOXICOLOGY REVIEW
NRTXDN 27,362,2006
TOXICOLOGY REVIEW
NRTXDN 27,369,2006
TOXICOLOGY REVIEW
NRTXDN 27,429,2006
TOXICOLOGY REVIEW
MUREAV 613,76,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 5 mg/m3 DTLVS* 3,149,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 mg(Mn)/m3, fume CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 mg(Mn)/m3, fume CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m3, fume CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 mg(Mn)/m3, fume CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3 (fume), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3 (fume), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m3 (dust), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg(Mn)/m3 (fume), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3 (dust), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 mg/m3 (fume), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 1 mg/m3 (fume), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.5 mg(Mn)/m3 (inhalable), 2005
Occupational Exposure Limit - GERMANY MAK 0.5 mg/m3 (inhalable), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.3 mg/m3 (respirable dust), APR2007
Occupational Exposure Limit - KOREA time-weighted average 1 mg/m3, short term exposure limit 3 mg/m3 (fume);
2006
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3 (dust), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(Mn)/m3, 2004
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg(Mn)/m3;
short term exposure limit 3 mg(Mn)/m3, 2004
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg/m3, 2004
Occupational Exposure Limit - MEXICO time-weighted average 1 mg(Mn)/m3 (fume), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 mg/m3 (dust), JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 mg/m3;
short term exposure limit 3 mg/m3 (fume), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 0.1 mg/m3, short term exposure limit 0.6 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.2 mg/m3, (total dust);
time-weighted average 0.1 mg/m3, (resp. dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 5 mg/m3 (fume), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg(Mn)/m3, 2005
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.5 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MANGANESE COMPDS (as Mn)-air time-weighted average 1 mg/m3;
short term exposure limit 3 mg/m3 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 44000;
Number of Industries 29;
Total Number of Facilities 1,963;
Number of Occupations 53;
Total Number of Employees Exposed 19,787
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5920;
Number of Industries 2;
Total Number of Facilities 26;
Number of Occupations 4;
Total Number of Employees Exposed 305;
Total Number of Female Employees Exposed 71
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5992;
Number of Industries 9;
Total Number of Facilities 235;
Number of Occupations 9;
Total Number of Employees Exposed 4,560;
Total Number of Female Employees Exposed 12
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 44000;
Number of Industries 316;
Total Number of Facilities 66,404;
Number of Occupations 125;
Total Number of Employees Exposed 756,403;
Total Number of Female Employees Exposed 15,912


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108025)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the production of steel, and in the manufacture of welding rod coatings and fluxes
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
OSHA ANALYTICAL METHOD #ID-125G
OSHA ANALYTICAL METHOD #ID121


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl., Philadelphia, PA 19103) V.1- 1971-
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CREOH* Critical Reviews in Oncology/Hematology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1983-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by The Institute of Chemical Biology, University of San Francisco. (San Francisco, CA 94117)
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in the production of steel, and in the manufacture of welding rod coatings and fluxes

NIOSH PROFILE (HEAVY METAL GREASES AND SOAPS), SRI, 2/77

NIOSH PROFILE (MANGANESE), TIRC, 9/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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