Volume 10, Number 12, December 2004

Avian Influenza H5N1 in Tigers and Leopards

Juthatip Keawcharoen,* Kanisak Oraveerakul,* Thijs Kuiken,† Ron A.M. Fouchier,† Alongkorn Amonsin,* Sunchai Payungporn,* Suwanna Noppornpanth,† Sumitra Wattanodorn,* Apiradee Theamboonlers,* Rachod Tantilertcharoen,* Rattapan Pattanarangsan,‡ Nlin Arya,‡ Parntep Ratanakorn,‡ Albert D.M.E. Osterhaus,† and Yong Poovorawan*
*Chulalongkorn University, Bangkok, Thailand; †Erasmus Medical Centre, Rotterdam, the Netherlands; and ‡Mahidol University, Salaya, Nakorn Pathom, Thailand

Figure 1. Histopathologic and immunohistochemical evidence of avian influenza A (H5N1) virus in leopard lung. A) Diffuse alveolar damage in the lung: alveoli and bronchioles (between arrowheads) are flooded with edema fluid and inflammatory cells. B) Inflammatory cells in alveolar lumen consist of alveolar macrophages (arrowhead) and neutrophils (arrow). C) Many cells in affected lung tissue express influenza virus antigen, visible as brown staining. D) Expression of influenza virus antigen in a bronchiole is visible mainly in nuclei of epithelial cells.

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This page last reviewed October 22, 2004

Emerging Infectious Diseases Journal
National Center for Infectious Diseases
Centers for Disease Control and Prevention