Testing Information

Testing Status of Agents at NTP

2,4-Dichlorophenol

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http://ntp.niehs.nih.gov/go/TS-10557-D

CASRN: 120-83-2

Formula: C6-H4-CL2-O

Synonyms/Common Names:

  • DCP

Known Uses:

IN SYNTHESIS OF ANTIHELMINTHIC BITHIONOL SULFOXIDE. CHEMICAL INTERMEDIATE. (TDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C55345) Completed 
    • NTIS No. PB90-106170  (Peer Review 04/18/1988)
      Citation: Toxicology and Carcinogenesis Studies of 2,4-Dichlorophenol (CAS No. 120-83-2) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C55345) Completed 
    • NTIS No. PB90-106170  (Peer Review 04/18/1988)
      Citation: Toxicology and Carcinogenesis Studies of 2,4-Dichlorophenol (CAS No. 120-83-2) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0,2500,40000 PPM/10 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C55345) Report Complete 
    • TR-353 (NTIS No. PB90-106170)  (Peer Review 04/18/1988)
      Toxicology and Carcinogenesis Studies of 2,4-Dichlorophenol (CAS No. 120-83-2) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: FR: 0,2500,5000, MR&M: 0,5000,10000 PPM/50 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (884240) Completed 
    • Citation: Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 55-137
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Positive 
  • Mouse Lymphoma  (636821) Completed 
    • Citation: Myhr B.C., McGregor, D., Bowers, L., Riach, C., Brown, A., Edwards, I., McBride, D., Martin, R., and Caspary, W.J. L5178Y mouse lymphoma cell mutation assay results with 41 compounds. Environ. Molec. Mutagen. Vol. 16 (Suppl 18) (1990) 138-167
    •  Positive 
  • Salmonella  (247994) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Inconclusive 

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Web page last updated on November 24, 2008