Testing Status of Agents at NTP
Polysorbate 80 (glycol)
CASRN: 9005-65-6
Formula: C18-H33-O2
Synonyms/Common Names:
- GLYCOL
- POLYOXYETHYLENE SORBITAN MONOOLEATE
- TWEEN 80
- (Z)-SORBITAN MONO-9-OCTADECENOATE POLY(OXY-1,2-ETHANEDIYL)-(9CI)
Known Uses:
EMULSIFIER AND DISPERSING AGENT FOR INTERNAL MEDICINAL PRODUCTS. DEFOAMER IN FOODS. NEUTRALIZER FOR QUATERNARY AMMONIUM COMPOUNDS. (TDB)
Short-Term Toxicity
- 14-Day (Dosed-Feed)
(C60286) Completed
- NTIS No. PB92-189331/AS
(Peer Review 07/10/1991)
Citation: Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- NTIS No. PB92-189331/AS
(Peer Review 07/10/1991)
- 13-Week (Dosed-Feed)
(C60286) Completed
- NTIS No. PB92-189331/AS
(Peer Review 07/10/1991)
Citation: Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Dose: 0,.31,50 %/10 PER GROUP
- NTIS No. PB92-189331/AS
(Peer Review 07/10/1991)
Long-Term Carcinogenicity
- 2-YEAR (Dosed-Feed)
(C60286) Report Complete
- TR-415 (NTIS No. PB92-189331/AS)
(Peer Review 07/10/1991)
Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Equivocal Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: 0,2.5,5.0%/20 PER GROUP
- TR-415 (NTIS No. PB92-189331/AS)
(Peer Review 07/10/1991)
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(862010) Completed
- Chromosome Aberation Positive
- Sister Chromatid Exchange Negative
- Salmonella
(405466) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative
Organ Systems Toxicity
- Conventional Teratology (Gavage)
(TER91009) Completed
- NTIS No. PB93-123826
Citation: Final Report on the Developmental Toxicity of Polyoxyethylene Sorbitan Monooleate in Sprague-Dawley Rats - Rats: Sprague Dawley
- Rats Maternal Positive
- Rats Fetal Positive
- Dose: 0, 500, 5000 MG/KG/DAY
- NTIS No. PB93-123826
Web page last updated on November 24, 2008