National Toxicology Program

CASRN: 72-54-8

Formula: C14 H10 CL4

Synonyms/Common Names:

• BENZENE, 1,1'-(2,2-DICHLOROETHYLIDENE)BIS(4-CHLORO- (9CI)
• RHOTHANE (TDE)
• TDE

Known Uses:

INSECTICIDE

Short-Term Toxicity

• 14-Day (Dosed-Feed)  (C00475) Completed 
  • NTIS No. PB286367  (Peer Review 06/29/1978)
    Citation: Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CAS No. 50-29-3, CAS No. 72-54-8, CAS No. 72-55-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
• 13-Week (Dosed-Feed)  (C00475) Completed 
  • NTIS No. PB286367  (Peer Review 06/29/1978)
    Citation: Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CAS No. 50-29-3, CAS No. 72-54-8, CAS No. 72-55-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Dose: R: 0,562,5620, M: 0,251,1590 PPM/5 PER GROUP

Long-Term Carcinogenicity

• 2-Year (Dosed-Feed)  (C00475) Report Complete 
  • TR-131 (NTIS No. PB286367)  (Peer Review 06/29/1978)
    Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CAS No. 50-29-3, CAS No. 72-54-8, CAS No. 72-55-9)
  • Rats: Osborne Mendel; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Equivocal 
  • Female Rats Negative 
  • Male Mice Negative 
  • Female Mice Negative 
  • Dose: FR: 0,850,1700 (AVG), MR: 0,1647,3294 (AVG), M: 0,411,822 (AVG) PPM/50 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (624997) Completed 
  • Chromosome Aberation Negative 
  • Sister Chromatid Exchange Negative 
• Salmonella  (748282) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Negative