National Toxicology Program

CASRN: 120-71-8

Related: M-CRESIDINE (CAS 102-50-1)

Formula: C8-H11-N-O

Synonyms/Common Names:

• 2-METHOXY-5-METHYLBENZENAMINE

Known Uses:

CHEMICAL INTERMEDIATE FOR DYES. (TDB)

Short-Term Toxicity

• 2-WEEK (Dosed-Feed)  (C02982B) Completed 
  • Mice: MMTV/RAS (Tg.SH); Mice: MMTV/MYC (Tg.M); Mice: MMTV/NEU (Tg.Nk)
  • Dose: 0, 2500, 5000, 10000, OR 20000 PPM
• 14-Day (Dosed-Feed)  (C02982) Completed 
  • NTIS No. PB295835  (Peer Review 06/29/1978)
    Citation: Bioassay of p-Cresidine for Possible Carcinogenicity (CAS No. 120-71-8)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C02982) Completed 
  • NTIS No. PB295835  (Peer Review 06/29/1978)
    Citation: Bioassay of p-Cresidine for Possible Carcinogenicity (CAS No. 120-71-8)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,.02,.3, M: 0,.04,.6 %/10 PER GROUP

Long-Term Carcinogenicity

• 26&39-WK (Dosed-Feed)  (C02982B) Completed 
  • Mice: MMTV/RAS (Tg.SH); Mice: MMTV/MYC (Tg.M); Mice: MMTV/NEU (Tg.Nk)
  • Dose: 0, 2500, OR 5000 PPM
• 2-Year (Dosed-Feed)  (C02982) Report Complete 
  • TR-142 (NTIS No. PB295835)  (Peer Review 06/29/1978)
    Bioassay of p-Cresidine for Possible Carcinogenicity (CAS No. 120-71-8)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Positive 
  • Female Rats Positive 
  • Male Mice Positive 
  • Female Mice Positive 
  • Dose: R: 0,.5,1.0, MM: 0,.22,.46, FM: 0,.22,.44 %/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (459789) Completed 
  • Chromosome Aberation Weakly Positive 
  • Sister Chromatid Exchange Weakly Positive 
• Micronucleus  (104686) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Salmonella (NCI)  (N-9378) Completed 
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli Environ. Mutagen. Vol. 7 (Suppl 5) (1985) 1-248
  • Salmonella-NCI  Positive 
• Salmonella  (496780) Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
  • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
  •  Positive