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Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001287 |
Chronic Inflammatory Demylinating Polyneuropathy (CIDP) is an autoimmune condition affecting the nervous system. Researchers believe the immune system begins attacking the cells covering nerves called myelin. The destruction of myelin causes muscle weakness, loss of sensation, abnormal levels of protein in the fluid surrounding the brain (CSF), and slowing of the nervous system. The disease progresses slowly and disables patients suffering from it.
CIDP is treated with steroids, plasmapheresis, and immunosuppressive drugs. Many patients initially respond to these treatments, but develop resistance to the therapy or experience side effects causing the treatments to be stopped.
Researchers believe that intravenous immunoglobulin (IVIg) may provide patients with CIDP a safer and more effective alternative to standard therapies for the disease. IVIg is a drug that has been used successfully to treat other immune-related diseases of the nervous system. However, because IVIg is so expensive, researchers believe it should first be proven effective on a small group of patients.
The study will take 60 patients with CIDP and divide them into two groups. Group one will receive 2 injections of IVIg once a month for three months. Group two will receive 2 injections of placebo "inactive injection of sterile water" once a month for three months. Following the three months of treatment, group one will begin taking the placebo and group two will begin taking IVIg for an additional 3 months. The drug will be considered effective if patients receiving it experience a significant improvement (>25%) in muscle strength.
Condition | Intervention | Phase |
---|---|---|
Demyelinating Diseases Paraproteinemias |
Drug: intravenous immunoglobulin (IVIg) |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Safety/Efficacy Study |
Official Title: | The Efficacy of High-Dose Intravenous Immunoglobulin in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) |
Estimated Enrollment: | 60 |
Study Start Date: | December 1990 |
Estimated Study Completion Date: | January 2001 |
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a slowly progressive disabling neuropathy characterized by subacute onset of muscle weakness, distal sensory deficit, elevated spinal fluid protein, and slow nerve conduction velocity with or without conduction block. A monoclonal gammopathy is at times present in the serum of some patients. Because immune-mediated mechanisms against peripheral nerve myelin are thought to be primarily responsible for the clinical manifestations of CIDP, the treatment of choice is with corticosteroids, plasmapheresis or immunosuppressive drugs. Although many patients initially respond to these agents, a large number of them become resistant or develop unacceptable side effects that necessitate their discontinuation. The need for a more effective and safe immunotherapy in CIDP patients prompted the present study using high-dose intravenous immunoglobulin (IVIg). IVIg is an immunomodulating agent which has been recently shown to be effective and safe in the treatment of a number of patients with immune-related neuromuscular diseases.
This is a double blind, randomized, placebo controlled, trial involving 60 patients, half of which will receive IVIg and the other half placebo (D5/W). Because IVIg is prohibitively expensive, a controlled trial is needed to provide convincing evidence of efficacy, and ensure that the benefit is not due to spontaneous improvement or to observer bias. The dose of IVIg is 2 GM/Kg divided into two daily doses administered monthly for six months. The drug will be considered effective if patients experience an increase of more than 25% in their baseline muscle strength. Muscle strength will be assessed with a series of objective dynamometric measurements performed before and after each monthly infusion.
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Selected patients should have CIDP with or without an associated monoclonal gammopathy.
Subjects should have clinical evidence of peripheral neuropathy with muscle weakness and sensory deficit.
Subjects should have evidence of clinical, histological or family history of another neuromuscular illness.
Subjects should have elevation of CSF protein during the course of the disease.
Subjects should have demyelination by nerve conduction study and/or nerve biopsy.
Suitable candidates for IVIg should be patients with active, bonefide CIDP who:
Subjects should not be pregnant or nursing.
Subjects should not be critically ill such as those requiring intravenous pressors for maintenance of cardiac output, patients with unstable respiratory insufficiency and patients with such severe muscle weakness requiring help for basic self care (Karnofsky performance scale less than 50).
No subjects below 18 years of age.
Patients should not have severe renal or hepatic disease and severe COPD or coronary artery disease.
Patients should not be allergic to IVIg or have a known IgA deficiency.
Study ID Numbers: | 910039, 91-N-0039 |
Study First Received: | November 3, 1999 |
Last Updated: | March 3, 2008 |
ClinicalTrials.gov Identifier: | NCT00001287 |
Health Authority: | United States: Federal Government |
Intravenous High-Dose Immunoglobulin Monoclonal Gammopathies Peripheral Nerve Demyelination CIDP Chronic Inflammatory Demyelinating Polyneuropathy |
Immunoproliferative Disorders Autoimmune Diseases Demyelinating Diseases Polyradiculoneuropathy Blood Protein Disorders Hematologic Diseases Polyneuropathies Paraproteinemias Demyelinating diseases Chronic inflammatory demyelinating polyneuropathy |
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating Antibodies Neuromuscular Diseases Immunoglobulins, Intravenous Peripheral Nervous System Diseases Rho(D) Immune Globulin Monoclonal gammopathy of undetermined significance Autoimmune Diseases of the Nervous System Immunoglobulins |
Immunologic Factors Immune System Diseases Physiological Effects of Drugs Nervous System Diseases Pharmacologic Actions |