Guidelines for PIs to
consider if submitting human genetics application to NIDA:
When preparing an application, researchers are strongly encouraged
to present a rationale that carefully balances important substantive,
methodological, and budgetary issues. In particular, applicants
are advised to address each of the following, when appropriate:
- Substantive focus with clear hypothesis (e.g., specific heritable
phenotypes, alternative phenotypes, endophenotypes)
- Sample selection (e.g., particularly informative sub-samples and
subgroups, understudied valuable populations) and generalizability
(i.e., population to which findings can be applied)
- Research design (e.g., genetically-informative, birth cohort, multi-generational,
selection by prenatal exposure, case-control)
- Statistical power (e.g., ability to detect effects within the proposed
study or in combination with other studies) and population stratification
- Number and timing of assessments when applicable (e.g., multiple
waves ranging from pre- to post-drug exposure, or from disorder onset
to remission)
- Selection and quality of assessments (e.g., diagnostic and/or symptom-based
scales, detailed measurement of salient individual and environmental
factors)
- Comorbidity (e.g., psychiatric, polysubstance, physical illness)
- Flexibility for future use of the data (e.g., consent forms have
potential for subsequent inquiry).
- Cost effectiveness
- Biomaterial collected to isolate genetic information (e.g., blood,
buccal cells, etc.)
- Compatibility/overlap with extant studies in the NIDA Genetics Consortium:
for a description of those studies see http://zork.wustl.edu/nida/study_descriptions/link.htm)
For studies requesting access to the NGC, the following additional
points need to be addressed:
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