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Method Development for the Analysis of Pbdes in Human Placenta Tissue
Principal Investigator
Li, An
Institute Receiving Award
University of Illinois at Chicago
Location
Chicago, IL
Grant Number
R03ES015608
Funding Organization
National Institute of Environmental Health Sciences
Award Funding Period
08 Jun 2007to31 Mar 2009
DESCRIPTION (provided by applicant): A large number of human placenta samples have been collected from a multi-racial cohort children health study at the Boston Medical Center and another study entitled "Family and Children of Ukraine". The work proposed here is a small project aimed at developing a laboratory procedure for the analysis of polybrominated diphenyl ethers (PBDEs) in human placental tissues. The work will include three tasks: analytical method development and validation, examination on the integrity of stored samples, and a preliminary data collection. We will explore the applicability of a matrix solid-phase dispersion (MSPD) method and compare it with the standard and conventional procedures. Analytical sensitivity enhancement will be through the optimization of the GC injection process using a programmable temperature vaporization (PTV) large volume injector. The result of this work will be needed to initiate future comprehensive studies on prenatal exposure of human to PBDEs. A laboratory procedure is to be developed in order to understand how a wide-spread environmental pollutant affects the health of human fetus before babies are born.
Crisp Terms/Key Words: high throughput technology, method development, animal tissue, glycerol, placenta, human tissue, halobiphenyl /halotriphenyl compound, analytical method
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