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Highly Pathogenic H5N1 Influenza Virus Infection in Migratory Birds
J. Liu,1*H. Xiao,2,4*F. Lei,3*Q. Zhu,5K. Qin,1X.-w. Zhang,6X.-l. Zhang,1D. Zhao,1G. Wang,2,4Y. Feng,2,4J. Ma,2W. Liu,2J. Wang,6G. F. Gao2
H5N1 avian influenza virus (AIV) has emerged as a pathogenicentity for a variety of species, including humans, in recentyears. Here we report an outbreak among migratory birds on LakeQinghaihu, China, in May and June 2005, in which more than athousand birds were affected. Pancreatic necrosis and abnormalneurological symptoms were the major clinical features. Sequencingof the complete genomes of four H5N1 AIV strains revealed themto be reassortants related to a peregrine falcon isolate fromHong Kong and to have known highly pathogenic characteristics.Experimental animal infections reproduced typical highly pathogenicAIV infection symptoms and pathology.
1 College of Veterinary Medicine, China Agricultural University, Beijing 100094, China. 2 Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China. 3 Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. 4 Graduate School, Chinese Academy of Sciences, Beijing, China. 5 Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China. 6 Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China.
* These authors contributed equally to this work.
To whom correspondence should be addressed. E-mail: gaof{at}im.ac.cn (G.F.G); jhl{at}cau.edu.cn (J.L.)
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