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 Wednesday, January 15, 2009 Volume 22   Number 2
Family History Population Research Genomics in Practice General Public
This weekly update provides information about the impact of human genomic research on disease prevention & population health. open mailbox for email deliveryGet email updates

Field synopsis on genes and cancer susceptibility publishedField synopsis on genes and cancer susceptibility published
A new field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility non-gov warning icon published online December 30, 2008, in the Journal of the National Cancer Institute Advance Access found that at most three of 1,123 genetic associations examined had “strong” credibility based on the amount of evidence, extent of replication, and protection from bias.

> Read an editorial by Yesupriya A, Gwinn M, Khoury MJ non-gov warning icon
> Read memo to the media non-gov warning icon


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blue dotGenomics In The News
blue dotScientific Literature
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 Upcoming Events
Genomics Announcements
New article, How to use an article about genetic association: B. Are the results of the study valid?non-gov warning icon published in the January 14, 2009 issue of the Journal of the American Medical Association. Authors: Attia J, Ioannidis J, Thakkinstian A, McEvoy M, Scott RJ, Minelli C, et al.
Presentations and other materials from the NIH and CDC Personal Genomics Workshop in December 2008 are now available online non-gov warning icon

U.S. Department of Health and Human Services releases an updated and improved version of the Surgeon General’s Internet-based family health history tool. Read the news release

American Society of Human Genetics and Genetic Alliance are sponsoring a Family Health History Public Service Announcement Campaign non-gov warning icon in the Washington, DC area this month. Learn more about the campaign. PDF only (590KB)
New article, Public Awareness and Use of Direct-to-Consumer Genetic Tests: Results From 3 State Population-Based Surveys, 2006, non-gov warning icon published online (ahead of print) on December 23, 2008 in American Journal of Public Health. Authors: Goddard KA, Duquette D, Zlot A, Johnson J, Annis-Emeott A, Lee PW, et al.


The American Public Health Association (APHA) Genomics Forum non-gov warning icon makes a call for genomics-related abstracts PDF only(576KB) for the 137th APHA Annual Meeting & Expo to be held November 7-11, 2009, in Philadelphia, Pennsylvania. Deadline: February 10, 2009. For more information, contact Dean Hosgood

Genomics In The News

  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.

Birth Defects

Study of changes in MSX gene family over 600 million years leads to new understanding of disease patterns, non-gov warning icon Medical News Today, January 14



Glitches in DNA repair genes predict prognosis in pancreatic cancer, non-gov warning icon Medical News Today, January 14

New technology for detecting gene fusions opens field in cancer research, non-gov warning icon Medical News Today, January 12

Meta-analysis confirms value of risk-reducing salpingo-oophorectomy for women with BRCA mutations, non-gov warning icon EurekAlert, January 13



Ethical, Legal, and Social Issues (ELSI)

NHGRI to fund genomics ELSI centers, non-gov warning icon Genome Web, January 12


Family History

Govt pushes electronic family tree for good health, non-gov warning icon Associated Press, January 12

African-American family conversations: Leave your children a legacy of health, non-gov warning icon Tri-State Defender, January 9

Grow an electronic family tree for your health, non-gov warning icon msnbc, January 12

New “EHR-Ready” family health history tool is launched, non-gov warning icon CLOUD, January 9


Genetic Testing

Genetic testing: Do you really want to know, non-gov warning icon Yahoo News, January 15

Your genome is just a click away, non-gov warning icon Network World, January 9

Unraveling genome has great potential, but we're not there quite yet, non-gov warning icon Tampa Bay Online, January 11



Mental Health

Epilepsy linked to genetic defect on chromosome
, non-gov warning icon Science Daily, January 14
Variants in a gene on the X chromosome are associated with increased susceptibility..., non-gov warning icon Medical News Today, January 12

Missing DNA the culprit in epilepsy, non-gov warning icon News-Medical.Net, January 12

Dr. Francis Lee recognized for developing genetic test to guide the treatment of depression, non-gov warning icon Medical News Today, January 10



Overeating may be in the genes for some kids, non-gov warning icon msnbc, January 11

Obesity starts in the head? Six newly discovered genes for obesity have a neural effect, non-gov warning icon Webwire, January 8


Other News

Genetic disease first discovered in Quebec 24 year ago explained by scientists at the MUHC and McGill University, non-gov warning icon Medical News Today, January 15

My Genome, my self, non-gov warning icon The New York Times Magazine, January 11

Hope for normal diet in devastating PKU genetic disease, non-gov warning icon Medical News Today, January 15

Discovery of gene that increases susceptibility to Crohn's disease, non-gov warning icon Medical News Today, January 9

Human epigenome next frontier of genomic research at UC San Diego, non-gov warning icon Newswise, January 13

KEGG Spider: Interpretation of genomics data in the context of the global gene, non-gov warning icon eHealth News, January 9

Gene treatment helps blind resident, non-gov warning icon, January 12

UT leads $2.5 million training program in pioneering area of genetic research, non-gov warning icon Bio-Medicine, January 9

Mayo discovery could cure Parkinson's, Lou
, non-gov warning icon, January 12

Whole genome study reveals clues to solving the mystery behind Kawasaki disease, non-gov warning icon Medical News Today, January 9

Genomics in Scientific Literature
Featured Item

How to use an article about genetic association: A: Background concepts
Attia J, et al.
JAMA 2009 Jan;301(1):74-81

 General Articles

Toward a genetics of cancer resistance
Klein G
Proc Natl Acad Sci U S A 2009 Jan

Commentary: Trailblazing a Research Agenda at the Interface of Pediatrics and Genomic Discovery--a Commentary on the Psychological Aspects of Genomics and Child Health
McBride CM & Guttmacher AE
J Pediatr Psychol 2009 Jan

Convergent genome wide association results for bipolar disorder and substance dependence
Johnson C, et al.
Am J Med Genet B Neuropsychiatr Genet 2009 Jan

Accuracy of the BRCAPRO model among women with bilateral breast cancer
Ready KJ, et al.
Cancer 2009 Jan

Olfaction, psychiatric disorders and autoimmunity: is there a common genetic association?
Ortega-Hernandez OD, et al.
Autoimmunity 2009 Jan;42(1):80-8

Identifying rarer genetic variants for common complex diseases: diseased versus neutral discovery panels
Curtin K, et al.
Ann Hum Genet 2009 Jan;73(Pt 1):54-60

Hardy-Weinberg Equilibrium Testing of Biological Ascertainment for Mendelian Randomization Studies
Rodriguez S, et al.
Am J Epidemiol 2009 Jan

Genetic Counseling: A Medical Approach
Cavalli P
Genet Test 2009 Jan

Quantifying and correcting for the winner's curse in genetic association studies
Xiao R & Boehnke M
Genet Epidemiol 2009 Jan

Plasma lipoproteins: genetic influences and clinical implications
Hegele RA
Nat Rev Genet 2009 Jan

Pharmacogenomics of warfarin: uncovering a piece of the warfarin mystery
Gulseth MP, et al.
Am J Health Syst Pharm 2009 Jan;66(2):123-33

MegaSNPHunter: a learning approach to detect disease predisposition SNPs and high level interactions in genome wide association study
Wan X, et al.
BMC Bioinformatics 2009 Jan;10(1):13

 Family History

Impact of communicating familial risk of diabetes on illness perceptions and self-reported behavioural outcomes: A randomized controlled trial
Pijl M, et al.
Diabetes Care 2009 Jan

Obesity in post menopausal women with a family history of breast cancer: prevalence and risk awareness
Begum P, et al.
Int Semin Surg Oncol 2009 Jan;6(1):1


 Genetic Testing

DNA testing for live kidney donors at risk for autosomal dominant polycystic kidney disease
Huang E, et al.
Transplantation 2009 Jan;87(1):133-7

Motivating factors for physician ordering of factor V Leiden genetic tests
Hindorff LA, et al.
Arch Intern Med 2009 Jan;169(1):68-74

Multiple genetic tests for susceptibility to smoking do not outperform simple family history
Gartner CE, et al.
Addiction 2009 Jan;104(1):118-26

Psychosocial Aspects of DNA Testing for Hereditary Hemochromatosis in At-Risk Individuals: A Systematic Review
Picot J, et al.
Genet Test 2009 Jan

Potential Consumers' Attitudes Toward Psychiatric Genetic Research and Testing and Factors Influencing Their Intentions to Test
Laegsgaard MM, et al.
Genet Test 2009 Jan

TPMT testing before azathioprine therapy?
Drug Ther Bull 2009 Jan;47(1):9-12


 Genome Wide

A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease
Burgner D, et al.
PLoS Genet 2009 Jan;5(1):e1000319



Variants of the Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) Gene and Risk of Stroke: A HuGE Gene-Disease Association Review and Meta-Analysis
Zintzaras E, et al.
Am J Epidemiol 2009 Jan

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The CDC National Office of Public Health Genomics makes available the above information as a public service only. Providing this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

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Page last updated:January 15, 2009 (archived document)
Content Source: National Office of Public Health Genomics