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Volume 358(1433);  May 29, 2003
Introduction
Raymond A. Dwek
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 845–846. doi: 10.1098/rstb.2003.1281.
PMCID: PMC1693189
Biosynthesis and degradation of mammalian glycosphingolipids.
Konrad Sandhoff and Thomas Kolter
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 847–861. doi: 10.1098/rstb.2003.1265.
PMCID: PMC1693173
Formation of functional cell membrane domains: the interplay of lipid- and protein-mediated interactions.
Thomas Harder
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 863–868. doi: 10.1098/rstb.2003.1274.
PMCID: PMC1693179
The fate and function of glycosphingolipid glucosylceramide.
Gerrit van Meer, Jasja Wolthoorn, and Sophie Degroote
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 869–873. doi: 10.1098/rstb.2003.1266.
PMCID: PMC1693184
Generation of CD1 tetramers as a tool to monitor glycolipid-specific T cells.
Stephan D Gadola, Anastasios Karadimitris, Nathan R Zaccai, Mariolina Salio, Nicolas Dulphy, Dawn Shepherd, E Yvonne Jones, and Vincenzo Cerundolo
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 875–877. doi: 10.1098/rstb.2003.1267.
PMCID: PMC1693178
Glycosphingolipid functions: insights from engineered mouse models.
Richard L Proia
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 879–883. doi: 10.1098/rstb.2003.1268.
PMCID: PMC1693182
Endocytic trafficking of glycosphingolipids in sphingolipid storage diseases.
Richard E Pagano
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 885–891. doi: 10.1098/rstb.2003.1275.
PMCID: PMC1693187
Neurobiology and cellular pathogenesis of glycolipid storage diseases.
Steven U Walkley
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 893–904. doi: 10.1098/rstb.2003.1276.
PMCID: PMC1693176
Biochemistry of glycosphingolipid storage disorders: implications for therapeutic intervention.
Johannes M Aerts, Carla Hollak, Rolf Boot, and Ans Groener
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 905–914. doi: 10.1098/rstb.2003.1273.
PMCID: PMC1693181
Enzyme replacement therapy: conception, chaos and culmination.
Roscoe O Brady
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 915–919. doi: 10.1098/rstb.2003.1269.
PMCID: PMC1693186
Gene therapy: prospects for glycolipid storage diseases.
Volkmar Gieselmann, Ulrich Matzner, Diana Klein, Jan Eric Mansson, Rudi D'Hooge, Peter D DeDeyn, Renate Lüllmann Rauch, Dieter Hartmann, and Klaus Harzer
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 921–925. doi: 10.1098/rstb.2003.1277.
PMCID: PMC1693175
Small-molecule therapeutics for the treatment of glycolipid lysosomal storage disorders.
Terry D Butters, Howard R Mellor, Keishi Narita, Raymond A Dwek, and Frances M Platt
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 927–945. doi: 10.1098/rstb.2003.1278.
PMCID: PMC1693180
Substrate reduction therapy in mouse models of the glycosphingolipidoses.
Frances M Platt, Mylvaganam Jeyakumar, Ulrika Andersson, Tanya Heare, Raymond A Dwek, and Terry D Butters
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 947–954. doi: 10.1098/rstb.2003.1279.
PMCID: PMC1693185
Substrate reduction therapy: clinical evaluation in type 1 Gaucher disease.
Chris Moyses
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 955–960. doi: 10.1098/rstb.2003.1271.
PMCID: PMC1693174
Gaucher disease and the clinical experience with substrate reduction therapy.
Ari Zimran and Deborah Elstein
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 961–966. doi: 10.1098/rstb.2003.1272.
PMCID: PMC1693183
Future perspectives for glycolipid research in medicine.
Timothy M Cox
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 967–973. doi: 10.1098/rstb.2003.1270.
PMCID: PMC1693188
A historical perspective of the glycosphingolipids and sphingolipidoses.
Richard W E Watts
Philos Trans R Soc Lond B Biol Sci. 2003 May 29; 358(1433): 975–983. doi: 10.1098/rstb.2003.1280.
PMCID: PMC1693177
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