| Alleviating Symptoms of Th2-Like Cytokine Mediated Disorders by Reducing IL-13 Receptor-Expressing Cells in the Respiratory Tract |
This invention relates to the alleviation of symptoms of Th2-like cytokine mediated disorders, such as allergy, asthma, and to hyperinflammatory responses in the respiratory tract to infectious diseases and parasitic infections, including tuberculosis, schistosomiasis, leishmania, and filariasis.
This invention claims a variety of methods and uses of a chimeric molecule comprising a toxic moiety and a targeting moiety that specificall... More ...
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| Novel Attenuated Strains of Mycobacterium Tuberculosis |
This invention provides for novel attenuated strains of Mycobacterium tuberculosis and M. bovis. Attenuation is achieved by deleting the gene encoding the alpha-crystallin heat shock protein ("acr gene"). This gene contributes to the virulence of the organism. Since this strain is isogenic with virulent M. tuberculosis but for this deletion, the full complement of antigens remains present and the organism is viable in v... More ...
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| Novel Anti-Mycobacterial Compositions and Their Use for the Treatment of Tuberculosis and Related Diseases |
This invention comprises a number of novel anti-mycobacterial compositions, which offer to significantly improve the treatment of mycobacterial infection such as tuberculosis. Mycobacterium is a genus of bacteria encompassing a number of organisms, many of which are highly pathogenic in humans. The most well known of these are M. tuberculosis, which causes pulmonary tuberculosis, and M. leprae, which causes leprosy. Tuberculo... More ...
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| Aerosolized Capreomycin for Inhibition of Pulmonary Tuberculosis |
This technology involves the methods of reformulation of Capreomycin for the aerosol treatment of pulmonary tuberculosis.
Tuberculosis is a devastating lung disease that is highly infectious and easily transmitted, especially in areas of overcrowding such as prisons. Furthermore, underdeveloped countries with large populations living in close quarters maintain an endemic disease reservoir limiting the health and economic viability of... More ...
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| Method of Diagnosing Multidrug Resistant Tuberculosis |
The invention relates to the discovery that a putative gene of Mycobacterium tuberculosis (MTb) with no previously identified function is responsible for the ability of the bacteria to activate a class of second line thioamide drugs used for MTb infections. The gene, termed "etaA", codes for the synthesis of a monooxigenase, the enzyme responsible for the oxidative activation of the drugs. Mutation in the etaA gene leads to the expression ... More ...
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| Mouse Fibroblasts Stably Expressing C-Type Lectin Receptors DC-SIGN and L-SIGN |
The NIH is pleased to offer for licensing mouse fibroblasts that stably express the C-type lectin receptors DC-SIGN and L-SIGN (CD209 and CD209L, respectively). L-SIGN and DC-SIGN both exhibit selectivity for highly mannosylated glycoproteins. DC-SIGN is also selective for certain Lewis X sugar groups. These types of interactions allow L-SIGN and DC-SIGN to interact with a wide spectrum of pathogens including HIV, hepatitis C virus, and SARS c... More ...
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